{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:02:19Z","timestamp":1785520939571,"version":"3.56.0"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"vor","delay-in-days":209,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Applied"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.nsa.2024.104085","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T17:58:14Z","timestamp":1722275894000},"page":"104085","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["The effect of physical exercise with cognitive training on inflammation and Alzheimer's disease biomarkers of Mild Cognitive Impairment patients"],"prefix":"10.1016","volume":"3","author":[{"given":"Georgios","family":"Katsipis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni E.","family":"Tzekaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni G.","family":"Andreadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Mouzakidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5035-4187","authenticated-orcid":false,"given":"Eleni N.","family":"Baldimtsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni M.","family":"Karathanasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Hassandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Galanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonis","family":"Hatzigeorgiadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Goudas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Zikas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giannis","family":"Evangelou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Papagiannakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Bellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Kokkotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6658-5764","authenticated-orcid":false,"given":"Themistoklis","family":"Tsatalas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9218-0114","authenticated-orcid":false,"given":"Giannis","family":"Giakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannis","family":"Theodorakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Tsolaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia A.","family":"Pantazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nsa.2024.104085_bib1","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.4314\/ahs.v19i2.45","article-title":"Aerobic exercise modulates cytokine profile and sleep quality in elderly","volume":"19","author":"Abd El-Kader","year":"2019","journal-title":"Afr. Health Sci."},{"key":"10.1016\/j.nsa.2024.104085_bib2","first-page":"327","article-title":"Alzheimer's disease facts and figures special report race, ethnicity and Alzheimer's in America","volume":"17","year":"2021","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.nsa.2024.104085_bib3","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1007\/s12035-018-1388-y","article-title":"The possibility of an infectious etiology of alzheimer disease","volume":"56","author":"Ashraf","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nsa.2024.104085_bib4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jns.2017.03.031","article-title":"Role of inflammatory molecules in the Alzheimer\u2019s disease progression and diagnosis","volume":"376","author":"Bagyinszky","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nsa.2024.104085_bib5","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.2266-11.2011","article-title":"Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes","author":"Barrientos","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nsa.2024.104085_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111236","article-title":"The effects of exercise interventions on the inflammatory profile of older adults: a systematic review of the recent literature","volume":"146","author":"Bautmans","year":"2021","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.nsa.2024.104085_bib7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/npp.2013.208","article-title":"Intra-hippocampal transplantation of neural precursor cells with transgenic over-expression of IL-1 receptor antagonist rescues memory and neurogenesis impairments in an Alzheimer's disease model","volume":"39","author":"Ben-Menachem-Zidon","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nsa.2024.104085_bib8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1600-0838.2011.01372.x","article-title":"Evidence for an exercise induced increase of TNF-\u03b1 and IL-6 in marathon runners","volume":"23","author":"Bernecker","year":"2013","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"10.1016\/j.nsa.2024.104085_bib9","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1186\/1471-2458-14-510","article-title":"Does physical activity prevent cognitive decline and dementia?: a systematic review and meta-analysis of longitudinal studies","volume":"14","author":"Blondell","year":"2014","journal-title":"BMC Publ."},{"key":"10.1016\/j.nsa.2024.104085_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-0043-119882","article-title":"Lifelong voluntary exercise modulates age-related changes in oxidative stress","volume":"39","author":"Bouzid","year":"2018","journal-title":"Int. J. Sports Med."},{"key":"10.1016\/j.nsa.2024.104085_bib11","article-title":"Aerobic exercise effects upon cognition in mild cognitive impairment: a systematic review of randomized controlled trials","author":"Cammisuli","year":"2017","journal-title":"Arch. Ital. Biol."