{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:06:39Z","timestamp":1773050799049,"version":"3.50.1"},"reference-count":75,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP-81185"],"award-info":[{"award-number":["MOP-81185"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.ntt.2009.12.002","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T10:09:27Z","timestamp":1261044567000},"page":"164-170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Differential effects of chronic ethanol exposure on cytochrome P450 2E1 and the hypothalamic\u2013pituitary\u2013adrenal axis in the maternal\u2013fetal unit of the guinea pig"],"prefix":"10.1016","volume":"32","author":[{"given":"Amy J.","family":"Hewitt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin R.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Kobus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margo","family":"Poklewska-Koziell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James N.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ntt.2009.12.002_bib1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1139\/y93-116","article-title":"Ethanol neuro-behavioural teratogenesis in the guinea pig: behavioural dysfunction and hippocampal morphologic change","volume":"71","author":"Abdollah","year":"1993","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ntt.2009.12.002_bib2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0892-0362(95)98055-6","article-title":"Maternal risk factors in fetal alcohol syndrome: provocative and permissive influences","volume":"17","author":"Abel","year":"1995","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2009.12.002_bib3","first-page":"89","article-title":"Endocrine balance as a factor in the etiology of the fetal alcohol syndrome","volume":"3","author":"Anderson","year":"1981","journal-title":"Neurobehav. Toxicol. Teratol."},{"key":"10.1016\/j.ntt.2009.12.002_bib4","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1074\/jbc.M510484200","article-title":"Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione","volume":"281","author":"Bai","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ntt.2009.12.002_bib5","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0166-2236(00)01948-2","article-title":"Neonatal glucocorticoids and the developing brain: short-term treatment with life-long consequences?","volume":"24","author":"Bakker","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ntt.2009.12.002_bib6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0165-3806(81)90071-7","article-title":"Prenatal ethanol exposure permanently reduces the number of pyramidal neurons in rat hippocampus","volume":"227","author":"Barnes","year":"1981","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2009.12.002_bib7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0006-2952(94)90235-6","article-title":"Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species","volume":"48","author":"Bondy","year":"1994","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ntt.2009.12.002_bib8","series-title":"Toxicology and Pharmacological Principles in Pediatrics","first-page":"199","article-title":"Disposition and fetal effects of ethanol during pregnancy","author":"Brien","year":"1988"},{"key":"10.1016\/j.ntt.2009.12.002_bib9","first-page":"21","article-title":"Effects of alcohol (ethanol) on the fetus","volume":"15","author":"Brien","year":"1991","journal-title":"J. Dev. Physiol."},{"key":"10.1016\/j.ntt.2009.12.002_bib10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1210\/jcem-45-3-435","article-title":"The maternal\u2013fetal cortisol gradient during pregnancy and at delivery","volume":"45","author":"Campbell","year":"1977","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ntt.2009.12.002_bib11","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0022-3565(24)36862-4","article-title":"Ethanol-mediated transplacental induction of CYP2E1 in fetal rat liver","volume":"282","author":"Carpenter","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ntt.2009.12.002_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.me.32.020181.001011","article-title":"Neuroendocrinological effects of alcohol","volume":"32","author":"Cicero","year":"1981","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.ntt.2009.12.002_bib13","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1139\/y86-182","article-title":"Pharmacokinetics of ethanol and its metabolite, acetaldehyde, and fetolethality in the third-trimester pregnant guinea pig for oral administration of acute, multiple-dose ethanol","volume":"64","author":"Clarke","year":"1986","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ntt.2009.12.002_bib14","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0090-9556(25)06961-2","article-title":"Disposition of ethanol and its proximate metabolite, acetaldehyde, in the near-term pregnant ewe for short term maternal administration of moderate-dose ethanol","volume":"16","author":"Clarke","year":"1988","journal-title":"Drug. Metab. Dispos."