{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:17:44Z","timestamp":1760242664023,"version":"build-2065373602"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.ntt.2013.05.002","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T08:17:51Z","timestamp":1368605871000},"page":"79-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Dietary and genetic manipulations of folate metabolism differentially affect neocortical functions in mice"],"prefix":"10.1016","volume":"38","author":[{"given":"J.A.","family":"Ash","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.V.","family":"Malysheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.G.","family":"Fiorenza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Bisogni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.A.","family":"Levitsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Strawderman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Caudill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"Stover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.J.","family":"Strupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ntt.2013.05.002_bb0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/10401230209147396","article-title":"Folinic acid (leucovorin) as an adjunctive treatment for SSRI-refractory depression","volume":"14","author":"Alpert","year":"2002","journal-title":"Ann Clin Psychiatry"},{"key":"10.1016\/j.ntt.2013.05.002_bb0010","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.archger.2004.07.005","article-title":"Vitamin B12, folate, homocysteine and dementia: are they really related?","volume":"40","author":"Ariogul","year":"2005","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0015","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.biopsych.2004.08.019","article-title":"Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions","volume":"57","author":"Arnsten","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.ntt.2013.05.002_bb0020","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1620\/tjem.126.111","article-title":"Avoidance behavior in folate-deficient rats","volume":"126","author":"Bachevalier","year":"1978","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.ntt.2013.05.002_bb0025","first-page":"205","article-title":"Blood thiamine and blood folate levels. A comparative study in control, alcoholic and folate-deficient subjects","volume":"51","author":"Bachevalier","year":"1981","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1016\/j.ntt.2013.05.002_bb0030","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ntt.2006.11.004","article-title":"Succimer chelation normalizes reactivity to reward omission and errors in lead-exposed rats","volume":"29","author":"Beaudin","year":"2007","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.ntt.2013.05.002_bb0035","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.biopsych.2006.06.030","article-title":"Dimensional analysis of ADHD subtypes in rats","volume":"61","author":"Blondeau","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.ntt.2013.05.002_bb0040","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/ajcn\/82.3.493","article-title":"Hyperhomocysteinemia and cognitive function: more than just a causal link?","volume":"82","author":"Bottiglieri","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0045","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1017\/S0033291700038447","article-title":"Folate deficiency, biopterin and monoamine metabolism in depression","volume":"22","author":"Bottiglieri","year":"1992","journal-title":"Psychol Med"},{"key":"10.1016\/j.ntt.2013.05.002_bb0050","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2165\/00003495-199448020-00002","article-title":"The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders","volume":"48","author":"Bottiglieri","year":"1994","journal-title":"Drugs"},{"key":"10.1016\/j.ntt.2013.05.002_bb0055","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/jnnp.69.2.228","article-title":"Homocysteine, folate, methylation, and monoamine metabolism in depression","volume":"69","author":"Bottiglieri","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.ntt.2013.05.002_bb0060","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.neuropharm.2007.10.016","article-title":"Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems","volume":"54","author":"Brocardo","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ntt.2013.05.002_bb0065","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1086\/344213","volume":"71","author":"Brody","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ntt.2013.05.002_bb0070","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/tpj.2009.29","article-title":"Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review","volume":"9","author":"Carr","year":"2009","journal-title":"Pharmacogenomics J"},{"key":"10.1016\/j.ntt.2013.05.002_bb0075","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/BF02982630","article-title":"Dietary and genetic compromise in folate availability reduces acetylcholine, cognitive performance and increases aggression: critical role of S-adenosyl methionine","volume":"12","author":"Chan","year":"2008","journal-title":"J Nutr Health Aging"},{"key":"10.1016\/j.ntt.2013.05.002_bb0080","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.3945\/jn.111.138859","article-title":"Folate intake, MTHFR genotype, and sex modulate choline metabolism in mice","volume":"141","author":"Chew","year":"2011","journal-title":"J Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0085","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/humu.20830","article-title":"The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects","volume":"30","author":"Christensen","year":"2009","journal-title":"Hum Mutat"},{"key":"10.1016\/j.ntt.2013.05.002_bb0095","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","article-title":"Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease","volume":"55","author":"Clarke","year":"1998","journal-title":"Arch Neurol"},{"key":"10.1016\/j.ntt.2013.05.002_bb0090","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1093\/ajcn\/86.5.1384","article-title":"Low vitamin B-12 status and risk of cognitive decline in older adults","volume":"86","author":"Clarke","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0100","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.3945\/jn.110.122044","article-title":"Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain","volume":"140","author":"Craciunescu","year":"2010","journal-title":"J Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0105","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.nutres.2010.09.008","article-title":"Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system