{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:07:44Z","timestamp":1785377264082,"version":"3.55.0"},"reference-count":95,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CB-284443"],"award-info":[{"award-number":["CB-284443"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["IFC-2016-1955"],"award-info":[{"award-number":["IFC-2016-1955"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.nrleng.2023.10.003","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T12:24:11Z","timestamp":1697545451000},"page":"671-680","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of rafts in neurological disorders"],"prefix":"10.1016","volume":"38","author":[{"given":"U.","family":"Meza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Romero-M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"S\u00e1nchez-Arm\u00e1ss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Rodr\u00edguez-Menchaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nrleng.2023.10.003_bib0005","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1126\/science.175.4023.720","article-title":"The fluid mosaic model of the structure of cell membranes","volume":"175","author":"Singer","year":"1972","journal-title":"Science"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0010","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1085\/jgp.201812153","article-title":"The lipid bilayer membrane and its protein constituents","volume":"150","author":"Robertson","year":"2018","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0015","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrm.2017.16","article-title":"The mystery of membrane organization: composition, regulation and roles of lipid rafts","volume":"18","author":"Sezgin","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0020","doi-asserted-by":"crossref","first-page":"5849","DOI":"10.1021\/acs.chemrev.8b00439","article-title":"Biological membrane organization and cellular signaling","volume":"119","author":"Cheng","year":"2019","journal-title":"Chem Rev"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0025","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fcell.2020.00284","article-title":"Interleaflet coupling of lipid nanodomains - insights from in vitro systems","volume":"8","author":"Sarmento","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0030","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1017\/S0033583500001797","article-title":"Phase transitions and fluidity characteristics of lipids and cell membranes","volume":"8","author":"Chapman","year":"1975","journal-title":"Q Rev Biophys"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0035","doi-asserted-by":"crossref","first-page":"6197","DOI":"10.1021\/bi00417a001","article-title":"Lipid sorting in epithelial cells","volume":"27","author":"Simons","year":"1988","journal-title":"Biochemistry"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0040","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","article-title":"Functional rafts in cell membranes","volume":"387","author":"Simons","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0045","first-page":"430","article-title":"Lipid rafts, detergent-resistant membranes, and raft targeting signals","volume":"21","author":"Brown","year":"2006","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0050","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0005-2736(87)90020-4","article-title":"Phase equilibria in the phosphatidylcholine-cholesterol system","volume":"905","author":"Ipsen","year":"1987","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0055","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1194\/jlr.E600002-JLR200","article-title":"Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function","volume":"47","author":"Pike","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0060","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0005-2736(03)00021-X","article-title":"Dynamics of raft molecules in the cell and artificial membranes: approaches by pulse EPR spin labeling and single molecule optical microscopy","volume":"1610","author":"Subczynski","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0065","doi-asserted-by":"crossref","first-page":"12369","DOI":"10.1021\/acs.langmuir.8b02047","article-title":"Quaternary amine-terminated quantum dots induce structural changes to supported lipid bilayers","volume":"34","author":"Mensch","year":"2018","journal-title":"Langmuir"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0070","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev-cellbio-100809-151736","article-title":"Dynamic organizing principles of the plasma membrane that regulate signal transduction: commemorating the fortieth anniversary of Singer and Nicolson\u2019s fluid-mosaic model","volume":"28","author":"Kusumi","year":"2012","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0075","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1073\/pnas.0507686103","article-title":"FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells","volume":"103","author":"Meyer","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0080","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s12035-013-8614-4","article-title":"Lipid rafts in neurodegeneration and neuroprotection","volume":"50","author":"Sonnino","year":"2014","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0085","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1194\/jlr.TR119000427","article-title":"Lipid rafts and neurodegeneration: structural and functional roles in physiologic aging and neurodegenerative diseases","volume":"61","author":"Grassi","year":"2020","journal-title":"J Lipid Res"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0090","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.neuron.2012.03.005","article-title":"Growth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane","volume":"73","author":"Vitriol","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0095","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0896-6273(04)00157-6","article-title":"Lipid rafts mediate chemotropic guidance of nerve growth cones","volume":"42","author":"Guirland","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0100","doi-asserted-by":"crossref","first-page":"12896","DOI":"10.1038\/ncomms12896","article-title":"A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors","volume":"7","author":"Averaimo","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0105","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1126\/science.1059391","article-title":"Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation","volume":"291","author":"Stein","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0110","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1242\/jcs.02296","article-title":"DCC association with lipid rafts is required for netrin-1-mediated axon guidance","volume":"118","author":"H\u00e9rincs","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0115","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.bbamem.2013.07.018","article-title":"Interaction