},{"key":"10.1016\/j.ntt.2009.12.002_bib15","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1056\/NEJM197805112981906","article-title":"The fetal alcohol syndrome","volume":"298","author":"Clarren","year":"1978","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ntt.2009.12.002_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0892-0362(02)00324-0","article-title":"Antioxidants and fetal protection against ethanol teratogenicity. I. Review of the experimental data and implications to humans","volume":"25","author":"Cohen-Kerem","year":"2003","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2009.12.002_bib17","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1530-0277.2001.tb02318.x","article-title":"Fetal and maternal sheep hypothalamus pituitary adrenal axis responses to chronic binge ethanol exposure during the third trimester equivalent","volume":"25","author":"Cudd","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.ntt.2009.12.002_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1677\/joe.0.0700207","article-title":"Plasma and adrenal cortisol concentrations in foetal, newborn and mother guinea-pigs during the perinatal period","volume":"70","author":"Dalle","year":"1976","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ntt.2009.12.002_bib19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.ntt.2009.12.002_bib20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/abio.1993.1335","article-title":"Determination of p-nitrophenol hydroxylase activity of rat liver microsomes by high-pressure liquid chromatography","volume":"212","author":"Duescher","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ntt.2009.12.002_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jchromb.2006.02.006","article-title":"Validation of a HPLC method for the determination of p-nitrophenol hydroxylase activity in rat hepatic microsomes","volume":"834","author":"Elbarbry","year":"2006","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.ntt.2009.12.002_bib22","first-page":"111","article-title":"Production of dated pregnant guinea pigs without postpartum matins","volume":"23","author":"Elvidge","year":"1972","journal-title":"J. Inst. Anim. Technol."},{"key":"10.1016\/j.ntt.2009.12.002_bib23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1139\/H07-175","article-title":"Alcohol consumption: the good, the bad, and the indifferent","volume":"33","author":"Ferreira","year":"2008","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.ntt.2009.12.002_bib24","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1203\/00006450-198507000-00010","article-title":"The development of antioxidant enzymatic defense in the perinatal rat lung: activities of superoxide dismutase, glutathione peroxidase, and catalase","volume":"19","author":"Gerdin","year":"1985","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ntt.2009.12.002_bib25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0892-0362(99)00074-4","article-title":"Effects of chronic prenatal ethanol exposure on locomotor activity, and hippocampal weight, neurons, and nitric oxide synthase activity of the young postnatal guinea pig","volume":"22","author":"Gibson","year":"2000","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2009.12.002_bib26","first-page":"104","article-title":"Fetal hypothalamic\u2013pituitary\u2013adrenal stress responses to invasive procedures are independent of maternal responses","volume":"86","author":"Gitau","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ntt.2009.12.002_bib27","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/15353702-0323006-07","article-title":"Alcohol teratogenesis: mechanisms of damage and strategies for intervention","volume":"230","author":"Goodlett","year":"2005","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.ntt.2009.12.002_bib28","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","article-title":"Determination of serum proteins by means of the biuret reaction","volume":"177","author":"Gornall","year":"1949","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ntt.2009.12.002_bib29","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ntt.2005.07.006","article-title":"Chronic prenatal ethanol exposure increases apoptosis in the hippocampus of the term fetal guinea pig","volume":"27","author":"Green","year":"2005","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2009.12.002_bib30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1071\/RD05128","article-title":"Effects of chronic prenatal ethanol exposure on mitochondrial glutathione and 8-iso-prostaglandin F2alpha concentrations in the hippocampus of the perinatal guinea pig","volume":"18","author":"Green","year":"2006","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.ntt.2009.12.002_bib31","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00427806","article-title":"Adrenocortical response to acute and chronic ethanol administration in rats","volume":"79","author":"Guaza","year":"1983","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ntt.2009.12.002_bib32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/alcalc\/agn105","article-title":"Foetal alcohol spectrum disorders and alterations in brain and behaviour","volume":"44","author":"Guerri","year":"2009","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.ntt.2009.12.002_bib33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/10408449891344173","article-title":"Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity","volume":"28","author":"Hakkola","year":"1998","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ntt.2009.12.002_bib34","first-page":"D541","article-title":"Ethanol, oxidative stress, reactive aldehydes, and the fetus","volume":"4","author":"Henderson","year":"1999","journal-title":"Front Biosci."},{"key":"10.1016\/j.ntt.2009.12.002_bib35","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1530-0277.1995.tb01572.x","article-title":"In utero ethanol exposure elicits oxidative stress in the rat fetus","volume":"19","author":"Henderson","year":"1995","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.ntt.2009.12.002_bib36","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1365-2826.2006.01479.x","article-title":"Chronic prenatal ethanol exposure increases glucocorticoid-induced glutamate release in the hippocampus of the near-term foetal guinea pig","volume":"18","author":"Iqbal","year":"2006","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ntt.2009.12.002_bib37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0968-0004(96)20008-8","article-title":"Reactive oxygen species and programmed cell death","volume":"21","author":"Jacobson","year":"1996","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ntt.2009.12.002_bib38","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/bmj.2.5608.804","article-title":"Adrenocortical response to ethanol in man","volume":"2","author":"Jenkins","year":"1968","journal-title":"Br. Med. J."