{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:06:39Z","timestamp":1761887199509,"version":"build-2065373602"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005343","name":"Fundaci\u00f3n IMSS","doi-asserted-by":"publisher","award":["FIS\/IMSS\/PROT\/G13\/1195","FIS\/IMSS\/PROT\/PRIO\/13\/023","FIS\/IMSS\/PROT\/G16\/1616"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/G13\/1195","FIS\/IMSS\/PROT\/PRIO\/13\/023","FIS\/IMSS\/PROT\/G16\/1616"]}],"id":[{"id":"10.13039\/501100005343","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.nrleng.2018.01.011","type":"journal-article","created":{"date-parts":[[2019,11,10]],"date-time":"2019-11-10T16:02:35Z","timestamp":1573401755000},"page":"337-345","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of genetic risk factors associated with ischaemic stroke in young Mexican patients"],"prefix":"10.1016","volume":"36","author":[{"given":"M.C.","family":"Jim\u00e9nez-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Santiago-Germ\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.F.","family":"Castillo-Henkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Alvarado-Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hern\u00e1ndez-Ju\u00e1rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lea\u00f1os-Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Majluf-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Isordia-Salas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.nrleng.2018.01.011_bib0005","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/CIRCRESAHA.115.306841","article-title":"Global burden of thrombosis: epidemiologic aspects","volume":"118","author":"Wendelboe","year":"2016","journal-title":"Circ Res"},{"issue":"12","key":"10.1016\/j.nrleng.2018.01.011_bib0010","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1161\/STROKEAHA.115.010954","article-title":"Nontraditional risk factors for ischemic stroke: an update","volume":"46","author":"Bang","year":"2015","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.nrleng.2018.01.011_bib0015","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/STROKEAHA.108.529883","article-title":"Analysis of 1008 consecutive patients aged 15 to 49 with first-ever ischemic stroke: the Helsinki young stroke registry","volume":"40","author":"Putaala","year":"2009","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.nrleng.2018.01.011_bib0020","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S1474-4422(10)70251-9","article-title":"Aetiological diagnosis of ischaemic stroke in young adults","volume":"9","author":"Ferro","year":"2010","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.nrleng.2018.01.011_bib0025","first-page":"93","article-title":"Factores gen\u00e9ticos del sistema hemost\u00e1tico en pacientes j\u00f3venes con infarto agudo de miocardio","volume":"78","author":"Isordia-Salas","year":"2010","journal-title":"Cir Cir"},{"issue":"10","key":"10.1016\/j.nrleng.2018.01.011_bib0030","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1111\/j.1538-7836.2005.01280.x","article-title":"The Discovery of TAFI","volume":"3","author":"Nesheim","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"6","key":"10.1016\/j.nrleng.2018.01.011_bib0035","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1182\/blood.V98.6.1992","article-title":"A novel, possibly functional, single nucleotide polymorphism in the coding region of the thrombin-activatable fibrinolysis inhibitor (TAFI) gene is also associated with TAFI levels","volume":"98","author":"Brouwers","year":"2001","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.nrleng.2018.01.011_bib0040","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1074\/jbc.M104444200","article-title":"Two naturally occurring variants of TAFI (Thr-325 and Ile-325) differ substantially with respect to thermal stability and antifibrinolytic activity of the enzyme","volume":"277","author":"Schneider","year":"2002","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.nrleng.2018.01.011_bib0045","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1182\/blood.V97.7.2053","article-title":"Identification of polymorphisms in the promoter and the 3\u2019 region of the TAFI gene: evidence that plasma TAFI antigen levels are strongly genetically controlled","volume":"97","author":"Henry","year":"2001","journal-title":"Blood"},{"issue":"24","key":"10.1016\/j.nrleng.2018.01.011_bib0050","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1056\/NEJM200006153422406","article-title":"Plasminogen-activator inhibitor type 1 and coronary artery disease","volume":"342","author":"Kohler","year":"2000","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1016\/j.nrleng.2018.01.011_bib0055","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1161\/01.CIR.99.19.2496","article-title":"Increased plasminogen activator inhibitor-1 and vasculopaty. A reconcilable paradox","volume":"99","author":"Sobel","year":"1999","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.nrleng.2018.01.011_bib0060","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/01.CIR.99.1.e1","article-title":"Evaluation of platelet membrane glycoproteins in coronary artery disease","volume":"99","author":"Gawaz","year":"1999","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.nrleng.2018.01.011_bib0065","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1172\/JCI114082","article-title":"The human platelet alloantigens, PLA1 and PLA2, are associated with a