{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:09:17Z","timestamp":1790622557944,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.ntt.2012.11.001","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T21:54:13Z","timestamp":1353966853000},"page":"7-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Different patterns of regional Purkinje cell loss in the cerebellar vermis as a function of the timing of prenatal ethanol exposure in an ovine model"],"prefix":"10.1016","volume":"35","author":[{"given":"Onkar B.","family":"Sawant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie R.","family":"Lunde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon E.","family":"Washburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jung A.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Goodlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Cudd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ntt.2012.11.001_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0376-8716(84)90012-7","article-title":"Prenatal effects of alcohol","volume":"14","author":"Abel","year":"1984","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.ntt.2012.11.001_bb0015","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/cne.901450402","article-title":"Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer","volume":"145","author":"Altman","year":"1972","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0005","series-title":"Maternal and Child Health (MCH)","article-title":"Alcohol Use during Pregnancy","author":"Anon.","year":"2003"},{"key":"10.1016\/j.ntt.2012.11.001_bb0020","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1469-8749.2001.tb00179.x","article-title":"Brain dysmorphology in individuals with severe prenatal alcohol exposure","volume":"43","author":"Archibald","year":"2001","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0025","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1469-8749.2002.tb00294.x","article-title":"MRI findings in children with school problems who had been exposed prenatally to alcohol","volume":"44","author":"Autti-Ramo","year":"2002","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0035","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/0014-4886(75)90164-8","article-title":"Ethanol-induced reductions in cerebellar growth of infant rats","volume":"48","author":"Bauer-Moffett","year":"1975","journal-title":"Exp Neurol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0030","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0006-8993(77)90310-9","article-title":"The effect of ethanol chronically administered to preweanling rats on cerebellar development: a morphological study","volume":"119","author":"Bauer-Moffett","year":"1977","journal-title":"Brain Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0040","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3109\/10826089309062191","article-title":"The consequences of prenatal substance use for the developing fetus, newborn, and young child","volume":"28","author":"Behnke","year":"1993","journal-title":"Int J Addict"},{"key":"10.1016\/j.ntt.2012.11.001_bb0050","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1530-0277.1990.tb00455.x","article-title":"Alcohol-induced neuronal loss in developing rats: increased brain damage with binge exposure","volume":"14","author":"Bonthius","year":"1990","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0045","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/(SICI)1096-9926(199604)53:4<230::AID-TERA5>3.0.CO;2-6","article-title":"Purkinje cell deficits in nonhuman primates following weekly exposure to ethanol during gestation","volume":"53","author":"Bonthius","year":"1996","journal-title":"Teratology"},{"key":"10.1016\/j.ntt.2012.11.001_bb0055","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/j.1530-0277.2006.00116.x","article-title":"The epidemiology of drinking among women of child-bearing age","volume":"30","author":"Caetano","year":"2006","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0060","first-page":"1178","article-title":"Alcohol consumption among women who are pregnant or who might become pregnant\u2014United States","volume":"53","author":"CDC","year":"2004"},{"key":"10.1016\/j.ntt.2012.11.001_bb0065","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0022-3476(78)80072-9","article-title":"Brain malformations related to prenatal exposure to ethanol","volume":"92","author":"Clarren","year":"1978","journal-title":"J Pediatr"},{"key":"10.1016\/j.ntt.2012.11.001_bb0070","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0892-0362(91)90084-A","article-title":"Effects of prenatal alcohol exposure at school age. I. Physical and cognitive development","volume":"13","author":"Coles","year":"1991","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0075","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0006-8993(85)90311-7","article-title":"Natural loss of Purkinje cells during development and increased loss with alcohol","volume":"325","author":"Cragg","year":"1985","journal-title":"Brain Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0080","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1530-0277.2001.tb02208.x","article-title":"Third trimester binge ethanol exposure results in fetal hypercapnea and acidemia but not hypoxemia in pregnant sheep","volume":"25","author":"Cudd","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0085","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.ntt.2012.11.001_bb0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0890-6238(95)02024-1","article-title":"Reproductive risks of binge drinking during pregnancy","volume":"10","author":"Gladstone","year":"1996","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0095","first-page":"738","article-title":"Alcohol-induced