},{"key":"10.1016\/j.ntt.2009.12.002_bib39","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.brainresrev.2007.06.013","article-title":"Fetal programming of hypothalamic\u2013pituitary\u2013adrenal (HPA) axis function and behavior by synthetic glucocorticoids","volume":"57","author":"Kapoor","year":"2008","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.ntt.2009.12.002_bib40","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0892-0362(00)00089-1","article-title":"Ethanol neurobehavioral teratogenesis and the role of the hippocampal glutamate-N-methyl-D-aspartate receptor-nitric oxide synthase system","volume":"22","author":"Kimura","year":"2000","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2009.12.002_bib41","first-page":"274","article-title":"Alcohol metabolism's damaging effects on the cell: a focus on reactive oxygen generation by the enzyme cytochrome P450 2E1","volume":"29","author":"Koop","year":"2006","journal-title":"Alcohol Res. Health"},{"key":"10.1016\/j.ntt.2009.12.002_bib42","first-page":"1181","article-title":"Fetal alcohol spectrum disorder","volume":"169","author":"Koren","year":"2003","journal-title":"CMAJ"},{"key":"10.1016\/j.ntt.2009.12.002_bib43","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0892-0362(03)00030-8","article-title":"Fetal alcohol exposure and temporal vulnerability: effects of binge-like alcohol exposure on the developing rat hippocampus","volume":"25","author":"Livy","year":"2003","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2009.12.002_bib44","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1053\/jhep.2001.22521","article-title":"Induction of catalase, alpha, and microsomal glutathione S-transferase in CYP2E1 overexpressing HepG2 cells and protection against short-term oxidative stress","volume":"33","author":"Mari","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.ntt.2009.12.002_bib45","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/BF01939957","article-title":"Differential changes in Cu, Zn and Mn superoxide dismutase activity in developing rat brain and liver","volume":"46","author":"Mariucci","year":"1990","journal-title":"Experientia"},{"key":"10.1016\/j.ntt.2009.12.002_bib46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0028-2243(84)90016-9","article-title":"The pregnant rabbit, guinea pig, sheep and rhesus monkey as models in reproductive physiology","volume":"18","author":"Martensson","year":"1984","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.ntt.2009.12.002_bib47","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0165-3806(98)00008-X","article-title":"Dynamic changes in glucocorticoid and mineralocorticoid receptor mRNA in the developing guinea pig brain","volume":"107","author":"Matthews","year":"1998","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.ntt.2009.12.002_bib48","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1203\/00006450-200003000-00003","article-title":"Antenatal glucocorticoids and programming of the developing CNS","volume":"47","author":"Matthews","year":"2000","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ntt.2009.12.002_bib49","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1081\/ERC-120016991","article-title":"Glucocorticoids, hypothalamo-pituitary-adrenal (HPA) development, and life after birth","volume":"28","author":"Matthews","year":"2002","journal-title":"Endocr. Res."},{"key":"10.1016\/j.ntt.2009.12.002_bib50","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1139\/y03-048","article-title":"Chronic prenatal ethanol exposure-induced decrease of guinea pig hippocampal CA1 pyramidal cell and cerebellar purkinje cell density","volume":"81","author":"McGoey","year":"2003","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ntt.2009.12.002_bib51","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1046\/j.1471-4159.1995.65062561.x","article-title":"Ethanol increases cytochrome P4502E1 and induces oxidative stress in astrocytes","volume":"65","author":"Montoliu","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ntt.2009.12.002_bib52","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3181\/00379727-207-43807","article-title":"Fish oil, alcohol, and liver pathology: role of cytochrome P450 2E1","volume":"207","author":"Morimoto","year":"1994","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.ntt.2009.12.002_bib53","series-title":"Handbook of Teratology","first-page":"119","article-title":"Summary of comparative embryology and teratology","author":"Nishimura","year":"1977"},{"key":"10.1016\/j.ntt.2009.12.002_bib54","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0025-7125(16)31246-9","article-title":"The effects of alcohol on the endocrine system","volume":"68","author":"Noth","year":"1984","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.ntt.2009.12.002_bib55","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0741-8329(86)90043-1","article-title":"Alcohol-induced microencephaly during the third trimester equivalent: relationship to dose and blood alcohol concentration","volume":"3","author":"Pierce","year":"1986","journal-title":"Alcohol"},{"key":"10.1016\/j.ntt.2009.12.002_bib56","first-page":"862","article-title":"In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: a potential role for 4-hydroxynonenal","volume":"25","author":"Ramachandran","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.ntt.2009.12.002_bib57","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jnr.10767","article-title":"Ethanol-induced oxidative stress precedes mitochondrially mediated apoptotic death of cultured fetal cortical neurons","volume":"74","author":"Ramachandran","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ntt.2009.12.002_bib58","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1471-4159.2006.03674.x","article-title":"Astrocyte