of membrane\/lipid rafts with the cytoskeleton: impact on signaling and function: membrane\/lipid rafts, mediators of cytoskeletal arrangement and cell signaling","volume":"1838","author":"Head","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0120","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1113\/JP270590","article-title":"Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function","volume":"594","author":"Egawa","year":"2016","journal-title":"J Physiol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0125","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1242\/jcs.060681","article-title":"Cholesterol reduction impairs exocytosis of synaptic vesicles","volume":"123","author":"Linetti","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0130","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1074\/jbc.M308798200","article-title":"Role of lipid microdomains in P\/Q-type calcium channel (Cav2.1) clustering and function in presynaptic membranes","volume":"279","author":"Taverna","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0135","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1111\/j.1471-4159.2008.05523.x","article-title":"Spatial memory formation induces recruitment of NMDA receptor and PSD-95 to synaptic lipid rafts","volume":"106","author":"Delint-Ram\u00edrez","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015697","article-title":"Loss of caveolin-1 accelerates neurodegeneration and aging","volume":"5","author":"Head","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0145","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.expneurol.2008.04.019","article-title":"Cholesterol depletion inhibits synaptic transmission and synaptic plasticity in rat hippocampus","volume":"212","author":"Frank","year":"2008","journal-title":"Exp Neurol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0150","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neuropharm.2012.06.053","article-title":"Lipid rafts, synaptic transmission and plasticity: impact in age-related neurodegenerative diseases","volume":"64","author":"Sebasti\u00e3o","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0155","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1038\/nn.4418","article-title":"Functional and structural underpinnings of neuronal assembly formation in learning","volume":"19","author":"Holtmaat","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0160","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.3390\/ijms20153810","article-title":"Lipid and lipid raft alteration in aging and neurodegenerative diseases: a window for the development of new biomarkers","volume":"20","author":"Mesa-Herrera","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0165","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1096\/fj.00-0815fje","article-title":"Essential role for cholesterol in synaptic plasticity and neuronal degeneration","volume":"15","author":"Koudinov","year":"2001","journal-title":"FASEB J"},{"issue":"2","key":"10.1016\/j.nrleng.2023.10.003_bib0170","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.neuroscience.2009.12.062","article-title":"Simvastatin enhances hippocampal long-term potentiation in C57BL\/6 mice","volume":"166","author":"Mans","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0175","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1042\/CS20050163","article-title":"Neurotrophin signalling in health and disease","volume":"110","author":"Chao","year":"2006","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0180","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0166-2236(00)01672-6","article-title":"The neurotrophin hypothesis for synaptic plasticity","volume":"23","author":"Schinder","year":"2000","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0185","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1101\/lm.428307","article-title":"Mutation at the TrkB PLC (gamma)-docking site affects hippocampal LTP and associative learning in conscious mice","volume":"14","author":"Gruart","year":"2007","journal-title":"Learn Mem"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0190","doi-asserted-by":"crossref","first-page":"6417","DOI":"10.1523\/JNEUROSCI.0690-07.2007","article-title":"Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development","volume":"27","author":"Suzuki","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0195","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1083\/jcb.200404106","article-title":"BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation","volume":"167","author":"Suzuki","year":"2004","journal-title":"J Cell Biol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0200","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.biopsych.2015.09.020","article-title":"Neuron-targeted caveolin-1 improves molecular signaling, plasticity, and behavior dependent on the hippocampus in adult and aged mice","volume":"81","author":"Mandyam","year":"2017","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0205","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.brainres.2006.05.086","article-title":"Cholesterol-enriched diet affects spatial learning and synaptic function in hippocampal synapses","volume":"1103","author":"Dufour","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0210","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/ana.21053","article-title":"Simvastatin enhances learning and memory independent of amyloid load in mice","volume":"60","author":"Li","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0215","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1111\/bph.15027","article-title":"Functional marriage in plasma membrane: critical cholesterol level-optimal protein activity","volume":"177","author":"Meza","year":"2020","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0220","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer\u2019s disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0225","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","article-title":"Amyloid-beta protein dimers isolated directly from Alzheimer\u2019s brains impair synaptic plasticity and memory","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0230","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1002\/pro.3906","article-title":"Progress toward Alzheimer\u2019s disease treatment: leveraging the achilles\u2019 heel of A\u03b2 oligomers?","volume":"29","author":"Fantini","year":"2020","journal-title":"Protein Sci"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0235","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1038\/s41467-020-16566-1","article-title":"A\u03b2(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage","volume":"11","author":"Ciudad","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0240","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/ncpneuro0549","article-title":"Mechanisms of disease: new therapeutic strategies for Alzheimer\u2019s disease--targeting