{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:32:15Z","timestamp":1786995135068,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.ntt.2008.01.002","type":"journal-article","created":{"date-parts":[[2008,1,15]],"date-time":"2008-01-15T07:36:48Z","timestamp":1200382608000},"page":"167-174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterization of the effects of inhaled perchloroethylene on sustained attention in rats performing a visual signal detection task"],"prefix":"10.1016","volume":"30","author":[{"given":"Wendy M.","family":"Oshiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q. Todd","family":"Krantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Bushnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ntt.2008.01.002_bib1","series-title":"Toxicological profile for tetrachloroethylene (update). Prepared by Sciences, International, under subcontract to Research Triangle Institute., Atlanta, GA","author":"Agency for Toxic Substancesand Disease Registry (ATSDR)","year":"1997"},{"key":"10.1016\/j.ntt.2008.01.002_bib2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3758\/BF03203477","article-title":"A LOTUS 1\u20132\u20133-based animal weighing system with a weight maintenance algorithm","volume":"24","author":"Ali","year":"1992","journal-title":"Behav. Res. Meth. Instrum. Comput."},{"key":"10.1016\/j.ntt.2008.01.002_bib3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF00381179","article-title":"Neurophysiological and psychophysical measurements reveal effects of acute low-level organic solvent exposure in humans","volume":"62","author":"Altmann","year":"1990","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.ntt.2008.01.002_bib4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/enrs.1995.1028","article-title":"Neurobehavioral and neurophysiological outcome of chronic low-level tetrachloroethene exposure measured in neighborhoods of dry cleaning shops","volume":"69","author":"Altmann","year":"1995","journal-title":"Environ. Res."},{"key":"10.1016\/j.ntt.2008.01.002_bib5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1464-0597.1992.tb00705.x","article-title":"Neurobehavioral and neurophysiological outcomes of acute repeated perchloroethylene exposure.","volume":"41","author":"Altmann","year":"1992","journal-title":"Appl. Psychol. Int. Rev."},{"key":"10.1016\/j.ntt.2008.01.002_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.taap.2004.09.011","article-title":"Volatile organic compounds inhibit human and rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes","volume":"205","author":"Bale","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ntt.2008.01.002_bib7","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/sj.bjp.0704874","article-title":"Inhibition of neuronal nicotinic acetylcholine receptors by the abused solvent, toluene","volume":"137","author":"Bale","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ntt.2008.01.002_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neuroscience.2004.08.040","article-title":"Alterations in glutamatergic and gabaergic ion channel activity in hippocampal neurons following exposure to the abused inhalant toluene","volume":"130","author":"Bale","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.ntt.2008.01.002_bib9","first-page":"567","article-title":"Health effects of toluene: a review","author":"Benignus","year":"1981","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ntt.2008.01.002_bib10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/toxsci\/kfi242","article-title":"Momentary brain concentration of trichloroethylene predicts the effects on rat visual function","volume":"87","author":"Boyes","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2008.01.002_bib11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/faat.1997.2287","article-title":"Concentration\u2013time relationships for the effects of inhaled trichloroethylene on signal detection behavior in rats","volume":"36","author":"Bushnell","year":"1997","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.ntt.2008.01.002_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0376-6357(99)00030-3","article-title":"Detection of visual signals by rats: effects of signal intensity, event rate and task type","volume":"46","author":"Bushnell","year":"1999","journal-title":"Behav. Processes"},{"key":"10.1016\/j.ntt.2008.01.002_bib13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0376-6357(03)00146-3","article-title":"Signal detection behavior in humans and rats: a comparison with matched tasks","volume":"64","author":"Bushnell","year":"2003","journal-title":"Behav. Processes"},{"key":"10.1016\/j.ntt.2008.01.002_bib14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0892-0362(94)90112-0","article-title":"Effects of toluene inhalation on detection of auditory signals in rats","volume":"16","author":"Bushnell","year":"1994","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2008.01.002_bib15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0892-0362(99)00078-1","article-title":"Behavioral components of tolerance to repeated inhalation of trichloroethylene (TCE) in rats","volume":"22","author":"Bushnell","year":"2000","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2008.01.002_bib16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s002130050446","article-title":"Detection