leucine33\/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing","volume":"83","author":"Newman","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nrleng.2018.01.011_bib0070","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.med.47.1.365","article-title":"The vascular biology of nitric oxide and its role in atherogenesis","volume":"47","author":"Lloyd-Jones","year":"1996","journal-title":"Annu Rev Med"},{"issue":"23","key":"10.1016\/j.nrleng.2018.01.011_bib0075","doi-asserted-by":"crossref","first-page":"17478","DOI":"10.1016\/S0021-9258(19)85359-0","article-title":"Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene","volume":"268","author":"Marsden","year":"1993","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.nrleng.2018.01.011_bib0080","doi-asserted-by":"crossref","first-page":"H1908","DOI":"10.1152\/ajpheart.2001.281.5.H1908","article-title":"eNOS 894T allele and coronary blood flow at rest and during adenosine-induced hyperemia","volume":"281","author":"Naber","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"10.1016\/j.nrleng.2018.01.011_bib0085","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nutr Genet"},{"issue":"1","key":"10.1016\/j.nrleng.2018.01.011_bib0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial: TOAST: Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.nrleng.2018.01.011_bib0095","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1161\/01.STR.0000063139.06585.45","article-title":"Thrombin-activable fibrinolysis inhibitor levels in the acute phase of ischemic stroke","volume":"34","author":"Montaner","year":"2003","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/j.nrleng.2018.01.011_bib0100","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1111\/j.1538-7836.2005.01484.x","article-title":"High functional levels of thrombin-activatable fibrinolysis inhibitor are associated with an increased risk of first ischemic stroke","volume":"3","author":"Leebeek","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"4","key":"10.1016\/j.nrleng.2018.01.011_bib0105","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1161\/01.ATV.0000259354.93789.a6","article-title":"Thrombin activatable fibrinolysis inhibitor activation peptide shows association with all major subtypes of ischemic stroke and with TAFI gene variation","volume":"27","author":"Ladenvall","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10.1016\/j.nrleng.2018.01.011_bib0110","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/j.1538-7836.2009.03350.x","article-title":"The role of thrombin activatable fibrinolysis inhibitor in arterial thrombosis at a young age: the ATTAC study","volume":"7","author":"de Bruijne","year":"2009","journal-title":"J Thromb Haemost"},{"issue":"3","key":"10.1016\/j.nrleng.2018.01.011_bib0115","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.thromres.2014.06.023","article-title":"Genetic variations in the thrombin-activatable fibrinolysis inhibitor gene and risk of cardiovascular disease: a systematic review and meta-analysis","volume":"134","author":"Shi","year":"2014","journal-title":"Thromb Res"},{"issue":"10","key":"10.1016\/j.nrleng.2018.01.011_bib0120","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1111\/j.1538-7836.2005.01484.x","article-title":"High functional levels of thrombin-activatable fibrinolysis inhibitor are associated with an increased risk of first ischemic stroke","volume":"3","author":"Leebeek","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"4","key":"10.1016\/j.nrleng.2018.01.011_bib0125","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1365-2141.2004.05219.x","article-title":"TAFI polymorphisms at amino acids 147 and 325 are not risk factors for cerebral infarction","volume":"127","author":"Akatsu","year":"2004","journal-title":"Br J Haematol"},{"issue":"5","key":"10.1016\/j.nrleng.2018.01.011_bib0130","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1160\/TH09-10-0682","article-title":"Association between the Thr325Ile polymorphism of the thrombin-activatable fibrinolysis inhibitor and stroke in the Ludwigshafen Risk and Cardiovascular Health Study","volume":"103","author":"Kozian","year":"2010","journal-title":"Thromb Haemost"},{"issue":"10","key":"10.1016\/j.nrleng.2018.01.011_bib0135","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1161\/01.STR.28.10.1913","article-title":"Risk factors for stroke due to cerebral infarction in young adults","volume":"28","author":"You","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.nrleng.2018.01.011_bib0140","doi-asserted-by":"crossref","first-page":"6519704","DOI":"10.1155\/2017\/6519704","article-title":"Hypofibrinolytic State in Subjects with Type 2 diabetes mellitus aggravated by the metabolic syndrome before clinical manifestations of atherothrombotic disease","volume":"2017","author":"Aburto-Mej\u00eda","year":"2017","journal-title":"Biomed Res Int"},{"issue":"10","key":"10.1016\/j.nrleng.2018.01.011_bib0145","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1161\/STROKEAHA.111.622217","article-title":"Plasminogen activator inhibitor-1 and thrombotic cerebrovascular diseases","volume":"43","author":"Tj\u00e4rnlund-Wolf","year":"2012","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.nrleng.2018.01.011_bib0150","doi-asserted-by":"crossref","first-page":"e9136","DOI":"10.1371\/journal.pone.0009136","article-title":"Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants","volume":"5","author":"Bentley","year":"2010","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.nrleng.2018.01.011_bib0155","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/MBC.0000000000000274","article-title":"Polymorphisms