tan in the brain, and this effect escalates with age","volume":"30","author":"Crivello","year":"2010","journal-title":"Nutr Res"},{"key":"10.1016\/j.ntt.2013.05.002_bb0110","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0091-3057(96)00175-X","article-title":"Effect of folate deficiency and folate and B12 excess on memory functioning in young chicks","volume":"56","author":"Crowe","year":"1997","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.ntt.2013.05.002_bb0115","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.pbb.2007.12.021","article-title":"Neurobehavioral mechanisms of impulsivity: fronto-striatal systems and functional neurochemistry","volume":"90","author":"Dalley","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.ntt.2013.05.002_bb0120","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.bcp.2006.12.004","article-title":"Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test","volume":"73","author":"Day","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ntt.2013.05.002_bb0125","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1037\/0735-7044.118.6.1196","article-title":"Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse: a mouse model of Down syndrome and Alzheimer's disease","volume":"118","author":"Driscoll","year":"2004","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.ntt.2013.05.002_bb0130","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ymgme.2007.02.001","article-title":"Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase","volume":"91","author":"Elmore","year":"2007","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.ntt.2013.05.002_bb0140","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/bdra.20111","article-title":"Behavioral effects of prenatal folate deficiency in mice","volume":"73","author":"Ferguson","year":"2005","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.ntt.2013.05.002_bb0135","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3945\/jn.112.169821","article-title":"Reduced MTHFD1 activity in male mice perturbs folate and choline dependent one-carbon metabolism as well as transsulfuration","volume":"143","author":"Field","year":"2013","journal-title":"J Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.devbrainres.2003.10.002","article-title":"Impaired sustained attention and altered reactivity to errors in an animal model of prenatal cocaine exposure","volume":"147","author":"Gendle","year":"2003","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.ntt.2013.05.002_bb0150","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0031-9384(95)00156-D","article-title":"Behavioral and neurochemical changes in folate-deficient mice","volume":"58","author":"Gospe","year":"1995","journal-title":"Physiol Behav"},{"key":"10.1016\/j.ntt.2013.05.002_bb0155","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0028-3908(03)00099-6","article-title":"Attentional effects of nicotinic agonists in rats","volume":"44","author":"Hahn","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ntt.2013.05.002_bb0160","doi-asserted-by":"crossref","first-page":"38381","DOI":"10.1074\/jbc.M205000200","article-title":"Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosynthesis","volume":"277","author":"Herbig","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ntt.2013.05.002_bb0165","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1399-0004.1998.tb02658.x","article-title":"Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects","volume":"53","author":"Hol","year":"1998","journal-title":"Clin Genet"},{"key":"10.1016\/j.ntt.2013.05.002_bb0170","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00213-006-0549-2","article-title":"Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task","volume":"189","author":"Hoyle","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ntt.2013.05.002_bb0175","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1046\/j.1460-9568.1999.00701.x","article-title":"Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype","volume":"11","author":"Humby","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.ntt.2013.05.002_bb0180","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jada.2008.10.046","article-title":"Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted","volume":"109","author":"Ivanov","year":"2009","journal-title":"J Am Diet Assoc"},{"key":"10.1016\/j.ntt.2013.05.002_bb0185","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/jn\/129.3.712","article-title":"Folate nutriture alters choline status of women and men fed low choline diets","volume":"129","author":"Jacob","year":"1999","journal-title":"J Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0190","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1096\/fj.09-153718","article-title":"Deletion of murine choline dehydrogenase results in diminished sperm motility","volume":"24","author":"Johnson","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.ntt.2013.05.002_bb0195","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.amjmed.2004.08.019","article-title":"Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur studies of successful aging","volume":"118","author":"Kado","year":"2005","journal-title":"Am J Med"},{"key":"10.1016\/j.ntt.2013.05.002_bb0200","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/jn\/124.11.2197","article-title":"Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver","volume":"124","author":"Kim","year":"1994","journal-title":"J Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0205","doi-asserted-by":"crossref","first-page":"16025","DOI":"10.1073\/pnas.0504285102","article-title":"Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans","volume":"102","author":"Kohlmeier","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ntt.2013.05.002_bb0215","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.1523\/JNEUROSCI.0940-08.2008","article-title":"Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase","volume":"28","author":"Kronenberg","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.ntt.2013.05.002_bb0210","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/156652409787847146","article-title":"Folic acid, neurodegenerative and neuropsychiatric