{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:24:11Z","timestamp":1790627051824,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.nrleng.2019.05.008","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T16:07:54Z","timestamp":1622045274000},"page":"325-333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neurological manifestations of neurofibromatosis type 1: our experience"],"prefix":"10.1016","volume":"37","author":[{"given":"S.B.","family":"S\u00e1nchez Marco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"L\u00f3pez Pis\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Calvo Escribano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Gonz\u00e1lez Viejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Miramar Gallart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Samper Villagrasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nrleng.2019.05.008_bib0005","first-page":"3002","article-title":"Neurofibromatosis type 1","volume":"Vol 2","author":"Sahin","year":"2016"},{"key":"10.1016\/j.nrleng.2019.05.008_bib0010","series-title":"Neurofibromatosis","first-page":"14","article-title":"Introducci\u00f3n e Historia. Epidemiolog\u00eda: prevalencia","author":"Pascual-Castroviejo","year":"2001"},{"key":"10.1016\/j.nrleng.2019.05.008_bib0015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/0883073812439435","article-title":"Attention skills in children with neurofibromatosis type 1","volume":"28","author":"Isenberg","year":"2013","journal-title":"J Child Neurol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0020","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1007\/s00247-006-0267-2","article-title":"Age-related findings on MRI in neurofibromatosis type 1","volume":"36","author":"Gill","year":"2006","journal-title":"Pediatr Radiol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0025","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.nrl.2012.11.005","article-title":"Evoluci\u00f3n de la demanda asistencial neuropedi\u00e1trica en un hospital espa\u00f1ol de tercer nivel a lo largo de 20 a\u00f1os","volume":"29","author":"Monge-Galindo","year":"2014","journal-title":"Neurolog\u00eda."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0030","first-page":"44","article-title":"Protocolo de seguimiento de la neurofibromatosis tipo 1","volume":"1","author":"Guill\u00e9n-Navarro","year":"2010","journal-title":"Protoc Diagn Pediatr."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0035","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/jmg.2006.045906","article-title":"Guidelines for the diagnosis and management of individuals with neurofibromatosis 1","volume":"44","author":"Ferner","year":"2007","journal-title":"J Med Genet."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0040","first-page":"e346","article-title":"Importancia del seguimiento de la evoluci\u00f3n natural de las enfermedades raras. A prop\u00f3sito de un caso de neurofibromatosis 1","volume":"115","author":"S\u00e1nchez Marco","year":"2017","journal-title":"Arch Argent Pediatr."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0045","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000347119","article-title":"Elevated head circumference-to-height ratio is an early and frequent feature in children with neurofibromatosis type 1","volume":"79","author":"Karvonen","year":"2013","journal-title":"Horm Res Paediatr."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0050","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/jmg.35.8.624","article-title":"Minor disease features in neurofibromatosis type 1 (NF1) and their possible value in diagnosis of NF1 in children < or \u00bc 6 years and clinically suspected of having NF1. Neurofibromatosis team of Sophia Children\u2019s Hospital","volume":"35","author":"Cnossen","year":"1998","journal-title":"J Med Genet."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0055","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1177\/0883073816664659","article-title":"Macrocephaly is not a predictor of optic pathway glioma development or treatment in neurofibromatosis type 1","volume":"31","author":"Morris","year":"2016","journal-title":"J Child Neurol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0060","first-page":"810","article-title":"Prospective evaluation of the brain in asymptomatic children with neurofibromatosis type 1: relationship of macrocephaly to T1 relaxation changes and structural brain abnormalities","volume":"22","author":"Steen","year":"2001","journal-title":"Am J Neuroradiol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0065","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s11689-015-9128-3","article-title":"Cerebral volumetric abnormalities in Neurofibromatosis type 1: associations with parent ratings of social and attention problems, executive dysfunction, and autistic mannerisms","volume":"7","author":"Huijbregts","year":"2015","journal-title":"J Neurodev Disord."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0070","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1007\/s00381-011-1554-2","article-title":"Macrocephaly in neurofibromatosis type 1: a sign post for optic pathway gliomas","volume":"27","author":"Schindera","year":"2011","journal-title":"Childs Nerv Syst."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0075","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/B978-0-444-52902-2.00053-9","article-title":"Neurofibromatosis type 1 (NF1): diagnosis and management","volume":"115","author":"Ferner","year":"2013","journal-title":"Handb Clin Neurol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0080","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1469-8749.2002.tb00780.x","article-title":"Treatment of ADHD in neurofibromatosis type 1","volume":"44","author":"Mautner","year":"2002","journal-title":"Dev Med Child Neurol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0085","first-page":"561","article-title":"Prevalence of sleep disorders in patients with neurofibromatosis type 1","volume":"30","author":"Mara\u00f1a-P\u00e9rez","year":"2015","journal-title":"Neurologia."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0090","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13023-014-0142-4","article-title":"The effect of methylphenidate on neurofibromatosis type 1: a randomised, double-blind, placebo-controlled, crossover trial","volume":"9","author":"Lion-Fran\u00e7ois","year":"2014","journal-title":"Orphanet J Rare Dis. [Internet]."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0095","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s10802-012-9627-6","article-title":"Improving working memory in children with attention-deficit\/hyperactivity disorder: the separate and combined effects of incentives and stimulant medication","volume":"40","author":"Strand","year":"2012","journal-title":"J Abnorm Child Psychol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0100","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1002\/ajmg.a.37186","article-title":"Prevalence and clinical presentation of headache in a National Neurofibromatosis 1 Service and impact on quality of life","volume":"167A","author":"Afridi","year":"2015","journal-title":"Am J Med Genet A."