{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T07:36:36Z","timestamp":1770017796556,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.ntt.2013.11.003","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T03:15:44Z","timestamp":1385003744000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Protective effects of the alcohol dehydrogenase-ADH1B*3 allele on attention and behavior problems in adolescents exposed to alcohol during pregnancy"],"prefix":"10.1016","volume":"41","author":[{"given":"Neil C.","family":"Dodge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph L.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra W.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ntt.2013.11.003_bb0005","series-title":"Manual for the child behavior checklist\/4-18 and 1991 profile","author":"Achenbach","year":"1991"},{"key":"10.1016\/j.ntt.2013.11.003_bb0015","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1176\/appi.ajp.159.1.36","article-title":"Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinic","volume":"159","author":"Biederman","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.ntt.2013.11.003_bb0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000469238","article-title":"Catalytic properties of human liver alcohol dehydrogenase isoenzymes","volume":"37","author":"Bosron","year":"1987","journal-title":"Enzyme"},{"key":"10.1016\/j.ntt.2013.11.003_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/aje\/kwh003","article-title":"Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review","volume":"159","author":"Brennan","year":"2004","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ntt.2013.11.003_bb0030","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0892-0362(91)90085-B","article-title":"Effects of prenatal alcohol exposure at school age. II. Attention and behavior","volume":"13","author":"Brown","year":"1991","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.ntt.2013.11.003_bb0035","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1097\/01.alc.0000175036.34076.a0","article-title":"The relation of prenatal alcohol exposure to cognitive processing speed and efficiency in childhood","volume":"29","author":"Burden","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0040","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1097\/00004583-199709000-00010","article-title":"Association of prenatal alcohol exposure with behavioral and learning problems in early adolescence","volume":"36","author":"Carmichael Olson","year":"1997","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.ntt.2013.11.003_bb0045","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/ajmg.10674","article-title":"Influence of ADH1B polymorphism on alcohol use and its subjective effects in a Jewish population","volume":"112","author":"Carr","year":"2002","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.ntt.2013.11.003_bb0050","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1530-0277.2010.01162.x","article-title":"Verbal and nonverbal memory in adults prenatally exposed to alcohol","volume":"34","author":"Coles","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0055","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1001\/archpsyc.64.11.1296","article-title":"Causal inferences regarding prenatal alcohol exposure and childhood externalizing problems","volume":"64","author":"D'Onofrio","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.ntt.2013.11.003_bb0060","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1097\/01.ALC.0000141816.14776.97","article-title":"Alcohol dehydrogenase 2*3 affects alterations in offspring facial morphology associated with maternal ethanol intake in pregnancy","volume":"28","author":"Das","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0065","doi-asserted-by":"crossref","first-page":"e1225","DOI":"10.1542\/peds.2008-1380","article-title":"Strengthening the case: prenatal alcohol exposure is associated with increased risk for conduct disorder","volume":"122","author":"Disney","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.ntt.2013.11.003_bb0070","series-title":"PPVT manual for forms L and M","author":"Dunn","year":"1981"},{"key":"10.1016\/j.ntt.2013.11.003_bb0075","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1530-0277.2006.00298.x","article-title":"Association of the ADH1B*3 allele with alcohol-related phenotypes in Trinidad","volume":"31","author":"Ehlers","year":"2007","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0085","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1530-0277.1996.tb01684.x","article-title":"Prenatal alcohol exposure and academic achievement at age six: a nonlinear fit","volume":"20","author":"Goldschmidt","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0080","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/15353702-0323006-07","article-title":"Alcohol teratogenesis: mechanisms of damage and strategies for intervention","volume":"230","author":"Goodlett","year":"2005","journal-title":"Exp Biol Med"},{"key":"10.1016\/j.ntt.2013.11.003_bb0225","unstructured":"Hollingshead AB. Four factor index of social status. Unpublished manuscript. Yale University; 1975."},{"key":"10.1016\/j.ntt.2013.11.003_bb0095","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1542\/peds.2004-0259","article-title":"A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 Institute of Medicine criteria","volume":"115","author":"Hoyme","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.ntt.2013.11.003_bb0100","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1530-0277.1996.tb01653.x","article-title":"Increased vulnerability to alcohol-related birth defects in the offspring of mothers over 30","volume":"20","author":"Jacobson","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0110","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1542\/peds.109.5.815","article-title":"Validity of maternal report of prenatal alcohol, cocaine, and smoking in relation to neurobehavioral outcome","volume":"109","author":"Jacobson","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.ntt.2013.11.003_bb0115","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1097\/01.ALC.0000145691.81233.FA","article-title":"Maternal age, alcohol abuse history, and quality of parenting as moderators of the effects of prenatal alcohol exposure on 7.5-year intellectual function","volume":"28","author":"Jacobson","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0120","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jpeds.2005.08.023","article-title":"Protective effects of the alcohol dehydrogenase-ADH1B allele in African American children exposed to alcohol during pregnancy","volume":"148","author":"Jacobson","year":"2006","journal-title":"J