{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:52:55Z","timestamp":1790355175236,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":228,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Applied"],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/j.nsa.2023.101133","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T02:25:52Z","timestamp":1692411952000},"page":"101133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Evaluating the pharmacodynamic effects of padsevonil in healthy volunteers using simultaneous [11C]-UCB-J PET and MR Arterial Spin Labeling measurements"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5862-640X","authenticated-orcid":false,"given":"Michel","family":"Koole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Lacroix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-208X","authenticated-orcid":false,"given":"Chunmeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2222-9813","authenticated-orcid":false,"given":"Hugues","family":"Chanteux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph Paul","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Van Laere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.nsa.2023.101133_bib1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0014-2999(92)90239-Z","article-title":"Central benzodiazepine receptors in human brain: estimation of regional Bmax and KD values with positron emission tomography","volume":"213","author":"Abadie","year":"1992","journal-title":"Eur. J. Pharmacol."},{"issue":"Apr","key":"10.1016\/j.nsa.2023.101133_bib2","article-title":"The relationship between dopamine neurotransmitter dynamics and the blood-oxygen-level-dependent (BOLD) signal: a review of pharmacological functional magnetic resonance imaging","volume":"12","author":"Bruinsma","year":"2018","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.nsa.2023.101133_bib4","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/mrm.21790","article-title":"Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields","volume":"60","author":"Dai","year":"2008","journal-title":"Magn. Reson. Med. : official journal of the Society of Magnetic Resonance in Medicine \/ Society of Magnetic Resonance in Medicine"},{"issue":"4","key":"10.1016\/j.nsa.2023.101133_bib5","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1002\/mrm.24335","article-title":"Volumetric measurement of perfusion and arterial transit delay using hadamard encoded continuous arterial spin labeling","volume":"69","author":"Dai","year":"2013","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.nsa.2023.101133_bib6","series-title":"Arterial Spin-Labeled Perfusion MRI in Basic and Clinical Neuroscience","author":"Detre","year":"2009"},{"key":"10.1016\/j.nsa.2023.101133_bib7","series-title":"Arterial Spin Labeling (ASL) Perfusion: Techniques and Clinical Use","author":"Ferr\u00e9","year":"2013"},{"issue":"348","key":"10.1016\/j.nsa.2023.101133_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf6667","article-title":"Imaging synaptic density in the living human brain","volume":"8","author":"Finnema","year":"2016","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.nsa.2023.101133_bib9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pharmthera.2009.03.002","article-title":"Target site occupancy: emerging generalizations from clinical and preclinical studies","volume":"122","author":"Grimwood","year":"2009","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.nsa.2023.101133_bib10","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.euroneuro.2019.04.001","article-title":"Modeling the acute pharmacological response to selective serotonin reuptake inhibitors in human brain using simultaneous PET\/MR imaging","volume":"29","author":"Gryglewski","year":"2019","journal-title":"Eur. Neuropsychopharmacol"},{"issue":"44","key":"10.1016\/j.nsa.2023.101133_bib11","doi-asserted-by":"crossref","first-page":"10671","DOI":"10.1523\/JNEUROSCI.1971-17.2017","article-title":"Functional characterization of 5-HT 1B receptor drugs in nonhuman primates using simultaneous PET-MR","volume":"37","author":"Hansen","year":"2017","journal-title":"J.\u00a0Neurosci."},{"issue":"4","key":"10.1016\/j.nsa.2023.101133_bib12","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1152\/jn.00114.2005","article-title":"Effect of benzodiazepine hypnotic triazolam on relationship of blood pressure and Pa <scp>co<\/scp> 2 to cerebral blood flow during human non-rapid eye movement sleep","volume":"95","author":"Hiroki","year":"2006","journal-title":"J.\u00a0Neurophysiol."},{"issue":"11","key":"10.1016\/j.nsa.2023.101133_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206583","article-title":"Test-retest reliability of task-based and resting-state blood oxygen level dependence and cerebral blood flow measures","volume":"13","author":"Holiga","year":"2018","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.nsa.2023.101133_bib14","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.tips.2004.05.009","article-title":"Human pharmacological MRI","volume":"25","author":"Honey","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.nsa.2023.101133_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/jcbfm.1994.13","article-title":"[ 11 C]tropanyl benzilate\u2014binding to muscarinic cholinergic receptors: methodology and kinetic modeling alternatives","volume":"14","author":"Koeppe","year":"1994","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol."},{"issue":"10","key":"10.1016\/j.nsa.2023.101133_bib16","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1097\/00004647-199910000-00012","article-title":"Kinetic modeling of N -[ 11 C]Methylpiperidin-4-yl propionate: alternatives for analysis of an irreversible positron emission tomography tracer for measurement of acetylcholinesterase activity in human brain","volume":"19","author":"Koeppe","year":"1999","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol."},{"issue":"2","key":"10.1016\/j.nsa.2023.101133_bib17","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00259-018-4119-8","article-title":"Quantifying SV2A density and drug occupancy in the human brain using [11C]UCB-J PET imaging and subcortical white matter as reference tissue","volume":"46","author":"Koole","year":"2019","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"issue":"S2","key":"10.1016\/j.nsa.2023.101133_bib18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00062-015-0457-0","article-title":"Pharmacological MRI (phMRI) of the human central nervous system","volume":"25","author":"Lanfermann","year":"2015","journal-title":"Clin. Neuroradiol."},{"issue":"8","key":"10.1016\/j.nsa.2023.101133_bib19","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0165-6147(00)01507-8","article-title":"Pharmacological magnetic resonance imaging: a new application for functional MRI","volume":"21","author":"Leslie","year":"2000","journal-title":"Trends Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.nsa.2023.101133_bib20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2125.2011.04085.x","article-title":"Positron emission tomography molecular imaging for drug development","volume":"73","author":"Matthews","year":"2012","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"4","key":"10.1016\/j.nsa.2023.101133_bib21","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/s00213-005-2270-y","article-title":"Neuronal effects of acute citalopram detected by pharmacoMRI","volume":"180","author":"McKie","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"10.1016\/j.nsa.2023.101133_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa183","article-title":"Padsevonil randomized Phase IIa trial in treatment-resistant focal epilepsy: a translational approach","volume":"2","author":"Muglia","year":"2020","journal-title":"Brain Commun"},{"issue":"5","key":"10.1016\/j.nsa.2023.101133_bib24","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/npp.2015.296","article-title":"Imaging agonist-induced D2\/D3 receptor desensitization and internalization in vivo with PET\/fMRI","volume":"41","author":"Sander","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nsa.2023.101133_bib25","volume":"110","author":"Sander","year":"2013"},{"issue":"6","key":"10.1016\/j.nsa.2023.101133_bib26","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1177\/0271678X20910038","article-title":"Advances in simultaneous PET\/MR for imaging neuroreceptor function","volume":"40","author":"Sander","year":"2020","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol."},{"issue":"12","key":"10.1016\/j.nsa.2023.101133_bib27","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1007\/s00259-016-3476-4","article-title":"Guidelines to PET measurements of the target occupancy in the brain for drug development","volume":"43","author":"Takano","year":"2016","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"key":"10.1016\/j.nsa.2023.101133_bib28","doi-asserted-by":"crossref","DOI":"10.3174\/ajnr.A5717","article-title":"Brain perfusion measurements using multidelay arterial spin-labeling are systematically biased by the number of delays","author":"van der Thiel","year":"2018","journal-title":"Am. J. Neuroradiol."},{"issue":"11","key":"10.1016\/j.nsa.2023.101133_bib29","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1038\/s41386-018-0145-2","article-title":"In vivo biased agonism at 5-HT1A receptors: characterisation by simultaneous PET\/MR imaging","volume":"43","author":"Vidal","year":"2018","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.nsa.2023.101133_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.119.261149","article-title":"Pharmacological profile of the novel antiepileptic drug candidate padsevonil: interactions with synaptic vesicle 2 proteins and the GABA A receptor","volume":"372","author":"Wood","year":"2020","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."}],"container-title":["Neuroscience Applied"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772408523001151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772408523001151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T17:30:05Z","timestamp":1702229405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772408523001151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":28,"alternative-id":["S2772408523001151"],"URL":"https:\/\/doi.org\/10.1016\/j.nsa.2023.101133","relation":{},"ISSN":["2772-4085"],"issn-type":[{"value":"2772-4085","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating the pharmacodynamic effects of padsevonil in healthy volunteers using simultaneous [11C]-UCB-J PET and MR Arterial Spin Labeling measurements","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Applied","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nsa.2023.101133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V. on behalf of European College of Neuropsychopharmacology.","name":"copyright","label":"Copyright"}],"article-number":"101133"}}