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0105","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1469-8749.2012.04399.x","article-title":"Behaviour in children with neurofibromatosis type 1: cognition, executive function, attention, emotion, and social competence","volume":"55","author":"Lehtonen","year":"2013","journal-title":"Dev Med Child Neurol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0110","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1177\/08830738030180050501","article-title":"Epilepsy in neurofibromatosis 1","volume":"18","author":"Vivarelli","year":"2003","journal-title":"J Child Neurol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0115","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1111\/epi.12348","article-title":"Epilepsy in individuals with neurofibromatosis type 1","volume":"54","author":"Ostendorf","year":"2013","journal-title":"Epilepsia."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0120","series-title":"The causes of epilepsy","first-page":"183","article-title":"The neurofibromatoses","author":"Ferner","year":"2011"},{"key":"10.1016\/j.nrleng.2019.05.008_bib0125","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.eplepsyres.2013.02.021","article-title":"Epilepsy surgery in neurofibromatosis type 1","volume":"105","author":"Barba","year":"2013","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0130","series-title":"Gene reviews. [Internet]","article-title":"Neurofibromatosis 1","author":"Friedmann","year":"1993-2018"},{"key":"10.1016\/j.nrleng.2019.05.008_bib0135","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1148\/radiology.195.3.7754001","article-title":"Neurofibromatosis type 1: pathologic substrate of high-signal-intensity foci in the brain","volume":"195","author":"DiPaolo","year":"1995","journal-title":"Radiology."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0140","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1469-8749.2011.04139.x","article-title":"Neurofibromatosis type 1 and cerebellar T2-hyperintensities: the relationship to cognitive functioning","volume":"54","author":"Piscitelli","year":"2012","journal-title":"Dev Med Child Neurol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0145","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1037\/neu0000151","article-title":"Examining the frontal subcortical brain vulnerability hypothesis in children with neurofibromatosis type 1: are T2-weighted hyperintensities related to executive dysfunction?","volume":"29","author":"Roy","year":"2015","journal-title":"Neuropsychology."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0150","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.critrevonc.2016.05.008","article-title":"Neurofibromatosis type 1 associated low grade gliomas: a comparison with sporadic low grade gliomas","volume":"104","author":"Helfferich","year":"2016","journal-title":"Crit Rev Oncol Hematol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0155","doi-asserted-by":"crossref","first-page":"530","DOI":"10.33588\/rn.4609.2008021","article-title":"Neurofibromatosis tipo 1 y gliomas de v\u00edas \u00f3pticas. Una serie de 80 pacientes","volume":"46","author":"Pascual-Castroviejo","year":"2008","journal-title":"Rev Neurol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0160","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1001\/jamaophthalmol.2013.1652","article-title":"Optic pathway gliomas: neoplasms, not hamartomas","volume":"131","author":"Liu","year":"2013","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0165","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.pediatrneurol.2012.02.001","article-title":"Cognitive profiles of neurofibromatosis type 1 patients with minor brain malformations","volume":"46","author":"Acosta","year":"2012","journal-title":"Pediatr Neurol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0170","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1001\/archneur.55.4.500","article-title":"Magnetic resonance imaging lesion analysis in neurofibromatosis type 1","volume":"55","author":"DiMario","year":"1998","journal-title":"Arch Neurol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0175","doi-asserted-by":"crossref","first-page":"S469","DOI":"10.4103\/2152-7806.185778","article-title":"Neurofibromatosis type 1 and Chiari type 1 malformation: a case report and literature review of a rare association","volume":"7","author":"Pozetti","year":"2016","journal-title":"Surg Neurol Int."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0180","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1177\/088307389300800417","article-title":"Bilateral temporal arachnoid cysts in neurofibromatosis","volume":"8","author":"Mart\u00ednez-Lage","year":"1993","journal-title":"J Child Neurol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0185","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1755-3768.2008.01431.x","article-title":"Arachnoid cyst causing an optic neuropathy in neurofibromatosis 1","volume":"88","author":"Wegener","year":"2010","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0190","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jns.2015.02.023","article-title":"Occurrence of multiple cerebral cavernous malformations in a patient with neurofibromatosis type 1","volume":"350","author":"Rerat","year":"2015","journal-title":"J Neurol Sci."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0195","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/brain\/122.3.473","article-title":"Neurological complications of neurofibromatosis type 1 in adulthood","volume":"122","author":"Creange","year":"1999","journal-title":"Brain."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0200","doi-asserted-by":"crossref","first-page":"18","DOI":"10.33588\/rn.4501.2006344","article-title":"[Aqueductal stenosis in the neurofibromatosis type 1. Presentation of 19 infantile patients]","volume":"45","author":"Pascual-Castroviejo","year":"2007","journal-title":"Rev Neurol."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0205","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1750-1172-7-75","article-title":"Growth dynamics of plexiform neurofibromas: a retrospective cohort study of 201 patients with neurofibromatosis 1","volume":"7","author":"Nguyen","year":"2012","journal-title":"Orphanet J Rare Dis."},{"key":"10.1016\/j.nrleng.2019.05.008_bib0210","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1056\/NEJMoa1605943","article-title":"Activity of selumetinib in neurofibromatosis type 1\u2013related plexiform neurofibromas","volume":"375","author":"Dombi","year":"2016","journal-title":"N Engl J Med."}],"container-title":["Neurolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580821000687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580821000687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:03:51Z","timestamp":1783695831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2173580821000687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S2173580821000687"],"URL":"https:\/\/doi.org\/10.1016\/j.nrleng.2019.05.008","relation":{},"ISSN":["2173-5808"],"issn-type":[{"value":"2173-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurological manifestations of neurofibromatosis type 1: our experience","name":"articletitle","label":"Article Title"},{"value":"Neurolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nrleng.2019.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.nrl.2019.05.003","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Sociedad Espa\u00f1ola de Neurolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}