{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:09:35Z","timestamp":1755216575607,"version":"3.43.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.nrleng.2025.06.006","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T02:02:26Z","timestamp":1750644146000},"page":"558-566","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple sclerosis mortality trends in Spain from 1981 to 2020"],"prefix":"10.1016","volume":"40","author":[{"given":"L.","family":"Cayuela","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"de Alb\u00f3niga-Chindurza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"G\u00f3mez Enjuto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lape\u00f1a-Motilva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sainz de la Maza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gonz\u00e1lez Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cayuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nrleng.2025.06.006_bib0005","unstructured":"MS International Federation. Accessible at https:\/\/www.atlasofms.org\/fact-sheet\/spain (Accessed January 2023)."},{"key":"10.1016\/j.nrleng.2025.06.006_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2020.102705","article-title":"Perceived discrimination in patients with multiple sclerosis and depressive symptomatology","volume":"48","author":"Ochoa-Morales","year":"2021","journal-title":"Mult Scler Relat Disord."},{"issue":"3","key":"10.1016\/j.nrleng.2025.06.006_bib0015","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1474-4422(18)30443-5","article-title":"Global, regional, and national burden of multiple sclerosis 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","year":"2019","journal-title":"Lancet Neurol"},{"issue":"10","key":"10.1016\/j.nrleng.2025.06.006_bib0020","doi-asserted-by":"crossref","first-page":"14348","DOI":"10.1007\/s11356-021-16604-5","article-title":"The trend analysis of neurological disorders as major causes of death and disability according to human development, 1990-2019","volume":"29","author":"Borumandnia","year":"2022","journal-title":"Environ Sci Pollut Res Int."},{"issue":"22","key":"10.1016\/j.nrleng.2025.06.006_bib0025","first-page":"00177","article-title":"Incidence and prevalence of multiple sclerosis in Spain: a systematic review","volume":"S2173-5808","author":"Garc\u00eda L\u00f3pez","year":"2022","journal-title":"Neurologia (Engl Ed)"},{"issue":"14","key":"10.1016\/j.nrleng.2025.06.006_bib0030","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult Scler."},{"key":"10.1016\/j.nrleng.2025.06.006_bib0035","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/ane.12615","article-title":"High prevalence and increasing incidence of multiple sclerosis in the Norwegian county of Buskerud","volume":"135","author":"Simonsen","year":"2017","journal-title":"Acta Neurol Scand"},{"issue":"20","key":"10.1016\/j.nrleng.2025.06.006_bib0040","article-title":"Incidence and prevalence of multiple sclerosis in China and other Asian countries","volume":"S0213-4853","author":"Zhang","year":"2020","journal-title":"Neurologia (Engl Ed)"},{"issue":"4","key":"10.1016\/j.nrleng.2025.06.006_bib0045","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/ijc.23118","article-title":"Effect of age, birth cohort and period of death on skin melanoma mortality in Spain, 1975 through 2004","volume":"122","author":"Cayuela","year":"2008","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.nrleng.2025.06.006_bib0050","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/annonc\/mdh147","article-title":"Age-period-cohort analysis of breast cancer mortality rates in Andalucia (Spain)","volume":"15","author":"Cayuela","year":"2004","journal-title":"Ann Oncol."},{"issue":"20","key":"10.1016\/j.nrleng.2025.06.006_bib0055","first-page":"30068","article-title":"Suicide mortality in Spain (1984-2018): age-period-cohort analysis","volume":"S1888-9891","author":"Cayuela","year":"2020","journal-title":"Rev Psiquiatr Salud Ment (Engl Ed)"},{"issue":"3","key":"10.1016\/j.nrleng.2025.06.006_bib0060","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000083000","article-title":"Mortality trends of multiple sclerosis in Spain, 1951-1997: an age-period-cohort analysis","volume":"24","author":"Llorca","year":"2005","journal-title":"Neuroepidemiology."},{"issue":"6","key":"10.1016\/j.nrleng.2025.06.006_bib0065","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00415-018-8832-9","article-title":"Sex ratio in multiple sclerosis mortality over 65 years; an age-period-cohort analysis in Norway","volume":"265","author":"Nakken","year":"2018","journal-title":"J Neurol."