{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:50:27Z","timestamp":1791312627332,"version":"4.3.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":65,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Applied"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.nsa.2024.104055","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T17:50:21Z","timestamp":1709747421000},"page":"104055","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Neuronal activation in the paraventricular thalamus and lateral habenula during activity-based anorexia in mice"],"prefix":"10.1016","volume":"3","author":[{"given":"Erik","family":"Sch\u00e9le","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nsa.2024.104055_bib1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/7854_2010_77","article-title":"Neurobiology driving hyperactivity in activity-based anorexia","volume":"6","author":"Adan","year":"2011","journal-title":"Curr Top Behav Neurosci"},{"issue":"6356","key":"10.1016\/j.nsa.2024.104055_bib2","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1126\/science.aan6747","article-title":"Thirst-associated preoptic neurons encode an aversive motivational drive","volume":"357","author":"Allen","year":"2017","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.nsa.2024.104055_bib3","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.neuroscience.2006.08.064","article-title":"Restricted feeding schedules phase shift daily rhythms of c-Fos and protein Per1 immunoreactivity in corticolimbic regions in rats","volume":"144","author":"Angeles-Castellanos","year":"2007","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.nsa.2024.104055_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"issue":"7551","key":"10.1016\/j.nsa.2024.104055_bib5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature14416","article-title":"Neurons for hunger and thirst transmit a negative-valence teaching signal","volume":"521","author":"Betley","year":"2015","journal-title":"Nature"},{"issue":"36","key":"10.1016\/j.nsa.2024.104055_bib6","doi-asserted-by":"crossref","first-page":"6280","DOI":"10.1523\/JNEUROSCI.0704-23.2023","article-title":"Paraventricular thalamic MC3R circuits link energy homeostasis with anxiety-related behavior","volume":"43","author":"Cho","year":"2023","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.nsa.2024.104055_bib7","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.comppsych.2007.12.007","article-title":"Compulsive exercise to control shape or weight in eating disorders: prevalence, associated features, and treatment outcome","volume":"49","author":"Dalle Grave","year":"2008","journal-title":"Compr Psychiatry"},{"issue":"3","key":"10.1016\/j.nsa.2024.104055_bib8","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41593-018-0318-7","article-title":"Temporal evolution of cortical ensembles promoting remote memory retrieval","volume":"22","author":"DeNardo","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.nsa.2024.104055_bib9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s40519-023-01545-4","article-title":"Food avoidance in anorexia nervosa: associated and predicting factors","volume":"28","author":"Di Lodovico","year":"2023","journal-title":"Eat. Weight Disord."},{"issue":"2","key":"10.1016\/j.nsa.2024.104055_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41593-019-0572-3","article-title":"Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus","volume":"23","author":"Gao","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.nsa.2024.104055_bib11","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.neuron.2013.03.025","article-title":"Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations","volume":"78","author":"Guenthner","year":"2013","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.nsa.2024.104055_bib12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41583-020-0292-4","article-title":"Circuits and functions of the lateral habenula in health and in disease","volume":"21","author":"Hu","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"issue":"24","key":"10.1016\/j.nsa.2024.104055_bib13","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1016\/j.cub.2018.11.020","article-title":"Calretinin neurons in the midline thalamus modulate starvation-induced arousal","volume":"28","author":"Hua","year":"2018","journal-title":"Curr. Biol."},{"issue":"2","key":"10.1016\/j.nsa.2024.104055_bib14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/cne.903040205","article-title":"Immunocytochemical localization of calretinin in the forebrain of the rat","volume":"304","author":"Jacobowitz","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nsa.2024.104055_bib15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fnsys.2013.00045","article-title":"The anterior thalamus provides a subcortical circuit supporting memory and spatial navigation","volume":"7","author":"Jankowski","year":"2013","journal-title":"Front. Syst. Neurosci."},{"issue":"1","key":"10.1016\/j.nsa.2024.104055_bib16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/cne.20769","article-title":"A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food reward","volume":"493","author":"Kelley","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nsa.2024.104055_bib17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.neubiorev.2015.08.005","article-title":"Placing the paraventricular nucleus of the thalamus within the brain circuits that control behavior","volume":"56","author":"Kirouac","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.nsa.2024.104055_bib18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s40337-023-00799-8","article-title":"Differences in sleep patterns between patients with anorexia nervosa and healthy controls: a cross-sectional study","volume":"11","author":"Kleppe","year":"2023","journal-title":"J Eat Disord"},{"issue":"19","key":"10.1016\/j.nsa.2024.104055_bib19","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1016\/j.cub.2019.07.069","article-title":"Orexin in the posterior paraventricular thalamus mediates hunger-related signals in the nucleus accumbens core","volume":"29","author":"Meffre","year":"2019","journal-title":"Curr. Biol."},{"issue":"7","key":"10.1016\/j.nsa.2024.104055_bib20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S2213-8587(13)70180-3","article-title":"Endocrine consequences of anorexia nervosa","volume":"2","author":"Misra","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"12","key":"10.1016\/j.nsa.2024.104055_bib21","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1038\/npp.2017.150","article-title":"Paraventricular thalamic control of food intake and reward: role of glucagon-like peptide-1 receptor signaling","volume":"42","author":"Ong","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"7","key":"10.1016\/j.nsa.2024.104055_bib22","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.tins.2021.03.001","article-title":"The paraventricular nucleus of the thalamus: an integrative node underlying homeostatic behavior","volume":"44","author":"Penzo","year":"2021","journal-title":"Trends Neurosci."