Purkinje cell loss with a single binge exposure in neonatal rats: a stereological study of temporal windows of vulnerability","volume":"21","author":"Goodlett","year":"1997","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0100","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0165-3806(90)90133-J","article-title":"Regional differences in the timing of dendritic outgrowth of Purkinje cells in the vermal cerebellum demonstrated by MAP2 immunocytochemistry","volume":"53","author":"Goodlett","year":"1990","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0741-8329(90)90070-S","article-title":"A single day of alcohol exposure during the brain growth spurt induces brain weight restriction and cerebellar Purkinje cell loss","volume":"7","author":"Goodlett","year":"1990","journal-title":"Alcohol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0110","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0892-0362(97)00102-5","article-title":"Binge neonatal alcohol intubations induce dose-dependent loss of Purkinje cells","volume":"20","author":"Goodlett","year":"1998","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0115","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.1530-0277.1993.tb00808.x","article-title":"The effects of the timing of ethanol exposure during the brain growth spurt on the number of cerebellar Purkinje and granule cell nuclear profiles","volume":"17","author":"Hamre","year":"1993","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0120","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/35084103","article-title":"Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans","volume":"412","author":"Hoeppner","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ntt.2012.11.001_bb0125","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(73)91092-1","article-title":"Recognition of the fetal alcohol syndrome in early infancy","volume":"302","author":"Jones","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/j.ntt.2012.11.001_bb0130","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/cne.900970204","article-title":"The morphogenesis and adult pattern of the lobules and fissures of the cerebellum of the white rat","volume":"97","author":"Larsell","year":"1952","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0135","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0306-4522(02)00344-5","article-title":"Time course and manner of Purkinje neuron death following a single ethanol exposure on postnatal day 4 in the developing rat","volume":"114","author":"Light","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.ntt.2012.11.001_bb0140","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0006-8993(01)03224-3","article-title":"Ethanol-induced alterations of neurotrophin receptor expression on Purkinje cells in the neonatal rat cerebellum","volume":"924","author":"Light","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0150","first-page":"168","article-title":"Drinking patterns and alcohol-related birth defects","volume":"25","author":"Maier","year":"2001","journal-title":"Alcohol Res Health"},{"key":"10.1016\/j.ntt.2012.11.001_bb0155","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0741-8329(00)00133-6","article-title":"Regional differences in cell loss associated with binge-like alcohol exposure during the first two trimesters equivalent in the rat","volume":"23","author":"Maier","year":"2001","journal-title":"Alcohol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0160","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0741-8329(94)90056-6","article-title":"Developing rat Purkinje cells are more vulnerable to alcohol-induced depletion during differentiation than during neurogenesis","volume":"11","author":"Marcussen","year":"1994","journal-title":"Alcohol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0165","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0896-6273(04)00069-8","article-title":"Microglia promote the death of developing Purkinje cells","volume":"41","author":"Marin-Teva","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.ntt.2012.11.001_bb0170","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/j.1530-0277.1996.tb01951.x","article-title":"A decrease in the size of the basal ganglia in children with fetal alcohol syndrome","volume":"20","author":"Mattson","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0175","series-title":"Tenth Special Report to the US Congress on Alcohol and Health US Department of Health and Human Services, Bethesda, MD","first-page":"285","article-title":"Underlying mechanisms of alcohol-induced damage to the fetus","author":"NIAAA","year":"2000"},{"key":"10.1016\/j.ntt.2012.11.001_bb0180","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/cne.903600311","article-title":"Acute exposure to alcohol during early postnatal life causes a deficit in the total number of cerebellar Purkinje cells in the rat","volume":"360","author":"Pauli","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0185","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0022-510X(79)90033-9","article-title":"Alcohol embryo- and fetopathy. Neuropathology of 3 children and 3 fetuses","volume":"41","author":"Peiffer","year":"1979","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.ntt.2012.11.001_bb0190","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/tera.1420400205","article-title":"Differential neuronal loss following early postnatal alcohol exposure","volume":"40","author":"Pierce","year":"1989","journal-title":"Teratology"},{"key":"10.1016\/j.ntt.2012.11.001_bb0195","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.alcohol.2006.06.004","article-title":"Binge alcohol exposure during all three trimesters alters bone strength and growth in fetal