disease","volume":"9","author":"Kronenberg","year":"2009","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.ntt.2013.05.002_bb0220","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1523\/JNEUROSCI.0719-05.2005","article-title":"Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat","volume":"25","author":"Lambe","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.ntt.2013.05.002_bb0225","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbr.2010.08.031","article-title":"Sex-dependent behavioral effects of Mthfr deficiency and neonatal GABA potentiation in mice","volume":"216","author":"Levav-Rabkin","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.ntt.2013.05.002_bb0230","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2010.10.074","article-title":"Persisting cognitive deficits induced by low-dose, subchronic treatment with MK-801 in adolescent rats","volume":"652","author":"Li","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.ntt.2013.05.002_bb0235","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ntt.2013.05.002_bb0240","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1074\/jbc.M808281200","article-title":"Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism","volume":"284","author":"MacFarlane","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ntt.2013.05.002_bb0245","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/carcin\/bgq270","article-title":"Mthfd1 is a modifier of chemically-induced Intestinal carcinogenesis","volume":"32","author":"MacFarlane","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ntt.2013.05.002_bb0250","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1515\/CCLM.2007.324","article-title":"Defects in homocysteine metabolism: diversity among hyperhomocyst(e)inemias","volume":"45","author":"Matthews","year":"2007","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.ntt.2013.05.002_bb0255","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/(SICI)1099-1166(199804)13:4<235::AID-GPS761>3.0.CO;2-8","article-title":"Total serum homocysteine in senile dementia of Alzheimer type","volume":"13","author":"McCaddon","year":"1998","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.ntt.2013.05.002_bb0260","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/01.STR.0000032550.90046.38","article-title":"Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland","volume":"33","author":"McIlroy","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.ntt.2013.05.002_bb0265","doi-asserted-by":"crossref","first-page":"1158S","DOI":"10.1093\/ajcn\/76.5.1158S","article-title":"Role of S-adenosyl-l-methionine in the treatment of depression: a review of the evidence","volume":"76","author":"Mischoulon","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0270","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1093\/ajcn\/82.4.866","article-title":"Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study","volume":"82","author":"Mooijaart","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0280","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/dev.20308","article-title":"A mouse model of fragile X syndrome exhibits heightened arousal and\/or emotion following errors or reversal of contingencies","volume":"50","author":"Moon","year":"2008","journal-title":"Dev Psychobiol"},{"key":"10.1016\/j.ntt.2013.05.002_bb0275","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1037\/a0019590","article-title":"Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome","volume":"124","author":"Moon","year":"2010","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.ntt.2013.05.002_bb0285","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1037\/0735-7044.116.4.624","article-title":"Enduring effects of prenatal cocaine exposure on attention and reaction to errors","volume":"116","author":"Morgan","year":"2002","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.ntt.2013.05.002_bb0290","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3233\/JAD-2006-9410","article-title":"Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer's disease","volume":"9","author":"Morris","year":"2006","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.ntt.2013.05.002_bb0295","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0003-9861(74)90410-X","article-title":"Folic acid deficiency and methyl group metabolism in rat brain: effects of L-dopa","volume":"160","author":"Ordonez","year":"1974","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.ntt.2013.05.002_bb0300","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/sj.ejhg.5201603","article-title":"Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population","volume":"14","author":"Parle-McDermott","year":"2006","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ntt.2013.05.002_bb0305","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1093\/cercor\/12.12.1254","article-title":"The frontal cortex of the rat and visual attentional performance: dissociable functions of distinct medial prefrontal subregions","volume":"12","author":"Passetti","year":"2002","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.ntt.2013.05.002_bb0310","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0306-4522(97)00392-8","article-title":"Changes in activities of dopamine and serotonin systems in the frontal cortex underlie poor choice accuracy and impulsivity of rats in an attention task","volume":"83","author":"Puumala","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.ntt.2013.05.002_bb0315","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/ajcn\/80.1.114","article-title":"Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia","volume":"80","author":"Quadri","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"Suppl. 1","key":"10.1016\/j.ntt.2013.05.002_bb0320","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.archger.2007.01.041","article-title":"Risk factors for dementia: data from the Conselice study of brain aging","volume":"44","author":"Ravaglia","year":"2007","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0325","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/ajcn\/63.3.306","article-title":"Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study","volume":"63","author":"Riggs","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0330","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.neuro.051508.135535","article-title":"The neuropsychopharmacology of fronto-executive function: monoaminergic modulation","volume":"32","author":"Robbins","year":"2009","journal-title":"Annu Rev Neurosci"},{"issue":"Suppl. 