{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:47:24Z","timestamp":1792176444867,"version":"4.4.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.ntt.2007.12.010","type":"journal-article","created":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T07:44:37Z","timestamp":1200296677000},"page":"118-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of perinatal oxycodone exposure on the response to CRH in late adolescent rats"],"prefix":"10.1016","volume":"30","author":[{"given":"Thitinart","family":"Sithisarn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrietta S.","family":"Bada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Randall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra J.","family":"Legan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ntt.2007.12.010_bib1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1196\/annals.1296.019","article-title":"Long-term effects of a single exposure to immobilization on the hypothalamic\u2013pituitary\u2013adrenal axis: neurobiologic mechanisms","volume":"1018","author":"Armario","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ntt.2007.12.010_bib2","doi-asserted-by":"crossref","first-page":"e348","DOI":"10.1542\/peds.2006-1404","article-title":"Impact of prenatal cocaine exposure on child behavior problems through school age","volume":"119","author":"Bada","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.ntt.2007.12.010_bib3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/00004703-200204000-00007","article-title":"Associations between physiological reactivity and children's behavior: advantages of a multisystem approach","volume":"23","author":"Bauer","year":"2002","journal-title":"J. Dev. Behav. Pediatr."},{"key":"10.1016\/j.ntt.2007.12.010_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0885-3924(96)00300-4","article-title":"A pharmacokinetic\/pharmacodynamic study of controlled-release oxycodone","volume":"13","author":"Benziger","year":"1997","journal-title":"J. Pain Symptom Manage."},{"key":"10.1016\/j.ntt.2007.12.010_bib5","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1124\/dmd.106.009746","article-title":"In vivo blood\u2013brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics\/pharmacodynamics","volume":"34","author":"Bostrom","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ntt.2007.12.010_bib6","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/jps.20327","article-title":"Oxycodone pharmacokinetics and pharmacodynamics in the rat in the presence of the P-glycoprotein inhibitor PSC833","volume":"94","author":"Bostrom","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ntt.2007.12.010_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/dev.420120309","article-title":"Failure of severe maternal stress or ACTH during pregnancy to affect emotionality of male rat offspring: implications of litter effects for prenatal studies","volume":"12","author":"Chapman","year":"1979","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.ntt.2007.12.010_bib8","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/S0022-3565(25)24040-X","article-title":"The influence of pharmacogenetics on opioid analgesia: studies with codeine and oxycodone in the Sprague\u2013Dawley\/Dark Agouti rat model","volume":"271","author":"Cleary","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ntt.2007.12.010_bib9","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1210\/endo.141.5.7455","article-title":"Rapid induction of corticotropin-releasing hormone gene transcription in the paraventricular nucleus of the developing rat","volume":"141","author":"Dent","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.ntt.2007.12.010_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(99)00086-5","article-title":"Hypothalamic\u2013pituitary\u2013adrenocortical and gonadal axes and sympathoadrenal activity of adult male rats prenatally exposed to morphine","volume":"263","author":"Dutriez-Casteloot","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ntt.2007.12.010_bib11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1203\/00006450-200110000-00003","article-title":"The impact of corticosteroids on the developing animal","volume":"50","author":"Edwards","year":"2001","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ntt.2007.12.010_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ntt.2004.09.004","article-title":"HPA axis dysregulation following prenatal opiate exposure and postnatal withdrawal","volume":"27","author":"Hamilton","year":"2005","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2007.12.010_bib13","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1006\/hbeh.1994.1044","article-title":"Gonadal steroid hormone receptors and sex differences in the hypothalamo-pituitary-adrenal axis","volume":"28","author":"Handa","year":"1994","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ntt.2007.12.010_bib14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1749-6632.1989.tb21018.x","article-title":"Developmental consequences of prenatal exposure to