{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:09:00Z","timestamp":1790777340915,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.ntt.2011.06.001","type":"journal-article","created":{"date-parts":[[2011,6,24]],"date-time":"2011-06-24T08:55:52Z","timestamp":1308905752000},"page":"686-697","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cytoarchitectonic and neurochemical differentiation of the visual system in ethanol-induced cyclopic zebrafish larvae"],"prefix":"10.1016","volume":"33","author":[{"given":"A.","family":"Santos-Ledo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.J.","family":"Arenzana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Porteros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Aij\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ar\u00e9valo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ntt.2011.06.001_bb0005","doi-asserted-by":"crossref","first-page":"10476","DOI":"10.1073\/pnas.162356199","article-title":"Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure","volume":"99","author":"Ahlgren","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ntt.2011.06.001_bb0010","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.brainresbull.2005.03.006","article-title":"Development of the cholinergic system in the brain and retina of the zebrafish","volume":"66","author":"Arenzana","year":"2005","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.ntt.2011.06.001_bb0015","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ntt.2006.02.001","article-title":"Teratogenic effects of ethanol exposure on zebrafish visual system development","volume":"28","author":"Arenzana","year":"2006","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0020","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00429-006-0084-2","article-title":"Tyrosine hydroxylase immunoreactivity in the developing visual pathway of the zebrafish","volume":"211","author":"Arenzana","year":"2006","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.ntt.2011.06.001_bb0025","first-page":"387","article-title":"Regulation of neurogenesis in the embryonic and adult brain by fibroblast growth factors","volume":"2","author":"Bartlett","year":"1994","journal-title":"Alcohol Alcohol Suppl"},{"issue":"1","key":"10.1016\/j.ntt.2011.06.001_bb0030","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.expneurol.2005.02.003","article-title":"Protective effects of melatonin against ethanol-induced reactive gliosis in hippocampus and cortex of young and aged rats","volume":"194","author":"Baydas","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0035","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0892-0362(02)00319-7","article-title":"Effects of embryonic exposure to ethanol on zebrafish visual function","volume":"24","author":"Bilotta","year":"2002","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0040","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ntt.2004.06.011","article-title":"Ethanol exposure alters zebrafish development: a novel model of fetal alcohol syndrome","volume":"26","author":"Bilotta","year":"2004","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0045","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/dbio.1998.8995","article-title":"Ethanol impairs migration of the prechordal plate in the zebrafish embryo","volume":"201","author":"Blader","year":"1998","journal-title":"Dev Biol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0050","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.ntt.2004.06.016","article-title":"Ethanol effects on the developing zebrafish: neurobehavior and skeletal morphogenesis","volume":"26","author":"Carvan","year":"2004","journal-title":"Neurotoxicol Teratol"},{"issue":"3","key":"10.1016\/j.ntt.2011.06.001_bb0055","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/cne.20782","article-title":"Calretinin immunoreactivity in the brain of the zebrafish, Danio rerio: distribution and comparison with some neuropeptides and neurotransmitter-synthesizing enzymes. I. Olfactory organ and forebrain","volume":"494","author":"Castro","year":"2006","journal-title":"J Comp Neurol"},{"issue":"1","key":"10.1016\/j.ntt.2011.06.001_bb0060","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0092-8674(03)00199-5","article-title":"The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance","volume":"113","author":"Charron","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.ntt.2011.06.001_bb0065","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/bdra.20019","article-title":"Gestational ethanol exposure disrupts the expression of fgf8 and sonic hedgehog during limb patterning","volume":"70","author":"Chrisman","year":"2004","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"2","key":"10.1016\/j.ntt.2011.06.001_bb0070","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.exer.2009.10.015","article-title":"Prox1 expression in rod precursors and M\u00fcller cells","volume":"90","author":"Cid","year":"2010","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ntt.2011.06.001_bb0075","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/cne.20111","article-title":"Cholinergic elements in the zebrafish central nervous system: histochemical and immunohistochemical analysis","volume":"474","author":"Clemente","year":"2004","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0080","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0161-813X(02)00009-8","article-title":"Inhibition of muscarinic receptor-induced proliferation of astroglial cells by ethanol: mechanisms and implications for the fetal alcohol syndrome","volume":"23","author":"Costa","year":"2002","journal-title":"Neurotoxicology"},{"issue":"2","key":"10.1016\/j.ntt.2011.06.001_bb0085","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.neuroscience.2005.08.090","article-title":"Neurogenesis