{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:11:23Z","timestamp":1769047883989,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T00:00:00Z","timestamp":1562371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.nrleng.2017.10.006","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T08:09:19Z","timestamp":1563264559000},"page":"369-376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epigenetic changes in headache"],"prefix":"10.1016","volume":"36","author":[{"given":"M.S.","family":"C\u00e1mara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mart\u00edn Bujanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mendioroz Iriarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nrleng.2017.10.006_bib0260","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S1474-4422(07)70126-6","article-title":"Migraine: a complex genetic disorder","volume":"6","author":"Wessman","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0265","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1056\/NEJMra010917","article-title":"Migraine \u2013 current understanding and treatment","volume":"346","author":"Goadsby","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0270","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1468-2982.2002.00310.x","article-title":"CGRP may play a causative role in migraine","volume":"22","author":"Lassen","year":"2002","journal-title":"Cephalalgia"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0275","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1056\/NEJMoa030505","article-title":"Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine","volume":"350","author":"Olesen","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0280","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(08)61626-8","article-title":"Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial","volume":"372","author":"Ho","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0285","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1212\/WNL.0b013e3181b87942","article-title":"Randomized, controlled trial of telcagepant for the acute treatment of migraine","volume":"73","author":"Connor","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0290","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s10194-015-0576-7","article-title":"DNA methylation of RAMP1 gene in migraine: an exploratory analysis","volume":"16","author":"Wan","year":"2015","journal-title":"J Headache Pain"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0295","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1177\/0333102410391487","article-title":"Epigenetic regulation of the calcitonin gene-related peptide gene in trigeminal glia","volume":"31","author":"Park","year":"2011","journal-title":"Cephalalgia"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0300","doi-asserted-by":"crossref","first-page":"e87616","DOI":"10.1371\/journal.pone.0087616","article-title":"Methylation of migraine-related genes in different tissues of the rat","volume":"9","author":"Labruijere","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0305","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/nn.2900","article-title":"Neuronal activity modifies the DNA methylation landscape in the adult brain","volume":"14","author":"Guo","year":"2011","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0310","article-title":"Epigenetic DNA methylation changes associated with headache chronification: a retrospective case\u2013control study","volume":"1","author":"Winsvold","year":"2017","journal-title":"Cephalalgia"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0315","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nm0202-136","article-title":"Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model","volume":"8","author":"Bolay","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2010.03.001","article-title":"Epigenetic chromatin modifications in the cortical spreading depression","volume":"1329","author":"Passaro","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0325","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.brainres.2012.05.043","article-title":"Cortical spreading depression differentially affects lisien methylation of H3 histone at neuroprotective genes and retrotransposon sequences","volume":"1467","author":"Rana","year":"2012","journal-title":"Brain Res"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0330","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tips.2004.12.008","article-title":"Medication-overuse headache: similarities with drug addiction","volume":"26","author":"Calabresi","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0335","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11916-011-0240-0","article-title":"Dependent behavior in patients with medication-overuse headache","volume":"16","author":"Fuh","year":"2012","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0340","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1212\/WNL.57.9.1694","article-title":"Clinical features of withdrawal headache following overuse of triptans and other headache drugs","volume":"57","author":"Katsarava","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0345","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1073\/pnas.1213364110","article-title":"HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner","volume":"110","author":"Malvaez","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0350","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40246-015-0051-1","article-title":"HDAC3 role in medication consumption in medication overuse headache patients: a pilot study","volume":"9","author":"Pisanu","year":"2015","journal-title":"Human Genomics"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0355","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1523\/JNEUROSCI.18-14-05124.1998","article-title":"Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury","volume":"18","author":"Herdegen","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0360","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0301-0082(99)00042-8","article-title":"JNK and p38 stresskinases \u2013 degenerative effectors of signal-transduction-cascades in the nervous system","volume":"61","author":"Mielke","year":"2000","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0365","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0092-8674(91)90241-P","article-title":"Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity","volume":"64","author":"Boyle","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0370","first-page":"3507","article-title":"Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73","volume":"12","author":"Smeal","year":"1992","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0375","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.bbrc.2008.09.073","article-title":"JNK1 regulates histone acetylation in trigeminal neurons following chemical stimulation","volume":"376","author":"Wu","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0380","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.nbd.2014.08.003","article-title":"MicroRNAs as modulators and biomarkers of inflammatory and neuropathic pain conditions","volume":"71","author":"Andersen","year":"2014","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0385","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00296-014-3139-3","article-title":"Profile of circulating microRNAs in fibromyalgia and their relation to symptom severity: an exploratory study","volume":"35","author":"Bjersing","year":"2015","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0390","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.gene.2011.03.003","article-title":"MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis","volume":"480","author":"Li","year":"2011","journal-title":"Gene"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0395","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1007\/s12035-015-9106-5","article-title":"Serum