of visual signals by rats: effects of chlordiazepoxide and cholinergic and adrenergic drugs on sustained attention","volume":"134","author":"Bushnell","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ntt.2008.01.002_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/toxsci\/kfm146","article-title":"A dosimetric analysis of the acute behavioral effects of inhaled toluene in rats","volume":"99","author":"Bushnell","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2008.01.002_bib18","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1080\/15287390701459155","article-title":"The role of physical activity and feeding schedule on the kinetics of inhaled and oral toluene in rats","volume":"70","author":"Bushnell","year":"2007","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.ntt.2008.01.002_bib19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0892-0362(99)00006-9","article-title":"Behavioral assessments of learning and attention in rats exposed perinatally to 3,3\u2032,4,4\u2032,5-pentachlorobiphenyl (PCB 126)","volume":"21","author":"Bushnell","year":"1999","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2008.01.002_bib20","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.etap.2004.12.026","article-title":"Developing an exposure\u2013dose\u2013response model for the acute neurotoxicity of organic solvents: overview and progress on in vitro models and dosimetry","volume":"19","author":"Bushnell","year":"2005","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ntt.2008.01.002_bib21","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0304-3940(94)90959-8","article-title":"Perchloroethylene exposure can induce colour vision loss","volume":"179","author":"Cavalleri","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ntt.2008.01.002_bib22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0300-483X(01)00544-3","article-title":"Behavioural effects of tetrachloroethylene exposure in rats: acute and subchronic studies","volume":"170","author":"Chen","year":"2002","journal-title":"Toxicol"},{"key":"10.1016\/j.ntt.2008.01.002_bib23","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/00043764-199506000-00008","article-title":"A behavioral evaluation of PCE exposure in patients and dry cleaners: a possible relationship between clinical and preclinical effects","volume":"37","author":"Echeverria","year":"1995","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.ntt.2008.01.002_bib24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0149-7634(05)80003-X","article-title":"CNS depressant effects of volatile organic solvents","volume":"15","author":"Evans","year":"1991","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ntt.2008.01.002_bib25","first-page":"243","article-title":"Neurobehavioral and neuroendocrine effects of occupational exposure to perchloroethylene","volume":"13","author":"Ferroni","year":"1992","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ntt.2008.01.002_bib26","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/toxsci\/59.2.268","article-title":"Gender-dependent behavioral and sensory effects of a commercial mixture of polychlorinated biphenyls (Aroclor 1254) in rats","volume":"59","author":"Geller","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2008.01.002_bib27","series-title":"Signal Detection Theory and Psychophysics","year":"1972"},{"key":"10.1016\/j.ntt.2008.01.002_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF02246150","article-title":"Dissociation between the attentional effects of infusions of a benzodiazepine receptor agonist and an inverse agonist into the basal forebrain","volume":"120","author":"Holley","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ntt.2008.01.002_bib29","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0091-3057(89)90285-2","article-title":"Parallel development of ethanol tolerance and operant compensatory behaviors in rats","volume":"34","author":"Holloway","year":"1989","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ntt.2008.01.002_bib30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/00039890209602925","article-title":"Is neurotoxicity associated with environmental trichloroethylene (TCE)?","volume":"57","author":"Kilburn","year":"2002","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.ntt.2008.01.002_bib31","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1177\/074823379300900301","article-title":"Effects on neurobehavioral performance of chronic exposure to chemically contaminated well water","volume":"9","author":"Kilburn","year":"1993","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.ntt.2008.01.002_bib32","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1600-0773.1990.tb00770.x","article-title":"Tolerance during inhalation of organic solvents","volume":"66","author":"Kjellstrand","year":"1990","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.ntt.2008.01.002_bib33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0892-0362(97)00074-3","article-title":"Neurotoxicologic examination of rats exposed to 1,1,2,2-tetrachloroethylene (perchloroethylene) vapor for 