1","key":"10.1016\/j.ntt.2013.05.002_bb0335","doi-asserted-by":"crossref","first-page":"i151","DOI":"10.1093\/cercor\/bhm066","article-title":"Differential regulation of fronto-executive function by the monoamines and acetylcholine","volume":"17","author":"Robbins","year":"2007","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.ntt.2013.05.002_bb0340","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1096\/fj.02-0456fje","article-title":"Homocysteine\u2013betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency","volume":"17","author":"Schwahn","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.ntt.2013.05.002_bb0345","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00426-008-0193-z","article-title":"Individual differences and developmental change in the ERN response: implications for models of ACC function","volume":"73","author":"Segalowitz","year":"2009","journal-title":"Psychol Res"},{"key":"10.1016\/j.ntt.2013.05.002_bb0350","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3233\/JAD-2006-9404","article-title":"Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease?","volume":"9","author":"Seshadri","year":"2006","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.ntt.2013.05.002_bb0355","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1289\/ehp.9263","article-title":"Succimer chelation improves learning, attention, and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure","volume":"115","author":"Stangle","year":"2007","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ntt.2013.05.002_bb0360","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.jada.2008.06.430","article-title":"Genetic and epigenetic contributions to human nutrition and health: managing genome\u2013diet interactions","volume":"108","author":"Stover","year":"2008","journal-title":"J Am Diet Assoc"},{"key":"10.1016\/j.ntt.2013.05.002_bb0365","series-title":"Human developmental neurotoxicology","first-page":"415","article-title":"Assessing the neurobehavioral effects of early toxicant exposure: a perspective from animal research","author":"Strupp","year":"2006"},{"key":"10.1016\/j.ntt.2013.05.002_bb0375","doi-asserted-by":"crossref","first-page":"35646","DOI":"10.1074\/jbc.M005864200","article-title":"Purification and properties of a folate-catabolizing enzyme","volume":"275","author":"Suh","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ntt.2013.05.002_bb0370","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev.nutr.21.1.255","article-title":"New perspectives on folate catabolism","volume":"21","author":"Suh","year":"2001","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0380","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.nutr.012809.104810","article-title":"Compartmentalization of mammalian folate-mediated one-carbon metabolism","volume":"30","author":"Tibbetts","year":"2010","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0385","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.3945\/jn.108.093641","article-title":"Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine","volume":"138","author":"Troen","year":"2008","journal-title":"J Nutr"},{"issue":"Spec No 1","key":"10.1016\/j.ntt.2013.05.002_bb0390","doi-asserted-by":"crossref","first-page":"R139","DOI":"10.1093\/hmg\/ddi100","article-title":"The impact of metabolism on DNA methylation","volume":"14","author":"Ulrey","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ntt.2013.05.002_bb0395","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.archger.2008.03.009","article-title":"Hyperhomocysteinemia and Alzheimer's disease: a systematic review","volume":"48","author":"Van Dam","year":"2009","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0400","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1080\/07315724.1995.10718539","article-title":"Choline deficiency and methotrexate treatment induces marked but reversible changes in hepatic folate concentrations, serum homocysteine and DNA methylation rates in rats","volume":"14","author":"Varela-Moreiras","year":"1995","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0405","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/00949659308811554","article-title":"Generalized linear mixed models \u2014 a pseudo-likelihood approach","volume":"48","author":"Wolfinger","year":"1993","journal-title":"J Stat Comput Simul"},{"key":"10.1016\/j.ntt.2013.05.002_bb0410","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/sj.npp.1300393","article-title":"Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor","volume":"29","author":"Young","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ntt.2013.05.002_bb0415","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.nutr.26.061505.111156","article-title":"Choline: critical role during fetal development and dietary requirements in adults","volume":"26","author":"Zeisel","year":"2006","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.ntt.2013.05.002_bb0420","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.brainres.2008.08.059","article-title":"Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models","volume":"1237","author":"Zeisel","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.ntt.2013.05.002_bb0425","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1753-4887.2009.00246.x","article-title":"Choline: an essential nutrient for public health","volume":"67","author":"Zeisel","year":"2009","journal-title":"Nutr Rev"},{"key":"10.1016\/j.ntt.2013.05.002_bb0430","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2174\/1389200023337586","article-title":"Catechol-O-methyltransferase (COMT)-mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics: importance in pathophysiology and pathogenesis","volume":"3","author":"Zhu","year":"2002","journal-title":"Curr Drug Metab"}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036213001311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036213001311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:19:02Z","timestamp":1760210342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892036213001311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":86,"alternative-id":["S0892036213001311"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2013.05.002","relation":{},"ISSN":["0892-0362"],"issn-type":[{"type":"print","value":"0892-0362"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary and genetic manipulations of folate metabolism differentially affect neocortical functions in mice","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2013.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}