},{"issue":"2","key":"10.1016\/j.nrleng.2025.06.006_bib0070","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1177\/1352458517691620","article-title":"Similar birth-cohort patterns in Crohn\u2019s disease and multiple sclerosis","volume":"24","author":"Sonnenberg","year":"2018","journal-title":"Mult Scler."},{"key":"10.1016\/j.nrleng.2025.06.006_bib0075","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/sim.4780060405","article-title":"Models for temporal variation in cancer rates. I: age-period and age-cohort models","volume":"6","author":"Clayton","year":"1987","journal-title":"Stat Med"},{"issue":"11","key":"10.1016\/j.nrleng.2025.06.006_bib0080","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1158\/1055-9965.EPI-14-0300","article-title":"A web tool for age-period-cohort analysis of cancer incidence and mortality rates","volume":"23","author":"Rosenberg","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"issue":"8","key":"10.1016\/j.nrleng.2025.06.006_bib0085","first-page":"377","article-title":"Mortalidad por esclerosis m\u00faltiple en Espa\u00f1a, 1951-1992 [Mortality due to multiple sclerosis in Spain, 1951-1992]","volume":"14","author":"Llorca","year":"1999","journal-title":"Neurologia."},{"issue":"1-2","key":"10.1016\/j.nrleng.2025.06.006_bib0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000484213","article-title":"Multiple sclerosis mortality by race\/ethnicity, age, sex, and time period in the United States, 1999-2015","volume":"50","author":"Amezcua","year":"2018","journal-title":"Neuroepidemiology."},{"key":"10.1016\/j.nrleng.2025.06.006_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2020.102240","article-title":"Mortality trend for multiple sclerosis in Italy during the period 1980-2015","volume":"44","author":"Bezzini","year":"2020","journal-title":"Mult Scler Relat Disord."},{"issue":"22","key":"10.1016\/j.nrleng.2025.06.006_bib0100","first-page":"30226","article-title":"Immunosenescence: the role of age in multiple sclerosis","volume":"S2173-5808","author":"Ostolaza Ib\u00e1\u00f1ez","year":"2022","journal-title":"Neurologia (Engl Ed)"},{"issue":"1","key":"10.1016\/j.nrleng.2025.06.006_bib0105","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1212\/WNL.0000000000013016","article-title":"Performance of the 2017 and 2010 revised McDonald criteria in predicting MS diagnosis after a clinically isolated syndrome: a MAGNIMS study","volume":"98","author":"Filippi","year":"2022","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.nrleng.2025.06.006_bib0110","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1177\/1352458520910496","article-title":"Challenges in multiple sclerosis diagnosis: misunderstanding and misapplication of the McDonald criteria","volume":"27","author":"Solomon","year":"2021","journal-title":"Mult Scler."},{"issue":"17","key":"10.1016\/j.nrleng.2025.06.006_bib0115","doi-asserted-by":"crossref","first-page":"e1641","DOI":"10.1212\/WNL.0000000000012726","article-title":"Effect of changes in MS diagnostic criteria over 25 years on time to treatment and prognosis in patients with clinically isolated syndrome","volume":"97","author":"Tintore","year":"2021","journal-title":"Neurology."},{"key":"10.1016\/j.nrleng.2025.06.006_bib0120","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3389\/fneur.2017.00577","article-title":"Meta-analysis of the age-dependent efficacy of multiple sclerosis treatments","volume":"8","author":"Weideman","year":"2017","journal-title":"Front Neurol."},{"issue":"4","key":"10.1016\/j.nrleng.2025.06.006_bib0125","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0398-7620(06)76730-X","article-title":"Comparability between ICD-9 and ICD-10 for the leading causes of death in Spain","volume":"54","author":"Cano-Serral","year":"2006","journal-title":"Rev Epidemiol Sante Publique."},{"issue":"3","key":"10.1016\/j.nrleng.2025.06.006_bib0130","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1468-1331.2012.03802.x","article-title":"Missed epidemics and missing links: international birth cohort trends in multiple sclerosis","volume":"20","author":"Ajdacic-Gross","year":"2013","journal-title":"Eur J Neurol."},{"issue":"1","key":"10.1016\/j.nrleng.2025.06.006_bib0135","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/ene.13160","article-title":"The change in the sex ratio in multiple sclerosis is driven by birth cohort effects","volume":"24","author":"Ajdacic-Gross","year":"2017","journal-title":"Eur J Neurol."},{"issue":"6578","key":"10.1016\/j.nrleng.2025.06.006_bib0140","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science."},{"key":"10.1016\/j.nrleng.2025.06.006_bib0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2022.104250","article-title":"Trends in the environmental risks associated with earlier onset in multiple sclerosis","volume":"68","author":"Huang","year":"2022","journal-title":"Mult Scler Relat Disord."