in adolescent brain is potently inhibited by ethanol","volume":"137","author":"Crews","year":"2006","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.ntt.2011.06.001_bb0090","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/cne.21320","article-title":"Ocular deficits associated with alcohol exposure during zebrafish development","volume":"502","author":"Dlugos","year":"2007","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0095","first-page":"28","article-title":"Gender differences in ethanol-induced behavioral sensitivity in zebrafish","author":"Dlugos","year":"2010","journal-title":"Alcohol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0100","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1006\/bbrc.2001.5511","article-title":"Developmental expression of alcohol dehydrogenase (ADH3) in zebrafish (Danio rerio)","volume":"286","author":"Dasmahapatra","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.ntt.2011.06.001_bb0105","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ntt.2009.04.065","article-title":"Gene expression changes in developing zebrafish as potential markers for rapid developmental neurotoxicity screening","volume":"32","author":"Fan","year":"2010","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0110","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/(SICI)1096-9861(19970519)381:4<449::AID-CNE5>3.0.CO;2-2","article-title":"Retinal patterning in the zebrafish mutant cyclops","volume":"381","author":"Fulwiler","year":"1997","journal-title":"J Comp Neurol"},{"issue":"10","key":"10.1016\/j.ntt.2011.06.001_bb0115","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1111\/j.1530-0277.2008.00761.x","article-title":"Differences in acute alcohol-induced behavioral responses among zebrafish populations","volume":"32","author":"Gerlai","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"issue":"1","key":"10.1016\/j.ntt.2011.06.001_bb0120","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1176\/ajp.157.1.127","article-title":"Striatal dopaminergic D(2) receptor density measured by [(123)I]iodobenzamide SPECT in the prediction of treatment outcome of alcohol-dependent patients","volume":"157","author":"Guardia","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.ntt.2011.06.001_bb0125","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.2741\/A230","article-title":"The effects of ethanol on glial cell proliferation: relevance to the fetal alcohol syndrome","volume":"2","author":"Guizzetti","year":"1997","journal-title":"Front Biosci"},{"key":"10.1016\/j.ntt.2011.06.001_bb0130","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1242\/dev.01165","article-title":"The wnt\/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells","volume":"131","author":"Hirabayashi","year":"2004","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.ntt.2011.06.001_bb0135","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ntt.2009.04.066","article-title":"Acute neuroactive drug exposures alter locomotor activity in larval zebrafish","volume":"32","author":"Irons","year":"2010","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0140","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1242\/dev.123.1.427","article-title":"Zebrafish mutations affecting retinotectal axon pathfinding","volume":"123","author":"Karlstrom","year":"1996","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.ntt.2011.06.001_bb0145","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1017\/S0952523807070423","article-title":"Mechanisms for persistent microphthalmia following ethanol exposure during retinal neurogenesis in zebrafish embryos","volume":"24","author":"Kashyap","year":"2007","journal-title":"Vis Neurosci"},{"issue":"12","key":"10.1016\/j.ntt.2011.06.001_bb0150","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1002\/dvdy.21806","article-title":"Isolation and expression analysis of Alzheimer's disease-related gene xb51 in zebrafish","volume":"237","author":"Kim","year":"2008","journal-title":"Dev Dyn"},{"key":"10.1016\/j.ntt.2011.06.001_bb0155","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1523\/JNEUROSCI.4478-05.2006","article-title":"Reversal of neuronal migration in a mouse model of fetal alcohol syndrome by controlling second-messenger signalings","volume":"26","author":"Kumada","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.ntt.2011.06.001_bb0160","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/jnr.21149","article-title":"How does alcohol impair neuronal migration?","volume":"85","author":"Kumada","year":"2007","journal-title":"J Neurosci Res"},{"issue":"2","key":"10.1016\/j.ntt.2011.06.001_bb0165","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/dvdy.20343","article-title":"Cell proliferation in the developing lateral line system of zebrafish embryos","volume":"233","author":"Laguerre","year":"2005","journal-title":"Dev Dyn"},{"key":"10.1016\/j.ntt.2011.06.001_bb0170","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/labinvest.3700516","article-title":"Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling","volume":"87","author":"Li","year":"2007","journal-title":"Lab Invest"},{"key":"10.1016\/j.ntt.2011.06.001_bb0175","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.ntt.2004.06.017","article-title":"Strain-dependent effects of developmental ethanol exposure in zebrafish","volume":"26","author":"Loucks","year":"2004","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0180","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/bdra.20387","article-title":"Molecular changes associated with teratogen-induced cyclopia","volume":"79","author":"Loucks","year":"2007","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"6","key":"10.1016\/j.ntt.2011.06.001_bb0185","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/bdra.20564","article-title":"Deciphering