APP processing in lipid rafts","volume":"3","author":"Cheng","year":"2007","journal-title":"Nat Clin Pract Neurol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0245","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.bbalip.2010.03.007","article-title":"Membrane rafts in Alzheimer\u2019s disease beta-amyloid production","volume":"1801","author":"Vetrivel","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0250","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3389\/fphys.2012.00189","article-title":"Lipid rafts and Alzheimer\u2019s disease: protein-lipid interactions and perturbation of signaling","volume":"3","author":"Hicks","year":"2012","journal-title":"Front Physiol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0255","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.1021\/bi200771m","article-title":"Mechanism of amyloid \u03b2-protein aggregation mediated by GM1 ganglioside clusters","volume":"50","author":"Ikeda","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0260","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3389\/fncel.2019.00309","article-title":"Alzheimer\u2019s disease as a membrane disorder: spatial cross-talk among beta-amyloid peptides, nicotinic acetylcholine receptors and lipid rafts","volume":"13","author":"Fabiani","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0265","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0896-6273(03)00840-7","article-title":"Cholesterol and the biology of Alzheimer\u2019s disease","volume":"41","author":"Wolozin","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0270","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1471-4159.2004.02849.x","article-title":"Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domains","volume":"92","author":"Molander-Melin","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0275","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/sj.embor.7400021","article-title":"Raft disorganization leads to reduced plasmin activity in Alzheimer\u2019s disease brains","volume":"4","author":"Ledesma","year":"2003","journal-title":"EMBO Rep"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0280","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3233\/JAD-2010-1242","article-title":"Lipid alterations in lipid rafts from Alzheimer\u2019s disease human brain cortex","volume":"19","author":"Mart\u00edn","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0285","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1006\/nbdi.2001.0422","article-title":"A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer\u2019s disease","volume":"8","author":"Refolo","year":"2001","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0290","doi-asserted-by":"crossref","first-page":"24985","DOI":"10.1074\/jbc.M100252200","article-title":"Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid","volume":"276","author":"Kakio","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0295","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.1021\/bi0255874","article-title":"Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid","volume":"41","author":"Kakio","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0300","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1194\/jlr.TR120000658","article-title":"Lipid rafts as a therapeutic target","volume":"61","author":"Sviridov","year":"2020","journal-title":"J Lipid Res"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0305","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.2119\/molmed.2011.00119","article-title":"Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson\u2019s disease and incidental Parkinson\u2019s disease","volume":"17","author":"Fabelo","year":"2011","journal-title":"Mol Med"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0310","first-page":"746","article-title":"Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases","volume":"5","author":"Vance","year":"2012","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0315","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuroscience.2013.04.025","article-title":"Lipid raft disarrangement as a result of neuropathological progresses: a novel strategy for early diagnosis?","volume":"245","author":"Marin","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0320","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neurobiolaging.2016.08.027","article-title":"Anomalies occurring in lipid profiles and protein distribution in frontal cortex lipid rafts in dementia with Lewy bodies disclose neurochemical traits partially shared by Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"49","author":"Marin","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0325","doi-asserted-by":"crossref","first-page":"31664","DOI":"10.1074\/jbc.M504894200","article-title":"A combinatorial code for the interaction of alpha-synuclein with membranes","volume":"280","author":"Kubo","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0330","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13024-015-0060-5","article-title":"Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson\u2019s disease","volume":"10","author":"Cha","year":"2015","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0335","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jmb.2004.02.014","article-title":"Structural determinants of PLD2 inhibition by alpha-synuclein","volume":"337","author":"Payton","year":"2004","journal-title":"J Mol Biol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0340","doi-asserted-by":"crossref","first-page":"32486","DOI":"10.1074\/jbc.M110.139576","article-title":"Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins","volume":"285","author":"Varkey","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0345","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1471-4159.2009.06150.x","article-title":"On the mechanism of internalization of alpha-synuclein into microglia: roles of ganglioside GM1 and lipid raft","volume":"110","author":"Park","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0350","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ebiom.2016.03.038","article-title":"Exogenous alpha-synuclein alters pre- and post-synaptic activity by fragmenting lipid rafts","volume":"7","author":"Emanuele","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2019.106272","article-title":"GM1 Ganglioside role in the interaction of Alpha-synuclein with lipid membranes: morphology and structure","volume":"255","author":"Perissinotto","year":"2019","journal-title":"Biophys Chem"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0360","doi-asserted-by":"crossref","DOI":"10.1177\/1759091418781889","article-title":"Sex-related abnormalities in substantia nigra lipids in Parkinson\u2019s disease","volume":"10","author":"Seyfried","year":"2018","journal-title":"ASN Neuro"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0365","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00041.2009","article-title":"Molecular mechanisms and potential therapeutical targets in