{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:43:06Z","timestamp":1790941386215,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.ntt.2007.10.001","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T12:50:11Z","timestamp":1196081411000},"page":"46-54","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Toluene-induced hearing loss in phenobarbital treated rats"],"prefix":"10.1016","volume":"30","author":[{"given":"Pierre","family":"Campo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Waniusiow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Cossec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lataye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Rieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Cosnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuella","family":"Burgart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ntt.2007.10.001_bib1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1600-0773.1999.tb02105.x","article-title":"Induction of hepatic CYP2B in foetal and neonatal rats after maternal administration of phenobarbital","volume":"84","author":"Asoh","year":"1999","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.ntt.2007.10.001_bib2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/hep.21234","article-title":"Phenobarbital regulates nuclear expression of HNF-4\u03b1 in mouse and rat hepatocytes independent of CAR and PXR","volume":"44","author":"Bell","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.ntt.2007.10.001_bib3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0892-0362(96)00214-0","article-title":"Toluene-induced hearing loss: a mid-frequency location of the cochlear lesions","volume":"19","author":"Campo","year":"1997","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2007.10.001_bib4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0892-0362(97)00093-7","article-title":"Combined effects of simultneous exposure to toluene and ethanol on auditory function in rats","volume":"20","author":"Campo","year":"1998","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2007.10.001_bib5","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0892-0362(99)00010-0","article-title":"Toluene and styrene intoxication route in the rat cochlea","volume":"21","author":"Campo","year":"1999","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2007.10.001_bib6","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0378-5955(01)00218-0","article-title":"Styrene-induced hearing loss: a membrane insult","volume":"154","author":"Campo","year":"2001","journal-title":"Hear. Res."},{"key":"10.1016\/j.ntt.2007.10.001_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0378-5955(94)90005-1","article-title":"Solvent-induced ototoxicity in rats: An atypical selective mid-frequency hearing deficit","volume":"80","author":"Crofton","year":"1994","journal-title":"Hear. Res."},{"key":"10.1016\/j.ntt.2007.10.001_bib8","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.18388\/abp.2000_3962","article-title":"Phenobarbital-induced expression of cytochromes P450 genes","volume":"47","author":"Czekaj","year":"2000","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.ntt.2007.10.001_bib9","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.yexmp.2004.07.002","article-title":"Induction of cytochrome P450 iso-enzymes by phenobarbital in pregnant rat and foetal livers and placenta","volume":"78","author":"Ejiri","year":"2005","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.ntt.2007.10.001_bib10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0378-5955(94)90071-X","article-title":"Progressive hair cell loss induced by toluene exposure","volume":"75","author":"Johnson","year":"1994","journal-title":"Hear. Res."},{"key":"10.1016\/j.ntt.2007.10.001_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/taap.1995.1041","article-title":"m-Xylene toxicokinetics in Phenobarbital-treated rats: comparison among inhalation exposure, oral administration, and intraperitoneal administration","volume":"131","author":"Kaneko","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ntt.2007.10.001_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.2486\/indhealth.35.489","article-title":"Determination of specific mercapturic acids as an index of exposure to environmental benzene, toluene and styrene","volume":"35","author":"Maestri","year":"1997","journal-title":"Ind. Health"},{"key":"10.1016\/j.ntt.2007.10.001_bib13","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/10590509409373464","article-title":"Toluene: evaluation of risks to human health from environmental exposure in Canada","volume":"12","author":"Meek","year":"1994","journal-title":"Environ. Carcinog. Ecotoxicol. Rev. C"},{"key":"10.1016\/j.ntt.2007.10.001_bib14","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.3109\/10408449409020137","article-title":"Styrene production, use, and human exposure","volume":"24","author":"Miller","year":"1994","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ntt.2007.10.001_bib15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/00039896.1994.9954988","article-title":"Occupational exposure to noise and ototoxic organic solvents","volume":"49","author":"Morata","year":"1994","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.ntt.2007.10.001_bib16","series-title":"\u201cNoise-induced hearing loss: basic mechanisms, prevention and control\u201d","first-page":"293","article-title":"Auditory function after single or combined exposure to styrene: a review","author":"Morata","year":"2001"},{"key":"10.1016\/j.ntt.2007.10.001_bib17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0378-5955(91)90041-7","article-title":"Frequency representation in the rat cochlea","volume":"51","author":"M\u00fcller","year":"1991","journal-title":"Hear. Res."},{"key":"10.1016\/j.ntt.2007.10.001_bib18","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/0020-711X(94)90175-9","article-title":"Induction of cytochrome P450 by toluene","volume":"26","author":"Nakajima","year":"1994","journal-title":"Int. J. Biochem."},{"key":"10.1016\/j.ntt.2007.10.001_bib19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0163-7258(90)90030-6","article-title":"Enzyme induction in the cytochrome P-450 system","volume":"45","author":"Okey","year":"1990","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ntt.2007.10.001_bib20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/019262339602400107","article-title":"An overview of current cytochromes P450 technology for assessing the safety and efficacy of new material","volume":"24","author":"Parkinson","year":"1996","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.ntt.2007.10.001_bib21","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1042\/bj2900637","article-title":"Phenobarbital induction of AP-1 binding activity mediates activation of glutathione S-transferase and quinone reductase gene expression","volume":"290","author":"Pinkus","year":"1993","journal-title":"Biochem. J."},{"key":"10.1016\/j.ntt.2007.10.001_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0361-9230(91)90290-Z","article-title":"The hearing loss associated with exposure to toluene is not caused by a metabolite","volume":"27","author":"Pryor","year":"1991","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ntt.2007.10.001_bib23","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s002040050403","article-title":"Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans","volume":"71","author":"Shimada","year":"1997","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ntt.2007.10.001_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00043764-200301000-00008","article-title":"Ototoxic effects of occupational exposure to styrene and co-exposure to styrene and noise","volume":"45","author":"Sliwinska-Kowalska","year":"2003","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.ntt.2007.10.001_bib25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0022-3565(25)12236-2","article-title":"Human cytochromes P450 isoform specificity in the regioselective metabolism of toluene and o-, m-, and p-xylene","volume":"276","author":"Tassaneeyakul","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ntt.2007.10.001_bib26","first-page":"83","article-title":"Inventaire des agents chimiques CMR utilises en France en 2005","volume":"205","author":"Vincent","year":"2006","journal-title":"Cah. Notes Doc."},{"issue":"281","key":"10.1016\/j.ntt.2007.10.001_bib27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1042\/bj2810577","article-title":"Phenobarbital induction of cytochromes P450 gene expression","volume":"1","author":"Waxman","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.ntt.2007.10.001_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408449209145319","article-title":"The human hepatic cytochromes P450 involved in drug metabolism","volume":"22","author":"Wrighton","year":"1992","journal-title":"Crit. Rev. Toxicol."}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089203620700339X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089203620700339X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:14:24Z","timestamp":1760210064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089203620700339X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S089203620700339X"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2007.10.001","relation":{},"ISSN":["0892-0362"],"issn-type":[{"value":"0892-0362","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toluene-induced hearing loss in phenobarbital treated rats","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2007.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}