the role of shh signaling in axial defects produced by ethanol exposure","volume":"85","author":"Loucks","year":"2009","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0190","first-page":"24","article-title":"Zebrafish fetal alcohol syndrome model: effects of ethanol are rescued by retinoic acid supplement","author":"Marrs","year":"2009","journal-title":"Alcohol"},{"issue":"10","key":"10.1016\/j.ntt.2011.06.001_bb0195","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1167\/iovs.05-0971","article-title":"Effects of ethanol on photoreceptors and visual function in developing zebrafish","volume":"48","author":"Matsui","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.ntt.2011.06.001_bb0200","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/neu.10339","article-title":"Polarity and laminar formation of the optic tectum in relation to retinal projection","volume":"59","author":"Nakamura","year":"2004","journal-title":"J Neurobiol"},{"issue":"1","key":"10.1016\/j.ntt.2011.06.001_bb0205","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.vascn.2006.04.004","article-title":"Neurotoxicity assessment using zebrafish","volume":"55","author":"Parng","year":"2007","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"9","key":"10.1016\/j.ntt.2011.06.001_bb0210","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1471-213X-9-58","article-title":"The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line","volume":"30","author":"Pistocchi","year":"2009","journal-title":"BMC Dev Biol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0215","first-page":"265","article-title":"Medical genetics: 1. Clinical teratology in the age of genomics","volume":"167","author":"Polifka","year":"2002","journal-title":"CMAJ"},{"key":"10.1016\/j.ntt.2011.06.001_bb0220","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ntt.2006.05.007","article-title":"Ethanol-dependent toxicity in zebrafish is partially attenuated by antioxidants","volume":"28","author":"Reimers","year":"2006","journal-title":"Neurotoxicol Teratol"},{"issue":"1","key":"10.1016\/j.ntt.2011.06.001_bb0225","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/112067210701700114","article-title":"Ocular manifestations in fetal alcohol syndrome","volume":"17","author":"Ribeiro","year":"2007","journal-title":"Eur J Ophthalmol"},{"issue":"4","key":"10.1016\/j.ntt.2011.06.001_bb0230","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1460-9568.2010.07317.x","article-title":"In vivo effects of morphine on neuronal fate and opioid receptor expression in zebrafish embryos","volume":"32","author":"S\u00e1nchez-Simon","year":"2010","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.ntt.2011.06.001_bb0235","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/cne.903440404","article-title":"Early eye morphogenesis in the zebrafish, Brachydanio rerio","volume":"344","author":"Schmitt","year":"1994","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0240","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1242\/dev.01247","article-title":"Sonic hedgehog, secreted by amacrine cells, acts as a short-range signal to direct differentiation and lamination in the zebrafish retina","volume":"131","author":"Shkumatava","year":"2004","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.ntt.2011.06.001_bb0245","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ntt.2004.09.002","article-title":"Prenatal ethanol preferentially enhances reactivity of the dopamine D1 but not D2 or D3 receptors in offspring","volume":"27","author":"Sobrian","year":"2005","journal-title":"Neurotoxicol Teratol"},{"issue":"12","key":"10.1016\/j.ntt.2011.06.001_bb0250","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1002\/cne.22335","article-title":"Comparative study of Pax2 expression in glial cells in the retina and optic nerve of birds and mammals","volume":"518","author":"Stanke","year":"2010","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0255","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1006\/dbio.2000.9629","article-title":"Function for Hedgehog genes in zebrafish retinal development","volume":"220","author":"Stenkamp","year":"2000","journal-title":"Dev Biol"},{"issue":"4","key":"10.1016\/j.ntt.2011.06.001_bb0260","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ntt.2010.03.001","article-title":"Zebrafish embryos exposed to alcohol undergo abnormal development of motor neurons and muscle fibers","volume":"32","author":"Sylvain","year":"2010","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.ntt.2011.06.001_bb0265","series-title":"The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio)","author":"Westerfield","year":"1995"},{"issue":"4","key":"10.1016\/j.ntt.2011.06.001_bb0270","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ijdevneu.2010.04.001","article-title":"Ethanol exposure affects cell movement during gastrulation and induces split axes in zebrafish embryos","volume":"28","author":"Zhang","year":"2010","journal-title":"Int J Dev Neurosci"}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036211000730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036211000730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:17:48Z","timestamp":1760210268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892036211000730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0892036211000730"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2011.06.001","relation":{},"ISSN":["0892-0362"],"issn-type":[{"value":"0892-0362","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytoarchitectonic and neurochemical differentiation of the visual system in ethanol-induced cyclopic zebrafish larvae","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2011.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}