{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:40:58Z","timestamp":1790919658257,"version":"4.1.0"},"reference-count":101,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.ntt.2005.10.001","type":"journal-article","created":{"date-parts":[[2005,11,24]],"date-time":"2005-11-24T07:10:06Z","timestamp":1132816206000},"page":"74-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Purkinje cell and cerebellar effects following developmental exposure to PCBs and\/or MeHg"],"prefix":"10.1016","volume":"28","author":[{"given":"Cindy S.","family":"Roegge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherilyn","family":"Villareal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Powers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Y.","family":"Klintsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Greenough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac N.","family":"Pessah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Schantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ntt.2005.10.001_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0006-8993(90)90017-6","article-title":"Vestibular site of action of hypothyroidism in the pigmented rat","volume":"536","author":"Acuna","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib2","doi-asserted-by":"crossref","first-page":"14187","DOI":"10.1016\/S0021-9258(18)77285-2","article-title":"Identification and localization of two triad junctional foot protein isoforms in mature avian fast twitch skeletal muscle","volume":"265","author":"Airey","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ntt.2005.10.001_bib3","series-title":"Development of the Cerebellar System: In Relation to its Evolution, Structure, and Functions","first-page":"726","article-title":"Epilogue: behavioral consequences of experimental interference with cerebellar development","author":"Altman","year":"1997"},{"key":"10.1016\/j.ntt.2005.10.001_bib4","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1203\/00006450-197509000-00012","article-title":"Endocrine studies of the untreated progeny of thyroidectomized rats","volume":"9","author":"Bakke","year":"1975","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib5","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0006-8993(71)90460-4","article-title":"Effect of thyroid hormone on the biochemical maturation of rat brain: postnatal cell formation","volume":"25","author":"Balazs","year":"1971","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.devbrainres.2005.01.007","article-title":"Maternal thyroid hormone increases HES expression in the fetal rat brain: an effect mimicked by exposure to a mixture of polychlorinated biphenyls (PCBs)","volume":"156","author":"Bansal","year":"2005","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib7","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1289\/ehp.99107879","article-title":"Polychlorinated biphenyls and methylmercury act synergistically to reduce rat brain dopamine content in vitro","volume":"107","author":"Bemis","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ntt.2005.10.001_bib8","first-page":"1123","article-title":"Polychlorinated biphenyls and methylmercury alter intracellular calcium concentrations in rat cerebellar granule cells","volume":"21","author":"Bemis","year":"2000","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ntt.2005.10.001_bib9","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1288\/00005537-197712000-00014","article-title":"Audiological and vestibular function tests in hypothyroidism","volume":"87","author":"Bhatia","year":"1977","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ntt.2005.10.001_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/toxsci\/kfg248","article-title":"Early developmental neurotoxicity of a PCB\/organochlorine mixture in rodents after gestational and lactational exposure","volume":"77","author":"Bowers","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2005.10.001_bib11","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0031-9384(02)00668-6","article-title":"Influences of early thyroid hormone manipulations: delays in pup motor and exploratory behavior are evident in adult operant performance","volume":"75","author":"Brosvic","year":"2002","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ntt.2005.10.001_bib12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/074823379801400107","article-title":"Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health","volume":"14","author":"Brouwer","year":"1998","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.ntt.2005.10.001_bib13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0163-1047(81)91468-0","article-title":"Early auditory and visual function in normal and hyperthyroid rats","volume":"31","author":"Brunjes","year":"1981","journal-title":"Behav. Neural. Biol."},{"key":"10.1016\/j.ntt.2005.10.001_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0091-6773(73)80154-3","article-title":"Locomotor deficits in adult rats with moderate to massive retardation of cerebellar development during infancy","volume":"9","author":"Brunner","year":"1973","journal-title":"Behav. Biol."},{"key":"10.1016\/j.ntt.2005.10.001_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0013-9351(77)90095-0","article-title":"Ultrastructural study of the latent effects of methyl mercury on the nervous system after prenatal exposure","volume":"13","author":"Chang","year":"1977","journal-title":"Environ. Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib16","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/00005072-197811000-00001","article-title":"Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero","volume":"37","author":"Choi","year":"1978","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ntt.2005.10.001_bib17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF00687746","article-title":"A Golgi and electron-microscopic study of cerebellum in methylmercury-poisoned neonatal mice","volume":"54","author":"Choi","year":"1981","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.ntt.2005.10.001_bib18","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0006-8993(73)90122-4","article-title":"Effects of thyroid deficiency on the different cell populations of the cerebellum in the young rat","volume":"63","author":"Clos","year":"1973","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib19","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1523\/JNEUROSCI.06-02-00448.1986","article-title":"Functional metabolic mapping during forelimb movement in rat: I. Stimulation of motor cortex","volume":"6","author":"Collins","year":"1986","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ntt.2005.10.001_bib20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1210\/endo-129-1-237","article-title":"Early hypothyroidism in rats causes increased adult testis and reproductive organ size but does not change testosterone levels","volume":"129","author":"Cooke","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.ntt.2005.10.001_bib21","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1530\/jrf.0.0970493","article-title":"Increased testis growth and sperm production in adult rats following transient neonatal goitrogen treatment: optimization of the propylthiouracil dose and effects of methimazole","volume":"97","author":"Cooke","year":"1993","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.ntt.2005.10.001_bib22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1006\/taap.1996.0013","article-title":"Neonatal polychlorinated biphenyl treatment increases adult testis size and sperm production in the rat","volume":"136","author":"Cooke","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ntt.2005.10.001_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0006-8993(75)91023-9","article-title":"Consequences of hypothyroidism during infancy on the function of cerebellar neurons in the adult rat","volume":"85","author":"Crepel","year":"1975","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/toxsci\/57.1.131","article-title":"PCBs, thyroid hormones, and ototoxicity in rats: cross-fostering experiments demonstrate the impact of postnatal lactation exposure","volume":"57","author":"Crofton","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2005.10.001_bib25","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0378-5955(00)00062-9","article-title":"Hearing loss following exposure during development to polychlorinated biphenyls: a cochlear site of action","volume":"144","author":"Crofton","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib26","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/ana.410350608","article-title":"Methylmercury poisoning: long-term clinical, radiological, toxicological, and pathological studies of an affected family","volume":"35","author":"Davis","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ntt.2005.10.001_bib27","first-page":"237","article-title":"Effects of experimental hypothyroidism on the surface structures of vestibular receptors in developing rats","volume":"105","author":"Dechesne","year":"1984","journal-title":"Rev. Laryngol Otol. Rhinol. (Bord)"},{"key":"10.1016\/j.ntt.2005.10.001_bib28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0165-3806(86)90163-X","article-title":"Effects of hypothyroidism on postnatal development in the peripheral vestibular system","volume":"390","author":"Dememes","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.tox.2004.06.011","article-title":"Influence of a combination of two tetrachlorobiphenyl congeners (PCB 47; PCB 77) on thyroid status, choline acetyltransferase (ChAT) activity, and short- and long-term memory in 30-day-old Sprague\u2013Dawley rats","volume":"203","author":"Donahue","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.ntt.2005.10.001_bib30","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/(SICI)1096-9861(19990823)411:2<267::AID-CNE7>3.0.CO;2-4","article-title":"Cerebellar Purkinje cell loss during life span of the heterozygous staggerer mouse (Rora(+)\/Rora(sg)) is gender-related","volume":"411","author":"Doulazmi","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ntt.2005.10.001_bib31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1210\/endo.142.1.7871","article-title":"Maternal hypothyroidism selectively affects the expression of neuroendocrine-specific protein A messenger ribonucleic acid in the proliferative zone of the fetal rat brain cortex","volume":"142","author":"Dowling","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.ntt.2005.10.001_bib32","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1177\/019262339702500612","article-title":"Pathology of minamata disease","volume":"25","author":"Eto","year":"1997","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.ntt.2005.10.001_bib33","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1046\/j.1440-1789.2000.00295.x","article-title":"Minamata