methadone","volume":"562","author":"Hans","year":"1989","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ntt.2007.12.010_bib15","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/S0022-3565(25)24685-7","article-title":"Differential antagonism of U69,593- and bremazocine-induced antinociception by (\u2212)-UPHIT: evidence of kappa opioid receptor multiplicity in mice","volume":"257","author":"Horan","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ntt.2007.12.010_bib16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0306-4530(03)00028-3","article-title":"Foster litters prevent hypothalamic\u2013pituitary\u2013adrenal axis sensitization mediated by neonatal maternal separation","volume":"29","author":"Huot","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ntt.2007.12.010_bib17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0163-6383(84)80027-2","article-title":"24-month neurobehavioral follow up of methadone-maintained mothers","volume":"7","author":"Johnson","year":"1984","journal-title":"Inf. Behav. Dev."},{"key":"10.1016\/j.ntt.2007.12.010_bib18","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1210\/endo-128-5-2567","article-title":"Effects of short and long duration hypothyroidism and hyperthyroidism on the plasma adrenocorticotropin and corticosterone responses to ovine corticotropin-releasing hormone in rats","volume":"128","author":"Kamilaris","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.ntt.2007.12.010_bib19","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/(SICI)1097-4695(19990905)40:3<302::AID-NEU3>3.0.CO;2-7","article-title":"Prenatal stress alters circadian activity of hypothalamo-pituitary-adrenal axis and hippocampal corticosteroid receptors in adult rats of both gender","volume":"40","author":"Koehl","year":"1999","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.ntt.2007.12.010_bib20","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1476-5381.1988.tb10310.x","article-title":"kappa-Opioid agonists produce antinociception after i.v. and i.c.v. but not intrathecal administration in the rat","volume":"93","author":"Leighton","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ntt.2007.12.010_bib21","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/0024-3205(94)00849-3","article-title":"The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats","volume":"54","author":"Leow","year":"1994","journal-title":"Life Sci."},{"key":"10.1016\/j.ntt.2007.12.010_bib22","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/BF02527731","article-title":"Effects of prenatal morphine on hypothalamic metabolism of neurotransmitters and gonadal and adrenal activities, during the early postnatal period in the rat","volume":"21","author":"Lesage","year":"1996","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ntt.2007.12.010_bib23","first-page":"331","article-title":"Consequences of prenatal morphine exposure on the hypothalamo-pituitary-adrenal axis in the newborn rat: effect of maternal adrenalectomy","volume":"10","author":"Lesage","year":"1998","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ntt.2007.12.010_bib24","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1542\/peds.110.6.1182","article-title":"The maternal lifestyle study: effects of substance exposure during pregnancy on neurodevelopmental outcome in 1-month-old infants","volume":"110","author":"Lester","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.ntt.2007.12.010_bib25","first-page":"557","article-title":"Congenital behavioral effects in mature rats prenatally exposed to levo-alpha-acetylmethadol (LAAM)","volume":"4","author":"Lichtblau","year":"1982","journal-title":"Neurobehav. Toxicol. Teratol."},{"key":"10.1016\/j.ntt.2007.12.010_bib26","first-page":"479","article-title":"Prenatal levo-alpha-acetylmethadol (LAAM) and\/or naloxone: effects on brain chemistry and postweaning behavior","volume":"5","author":"Lichtblau","year":"1983","journal-title":"Neurobehav. Toxicol. Teratol."},{"key":"10.1016\/j.ntt.2007.12.010_bib27","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1523\/JNEUROSCI.3777-05.2006","article-title":"The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus","volume":"26","author":"Lund","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ntt.2007.12.010_bib28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0149-7634(03)00014-9","article-title":"Prenatal stress and long-term consequences: implications of glucocorticoid hormones","volume":"27","author":"Maccari","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ntt.2007.12.010_bib29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0892-0362(99)00024-0","article-title":"Prenatal intravenous cocaine adversely affects attentional processing in preweanling rats","volume":"21","author":"Mactutus","year":"1999","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2007.12.010_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0892-0362(94)90116-3","article-title":"Chronic intravenous model for studies of drug (Ab)use in the pregnant and\/or group-housed rat: an initial study with cocaine","volume":"16","author":"Mactutus","year":"1994","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2007.12.010_bib31","first-page":"129","article-title":"Evidence