sheep","volume":"38","author":"Ramadoss","year":"2006","journal-title":"Alcohol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0200","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1111\/j.1530-0277.2007.00477.x","article-title":"Temporal vulnerability of fetal cerebellar Purkinje cells to chronic binge alcohol exposure: ovine model","volume":"31","author":"Ramadoss","year":"2007","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0205","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1530-0277.2007.00422.x","article-title":"All three trimester binge alcohol exposure causes fetal cerebellar purkinje cell loss in the presence of maternal hypercapnea, acidemia, and normoxemia: ovine model","volume":"31","author":"Ramadoss","year":"2007","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0210","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/35084096","article-title":"Phagocytosis promotes programmed cell death in C. elegans","volume":"412","author":"Reddien","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ntt.2012.11.001_bb0215","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0736-5748(88)90052-4","article-title":"The effects of intrauterine growth retardation on the development of the Purkinje cell dendritic tree in the cerebellar cortex of fetal sheep: a note on the ontogeny of the Purkinje cell","volume":"6","author":"Rees","year":"1988","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.ntt.2012.11.001_bb0220","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0378-3782(83)90065-8","article-title":"Ethanol-sensitive times for the human conceptus","volume":"8","author":"Renwick","year":"1983","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.ntt.2012.11.001_bb0225","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/j.1530-0277.1995.tb01600.x","article-title":"Abnormalities of the corpus callosum in children prenatally exposed to alcohol","volume":"19","author":"Riley","year":"1995","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0230","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ajmg.c.30014","article-title":"Teratogenic effects of alcohol: a decade of brain imaging","volume":"127C","author":"Riley","year":"2004","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.ntt.2012.11.001_bb0240","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1093\/cercor\/12.8.856","article-title":"Regional brain shape abnormalities persist into adolescence after heavy prenatal alcohol exposure","volume":"12","author":"Sowell","year":"2002","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.ntt.2012.11.001_bb0235","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/cercor\/bhm039","article-title":"Abnormal cortical thickness and brain-behavior correlation patterns in individuals with heavy prenatal alcohol exposure","volume":"18","author":"Sowell","year":"2008","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.ntt.2012.11.001_bb0245","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.6992275","article-title":"Teratogenic effects of alcohol in humans and laboratory animals","volume":"209","author":"Streissguth","year":"1980","journal-title":"Science"},{"key":"10.1016\/j.ntt.2012.11.001_bb0250","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1542\/peds.99.2.232","article-title":"Magnetic resonance imaging of brain anomalies in fetal alcohol syndrome","volume":"99","author":"Swayze","year":"1997","journal-title":"Pediatrics"},{"key":"10.1016\/j.ntt.2012.11.001_bb0255","first-page":"638","article-title":"Alcohol-related birth defects: an update","volume":"103","author":"Warren","year":"1988","journal-title":"Public Health Rep"},{"key":"10.1016\/j.ntt.2012.11.001_bb0260","doi-asserted-by":"crossref","first-page":"202S","DOI":"10.1111\/j.1530-0277.2001.tb02397.x","article-title":"Fetal alcohol syndrome: an international perspective","volume":"25","author":"Warren","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb9000","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.alcohol.2012.10.004","article-title":"The role of cortisol in chronic binge alcohol induced cerebellar injury: ovine model","volume":"47","author":"Washburn","year":"2013","journal-title":"Alcohol"},{"key":"10.1016\/j.ntt.2012.11.001_bb0265","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1530-0277.1990.tb01820.x","article-title":"Cell population depletion associated with fetal alcohol brain damage: mechanisms of BAC-dependent cell loss","volume":"14","author":"West","year":"1990","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0270","first-page":"1051","article-title":"Alcohol-mediated Purkinje cell loss in the absence of hypoxemia during the third trimester in an ovine model system","volume":"25","author":"West","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2012.11.001_bb0275","first-page":"288","article-title":"Neurodegenerative disease: neurodegenerative networking","volume":"13","author":"Yates","year":"2012","journal-title":"Nat Rev Neurosci"}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036212001742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036212001742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:17:03Z","timestamp":1760210223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892036212001742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":55,"alternative-id":["S0892036212001742"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2012.11.001","relation":{},"ISSN":["0892-0362"],"issn-type":[{"value":"0892-0362","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Different patterns of regional Purkinje cell loss in the cerebellar vermis as a function of the timing of prenatal ethanol exposure in an ovine model","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2012.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}