},{"key":"10.1016\/j.nsa.2024.104085_bib12","article-title":"P-Tau\/A\u03b242 and a\u03b242\/40 ratios in csf are equally predictive of amyloid pet status","author":"Campbell","year":"2021","journal-title":"Alzheimer's Dementia: Diagnosis, Assessment and Disease Monitoring"},{"key":"10.1016\/j.nsa.2024.104085_bib13","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1152\/physiol.00039.2014","article-title":"Mitochondria, muscle health, and exercise with advancing age","volume":"30","author":"Carter","year":"2015","journal-title":"Physiology"},{"key":"10.1016\/j.nsa.2024.104085_bib14","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3233\/JAD-160212","article-title":"Oral infections and cytokine levels in patients with Alzheimer's disease and mild cognitive impairment compared with controls","volume":"52","author":"Cestari","year":"2016","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.nsa.2024.104085_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-021-01476-7","article-title":"Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer's disease","author":"Chen","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nsa.2024.104085_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-021-01476-7","article-title":"Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer's disease","author":"Chen","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nsa.2024.104085_bib17","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-035980","article-title":"Outcomes tested in non-pharmacological interventions in mild cognitive impairment and mild dementia: a scoping review","volume":"10","author":"Couch","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.nsa.2024.104085_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbi.2018.02.013","article-title":"Rethinking IL-6 and CRP: why they are more than inflammatory biomarkers, and why it matters","volume":"70","author":"Del Giudice","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nsa.2024.104085_bib19","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.2147\/CIA.S169565","article-title":"Physical activity can improve cognition in patients with Alzheimer\u2019s disease: a systematic review and meta-analysis of randomized controlled trials","volume":"13","author":"Du","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.nsa.2024.104085_bib20","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S1474-4422(21)00066-1","article-title":"Clinical diagnosis of Alzheimer's disease: recommendations of the international working group","volume":"20","author":"Dubois","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nsa.2024.104085_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jneuroim.2015.04.014","article-title":"The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease","volume":"283","author":"Dursun","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nsa.2024.104085_bib23","first-page":"179","article-title":"Plasma amyloid \u03b2 42\/40 ratios as biomarkers for amyloid \u03b2 cerebral deposition in cognitively normal individuals","volume":"8","author":"Fandos","year":"2017","journal-title":"Alzheimer's Dementia: Diagnosis, Assessment & Disease Monitoring"},{"key":"10.1016\/j.nsa.2024.104085_bib24","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.3390\/nu10111780","article-title":"Regular practice of moderate physical activity by older adults ameliorates their anti-inflammatory status","volume":"10","author":"Ferrer","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.nsa.2024.104085_bib25","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.nsa.2024.104085_bib26","article-title":"Effects of physical exercise on Alzheimer's disease biomarkers: a systematic review of intervention studies","author":"Frederiksen","year":"2018","journal-title":"J. Alzheim. Dis."},{"issue":"2","key":"10.1016\/j.nsa.2024.104085_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/brainsci7020022","article-title":"Physical activity: a viable way to reduce the risks of mild cognitive impairment, Alzheimer\u2019s disease, and vascular dementia in older adults","volume":"7","author":"Gallaway","year":"2017","journal-title":"Brain Sci."},{"key":"10.1016\/j.nsa.2024.104085_bib29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000530907","article-title":"CSF A\u03b240 levels do not correlate with the clinical manifestations of Alzheimer's disease","volume":"22","author":"Garcia Castro","year":"2022","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.nsa.2024.104085_bib30","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pharep.2015.07.006","article-title":"Therapeutic strategies for Alzheimer's disease in clinical trials","volume":"68","author":"Gody\u0144","year":"2016","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.nsa.2024.104085_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/726861","article-title":"Exercise induced adipokine changes and the metabolic syndrome","volume":"2014","author":"Golbidi","year":"2014","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.nsa.2024.104085_bib32","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1001\/archneur.64.3.354","article-title":"Association of low plasma abeta42\/abeta40 ratios with increased imminent risk for mild cognitive impairment and alzheimer disease","volume":"64","author":"Graff-Radford","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nsa.2024.104085_bib33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1249\/JES.0000000000000192","article-title":"Exercise-induced mitophagy in skeletal muscle and heart","volume":"47","author":"Guan","year":"2019","journal-title":"Exerc. Sport Sci. Rev."