13\u00a0weeks","volume":"20","author":"Mattsson","year":"1998","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2008.01.002_bib34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s002130050048","article-title":"The role of nicotinic and muscarinic acetylcholine receptors in attention","volume":"148","author":"Mirza","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ntt.2008.01.002_bib35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2486\/indhealth.24.157","article-title":"Behavioral change after single exposure to toluene, and brain toluene levels in rats","volume":"24","author":"Miyagawa","year":"1986","journal-title":"Ind. Health"},{"key":"10.1016\/j.ntt.2008.01.002_bib36","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0892-0362(01)00182-9","article-title":"Characterizing tolerance to trichloroethylene (TCE): effects of repeated inhalation of TCE on performance of a signal detection task in rats","volume":"23","author":"Oshiro","year":"2001","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2008.01.002_bib37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ntt.2006.11.001","article-title":"Repeated inhalation of toluene by rats performing a signal detection task leads to behavioral tolerance on some performance measures","volume":"29","author":"Oshiro","year":"2007","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2008.01.002_bib38","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ntt.2003.12.005","article-title":"A search for residual behavioral effects of trichloroethylene (TCE) in rats exposed as young adults","volume":"26","author":"Oshiro","year":"2004","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2008.01.002_bib39","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00213-002-1221-0","article-title":"Effects of nicotine and mecamylamine on choice accuracy in an operant visual signal detection task in female rats","volume":"164","author":"Rezvani","year":"2002","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ntt.2008.01.002_bib40","series-title":"Behavioral assessments of Long\u2013Evans rats following a 13-week subchronic toluene exposure","author":"Samsam","year":"2007"},{"key":"10.1016\/j.ntt.2008.01.002_bib41","series-title":"SAS for Windows V. 9.1","author":"SAS","year":"2002"},{"key":"10.1016\/j.ntt.2008.01.002_bib42","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1289\/ehp.02110655","article-title":"Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity","volume":"110","author":"Schreiber","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ntt.2008.01.002_bib43","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1124\/jpet.105.090027","article-title":"Perturbation of voltage-sensitive Ca2+ channel function by volatile organic solvents","volume":"315","author":"Shafer","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ntt.2008.01.002_bib44","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/00008877-199308000-00003","article-title":"Tolerance and sensitization to the behavioral effects of drugs","volume":"4","author":"Stewart","year":"1993","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.ntt.2008.01.002_bib45","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/00039896.1970.10665543","article-title":"Experimental human exposure to tetrachloroethylene","volume":"20","author":"Stewart","year":"1970","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.ntt.2008.01.002_bib46","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF02245840","article-title":"Effects of nicotinic acetylcholine receptor ligands on behavioral vigilance in rats","volume":"118","author":"Turchi","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ntt.2008.01.002_bib47","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0091-3057(97)00046-4","article-title":"Behavioral effects of trichloroethylene and tetrachloroethylene in mice","volume":"58","author":"Umezu","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ntt.2008.01.002_bib48","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF00451677","article-title":"Learning alcohol tolerance: the contribution of response expectancies","volume":"98","author":"Vogel-Sprott","year":"1989","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ntt.2008.01.002_bib49","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/009841096161690","article-title":"Schedule-controlled operant behavior of rats following oral administration of perchloroethylene: time course and relationship to blood and brain solvent levels","volume":"47","author":"Warren","year":"1996","journal-title":"J. Toxicol. Environ. Health"}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036208000159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036208000159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:13:07Z","timestamp":1760209987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892036208000159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0892036208000159"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2008.01.002","relation":{},"ISSN":["0892-0362"],"issn-type":[{"value":"0892-0362","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of the effects of inhaled perchloroethylene on sustained attention in rats performing a visual signal detection task","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2008.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}