Huntington\u2019s disease","volume":"90","author":"Zuccato","year":"2010","journal-title":"Physiol Rev"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0370","doi-asserted-by":"crossref","first-page":"9932","DOI":"10.1523\/JNEUROSCI.3355-05.2005","article-title":"Dysfunction of the cholesterol biosynthetic pathway in Huntington\u2019s disease","volume":"25","author":"Valenza","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0375","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00238752","article-title":"Striatal ganglioside levels in the rat following kainic acid lesions: comparison with Huntington\u2019s disease","volume":"44","author":"Higatsberger","year":"1981","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0380","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.nbd.2007.05.003","article-title":"Glycolipid and ganglioside metabolism imbalances in Huntington\u2019s disease","volume":"27","author":"Desplats","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0385","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jnr.22184","article-title":"Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington\u2019s disease","volume":"88","author":"Valencia","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0390","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.15252\/emmm.201707763","article-title":"Disease-modifying effects of ganglioside GM1 in Huntington\u2019s disease models","volume":"9","author":"Alpaugh","year":"2017","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0395","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1093\/hmg\/ddl434","article-title":"Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo","volume":"15","author":"Trushina","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0400","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1471-4159.2010.06912.x","article-title":"Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington\u2019s disease","volume":"115","author":"del Toro","year":"2010","journal-title":"J Neurochem"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0405","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/brain\/awv384","article-title":"CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington\u2019s disease","volume":"139","author":"Boussicault","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0410","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1046\/j.1469-1809.2003.00034.x","article-title":"Smith-Lemli-Opitz syndrome and the DHCR7 gene","volume":"67","author":"Jira","year":"2003","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0415","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1172\/JCI200112103","article-title":"7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz\/RSH syndrome","volume":"108","author":"Fitzky","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0420","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1194\/jlr.M300232-JLR200","article-title":"Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome","volume":"45","author":"Keller","year":"2004","journal-title":"J Lipid Res"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0425","doi-asserted-by":"crossref","first-page":"33540","DOI":"10.1074\/jbc.M104776200","volume":"276","author":"Xu","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0430","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.neurobiolaging.2006.06.026","article-title":"Expression and p75 neurotrophin receptor dependence of cholesterol synthetic enzymes in adult mouse brain","volume":"28","author":"Korade","year":"2007","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0435","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.3390\/ijms20184392","article-title":"Current challenges in understanding the cellular and molecular mechanisms in Niemann-Pick disease type C1","volume":"20","author":"Br\u00e4uer","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0440","doi-asserted-by":"crossref","first-page":"20179","DOI":"10.1074\/jbc.M001793200","article-title":"Embryonic striatal neurons from niemann-pick type C mice exhibit defects in cholesterol metabolism and neurotrophin responsiveness","volume":"275","author":"Henderson","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0445","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1016\/j.febslet.2006.06.008","article-title":"Lipid imbalance in the neurological disorder, Niemann-Pick C disease","volume":"580","author":"Vance","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0450","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1474-4422(03)00619-7","article-title":"Dementia with Lewy bodies","volume":"3","author":"McKeith","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0455","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/bpa.12085","article-title":"Biology of AQP4 and anti-AQP4 antibody: therapeutic implications for NMO","volume":"23","author":"Verkman","year":"2013","journal-title":"Brain Pathol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0460","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.brainres.2014.08.014","article-title":"Targeting of aquaporin 4 into lipid rafts and its biological significance","volume":"1583","author":"Asakura","year":"2014","journal-title":"Brain Res"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0465","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.tcb.2004.12.002","article-title":"The highways and byways of prion protein trafficking","volume":"15","author":"Campana","year":"2005","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0470","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/09687860500449994","article-title":"The prion protein and lipid rafts","volume":"23","author":"Taylor","year":"2006","journal-title":"Mol Membr Biol"},{"key":"10.1016\/j.nrleng.2023.10.003_bib0475","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.3390\/v6114505","article-title":"Cholesterol balance in prion diseases and Alzheimer\u2019s disease","volume":"6","author":"Hannaoui","year":"2014","journal-title":"Viruses"}],"container-title":["Neurolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580823000573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580823000573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T03:36:06Z","timestamp":1761881766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2173580823000573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":95,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S2173580823000573"],"URL":"https:\/\/doi.org\/10.1016\/j.nrleng.2023.10.003","relation":{},"ISSN":["2173-5808"],"issn-type":[{"value":"2173-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of rafts in neurological disorders","name":"articletitle","label":"Article Title"},{"value":"Neurolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nrleng.2023.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.nrl.2021.01.008","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Sociedad Espa\u00f1ola de Neurolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}