},{"key":"10.1016\/j.nsa.2024.104085_bib34","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jalz.2007.08.006","article-title":"Core candidate neurochemical and imaging biomarkers of Alzheimer's disease","volume":"4","author":"Hampel","year":"2008","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.nsa.2024.104085_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/alz.12613","article-title":"Plasma amyloid beta predicts conversion to dementia in subjects with mild cognitive impairment: the BALTAZAR study","author":"Hanon","year":"2022","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.nsa.2024.104085_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2017.00144","article-title":"Voluntary exercise promotes glymphatic clearance of amyloid beta and reduces the activation of astrocytes and microglia in aged mice","volume":"10","author":"He","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nsa.2024.104085_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1539-6053.2009.01034.x","article-title":"Enrichment effects on adult cognitive development","volume":"9","author":"Hertzog","year":"2008","journal-title":"Psychol. Sci. Publ. Interest"},{"key":"10.1016\/j.nsa.2024.104085_bib38","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nrn2298","article-title":"Be smart, exercise your heart: exercise effects on brain and cognition","volume":"9","author":"Hillman","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nsa.2024.104085_bib39","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1210\/jc.2008-0425","article-title":"Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance","volume":"93","author":"Hivert","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.nsa.2024.104085_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111424","article-title":"Biomarkers for evaluating the effects of exercise interventions in patients with MCI or dementia: a systematic review and meta-analysis","volume":"151","author":"Huang","year":"2021","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.nsa.2024.104085_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2015.00187","article-title":"Biochemical markers of physical exercise on mild cognitive impairment and dementia: systematic review and perspectives","volume":"6","author":"Jensen","year":"2015","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nsa.2024.104085_bib43","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1007\/s10495-013-0884-9","article-title":"Treadmill exercise represses neuronal cell death and inflammation during a\u03b2-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice","volume":"18","author":"Kang","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.nsa.2024.104085_bib44","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.arr.2017.09.003","article-title":"Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: a meta-analysis","volume":"40","author":"Karssemeijer","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.nsa.2024.104085_bib45","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI117899","article-title":"The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase","volume":"95","author":"Kern","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nsa.2024.104085_bib46","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/psyg.12218","article-title":"Serum tumour necrosis factor-\u03b1 and interleukin-6 levels in Alzheimer's disease and mild cognitive impairment","volume":"17","author":"Kim","year":"2017","journal-title":"Psychogeriatrics"},{"key":"10.1016\/j.nsa.2024.104085_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112105","article-title":"Protective effect of exercise training against the progression of Alzheimer's disease in 3xTg-AD mice","author":"Kim","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nsa.2024.104085_bib48","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.4049\/jimmunol.1100620","article-title":"Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal \u03b2-catenin pathway function in an Alzheimer's disease model","volume":"187","author":"Kitazawa","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.nsa.2024.104085_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2011.10.006","article-title":"Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the Hippocampus of aged mice","author":"Kohman","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nsa.2024.104085_bib50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/TGR.0b013e31821e59a9","article-title":"RHEA,* a nonpharmacological cognitive training intervention in patients with mild cognitive impairment","volume":"27","author":"Kounti","year":"2011","journal-title":"Top. Geriatr. Rehabil."},{"key":"10.1016\/j.nsa.2024.104085_bib51","doi-asserted-by":"crossref","DOI":"10.1001\/archneurol.2011.1841","article-title":"Plasma amyloid-\u03b2 as a predictor of dementia and cognitive decline","volume":"69","author":"Koyama","year":"2012","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nsa.2024.104085_bib52","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12877-016-0315-1","article-title":"Influence of combined physical and cognitive training on cognition: a systematic review","volume":"16","author":"Lauenroth","year":"2016","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.nsa.2024.104085_bib53","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-5728(99)00226-X","article-title":"Increased plasma levels of interleukin-1, interleukin-6 and alpha-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?","volume":"103","author":"Licastro","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nsa.2024.104085_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2017.00147","article-title":"A life-long approach to physical activity for brain health","author":"Macpherson","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nsa.2024.104085_bib55","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.nbd.2009.01.006","article-title":"Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology","volume":"34","author":"McAlpine","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nsa.2024.104085_bib56","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00401-013-1177-7","article-title":"The