microRNA signatures in migraineurs during attacks and in pain-free periods","volume":"53","author":"Andersen","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0400","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3109\/07853890.2015.1071871","article-title":"MicroRNA profiling in migraine without aura: pilot study","volume":"47","author":"Tafuri","year":"2015","journal-title":"Ann Med"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0405","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S1359-6446(05)03637-8","article-title":"The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets","volume":"11","author":"Myers","year":"2006","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0410","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1529-8027.2010.00260.x","article-title":"Traumaticperipheral nerve injuries: epidemiological findings, neuropathic pain and quality of life in 158 patients","volume":"15","author":"Ciaramitaro","year":"2010","journal-title":"J Peripher Nerv Syst"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0415","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1302\/0301-620X.94B4.28483","article-title":"Nerve injuries sustained during warfare: Part I. Epidemiology","volume":"94","author":"Birch","year":"2012","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0420","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1212\/WNL.0b013e31827b1aa1","article-title":"Inflammation in complex regional pain syndrome: a systematic review and metaanalysis","volume":"80","author":"Parkitny","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0425","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pain.2007.07.031","article-title":"Differential expression patterns of cytokines in complex regional pain syndrome","volume":"132","author":"\u00dcceyler","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0430","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.pain.2010.07.020","article-title":"Anti-inflammatory treatment of complex regional pain syndrome","volume":"151","author":"Fischer","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0435","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1474-4422(11)70106-5","article-title":"Clinical features and pathophysiology of complex regional pain syndrome","volume":"10","author":"Marinus","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0440","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fnmol.2013.00033","article-title":"MicroRNAs in nociceptive circuits as predictors of future clinical applications","volume":"6","author":"Kress","year":"2013","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0445","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/j.1532-2149.2012.00197.x","article-title":"Regulation of \u03bc-opioid type 1 receptors by microRNA134 in dorsal root ganglion neurons following peripheral inflammation","volume":"17","author":"Ni","year":"2013","journal-title":"Eur J Pain"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0450","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pain.2012.09.002","article-title":"MicroRNA-mediated GABA A\u03b1-1 receptor subunit down-regulation in adult spinal cord following neonatal cystitis-induced chronic visceral pain in rats","volume":"154","author":"Sengupta","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0455","doi-asserted-by":"crossref","first-page":"10860","DOI":"10.1523\/JNEUROSCI.1980-10.2010","article-title":"Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds","volume":"30","author":"Zhao","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0460","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1038\/emboj.2011.249","article-title":"Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain","volume":"30","author":"Favereaux","year":"2011","journal-title":"EMBO J"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0465","doi-asserted-by":"crossref","first-page":"15294","DOI":"10.1523\/JNEUROSCI.0921-11.2011","article-title":"Change in microRNAs associated with neuronal adaptive responses in the nucleus accumbens under neuropathic pain","volume":"31","author":"Imai","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0470","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1744-8069-3-15","article-title":"Down regulation of selective microRNAs in trigeminal ganglion neurons following inflammatory muscle pain","volume":"3","author":"Bai","year":"2007","journal-title":"Mol Pain"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0475","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.neuroscience.2009.08.033","article-title":"Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation","volume":"164","author":"Aldrich","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0480","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1744-8069-7-17","article-title":"Differential expression of microRNAs in mouse pain models","volume":"7","author":"Kusuda","year":"2011","journal-title":"Mol Pain"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0485","first-page":"e1","article-title":"MicroRNA changes in the mouse prefrontal cortex after inflammatory pain","volume":"801","author":"Poh","year":"2011","journal-title":"Eur J Pain"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0490","doi-asserted-by":"crossref","first-page":"e17670","DOI":"10.1371\/journal.pone.0017670","article-title":"Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain","volume":"6","author":"Von Schack","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0495","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/pme.12066","article-title":"The miRNA and mRNA changes in rat hippocampi after chronic constriction injury","volume":"14","author":"Arai","year":"2013","journal-title":"Pain Med"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0500","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3892\/ijmm.2012.1163","article-title":"MicroRNA changes in the dorsal horn of the spinal cord of rats with chronic constriction injury: a TaqMan\u00ae Low Density Array study","volume":"31","author":"Genda","year":"2013","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0505","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbrc.2013.04.089","article-title":"Nerve injury-induced up regulation of miR-21 in the primary sensory neurons contributes to neuropathic pain in rats","volume":"435","author":"Sakai","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.nrleng.2017.10.006_bib0510","doi-asserted-by":"crossref","first-page":"460","DOI":"10.33588\/rn.6310.2016091","article-title":"P\u00e9ptido relacionado con el gen de la calcitonina: un neurop\u00e9ptido clave en la migra\u00f1a","volume":"63","author":"Ramos-Romero","year":"2016","journal-title":"Rev Neurol"}],"container-title":["Neurolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580819301002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580819301002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T03:32:06Z","timestamp":1761881526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2173580819301002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S2173580819301002"],"URL":"https:\/\/doi.org\/10.1016\/j.nrleng.2017.10.006","relation":{},"ISSN":["2173-5808"],"issn-type":[{"value":"2173-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic changes in headache","name":"articletitle","label":"Article Title"},{"value":"Neurolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nrleng.2017.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.nrl.2017.10.010","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Sociedad Espa\u00f1ola de Neurolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}