{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T12:33:35Z","timestamp":1793622815203,"version":"4.5.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.nrleng.2026.501936","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:34:08Z","timestamp":1777116848000},"page":"501936","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Old drugs, new indications: Effectiveness of amantadine for epileptic encephalopathy in paediatric patients with spike-wave activation in sleep or refractory absence seizures"],"prefix":"10.1016","volume":"41","author":[{"given":"V.","family":"Soto-Insuga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gonz\u00e1lez-Alguacil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Cantar\u00edn Extremera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Garc\u00eda Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Guti\u00e9rrez Delicado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Mansilla Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Duat Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Esteso Ordu\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Garc\u00eda Pe\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nrleng.2026.501936_bib0080","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/02699052.2020.1723697","article-title":"Amantadine and memantine: a comprehensive review for acquired brain injury","volume":"34","author":"Ma","year":"2020","journal-title":"Brain Inj"},{"key":"10.1016\/j.nrleng.2026.501936_bib0085","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.braindev.2021.05.012","article-title":"A retrospective analysis of memantine use in a neurology clinic","volume":"43","author":"Bouhadoun","year":"2021","journal-title":"Brain Dev"},{"key":"10.1016\/j.nrleng.2026.501936_bib0090","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1212\/WNL.35.4.579","article-title":"Amantadine in the treatment of refractory epilepsy in childhood: an open trial in 10 patients","volume":"35","author":"Shields","year":"1985","journal-title":"Neurology"},{"key":"10.1016\/j.nrleng.2026.501936_bib0095","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/epi.17241","article-title":"International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: position paper by the ILAE Task Force on Nosology and Definitions","volume":"63","author":"Specchio","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.nrleng.2026.501936_bib0100","first-page":"309","article-title":"A girl with refractory childhood absence epilepsy improved by add-on amantadine therapy","volume":"39","author":"Matsushige","year":"2007","journal-title":"No To Hattatsu"},{"key":"10.1016\/j.nrleng.2026.501936_bib0105","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.yebeh.2018.04.018","article-title":"Amantadine: a new treatment for refractory electrical status epilepticus in sleep","volume":"84","author":"Wilson","year":"2018","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.nrleng.2026.501936_bib0110","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pediatrneurol.2012.02.004","article-title":"Amantadine for the treatment of refractory absence seizures in children","volume":"46","author":"Perry","year":"2012","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.nrleng.2026.501936_bib0115","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0022-3476(05)81922-5","article-title":"Effect of add-on amantadine therapy for refractory absence epilepsy","volume":"121","author":"Shahar","year":"1992","journal-title":"J Pediatr"},{"key":"10.1016\/j.nrleng.2026.501936_bib0120","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4103\/JPN.JPN_51_17","article-title":"Amantadine for the treatment of refractory absence seizures in children","volume":"13","author":"Sreedharan","year":"2018","journal-title":"J Pediatr Neurosci"},{"key":"10.1016\/j.nrleng.2026.501936_bib0125","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.braindev.2021.05.012","article-title":"A retrospective analysis of memantine use in a pediatric neurology clinic","volume":"43","author":"Bouhadoun","year":"2021","journal-title":"Brain Dev"},{"key":"10.1016\/j.nrleng.2026.501936_bib0130","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1056\/NEJMoa0902014","article-title":"Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy","volume":"362","author":"Glauser","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nrleng.2026.501936_bib0135","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.ajhg.2016.07.013","article-title":"GRIN2D recurrent de novo dominant mutation causes a severe epileptic encephalopathy treatable with NMDA receptor channel blockers","volume":"99","author":"Li","year":"2016","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.nrleng.2026.501936_bib0140","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1093\/brain\/awaa147","article-title":"Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice","volume":"143","author":"Amador","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.nrleng.2026.501936_bib0145","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/brain\/awac380","article-title":"Randomized placebo-controlled crossover trial of memantine in children with epileptic encephalopathy","volume":"146","author":"Schiller","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.nrleng.2026.501936_bib0150","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1055\/s-0041-1739130","article-title":"Favorable response to \u201cmemantine\u201d in a child with GRIN2B epileptic encephalopathy","volume":"53","author":"Chidambaram","year":"2022","journal-title":"Neuropediatrics"}],"container-title":["Neurolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580826000337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173580826000337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T12:24:44Z","timestamp":1793622284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2173580826000337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2173580826000337"],"URL":"https:\/\/doi.org\/10.1016\/j.nrleng.2026.501936","relation":{},"ISSN":["2173-5808"],"issn-type":[{"value":"2173-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Old drugs, new indications: Effectiveness of amantadine for epileptic encephalopathy in paediatric patients with spike-wave activation in sleep or refractory absence seizures","name":"articletitle","label":"Article Title"},{"value":"Neurolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nrleng.2026.501936","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Sociedad Espa\u00f1ola de Neurolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"501936"}}