amyloid cascade-inflammatory hypothesis of alzheimer disease: implications for therapy","volume":"126","author":"McGeer","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nsa.2024.104085_bib57","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/13543784.2017.1323868","article-title":"Why do trials for Alzheimer's disease drugs keep failing? A discontinued drug perspective for 2010-2015","volume":"26","author":"Mehta","year":"2017","journal-title":"Expet Opin. Invest. Drugs"},{"key":"10.1016\/j.nsa.2024.104085_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/2012798","article-title":"Mitochondrial function and mitophagy in the elderly: effects of exercise","volume":"2017","author":"Moreira","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.nsa.2024.104085_bib59","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nature25456","article-title":"High-performance plasma amyloid-\u03b2 biomarkers for Alzheimer's disease","volume":"554","author":"Nakamura","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.nsa.2024.104085_bib60","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2174\/156720501108140910122849","article-title":"Physical exercise in MCI elderly promotes reduction of pro-inflammatory cytokines and improvements on cognition and BDNF peripheral levels","volume":"11","author":"Nascimento","year":"2014","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.nsa.2024.104085_bib61","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2174\/156720501108140910122849","article-title":"Physical exercise in MCI elderly promotes reduction of pro-inflammatory cytokines and improvements on cognition and BDNF peripheral levels","volume":"11","author":"Nascimento","year":"2014","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.nsa.2024.104085_bib62","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1006\/nimg.2002.1167","article-title":"The role of the dorsolateral prefrontal cortex: evidence from the effects of contextual constraint in a sentence completion task","volume":"16","author":"Nathaniel-James","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.nsa.2024.104085_bib63","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1212\/01.WNL.0000147478.03911.28","article-title":"Benefits of cognitive-motor intervention in MCI and mild to moderate alzheimer disease","volume":"63","author":"Olazar\u00e1n","year":"2004","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.nsa.2024.104085_bib64","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1474-4422(16)00070-3","article-title":"CSF and blood biomarkers for the diagnosis of Alzheimer\u2019s disease: a systematic review and meta-analysis","volume":"15","author":"Olsson","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nsa.2024.104085_bib65","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s12974-021-02332-7","article-title":"Biologic TNF-\u03b1 inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy","volume":"18","author":"Ou","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nsa.2024.104085_bib66","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1440-1711.2000.t01-11-.x","article-title":"Exercise and cytokines","volume":"78","author":"Pedersen","year":"2000","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.nsa.2024.104085_bib67","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1034\/j.1600-0838.2003.20218.x","article-title":"Possible beneficial role of exercise in modulating low\u2010grade inflammation in the elderly","volume":"13","author":"Pedersen","year":"2003","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"10.1016\/j.nsa.2024.104085_bib68","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tips.2007.02.002","article-title":"Beneficial health effects of exercise \u2013 the role of IL-6 as a myokine","volume":"28","author":"Pedersen","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.nsa.2024.104085_bib69","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1007\/s00421-020-04447-w","article-title":"Exercise training improves vascular function in patients with Alzheimer's disease","volume":"120","author":"Pedrinolla","year":"2020","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.nsa.2024.104085_bib70","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1093\/brain\/awab223","article-title":"Plasma GFAP is an early marker of amyloid-\u03b2 but not tau pathology in Alzheimer's disease","volume":"144","author":"Pereira","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.nsa.2024.104085_bib71","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1001\/archneur.62.7.1160","article-title":"Mild cognitive impairment as a clinical entity and treatment target","volume":"62","author":"Petersen","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nsa.2024.104085_bib72","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1017\/S1092852900016151","article-title":"Mild cognitive impairment: an overview","volume":"13","author":"Petersen","year":"2008","journal-title":"CNS Spectr."},{"key":"10.1016\/j.nsa.2024.104085_bib73","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1152\/japplphysiol.00164.2004","article-title":"The anti-inflammatory effect of exercise","volume":"98","author":"Petersen","year":"2005","journal-title":"J. Appl. Physiol."},{"issue":"6301","key":"10.1016\/j.nsa.2024.104085_bib74","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.aag2590","article-title":"How neuroinflammation contributes to neurodegeneration","volume":"353","author":"Ransohoff","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.nsa.2024.104085_bib75","series-title":"Cochrane Database of Systematic Reviews","article-title":"Plasma and cerebro spinal fluid amyloid beta 42, 40 and the 42:40 ratio for diagnosis of incipient dementia in a population with objective cognitive decline","author":"Ritchie","year":"2010"},{"key":"10.1016\/j.nsa.2024.104085_bib76","doi-asserted-by":"crossref","DOI":"10.1007\/s00429-013-0693-5","article-title":"Microglial response to Alzheimer's disease is differentially modulated by voluntary wheel running and enriched environments","author":"Rodr\u00edguez","year":"2015","journal-title":"Brain Struct. Funct."