that a single exposure to aversive stimuli triggers long-lasting effects in the hypothalamus\u2013pituitary\u2013adrenal axis that consolidate with time","volume":"13","author":"Marti","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ntt.2007.12.010_bib32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1043-2760(02)00690-2","article-title":"Early programming of the hypothalamo-pituitary-adrenal axis","volume":"13","author":"Matthews","year":"2002","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ntt.2007.12.010_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-3806(94)00153-Q","article-title":"Sex-specific effects of prenatal stress on hypothalamic\u2013pituitary\u2013adrenal responses to stress and brain glucocorticoid receptor density in adult rats","volume":"84","author":"McCormick","year":"1995","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.ntt.2007.12.010_bib34","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1542\/peds.113.6.1677","article-title":"The maternal lifestyle study: cognitive, motor, and behavioral outcomes of cocaine-exposed and opiate-exposed infants through three years of age","volume":"113","author":"Messinger","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.ntt.2007.12.010_bib35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/dev.20195","article-title":"Can knowledge of developmental processes illuminate the evolution of parental care?","volume":"49","author":"Michel","year":"2007","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.ntt.2007.12.010_bib36","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0022-3565(24)37664-5","article-title":"Chronic exposure to morphine decreases physiologically active corticosterone in both male and female rats but by different mechanisms","volume":"286","author":"Nock","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ntt.2007.12.010_bib37","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1210\/en.2005-1054","article-title":"Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood","volume":"147","author":"Richardson","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.ntt.2007.12.010_bib38","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1159\/000074884","article-title":"Adrenocorticotropin stress response but not glucocorticoid-negative feedback is altered by prenatal morphine exposure in adult male rats","volume":"78","author":"Rimanoczy","year":"2003","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ntt.2007.12.010_bib39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3959(97)00093-6","article-title":"The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated","volume":"73","author":"Ross","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.ntt.2007.12.010_bib40","series-title":"Office of Applied Studies, National household survey on drug abuse 2002, 2003, 2004, and 2005","author":"SAMHSA","year":"2006"},{"key":"10.1016\/j.ntt.2007.12.010_bib41","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1365-2826.2004.01195.x","article-title":"Gonadectomy reverses the sexually diergic patterns of circadian and stress-induced hypothalamic\u2013pituitary\u2013adrenal axis activity in male and female rats","volume":"16","author":"Seale","year":"2004","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ntt.2007.12.010_bib42","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1365-2826.2004.01258.x","article-title":"Gonadal steroid replacement reverses gonadectomy-induced changes in the corticosterone pulse profile and stress-induced hypothalamic\u2013pituitary\u2013adrenal axis activity of male and female rats","volume":"16","author":"Seale","year":"2004","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ntt.2007.12.010_bib43","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.brainresbull.2005.02.030","article-title":"Alterations of prenatal morphine exposure in mu-opioid receptor density in hypothalamic nuclei associated with sexual behavior","volume":"65","author":"Slamberova","year":"2005","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ntt.2007.12.010_bib44","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000082359","article-title":"Hypothalamo-pituitary-adrenal axis-regulated stress response and negative feedback sensitivity is altered by prenatal morphine exposure in adult female rats","volume":"80","author":"Slamberova","year":"2004","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ntt.2007.12.010_bib45","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","volume":"24","author":"Spear","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ntt.2007.12.010_bib46","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3109\/00952997609077202","article-title":"Relationship of neonatal withdrawal to maternal methadone dose","volume":"3","author":"Strauss","year":"1976","journal-title":"Am. J. Drug Alcohol Abuse"},{"issue":"11 Suppl","key":"10.1016\/j.ntt.2007.12.010_bib47","first-page":"3","article-title":"Children of methadone-treated women at five years of