},{"issue":"2","key":"10.1016\/j.nrleng.2025.06.006_bib0150","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1177\/1352458517691620","article-title":"Similar birth-cohort patterns in Crohn\u2019s disease and multiple sclerosis","volume":"24","author":"Sonnenberg","year":"2018","journal-title":"Mult Scler."},{"issue":"8","key":"10.1016\/j.nrleng.2025.06.006_bib0155","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1177\/13524585211061861","article-title":"Body mass index as a predictor of MS activity and progression among participants in BENEFIT","volume":"28","author":"Escobar","year":"2022","journal-title":"Mult Scler."},{"key":"10.1016\/j.nrleng.2025.06.006_bib0160","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.msard.2017.07.020","article-title":"Smoking and multiple sclerosis: A systematic review and meta-analysis using the Bradford Hill criteria for causation","volume":"17","author":"Degelman","year":"2017","journal-title":"Mult Scler Relat Disord"},{"issue":"22","key":"10.1016\/j.nrleng.2025.06.006_bib0165","doi-asserted-by":"crossref","first-page":"e1954","DOI":"10.1212\/WNL.0000000000005612","article-title":"Incidence of MS has increased markedly over six decades in Denmark particularly with late onset and in women","volume":"90","author":"Koch-Henriksen","year":"2018","journal-title":"Neurology."},{"issue":"6","key":"10.1016\/j.nrleng.2025.06.006_bib0170","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/eurpub\/ckac165","article-title":"Trends in smoking-attributable mortality in Spain: 1990-2018","volume":"32","author":"Rey-Brandariz","year":"2022","journal-title":"Eur J Public Health."},{"issue":"1","key":"10.1016\/j.nrleng.2025.06.006_bib0175","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00008469-200302000-00009","article-title":"Prevalence of cigarette smoking by birth cohort among males and females in Spain, 1910-1990","volume":"12","author":"Fernandez","year":"2003","journal-title":"Eur J Cancer Prev."},{"issue":"10","key":"10.1016\/j.nrleng.2025.06.006_bib0180","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1177\/1352458513483889","article-title":"Childhood body mass index and multiple sclerosis risk: a long-term cohort study","volume":"19","author":"Munger","year":"2013","journal-title":"Mult Scler."},{"key":"10.1016\/j.nrleng.2025.06.006_bib0185","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1038393","article-title":"Multiple sclerosis and obesity: The role of adipokines","volume":"13","author":"Correale","year":"2022","journal-title":"Front Immunol."},{"issue":"6","key":"10.1016\/j.nrleng.2025.06.006_bib0190","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.medcli.2016.11.022","article-title":"Prevalence of obesity and diabetes in Spanish adults 1987-2012","volume":"148","author":"Basterra-Gortari","year":"2017","journal-title":"Med Clin (Barc)."},{"issue":"6","key":"10.1016\/j.nrleng.2025.06.006_bib0195","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.recesp.2016.02.010","article-title":"Prevalence of general obesity and abdominal obesity in the Spanish adult population (Aged 25-64 Years) 2014-2015: the ENPE study","volume":"69","author":"Aranceta-Bartrina","year":"2016","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"issue":"3","key":"10.1016\/j.nrleng.2025.06.006_bib0200","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2105\/AJPH.71.3.231","article-title":"The quality and utility of death certificate data","volume":"71","author":"Glasser","year":"1981","journal-title":"Am J Public Health."},{"key":"10.1016\/j.nrleng.2025.06.006_bib0205","series-title":"In: StatPearls [Internet]","article-title":"Epidemiology Of Study Design","author":"Munnangi","year":"2022"}],"container-title":["Neurolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580825000537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580825000537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T15:11:25Z","timestamp":1754320285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2173580825000537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S2173580825000537"],"URL":"https:\/\/doi.org\/10.1016\/j.nrleng.2025.06.006","relation":{},"ISSN":["2173-5808"],"issn-type":[{"type":"print","value":"2173-5808"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple sclerosis mortality trends in Spain from 1981 to 2020","name":"articletitle","label":"Article Title"},{"value":"Neurolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nrleng.2025.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.nrl.2023.06.014","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Sociedad Espa\u00f1ola de Neurolog\u00eda.","name":"copyright","label":"Copyright"}]}}