disease","volume":"20","author":"Eto","year":"2000","journal-title":"Neuropathology"},{"key":"10.1016\/j.ntt.2005.10.001_bib34","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1677\/joe.0.1750597","article-title":"Influence of maternal hyperthyroidism in the rat on the expression of neuronal and astrocytic cytoskeletal proteins in fetal brain","volume":"175","author":"Evans","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ntt.2005.10.001_bib35","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/0169-328X(93)90010-M","article-title":"Gene expression in the developing cerebellum during perinatal hypo- and hyperthyroidism","volume":"17","author":"Figueiredo","year":"1993","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-5955(96)80004-9","article-title":"Thyroxine affects physiological and morphological development of the ear","volume":"97","author":"Freeman","year":"1996","journal-title":"Hear. Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib37","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1289\/ehp.6672","article-title":"Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors","volume":"112","author":"Gauger","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ntt.2005.10.001_bib38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0165-0270(81)90045-5","article-title":"Analysis of thick brain sections by obverse\u2013reverse computer microscopy: application of a new, high clarity Golgi\u2013Nissl stain","volume":"4","author":"Glaser","year":"1981","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ntt.2005.10.001_bib39","first-page":"94","article-title":"Thyroxine replacement attenuates hypothyroxinemia, hearing loss, and motor deficits following developmental exposure to Aroclor 1254 in rats","volume":"45","author":"Goldey","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2005.10.001_bib40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/taap.1995.1210","article-title":"Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats","volume":"135","author":"Goldey","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ntt.2005.10.001_bib41","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0892-0362(01)00155-6","article-title":"Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants","volume":"23","author":"Grandjean","year":"2001","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2005.10.001_bib42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0006-8993(96)01480-1","article-title":"Hypothyroidism coordinately and transiently affects myelin protein gene expression in most rat brain regions during postnatal development","volume":"752","author":"Ibarrola","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib43","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1210\/endo.137.3.8603571","article-title":"Cell-specific effects of thyroid hormone on RC3\/neurogranin expression in rat brain","volume":"137","author":"Iniguez","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.ntt.2005.10.001_bib44","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev.ne.12.030189.000505","article-title":"Long-term depression","volume":"12","author":"Ito","year":"1989","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ntt.2005.10.001_bib45","doi-asserted-by":"crossref","first-page":"H1429","DOI":"10.1152\/ajpheart.2000.278.5.H1429","article-title":"Thyroid hormone-induced overexpression of functional ryanodine receptors in the rabbit heart","volume":"278","author":"Jiang","year":"2000","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.ntt.2005.10.001_bib46","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0300-483X(94)90025-6","article-title":"Thyroxine normalizes polychlorinated biphenyl (PCB) dose-related depression of choline acetyltransferase (ChAT) activity in hippocampus and basal forebrain of 15-dayold rats","volume":"94","author":"Juarez de Ku","year":"1994","journal-title":"Toxicology"},{"key":"10.1016\/j.ntt.2005.10.001_bib47","article-title":"Design and Analysis: A Researcher's Handbook","author":"Keppel","year":"1982"},{"key":"10.1016\/j.ntt.2005.10.001_bib48","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.devbrainres.2004.11.004","article-title":"Hydroxylated metabolites of polychlorinated biphenyls inhibit thyroid-hormone-dependent extension of cerebellar Purkinje cell dendrites","volume":"154","author":"Kimura-Kuroda","year":"2005","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib49","first-page":"559","article-title":"Developmental hormonal profiles accompanying the neonatal hypothyroidism-induced increase in adult testicular size and sperm production in the rat","volume":"131","author":"Kirby","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.ntt.2005.10.001_bib50","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0006-8993(98)00495-8","article-title":"Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats: I. Behavioral results","volume":"800","author":"Klintsova","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib51","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0006-8993(02)02492-7","article-title":"Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats: II. A quantitative stereological study of synaptic plasticity in female rat cerebellum","volume":"937","author":"Klintsova","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib52","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1152\/jn.1995.74.5.2184","article-title":"Ca2+ release from Ca2+ stores, particularly from ryanodine-sensitive Ca2+ stores, is required for the induction of LTD in cultured cerebellar Purkinje cells","volume":"74","author":"Kohda","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ntt.2005.10.001_bib53","first-page":"31","article-title":"Dose\u2013response examination of UDP-glucuronosyltransferase inducers and their ability to increase both TGF-beta expression and thyroid follicular cell apoptosis","volume":"46","author":"Kolaja","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2005.10.001_bib54","first-page":"3105","article-title":"Developmental disorders of the brain can be caused by PCBs; low doses of hydroxy-PCBs disrupt thyroid hormone-dependent dendrite formation from Purkinje neurons in culture","volume":"66","author":"Kuroda","year":"2004","journal-title":"Organohalog. Compd."},{"key":"10.1016\/j.ntt.2005.10.001_bib55","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF00296508","article-title":"Structural preservation of cerebellar granule cells following neurointoxication with methyl mercury: a stereological study of the rat cerebellum","volume":"90","author":"Larsen","year":"1995","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.ntt.2005.10.001_bib56","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/14734220510007842","article-title":"The roles of dendritic spine shapes in Purkinje cells","volume":"4","author":"Lee","year":"2005","journal-title":"Cerebellum"},{"key":"10.1016\/j.ntt.2005.10.001_bib57","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1523\/JNEUROSCI.08-06-01905.1988","article-title":"Infrapyramidal mossy fibers and two-way avoidance learning: developmental modification of hippocampal circuitry and adult behavior of rats and mice","volume":"8","author":"Lipp","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ntt.2005.10.001_bib58","first-page":"587","article-title":"Unbiased estimate of cerebellar granule cell numbers in hypothyroid and in sex-age-matched control rats","volume":"29","author":"Madeira","year":"1988","journal-title":"J. Hirnforsch."},{"key":"10.1016\/j.ntt.2005.10.001_bib59","first-page":"133","article-title":"Long-lasting neurostructural consequences in the rat hippocampus by developmental exposure to a mixture of polychlorinated biphenyls","author":"Mervis","year":"2002","journal-title":"The Toxicologist"},{"key":"10.1016\/j.ntt.2005.10.001_bib60","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1749-6632.1991.tb19603.x","article-title":"Congenital hypothyroidism. Vestibular and auditory damage in the pigmented rat","volume":"630","author":"Meza","year":"1991","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ntt.2005.10.001_bib61","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0736-5748(95)00100-X","article-title":"Development of vestibular and auditory function: effects of hypothyroidism and thyroxine replacement therapy on nystagmus and auditory evoked potentials in the pigmented rat","volume":"14","author":"Meza","year":"1996","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.ntt.2005.10.001_bib62","series-title":"Congenital Hypothyroidism","first-page":"85","article-title":"Thyroid hormone and the developing brain","author":"Morreale de Escobar","year":"1983"},{"key":"10.1016\/j.ntt.2005.10.001_bib63","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/taap.1996.0034","article-title":"Alterations in rat brain thyroid hormone status following pre- and postnatal exposure to polychlorinated biphenyls (Aroclor 1254)","volume":"136","author":"Morse","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ntt.2005.10.001_bib64","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/taap.1996.0164","article-title":"Persistent alterations in regional brain glial fibrillary acidic protein and synaptophysin levels following pre- and postnatal polychlorinated biphenyl exposure","volume":"139","author":"Morse","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ntt.2005.10.001_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-4886(88)90060-X","article-title":"Effect of thyroxine replacement therapy on the growth patterns of body, brain, and cerebellum in the neonatal hypothyroid rat","volume":"101","author":"Nathaniel","year":"1988","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ntt.2005.10.001_bib66","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/14734220510007860","article-title":"Perinatal exposure to polychlorinated biphenyls differentially affects cerebellar development and motor functions in male and female rat neonates","volume":"4","author":"Nguon","year":"2005","journal-title":"Cerebellum"},{"key":"10.1016\/j.ntt.2005.10.001_bib67","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0006-8993(72)90363-0","article-title":"The effects of early hypo- and hyperthyroidism on the development of the rat cerebellar cortex. II. Synaptogenesis in the molecular layer","volume":"44","author":"Nicholson","year":"1972","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib68","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1126\/science.176.4034.530","article-title":"Synaptogenesis in the rat cerebellum: effects of early hypo- and hyperthyroidism","volume":"176","author":"Nicholson","year":"1972","journal-title":"Science"},{"key":"10.1016\/j.ntt.2005.10.001_bib69","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0165-3806(91)90093-X","article-title":"Thyroid hormone modulates the development of cholinergic terminal fields in the rat forebrain: relation to nerve growth factor receptor","volume":"59","author":"Oh","year":"1991","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib70","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0013-9351(87)80086-5","article-title":"Neurobehavioral and somatic effects of perinatal PCB exposure in rats","volume":"44","author":"Overmann","year":"1987","journal-title":"Environ. Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib71","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0006-8993(87)90556-7","article-title":"Selective persistent reduction in choline acetyltransferase activity in basal forebrain of the rat after thyroid deficiency during early life","volume":"422","author":"Patel","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib72","article-title":"The Rat Nervous System","author":"Paxinos","year":"1995"},{"key":"10.1016\/j.ntt.2005.10.001_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/h0077589","article-title":"Effects of differential interference with postnatal cerebellar neurogenesis on motor performance, activity level, and maze learning of rats: a developmental study","volume":"93","author":"Pellegrino","year":"1979","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.ntt.2005.10.001_bib74","article-title":"A Stereotaxic Atlas of the Rat Brain","author":"Pellegrino","year":"1979"},{"key":"10.1016\/j.ntt.2005.10.001_bib75","series-title":"PCBs: Recent Advances in Environmental Toxicology and Health Effects","first-page":"179","article-title":"Etiology of PCB neurotoxicity: from molecules to cellular dysfunction","author":"Pessah","year":"2001"},{"key":"10.1016\/j.ntt.2005.10.001_bib76","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0006-291X(85)91699-7","article-title":"The calcium\u2013ryanodine receptor complex of skeletal and cardiac muscle","volume":"128","author":"Pessah","year":"1985","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ntt.2005.10.001_bib77","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0026-895X(25)10426-4","article-title":"Ca2+-activated ryanodine binding: mechanisms of sensitivity and intensity modulation by Mg2+, caffeine, and adenine nucleotides","volume":"31","author":"Pessah","year":"1987","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ntt.2005.10.001_bib78","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0278-5846(99)00035-4","article-title":"Dose- and age-dependent alterations in choline acetyltransferase (ChAT) activity, learning and memory, and thyroid hormones in 15-and 30-day old rats exposed to 1.25 or 12.5 PPM polychlorinated biphenyl (PCB) beginning at conception","volume":"23","author":"Provost","year":"1999","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ntt.2005.10.001_bib79","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0006-8993(77)90405-X","article-title":"Effects of thyroid dysfunction on the development of the rat cerebellum, with special reference to cell death within the internal granular layer","volume":"120","author":"Rabie","year":"1977","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib80","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0165-3806(86)90101-X","article-title":"Thyroid state and cholecalcin (calcium-binding protein) in cerebellum of the developing rat","volume":"394","author":"Rabie","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib81","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/BF03345199","article-title":"Effect of thyroid hormone on the development and gene expression of hormone receptors in rat testes in vivo","volume":"26","author":"Rao","year":"2003","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.ntt.2005.10.001_bib82","first-page":"105","article-title":"Comparative effects of underfeeding, hypothyroidism and hyperthyroidism upon the histological maturation of the molecular zone of the cerebellar cortex in the young rat","volume":"61","author":"Rebiere","year":"1972","journal-title":"Arch. Anat. Microsc. Morphol. Exp."},{"key":"10.1016\/j.ntt.2005.10.001_bib83","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/toxsci\/57.1.121","article-title":"Gestational-lactational exposure to Aroclor 1254 impairs radial-arm maze performance in male rats","volume":"57","author":"Roegge","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2005.10.001_bib84","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/toxsci\/kfg252","article-title":"Motor impairment in rats exposed to PCBs and methylmercury during early development","volume":"77","author":"Roegge","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2005.10.001_bib85","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s002210050800","article-title":"Modulation of mRNA expression of the neurotrophins of the nerve-growth-factor family and their receptors in the septum and hippocampus of rats after transient postnatal thyroxine treatment: II. Effects on p75 and trk receptor expression","volume":"127","author":"Roskoden","year":"1999","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib86","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1677\/joe.0.1210331","article-title":"Effect of maternal hypothyroxinaemia during fetal life on the calmodulinregulated phosphatase activity in the brain of the adult progeny in the rat","volume":"121","author":"Ruiz de Elvira","year":"1989","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ntt.2005.10.001_bib87","unstructured":"H.J. Sable, S.L. Schantz, Toxicant Models: PCBs. In E. D. Levin, J. J. Buccafusco (Eds.), Animal Models of Cognitive Impairment. CRC Press, Boca Raton, in press."