{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:43:08Z","timestamp":1792082588644,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.ntt.2005.06.006","type":"journal-article","created":{"date-parts":[[2005,7,23]],"date-time":"2005-07-23T08:07:56Z","timestamp":1122106076000},"page":"585-592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["Behavioral and neurochemical effects on rat offspring after prenatal exposure to ethanol"],"prefix":"10.1016","volume":"27","author":[{"given":"Lyvia M.V.","family":"Carneiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Paulo L.","family":"Di\u00f3genes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvania M.M.","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislei F.","family":"Arag\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle C.","family":"Noronha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia B.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauce S.B.","family":"Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ntt.2005.06.006_bib1","series-title":"Fetal Alcohol Syndrome","author":"Abel","year":"1981"},{"key":"10.1016\/j.ntt.2005.06.006_bib2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0003-3472(73)80065-X","article-title":"Tests for emotionality in rats and mice: a review","volume":"21","author":"Archer","year":"1973","journal-title":"Anim. Behav."},{"key":"10.1016\/j.ntt.2005.06.006_bib3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1469-8749.2001.tb00179.x","article-title":"Brain dysmorphology in individuals with severe prenatal alcohol exposure","volume":"43","author":"Archilbald","year":"2001","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.ntt.2005.06.006_bib4","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/(SICI)1098-1063(2000)10:1<94::AID-HIPO11>3.0.CO;2-T","article-title":"Effects of prenatal alcohol exposure on the hippocampus: spatial behavior, electrophysiology and neuroanatomy","volume":"10","author":"Berman","year":"2000","journal-title":"Hippocampus"},{"key":"10.1016\/j.ntt.2005.06.006_bib5","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/0002-9378(95)90275-9","article-title":"Effects of prenatal ethanol exposure on the hippocampal neurochemistry of albino rats at 90 days of postnatal age","volume":"173","author":"Black","year":"1995","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ntt.2005.06.006_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0892-0362(95)02027-6","article-title":"Effects of prenatal ethanol exposure on dopamine systems in C57BL\/6J mice","volume":"18","author":"Boggan","year":"1996","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2005.06.006_bib7","first-page":"109","article-title":"Prenatal ethanol diminishes reactivity of presumed dopamine D3 receptors in rats","volume":"47","author":"Brus","year":"1995","journal-title":"Pol. J. Pharmacol."},{"key":"10.1016\/j.ntt.2005.06.006_bib8","first-page":"174","article-title":"Alcohol and the developing brain: neuroanatomical studies","volume":"27","author":"Chen","year":"2003","journal-title":"Alcohol Res. Health"},{"key":"10.1016\/j.ntt.2005.06.006_bib9","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0161-813X(02)00009-8","article-title":"Inhibition of muscarinic receptor-induced proliferation of astroglial cells by ethanol: mechanisms and implications for the Fetal Alcohol Syndrome","volume":"23","author":"Costa","year":"2002","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ntt.2005.06.006_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1997.77.1.1","article-title":"Cellular and molecular neuroscience of alcoholism","volume":"77","author":"Diamond","year":"1997","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ntt.2005.06.006_bib11","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1523\/JNEUROSCI.03-10-01963.1983","article-title":"Muscarinic receptor binding and oxidative activities in the adult rat superior cervical ganglion: effects of 6-hydroxydopamine on nerve growth factor","volume":"3","author":"Dombrowski","year":"1983","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ntt.2005.06.006_bib12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/jnr.490270214","article-title":"Effects of in utero exposure on the developing dopaminergic system in rats","volume":"27","author":"Druse","year":"1990","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ntt.2005.06.006_bib13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0278-5846(94)90023-X","article-title":"Serotonergic mechanisms in anxiety","volume":"18","author":"Eison","year":"1994","journal-title":"Prog. Neuro-psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ntt.2005.06.006_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0002-9378(87)90199-2","article-title":"Alcohol teratogenicity in the human: a detailed assessment of specificity, critical period, and threshold","volume":"156","author":"Ernhart","year":"1987","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ntt.2005.06.006_bib15","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1111\/j.1530-0277.1999.tb04089.x","article-title":"Role of nitric oxide-dependent pathways in ethanol-induced anxiolytic effects in rats","volume":"23","author":"Ferreira","year":"1999","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.ntt.2005.06.006_bib16","first-page":"153","article-title":"Transmembrane signaling, G proteins, and adenylyl cyclase","volume":"85","author":"Gilman","year":"1989","journal-title":"Harvey Lect."},{"key":"10.1016\/j.ntt.2005.06.006_bib17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0091-3057(95)02135-3","article-title":"Role of 5-HT in stress, anxiety and depression","volume":"54","author":"Graeff","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ntt.2005.06.006_bib18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/1029842021000010884","article-title":"Mechanisms involved in central nervous system dysfunctions induced by prenatal ethanol exposure","volume":"4","author":"Guerri","year":"2002","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ntt.2005.06.006_bib19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0304-3940(03)00431-2","article-title":"Ethanol inhibits muscarinic receptor-mediated DNA synthesis and signal transduction in human fetal astrocytes","volume":"344","author":"Guizetti","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ntt.2005.06.006_bib20","first-page":"91","article-title":"Changes in brain muscarinic and beta-adrenoreceptors of the offspring of ethanol-consuming mothers (experiments on rats)","volume":"17","author":"Hadjiivanova","year":"1991","journal-title":"Acta Physiol. Pharmacol. Bulg."