age","author":"Strauss","year":"1979","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ntt.2007.12.010_bib48","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0024-3205(03)00407-7","article-title":"Dynorphin and the hypothalamo-pituitary-adrenal axis during fetal development","volume":"73","author":"Szeto","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.ntt.2007.12.010_bib49","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1469-7610.2006.01714.x","article-title":"Antenatal maternal stress and long-term effects on child neurodevelopment: how and why?","volume":"48","author":"Talge","year":"2007","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.ntt.2007.12.010_bib50","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0022-3565(25)12946-7","article-title":"kappa-Opioid agonist, U50,488H, stimulates ovine fetal pituitary\u2013adrenal function via hypothalamic arginine-vasopressin and corticotrophin-releasing factor","volume":"277","author":"Taylor","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ntt.2007.12.010_bib51","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1046\/j.1460-9568.1999.00705.x","article-title":"Long-term effects of prenatal stress and postnatal handling on age-related glucocorticoid secretion and cognitive performance: a longitudinal study in the rat","volume":"11","author":"Vallee","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ntt.2007.12.010_bib52","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/adc.64.2.235","article-title":"Neonatal behavior after drug dependent pregnancy","volume":"64","author":"van Baar","year":"1989","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ntt.2007.12.010_bib53","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1097\/00004583-200011000-00019","article-title":"Hypothalamic\u2013pituitary\u2013adrenal axis and autonomic nervous system activity in disruptive children and matched controls","volume":"39","author":"van Goozen","year":"2000","journal-title":"J. Am. Acad. Child Adolesc. Psych."},{"key":"10.1016\/j.ntt.2007.12.010_bib54","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0006-3223(97)00253-9","article-title":"Salivary cortisol and cardiovascular activity during stress in oppositional-defiant disorder boys and normal controls","volume":"43","author":"van Goozen","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ntt.2007.12.010_bib55","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0306-4530(01)00049-X","article-title":"Prenatal opiate exposure: long-term CNS consequences in the stress system of the offspring","volume":"27","author":"Vathy","year":"2002","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ntt.2007.12.010_bib56","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1046\/j.1365-2826.2002.00798.x","article-title":"Functional cross-talk between the hypothalamic\u2013pituitary\u2013gonadal and \u2013adrenal axes","volume":"14","author":"Viau","year":"2002","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ntt.2007.12.010_bib57","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2826.1994.tb00578.x","article-title":"The neuroendocrinology of the adrenal cortex","volume":"6","author":"Vinson","year":"1994","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ntt.2007.12.010_bib58","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1210\/endo.132.3.8382596","article-title":"Neonatal facilitation of stress-induced adrenocorticotropin secretion by prior stress: evidence for increased central drive to the pituitary","volume":"132","author":"Walker","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.ntt.2007.12.010_bib59","doi-asserted-by":"crossref","DOI":"10.1007\/s11064-007-9339-4","article-title":"Gender differences in the effects of prenatal stress on brain development and behaviour","author":"Weinstock","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ntt.2007.12.010_bib60","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(92)91049-K","article-title":"Prenatal stress selectively alters the reactivity of the hypothalamic\u2013pituitary adrenal system in the female rat","volume":"595","author":"Weinstock","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2007.12.010_bib61","series-title":"Maternal Substance Abuse and the Developing Nervous System","first-page":"241","article-title":"Maternal exposure to opioids and the developing nervous system: laboratory findings","author":"Zagon","year":"1992"}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036208000020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036208000020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:12:15Z","timestamp":1760209935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892036208000020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0892036208000020"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2007.12.010","relation":{},"ISSN":["0892-0362"],"issn-type":[{"value":"0892-0362","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of perinatal oxycodone exposure on the response to CRH in late adolescent rats","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2007.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}