},{"issue":"6413","key":"10.1016\/j.nsa.2024.104055_bib23","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1126\/science.aat2512","article-title":"The paraventricular thalamus is a critical thalamic area for wakefulness","volume":"362","author":"Ren","year":"2018","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.nsa.2024.104055_bib24","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1037\/h0025205","article-title":"Self-starvation of rats living in activity wheels on a restricted feeding schedule","volume":"64","author":"Routtenberg","year":"1967","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.nsa.2024.104055_bib25","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3389\/fnins.2016.00475","article-title":"Activity-based anorexia reduces body weight without inducing a separate food intake microstructure or activity phenotype in female rats-mediation via an activation of distinct brain nuclei","volume":"10","author":"Scharner","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nsa.2024.104055_bib26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.euroneuro.2023.02.014","article-title":"Engagement of the brain orexin system in activity-based anorexia behaviour in mice","volume":"70","author":"Schele","year":"2023","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/j.nsa.2024.104055_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/eat.24143","article-title":"Persistent avoidance of virtual food in anorexia nervosa-restrictive type: results from motion tracking in a virtual stopping task","author":"Schroeder","year":"2024","journal-title":"Int. J. Eat. Disord."},{"issue":"25","key":"10.1016\/j.nsa.2024.104055_bib28","doi-asserted-by":"crossref","first-page":"12488","DOI":"10.1073\/pnas.1903334116","article-title":"Stress transforms lateral habenula reward responses into punishment signals","volume":"116","author":"Shabel","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.nsa.2024.104055_bib29","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1523\/JNEUROSCI.1202-15.2016","article-title":"Lateral hypothalamic area glutamatergic neurons and their projections to the lateral habenula regulate feeding and reward","volume":"36","author":"Stamatakis","year":"2016","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.nsa.2024.104055_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-26306-8","article-title":"Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior","volume":"12","author":"Swanson","year":"2022","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.nsa.2024.104055_bib31","doi-asserted-by":"crossref","first-page":"coz001","DOI":"10.1093\/conphys\/coz001","article-title":"Faecal glucocorticoid metabolite profiles in diademed sifakas increase during seasonal fruit scarcity with interactive effects of age\/sex class and habitat degradation","volume":"7","author":"Tecot","year":"2019","journal-title":"Conserv Physiol"},{"issue":"1","key":"10.1016\/j.nsa.2024.104055_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/cne.1398","article-title":"Activation of the central nervous system in obese Zucker rats during food deprivation","volume":"441","author":"Timofeeva","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nsa.2024.104055_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.crneur.2023.100109","article-title":"Neuromodulation of the anterior thalamus: current approaches and opportunities for the future","volume":"5","author":"Venkatesh","year":"2023","journal-title":"Curr Res Neurobiol"},{"issue":"7","key":"10.1016\/j.nsa.2024.104055_bib34","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/hipo.23271","article-title":"Calretinin and calbindin architecture of the midline thalamus associated with prefrontal-hippocampal circuitry","volume":"31","author":"Viena","year":"2021","journal-title":"Hippocampus"},{"issue":"1","key":"10.1016\/j.nsa.2024.104055_bib35","article-title":"Metabolic and neuroendocrine adaptations to undernutrition in anorexia nervosa: from a clinical to a basic research point of view","volume":"36","author":"Viltart","year":"2018","journal-title":"Horm Mol Biol Clin Investig"},{"issue":"8","key":"10.1016\/j.nsa.2024.104055_bib36","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/s41588-019-0439-2","article-title":"Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa","volume":"51","author":"Watson","year":"2019","journal-title":"Nat. Genet."},{"issue":"1\u20132","key":"10.1016\/j.nsa.2024.104055_bib37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0006-8993(94)91517-2","article-title":"Dopamine agonists and stress produce different patterns of Fos-like immunoreactivity in the lateral habenula","volume":"633","author":"Wirtshafter","year":"1994","journal-title":"Brain Res."},{"issue":"6340","key":"10.1016\/j.nsa.2024.104055_bib38","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.aam7100","article-title":"Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation","volume":"356","author":"Zhang","year":"2017","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.nsa.2024.104055_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111824","article-title":"A paraventricular thalamus to central amygdala neural circuit modulates acute stress-induced heightened wakefulness","volume":"41","author":"Zhao","year":"2022","journal-title":"Cell Rep."}],"container-title":["Neuroscience Applied"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772408524001200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772408524001200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T23:19:15Z","timestamp":1731021555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772408524001200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":39,"alternative-id":["S2772408524001200"],"URL":"https:\/\/doi.org\/10.1016\/j.nsa.2024.104055","relation":{},"ISSN":["2772-4085"],"issn-type":[{"value":"2772-4085","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuronal activation in the paraventricular thalamus and lateral habenula during activity-based anorexia in mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Applied","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nsa.2024.104055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author. Published by Elsevier B.V. on behalf of European College of Neuropsychopharmacology.","name":"copyright","label":"Copyright"}],"article-number":"104055"}}