},{"key":"10.1016\/j.ntt.2005.06.006_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0166-4328(03)00028-7","article-title":"Children with Fetal Alcohol Syndrome are impaired at place learning but not cued-navigation in a virtual Morris water task","volume":"143","author":"Hamilton","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ntt.2005.06.006_bib22","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0028-3908(02)00330-1","article-title":"Behavioral action of ethanol in Porsolt\u00b4s forced swim test: modulation by 3 alpha-hydroxy-5 alpha-pregnan-20-one","volume":"43","author":"Hirani","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ntt.2005.06.006_bib23","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0024-3205(91)90261-9","article-title":"High affinity dopamine D2 receptor radioligants: 2. [125I] M Epidepride, a potent and specific radioligand for the characterization of striatal and extra-striatal dopamine D2 receptors","volume":"49","author":"Kessler","year":"1991","journal-title":"Life Sci."},{"key":"10.1016\/j.ntt.2005.06.006_bib24","first-page":"180","article-title":"The use of a plus-maze to measure anxiety in the mouse","volume":"92","author":"Lister","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ntt.2005.06.006_bib25","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0892-0362(03)00030-8","article-title":"Fetal alcohol exposure and temporal vulnerability: effects of binge-like alcohol exposure on the developing rat hippocampus","volume":"25","author":"Livy","year":"2003","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2005.06.006_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ntt.2005.06.006_bib27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0031-9384(02)00971-X","article-title":"Effects of alcohol exposure during development on social behavior in rats","volume":"78","author":"Lugo","year":"2003","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ntt.2005.06.006_bib28","series-title":"Basic and Clinical Pharmacology","first-page":"382","article-title":"The alcohols","author":"Masters","year":"2001"},{"key":"10.1016\/j.ntt.2005.06.006_bib29","first-page":"185","article-title":"Teratogenic effects of alcohol on brain and behavior","volume":"25","author":"Mattson","year":"2001","journal-title":"Alcohol Res. Health"},{"key":"10.1016\/j.ntt.2005.06.006_bib30","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0022-3565(25)20710-8","article-title":"Classification of typical and atypical antipsychotic drugs on the basis of dopamine D1- and D2- and serotonin pKi values","volume":"251","author":"Meltzer","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ntt.2005.06.006_bib31","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/nlme.1999.3909","article-title":"Fetal alcohol-exposed rats exhibit differential responses to cholinergic drugs on a delay-dependent memory task","volume":"72","author":"Nagahara","year":"1999","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.ntt.2005.06.006_bib32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/1355621961000124956","article-title":"Alcoholism and the dopaminergic system: a review","volume":"1","author":"Noble","year":"1996","journal-title":"Addict. Biol."},{"key":"10.1016\/j.ntt.2005.06.006_bib33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0892-0362(01)00211-2","article-title":"A preliminary investigation of the effects of maternal ethanol intake during gestation and lactation on brain adenosine A1 receptor expression in rat offspring","volume":"24","author":"Othman","year":"2002","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2005.06.006_bib34","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatment","volume":"277","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.ntt.2005.06.006_bib35","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0892-0362(99)00017-3","article-title":"In utero alcohol and postnatal methylphenidate: locomotion and dopamine receptors","volume":"21","author":"Randall","year":"1999","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2005.06.006_bib36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ajmg.c.30014","article-title":"Teratogenic effects of alcohol: a decade of brain imaging","volume":"127C","author":"Riley","year":"2004","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ntt.2005.06.006_bib37","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0006-8993(93)90080-7","article-title":"The effects of in utero ethanol administration on the electrophysiological activity of rat nigrostriatal dopaminergic neurons","volume":"624","author":"Shen","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.06.006_bib38","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1111\/j.1530-0277.1999.tb04076.x","article-title":"Prenatal alcohol reduces the activity of adult mid brain dopamine neurons","volume":"23","author":"Shen","year":"1999","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.ntt.2005.06.006_bib39","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0892-0362(03)00074-6","article-title":"Critical periods for ethanol-induced cell loss in the hippocampal formation","volume":"25","author":"Tran","year":"2003","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2005.06.006_bib40","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1590\/S0100-879X2003000400013","article-title":"Effect of one-week ethanol treatment on monoamine levels and dopaminergic receptors in rat striatum","volume":"36","author":"Vasconcelos","year":"2003","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.ntt.2005.06.006_bib41","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0165-3806(90)90197-7","article-title":"Fetal ethanol exposure diminishes hippocampal beta-adrenergic receptor density while sparing muscarinic receptors during development","volume":"55","author":"Wigal","year":"1990","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.ntt.2005.06.006_bib42","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/(SICI)1098-1063(2000)10:1<88::AID-HIPO10>3.0.CO;2-L","article-title":"Ethanol, memory, and hippocampal function: a review of recent findings","volume":"10","author":"White","year":"2000","journal-title":"Hippocampus"}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089203620500084X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089203620500084X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:10:18Z","timestamp":1760209818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089203620500084X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S089203620500084X"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2005.06.006","relation":{},"ISSN":["0892-0362"],"issn-type":[{"value":"0892-0362","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Behavioral and neurochemical effects on rat offspring after prenatal exposure to ethanol","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2005.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}