},{"key":"10.1016\/j.ntt.2005.10.001_bib88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-3806(84)90170-6","article-title":"Persistent, differential alterations in developing cerebellar cortex of male and female mice after methylmercury exposure","volume":"314","author":"Sager","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib89","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1523\/JNEUROSCI.06-02-00463.1986","article-title":"Functional metabolic mapping during forelimb movement in rat, II. Stimulation of forelimb muscles","volume":"6","author":"Santori","year":"1986","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ntt.2005.10.001_bib90","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1442-200X.1987.tb00019.x","article-title":"Quantitative analysis of cerebellovestibular function in congenital hypothyroidism","volume":"29","author":"Sato","year":"1987","journal-title":"Acta. Paediatr. Jpn."},{"key":"10.1016\/j.ntt.2005.10.001_bib91","first-page":"457","article-title":"Long-term effects of developmental exposure to 2,2\u2032,3,5\u2032,6-pentachlorobiphenyl (PCB 95) on locomotor activity, spatial learning and memory and brain ryanodine binding","volume":"18","author":"Schantz","year":"1997","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ntt.2005.10.001_bib92","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0892-0362(02)00320-3","article-title":"Cognitive development in preschool children prenatally exposed to PCBs and MeHg","volume":"25","author":"Stewart","year":"2003","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2005.10.001_bib93","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1210\/en.2003-0395","article-title":"Pre- and postnatal propylthiouracil-induced hypothyroidism impairs synaptic transmission and plasticity in area CA1 of the neonatal rathippocampus","volume":"144","author":"Sui","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.ntt.2005.10.001_bib94","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1159\/000179015","article-title":"Long-term perspectives of thyroxine administration in neonatal rats","volume":"10","author":"Varma","year":"1979","journal-title":"Horm. Res."},{"key":"10.1016\/j.ntt.2005.10.001_bib95","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/ar.1092310411","article-title":"Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator","volume":"231","author":"West","year":"1991","journal-title":"Anat. Rec."},{"key":"10.1016\/j.ntt.2005.10.001_bib96","first-page":"405","article-title":"Effects of developmental exposure to PCBs and methylmercury on auditory function","volume":"63","author":"Widholm","year":"2003","journal-title":"Organohalog. Compd."},{"key":"10.1016\/j.ntt.2005.10.001_bib97","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/toxsci\/kfh290","article-title":"Spatial alternation deficits following developmental exposure to Aroclor 1254 and\/or methylmercury in rats","volume":"82","author":"Widholm","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2005.10.001_bib98","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0026-895X(25)08790-5","article-title":"Ortho-substituted polychlorinated biphenyls alter calcium regulation by a ryanodine receptor-mediated mechanism: structural specificity toward skeletal- and cardiac-type microsomal calcium release channels","volume":"49","author":"Wong","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ntt.2005.10.001_bib99","first-page":"443","article-title":"Ortho-substituted 2,2\u2032,3,5\u2032,6-pentachlorobiphenyl (PCB 95) alters rat hippocampal ryanodine receptors and neuroplasticity in vitro: evidence for altered hippocampal function","volume":"18","author":"Wong","year":"1997","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ntt.2005.10.001_bib100","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000145006","article-title":"Strain and sex differences in the rat brain","volume":"103","author":"Yanai","year":"1979","journal-title":"Acta Anat. (Basel)"},{"key":"10.1016\/j.ntt.2005.10.001_bib101","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1210\/endo.141.1.7273","article-title":"Developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of RC3\/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain","volume":"141","author":"Zoeller","year":"2000","journal-title":"Endocrinology"}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036205001431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036205001431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:11:42Z","timestamp":1760209902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892036205001431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":101,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0892036205001431"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2005.10.001","relation":{},"ISSN":["0892-0362"],"issn-type":[{"value":"0892-0362","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Purkinje cell and cerebellar effects following developmental exposure to PCBs and\/or MeHg","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2005.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}