},{"issue":"1","key":"10.1016\/j.nsa.2024.104085_bib77","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cger.2009.11.002","article-title":"Healthy brain aging: role of exercise and physical activity","volume":"26","author":"Rolland","year":"2010","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.nsa.2024.104085_bib78","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.neurobiolaging.2008.01.014","article-title":"Inflammatory markers in AD and MCI patients with different biomarker profiles","volume":"30","author":"Schuitemaker","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nsa.2024.104085_bib79","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3233\/JAD-2012-121078","article-title":"Exercise-induced noradrenergic activation enhances memory consolidation in both normal aging and patients with amnestic mild cognitive impairment","volume":"32","author":"Segal","year":"2012","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.nsa.2024.104085_bib80","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02187","article-title":"Effects of acute and chronic exercise on immunological parameters in the elderly aged: can physical activity counteract the effects of aging?","volume":"9","author":"Sellami","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nsa.2024.104085_bib81","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.brainres.2010.10.053","article-title":"Anti-TNF-\u03b1 reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP\/PS1 transgenic mouse brains","volume":"1368","author":"Shi","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.nsa.2024.104085_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.111079","article-title":"Is inflammageing influenced by the microbiota in the aged gut? A systematic review","volume":"141","author":"Shintouo","year":"2020","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.nsa.2024.104085_bib83","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fncel.2018.00072","article-title":"An inflammation-centric view of neurological disease: beyond the neuron","volume":"12","author":"Skaper","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nsa.2024.104085_bib84","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijnurstu.2018.01.002","article-title":"The effectiveness of physical exercise on cognitive and psychological outcomes in individuals with mild cognitive impairment: a systematic review and meta-analysis","volume":"79","author":"Song","year":"2018","journal-title":"Int. J. Nurs. Stud."},{"key":"10.1016\/j.nsa.2024.104085_bib85","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12640-012-9373-0","article-title":"Neuroprotective effect of physical exercise in a mouse model of Alzheimer's disease induced by \u03b2-amyloid1\u201340 peptide","volume":"24","author":"Souza","year":"2013","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.nsa.2024.104085_bib86","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s13760-019-01112-8","article-title":"CSF biomarkers and amyloid PET: concordance and diagnostic accuracy in a MCI cohort","volume":"119","author":"Spallazzi","year":"2019","journal-title":"Acta Neurol. Belg."},{"key":"10.1016\/j.nsa.2024.104085_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fj.02-0670fje","article-title":"Exercise and IL\u20106 infusion inhibit endotoxin\u2010induced TNF\u2010\u03b1 production in humans","volume":"17","author":"Starkie","year":"2003","journal-title":"Faseb. J."},{"key":"10.1016\/j.nsa.2024.104085_bib88","doi-asserted-by":"crossref","first-page":"E433","DOI":"10.1152\/ajpendo.00074.2003","article-title":"IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans","volume":"285","author":"Steensberg","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"10.1016\/j.nsa.2024.104085_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.jagp.2015.07.007","article-title":"Drug and exercise treatment of alzheimer disease and mild cognitive impairment: a systematic review and meta-analysis of effects on cognition in randomized controlled trials","author":"Str\u00f6hle","year":"2015","journal-title":"Am. J. Geriatr. Psychiatr."},{"key":"10.1016\/j.nsa.2024.104085_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2018.04.040","article-title":"Physical exercise reserved amyloid-beta induced brain dysfunctions by regulating hippocampal neurogenesis and inflammatory response via MAPK signaling","volume":"1697","author":"Sun","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.nsa.2024.104085_bib91","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s40279-013-0140-z","article-title":"Autophagic cellular responses to physical exercise in skeletal muscle","volume":"44","author":"Tam","year":"2014","journal-title":"Sports Med."},{"key":"10.1016\/j.nsa.2024.104085_bib92","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.12255","article-title":"Voluntary running attenuates memory loss, decreases neuropathological changes and induces neurogenesis in a mouse model of Alzheimer's disease","author":"Tapia-Rojas","year":"2016","journal-title":"Brain Pathol."