{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:33:12Z","timestamp":1712968392443},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","elsevier.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.nrleng.2021.08.003","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T15:14:11Z","timestamp":1712934851000},"page":"321-328","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel multifunctional nanoliposomes inhibit \u03b1-synuclein fibrillization, attenuate microglial activation, and silence the expression of SNCA gene"],"prefix":"10.1016","volume":"39","author":[{"given":"A.","family":"Jebali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rashidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Keikha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Daliri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.F.","family":"Outeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nrleng.2021.08.003_bib0130","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3390\/biom11070931","article-title":"\u03b1-Synuclein strains: does amyloid conformation explain the heterogeneity of synucleinopathies?","volume":"11","author":"Hoppe","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0135","series-title":"Emerging concepts in synucleinopathies","author":"Outeiro","year":"2021"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0140","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1566-2772(01)00023-8","article-title":"Synucleinopathies: a pathological and molecular review","volume":"1","author":"Murray","year":"2001","journal-title":"Clin Neurosci Res"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0145","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1471-4159.2007.04764.x","article-title":"Neuropathology, biochemistry, and biophysics of \u03b1-synuclein aggregation","volume":"103","author":"Uversky","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0150","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1002\/ange.201711854","article-title":"Cytotoxic oligomers and fibrils trapped in a gel-like state of \u03b1-synuclein assemblies","volume":"130","author":"Kumar","year":"2018","journal-title":"Angew Chem"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0155","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0074-7742(07)82012-5","article-title":"Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder?","volume":"82","author":"Rogers","year":"2007","journal-title":"Int Rev Neurobiol"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0160","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1097\/NEN.0b013e31818e5e99","article-title":"Targeted overexpression of human \u03b1-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease","volume":"67","author":"Theodore","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0165","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/jnc.13772","article-title":"Pathogenic mechanisms of prion protein, amyloid \u03b2 and \u03b1 synuclein misfolding: the prion concept and neurotoxicity of protein oligomers","volume":"139","author":"Ugalde","year":"2016","journal-title":"J Neurochem"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0170","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0301-0082(98)00045-8","article-title":"The role of tumour necrosis factor, interleukin 6, interferon-\u03b3 and inducible nitric oxide synthase in the development and pathology of the nervous system","volume":"56","author":"Mu\u00f1oz-Fern\u00e1ndez","year":"1998","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nm.4269","article-title":"\u03b1-Synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies","volume":"23","author":"Wong","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0180","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fbioe.2020.00112","article-title":"Antioxidant nanoparticles for concerted inhibition of \u03b1-synuclein fibrillization, and attenuation of microglial intracellular aggregation and activation","volume":"8","author":"Zhao","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0185","doi-asserted-by":"crossref","first-page":"9174","DOI":"10.1039\/C8NR00632F","article-title":"The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's disease","volume":"10","author":"Aliakbari","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0190","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3390\/nano10020235","article-title":"Cerium oxide nanoparticles rescue \u03b1-synuclein-induced toxicity in a yeast model of Parkinson's disease","volume":"10","author":"Ruotolo","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0195","doi-asserted-by":"crossref","first-page":"6156","DOI":"10.1021\/nl403490e","article-title":"Influence of gold nanoparticles on the kinetics of \u03b1-synuclein aggregation","volume":"13","author":"\u00c1lvarez","year":"2013","journal-title":"Nano Lett"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0200","doi-asserted-by":"crossref","first-page":"577352","DOI":"10.1016\/j.jneuroim.2020.577352","article-title":"Attenuation of inflammatory response in the EAE model by PEGlated nanoliposome of pistachio oils","volume":"347","author":"Jebali","year":"2020","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0205","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/026520499289220","article-title":"Preparation of liposomes by reverse-phase evaporation using alternative organic solvents","volume":"16","author":"Cortesi","year":"1999","journal-title":"J Microencapsulation"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0210","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/brain\/awx056","article-title":"Glycation potentiates \u03b1-synuclein-associated neurodegeneration in synucleinopathies","volume":"140","author":"Vicente Miranda","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0215","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","article-title":"Microglial activation and chronic neurodegeneration","volume":"7","author":"Lull","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0220","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/1097-4547(20000715)61:2<121::AID-JNR1>3.0.CO;2-4","article-title":"Neuropathology of synuclein aggregates: new insights into mechanisms of neurodegenerative diseases","volume":"61","author":"Duda","year":"2000","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0225","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1073\/pnas.1100976108","article-title":"In vivo demonstration that \u03b1-synuclein oligomers are toxic","volume":"108","author":"Winner","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0230","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1042\/BJ20150617","article-title":"Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease","volume":"471","author":"Gustot","year":"2015","journal-title":"Biochem J"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0235","doi-asserted-by":"crossref","first-page":"17579","DOI":"10.1074\/jbc.M112.434787","article-title":"A blood\u2013brain barrier (BBB) disrupter is also a potent \u03b1-synuclein (\u03b1-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD)","volume":"288","author":"Shaltiel-Karyo","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42004-020-00412-y","article-title":"Screening of small molecules using the inhibition of oligomer formation in \u03b1-synuclein aggregation as a selection parameter","volume":"3","author":"Staats","year":"2020","journal-title":"Commun Chem"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0245","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fpsyt.2020.00122","article-title":"The anti-inflammatory role of omega-3 polyunsaturated fatty acids metabolites in pre-clinical models of psychiatric, neurodegenerative and neurological disorders","volume":"11","author":"Giacobbe","year":"2020","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.nrleng.2021.08.003_bib0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-43772-9","article-title":"Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting \u03b1-synuclein as a novel therapy for Parkinson's disease","volume":"9","author":"Uehara","year":"2019","journal-title":"Sci Rep"}],"container-title":["Neurolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580824000348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580824000348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T15:14:30Z","timestamp":1712934870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2173580824000348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S2173580824000348"],"URL":"https:\/\/doi.org\/10.1016\/j.nrleng.2021.08.003","relation":{},"ISSN":["2173-5808"],"issn-type":[{"value":"2173-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel multifunctional nanoliposomes inhibit \u03b1-synuclein fibrillization, attenuate microglial activation, and silence the expression of SNCA gene","name":"articletitle","label":"Article Title"},{"value":"Neurolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nrleng.2021.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Sociedad Espa\u00f1ola de Neurolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}