control of fetal cortical neuron glutathione homeostasis: up-regulation by ethanol","volume":"96","author":"Rathinam","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ntt.2009.12.002_bib59","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0090-9556(25)08248-0","article-title":"p-nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol","volume":"13","author":"Reinke","year":"1985","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ntt.2009.12.002_bib60","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1469-8749.1999.tb00518.x","article-title":"Brain perfusion SPECT and MRI in foetal alcohol syndrome","volume":"41","author":"Riikonen","year":"1999","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.ntt.2009.12.002_bib61","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/15353702-0323006-03","article-title":"Fetal alcohol spectrum disorders: an overview with emphasis on changes in brain and behavior","volume":"230","author":"Riley","year":"2005","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.ntt.2009.12.002_bib62","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0022-3565(25)21776-1","article-title":"Effect of ethanol on the hypothalamic\u2013pituitary\u2013adrenal axis in the rat: role of corticotropin-releasing factor (CRF)","volume":"229","author":"Rivier","year":"1984","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ntt.2009.12.002_bib63","doi-asserted-by":"crossref","first-page":"6895","DOI":"10.1016\/j.febslet.2005.11.029","article-title":"Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes","volume":"579","author":"Robin","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ntt.2009.12.002_bib64","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1023\/A:1026021307833","article-title":"Stress and plasticity in the limbic system","volume":"28","author":"Sapolsky","year":"2003","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ntt.2009.12.002_bib65","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1530-0277.1990.tb01220.x","article-title":"Fetal alcohol syndrome: current status of pathogenesis","volume":"14","author":"Schenker","year":"1990","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.ntt.2009.12.002_bib66","series-title":"The Biology of the Guinea Pig","first-page":"63","article-title":"Physiology","author":"Sisk","year":"1976"},{"key":"10.1016\/j.ntt.2009.12.002_bib67","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1139\/y91-082","article-title":"Effects of ethanol exposure on the embryo-fetus: experimental considerations, mechanisms, and the role of prostaglandins","volume":"69","author":"Smith","year":"1991","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ntt.2009.12.002_bib68","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0160-5402(85)90033-6","article-title":"Gas\u2013liquid chromatographic analysis of ethanol and acetaldehyde in blood with minimal artifactual acetaldehyde formation","volume":"14","author":"Steenaart","year":"1985","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.ntt.2009.12.002_bib69","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1001\/jama.1991.03460150065025","article-title":"Fetal alcohol syndrome in adolescents and adults","volume":"265","author":"Streissguth","year":"1991","journal-title":"JAMA"},{"key":"10.1016\/j.ntt.2009.12.002_bib70","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/jnr.20502","article-title":"Astrocytes protect neurons from ethanol-induced oxidative stress and apoptotic death","volume":"80","author":"Watts","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ntt.2009.12.002_bib71","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1365-2826.2008.01669.x","article-title":"Prenatal alcohol exposure: foetal programming, the hypothalamic\u2013pituitary\u2013adrenal axis and sex differences in outcome","volume":"20","author":"Weinberg","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ntt.2009.12.002_bib72","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1365-2826.2001.00601.x","article-title":"Prenatal stress, glucocorticoids and the programming of the brain","volume":"13","author":"Welberg","year":"2001","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ntt.2009.12.002_bib73","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF02098878","article-title":"Fetal alcohol syndrome: the vulnerability of the developing brain and possible mechanisms of damage","volume":"9","author":"West","year":"1994","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.ntt.2009.12.002_bib74","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1017\/S1355617708081368","article-title":"Effects of prenatal alcohol exposure on hippocampal volume, verbal learning, and verbal and spatial recall in late childhood","volume":"14","author":"Willoughby","year":"2008","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.ntt.2009.12.002_bib75","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0022-3565(25)39560-1","article-title":"Ethanol consumption by the nursing mother induces cytochrome P-4502E1 in neonatal rat liver","volume":"267","author":"Wu","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036209002013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036209002013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:15:20Z","timestamp":1760210120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892036209002013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0892036209002013"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2009.12.002","relation":{},"ISSN":["0892-0362"],"issn-type":[{"value":"0892-0362","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential effects of chronic ethanol exposure on cytochrome P450 2E1 and the hypothalamic\u2013pituitary\u2013adrenal axis in the maternal\u2013fetal unit of the guinea pig","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2009.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}