Pediatr"},{"key":"10.1016\/j.ntt.2013.11.003_bb0125","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1530-0277.2007.00585.x","article-title":"Impaired eyeblink conditioning in children with fetal alcohol syndrome","volume":"32","author":"Jacobson","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0105","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1530-0277.2010.01360.x","article-title":"Number processing in adolescents with prenatal alcohol exposure and ADHD: differences in the neurobehavioral phenotype","volume":"35","author":"Jacobson","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0130","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1530-0277.2010.01341.x","article-title":"Impaired delay and trace eyeblink conditioning in school-age children with fetal alcohol syndrome","volume":"35","author":"Jacobson","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0135","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1037\/0021-843X.109.3.488","article-title":"Age and gender differences in oppositional behavior and conduct problems: a cross-sectional household study of middle childhood and adolescence","volume":"109","author":"Lahey","year":"2000","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.ntt.2013.11.003_bb0140","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jaac.2010.12.004","article-title":"Prenatal alcohol exposure is associated with conduct disorder in adolescence: findings from a birth cohort","volume":"50","author":"Larkby","year":"2011","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.ntt.2013.11.003_bb0145","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/00008571-200411000-00003","article-title":"Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism","volume":"14","author":"Lee","year":"2004","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.ntt.2013.11.003_bb0150","first-page":"226","article-title":"Parent ratings of behavior in children with heavy prenatal alcohol exposure and IQ-matched controls","volume":"24","author":"Mattson","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0155","first-page":"239","article-title":"Fetal alcohol effects among North American Indians: evidence and implications for society","volume":"15","author":"May","year":"1991","journal-title":"Alcohol Health Res World"},{"key":"10.1016\/j.ntt.2013.11.003_bb0160","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1111\/j.1530-0277.2010.01205.x","article-title":"ADH1B*3 and response to alcohol in African-Americans","volume":"34","author":"McCarthy","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0165","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0022-3565(24)37143-5","article-title":"Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans","volume":"283","author":"McCarver","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.ntt.2013.11.003_bb0170","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1037\/0033-2909.114.2.376","article-title":"Statistical difficulties of detecting interactions and moderator effects","volume":"114","author":"McClelland","year":"1993","journal-title":"Psychol Bull"},{"key":"10.1016\/j.ntt.2013.11.003_bb0175","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1360-0443.2009.02756.x","article-title":"Evidence of a complex association between dose, pattern and timing of prenatal alcohol exposure and child behavior problems","volume":"105","author":"O'Leary","year":"2009","journal-title":"Addiction"},{"key":"10.1016\/j.ntt.2013.11.003_bb0180","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1086\/341290","article-title":"A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity","volume":"71","author":"Osier","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ntt.2013.11.003_bb0190","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1530-0277.1999.tb04227.x","article-title":"Behavioral and psychosocial profiles of alcohol-exposed children","volume":"23","author":"Roebuck","year":"1999","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0195","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1469-1809.1971.tb00238.x","article-title":"Developmental changes and polymorphism in human alcohol dehydrogenase","volume":"34","author":"Smith","year":"1971","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.ntt.2013.11.003_bb0200","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1542\/peds.108.2.e34","article-title":"Prenatal alcohol exposure and childhood behavior at age 6 to 7years: I. Dose\u2013response effect","volume":"108","author":"Sood","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.ntt.2013.11.003_bb0205","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1067\/mpd.2002.128112","article-title":"Alcohol dehydrogenase 2 genotypes, maternal alcohol use, and infant outcome","volume":"141","author":"Stoler","year":"2002","journal-title":"J Pediatr"},{"key":"10.1016\/j.ntt.2013.11.003_bb0210","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1530-0277.1990.tb01224.x","article-title":"Moderate prenatal alcohol exposure: effects on child IQ and learning problems at age 7 1\/2years","volume":"14","author":"Streissguth","year":"1990","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0215","first-page":"1719","article-title":"Alcohol dehydrogenase-2*2 allele is associated with decreased prevalence of fetal alcohol syndrome in the mixed-ancestry population of the Western Cape Province, South Africa","volume":"25","author":"Viljoen","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ntt.2013.11.003_bb0220","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/bdra.20125","article-title":"Genetic polymorphisms: impact on the risk of fetal alcohol spectrum disorder","volume":"73","author":"Warren","year":"2005","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.ntt.2013.11.003_bb0230","series-title":"Statistical principles in experimental design","author":"Winer","year":"1971"}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036213002195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036213002195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:18:40Z","timestamp":1760210320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892036213002195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":43,"alternative-id":["S0892036213002195"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2013.11.003","relation":{},"ISSN":["0892-0362"],"issn-type":[{"value":"0892-0362","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of the alcohol dehydrogenase-ADH1B*3 allele on attention and behavior problems in adolescents exposed to alcohol during pregnancy","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2013.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}