in prothrombotic genes in young stroke patients in Greece: a case-controlled study","volume":"26","author":"Ranellou","year":"2015","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"1","key":"10.1016\/j.nrleng.2018.01.011_bib0160","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s12035-015-9549-8","article-title":"Association between plasminogen activator inhibitor-1 genetic polymorphisms and stroke susceptibility","volume":"54","author":"Hu","year":"2017","journal-title":"Mol Neurobiol"},{"issue":"1","key":"10.1016\/j.nrleng.2018.01.011_bib0165","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1538-7836.2009.03663.x","article-title":"The decrease in procarboxypeptidase U (TAFI) concentration in acute ischemic stroke correlates with stroke severity, evolution and outcome","volume":"8","author":"Brouns","year":"2010","journal-title":"J Thromb Haemost"},{"issue":"9","key":"10.1016\/j.nrleng.2018.01.011_bib0170","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1161\/STROKEAHA.116.014091","article-title":"Inhibition of thrombin-activable fibrinolysis inhibitor and plasminogen activator inhibitor-1 reduces ischemic brain damage in mice","volume":"47","author":"Denome","year":"2016","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.nrleng.2018.01.011_bib0175","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0049-3848(02)00356-0","article-title":"PLA1\/A2 polymorphism of the platelet glycoprotein receptor IIb\/IIIa in young patients with cryptogenic TIA or ischemic stroke","volume":"108","author":"Van Goor","year":"2002","journal-title":"Thromb Res"},{"issue":"1","key":"10.1016\/j.nrleng.2018.01.011_bib0180","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/01.STR.0000251719.59141.36","article-title":"Smoking and the platelet fibrinogen receptor glycoprotein IIb\/IIIA PlA1\/A2 polymorphism interact in the risk of lacunar stroke and midterm survival","volume":"38","author":"Oksala","year":"2007","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.nrleng.2018.01.011_bib0185","first-page":"155","article-title":"The effects of platelet receptor GPIIb\/IIIa polymorphism (Leu Pro33) on the receptor expression and platelet aggregation in patients with ischaemic stroke","volume":"24","author":"Pongr\u00e1cz","year":"2007","journal-title":"Turk J Haematol"},{"issue":"7","key":"10.1016\/j.nrleng.2018.01.011_bib0190","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/01616412.2016.1181376","article-title":"Association between Endothelial nitric oxide synthase G894T gene polymorphism and risk of ischemic stroke in North Indian population: a case-control study","volume":"38","author":"Kumar","year":"2016","journal-title":"Neurol Res"},{"issue":"1","key":"10.1016\/j.nrleng.2018.01.011_bib0195","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/0028-3886.198170","article-title":"Association between endothelial nitric oxide synthase gene polymorphisms and risk of ischemic stroke: a meta-analysis","volume":"65","author":"Kumar","year":"2017","journal-title":"Neurol India"},{"issue":"2","key":"10.1016\/j.nrleng.2018.01.011_bib0200","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1586\/14737175.2014.875471","article-title":"Potential serum biomarkers in the pathophysiological processes of stroke","volume":"14","author":"Miao","year":"2014","journal-title":"Expert Rev Neurother"},{"issue":"3","key":"10.1016\/j.nrleng.2018.01.011_bib0205","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/00207454.2016.1183126","article-title":"Methylenetetrahydrofolate reductase C677T polymorphism, hypertension and risk of stroke: a prospective, nested case-control study","volume":"127","author":"Jiang","year":"2017","journal-title":"Int J Neurosci"},{"issue":"5","key":"10.1016\/j.nrleng.2018.01.011_bib0210","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1159\/000289349","article-title":"The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with idiopathic ischemic stroke in the young Mexican-Mestizo population","volume":"29","author":"Isordia-Salas","year":"2010","journal-title":"Cerebrovasc Dis."},{"issue":"9","key":"10.1016\/j.nrleng.2018.01.011_bib0215","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/gm185","article-title":"Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned","volume":"2","author":"Maasz","year":"2010","journal-title":"Genome Med."}],"container-title":["Neurolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580819301361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580819301361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T03:32:12Z","timestamp":1761881532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2173580819301361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S2173580819301361"],"URL":"https:\/\/doi.org\/10.1016\/j.nrleng.2018.01.011","relation":{},"ISSN":["2173-5808"],"issn-type":[{"type":"print","value":"2173-5808"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of genetic risk factors associated with ischaemic stroke in young Mexican patients","name":"articletitle","label":"Article Title"},{"value":"Neurolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nrleng.2018.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.nrl.2018.01.010","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Sociedad Espa\u00f1ola de Neurolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}