},{"key":"10.1016\/j.nsa.2024.104085_bib93","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0197-4580(01)00328-1","article-title":"Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid","volume":"23","author":"Teunissen","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nsa.2024.104085_bib94","doi-asserted-by":"crossref","DOI":"10.1002\/mds.28994","article-title":"A longitudinal study of plasma PTau181 in mild cognitive impairment with lewy bodies and Alzheimer's disease","author":"Thomas","year":"2022","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nsa.2024.104085_bib95","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3164\/jcbn.16-108","article-title":"Effects of exercise training on nitric oxide, blood pressure and antioxidant enzymes","volume":"60","author":"Tsukiyama","year":"2017","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.nsa.2024.104085_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111344","article-title":"The pleiotropic beneficial intervention of olive oil intake on the Alzheimer's disease onset via fibrinolytic system","volume":"150","author":"Tzekaki","year":"2021","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.nsa.2024.104085_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.dscb.2023.100090","article-title":"VRADA training system as a non-pharmacological dual intervention to alleviate symptoms of the pathophysiology of mild cognitive impairment","volume":"11","author":"Tzekaki","year":"2023","journal-title":"Brain Disord"},{"key":"10.1016\/j.nsa.2024.104085_bib98","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S1474-4422(06)70501-4","article-title":"Plasma abeta (1-40) and abeta (1-42) and the risk of dementia: a prospective case-cohort study","volume":"5","author":"van Oijen","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nsa.2024.104085_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111502","article-title":"Effect of involuntary chronic physical exercise on beta-amyloid protein in experimental models of Alzheimer's disease: systematic review and meta-analysis","volume":"153","author":"Vasconcelos-Filho","year":"2021","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.nsa.2024.104085_bib100","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/gps.5289","article-title":"Effects of non\u2010pharmacological therapies for people with mild cognitive impairment. A bayesian network meta\u2010analysis","volume":"35","author":"Wang","year":"2020","journal-title":"Int. J. Geriatr. Psychiatr."},{"key":"10.1016\/j.nsa.2024.104085_bib101","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.3390\/jcm9113452","article-title":"Diagnostic utility of selected serum dementia biomarkers: amyloid \u03b2-40, amyloid \u03b2-42, tau protein, and YKL-40: a review","volume":"9","author":"Wilczy\u0144ska","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.nsa.2024.104085_bib22","first-page":"619","article-title":"Ethical Principles For Medical Research Involving Human Subjects (Declaration of Helsinki). Code of Ethics of the world medical association","volume":"91","year":"1964","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.nsa.2024.104085_bib102","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1186\/s40001-023-01512-w","article-title":"The FDA-approved anti-amyloid-\u03b2 monoclonal antibodies for the treatment of Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials","volume":"28","author":"Wu","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.nsa.2024.104085_bib103","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3758\/BF03196201","article-title":"Directing attention to movement effects enhances learning: a review","volume":"8","author":"Wulf","year":"2001","journal-title":"Psychon. Bull. Rev."},{"key":"10.1016\/j.nsa.2024.104085_bib104","article-title":"Treadmill exercise decreases A\u03b2 deposition and counteracts cognitive decline in APP\/PS1 mice, possibly via hippocampal microglia modifications","author":"Zhang","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nsa.2024.104085_bib105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/8704016","article-title":"The mechanism of TNF-\u03b1-mediated accumulation of phosphorylated tau protein and its modulation by propofol in primary mouse hippocampal neurons: role of mitophagy, NLRP3, and P62\/keap1\/nrf2 pathway","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.nsa.2024.104085_bib106","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12902-019-0402-3","article-title":"Relationship between inflammatory markers and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study","volume":"19","author":"Zheng","year":"2019","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.nsa.2024.104085_bib107","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1742-2094-9-47","article-title":"Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways","volume":"9","author":"Zilka","year":"2012","journal-title":"J. Neuroinflammation"}],"container-title":["Neuroscience Applied"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772408524001509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772408524001509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T22:52:46Z","timestamp":1731538366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772408524001509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":105,"alternative-id":["S2772408524001509"],"URL":"https:\/\/doi.org\/10.1016\/j.nsa.2024.104085","relation":{},"ISSN":["2772-4085"],"issn-type":[{"value":"2772-4085","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of physical exercise with cognitive training on inflammation and Alzheimer's disease biomarkers of Mild Cognitive Impairment patients","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Applied","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nsa.2024.104085","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of European College of Neuropsychopharmacology.","name":"copyright","label":"Copyright"}],"article-number":"104085"}}