{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:35:41Z","timestamp":1789724141260,"version":"4.0.1"},"reference-count":140,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.ntt.2018.01.009","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T20:17:32Z","timestamp":1518725852000},"page":"50-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Prenatal substance exposure and offspring development: Does DNA methylation play a role?"],"prefix":"10.1016","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-0576","authenticated-orcid":false,"given":"Valerie S.","family":"Knopik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8924-6597","authenticated-orcid":false,"given":"Kristine","family":"Marceau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Cinnamon","family":"Bidwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-8757","authenticated-orcid":false,"given":"Emily","family":"Rolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0005","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/14622200801978672","article-title":"Correlates of cigarette smoking during pregnancy and its genetic and environmental overlap with nicotine dependence","volume":"10","author":"Agrawal","year":"2008","journal-title":"Nicotine Tob. Res."},{"key":"10.1016\/j.ntt.2018.01.009_bb0010","series-title":"Epigenetics","author":"Allis","year":"2015"},{"issue":"9","key":"10.1016\/j.ntt.2018.01.009_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074691","article-title":"Patterning in placental 11-B hydroxysteroid dehydrogenase methylation according to prenatal socioeconomic adversity","volume":"8","author":"Appleton","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0020","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00467-009-1432-2","article-title":"Growth and body composition in very young SGA children","volume":"25","author":"Argente","year":"2010","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ntt.2018.01.009_bb0025","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.alcohol.2016.10.010","article-title":"Adolescent binge-pattern alcohol exposure alters genome-wide DNA methylation patterns in the hypothalamus of alcohol-naive male offspring","volume":"60","author":"Asimes","year":"2017","journal-title":"Alcohol"},{"issue":"2","key":"10.1016\/j.ntt.2018.01.009_bb0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1530\/ror.0.0020105","article-title":"Fetal undernutrition and disease in later life","volume":"2","author":"Barker","year":"1997","journal-title":"Rev. Reprod."},{"issue":"9","key":"10.1016\/j.ntt.2018.01.009_bb0035","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1111\/acer.12497","article-title":"Fetal alcohol programming of hypothalamic proopiomelanocortin system by epigenetic mechanisms and later life vulnerability to stress","volume":"38","author":"Bekdash","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0040","doi-asserted-by":"crossref","first-page":"789","DOI":"10.15288\/jsad.2017.78.789","article-title":"Prenatal exposure effects on early adolescent substance use: preliminary evidence from a genetically informed bayesian approach","volume":"78","author":"Bidwell","year":"2017","journal-title":"J. Stud. Alcohol Drugs"},{"issue":"7143","key":"10.1016\/j.ntt.2018.01.009_bb0045","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature05913","article-title":"Perceptions of epigenetics","volume":"447","author":"Bird","year":"2007","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0050","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1080\/09603123.2010.544032","article-title":"Prenatal exposure to cigarette smoke and childhood externalizing behavioral problems: a propensity score matching approach","volume":"21","author":"Boutwell","year":"2011","journal-title":"Int. J. Environ. Health Res."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0055","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1164\/rccm.200901-0135OC","article-title":"Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation","volume":"180","author":"Breton","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"6","key":"10.1016\/j.ntt.2018.01.009_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099716","article-title":"Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation","volume":"9","author":"Breton","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0065","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1192\/bjp.166.5.601","article-title":"Increased risk of affective disorders in males after second trimester prenatal exposure to the Dutch hunger winter of 1944\u201345","volume":"166","author":"Brown","year":"1995","journal-title":"Br. J. Psychiatry J. Ment. Sci."},{"issue":"3","key":"10.1016\/j.ntt.2018.01.009_bb0070","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0749-3797(98)00089-0","article-title":"Effects of smoking during pregnancy. Five meta-analyses","volume":"16","author":"Castles","year":"1999","journal-title":"Am. J. Prev. Med."},{"issue":"11","key":"10.1016\/j.ntt.2018.01.009_bb0075","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.4161\/15592294.2014.971593","article-title":"Fetal lung and placental methylation is associated with in utero nicotine exposure","volume":"9","author":"Chhabra","year":"2014","journal-title":"Epigenetics"},{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0080","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/thx.54.4.357","article-title":"Health effects of passive smoking-10: summary of effects of parental smoking on the respiratory health of children and implications for research","volume":"54","author":"Cook","year":"1999","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.ntt.2018.01.009_bb0085","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0892-0362(02)00271-4","article-title":"Alcohol, tobacco and marijuana use among pregnant teenagers: 6-year follow-up of offspring growth effects","volume":"24","author":"Cornelius","year":"2002","journal-title":"Neurotoxicol. Teratol."},{"issue":"39","key":"10.1016\/j.ntt.2018.01.009_bb0090","doi-asserted-by":"crossref","first-page":"16881","DOI":"10.1073\/pnas.1009459107","article-title":"Prenatal undernutrition and cognitive function in late adulthood","volume":"107","author":"de Rooij","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0095","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1097\/AOG.0000000000000208","article-title":"Increase in prescription opioid use during pregnancy among Medicaid-enrolled women","volume":"123","author":"Desai","year":"2014","journal-title":"Obstet. Gynecol."},{"issue":"8","key":"10.1016\/j.ntt.2018.01.009_bb0100","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.biopsych.2011.06.027","article-title":"Maternal cannabis use alters ventral striatal dopamine D2 gene regulation in the offspring","volume":"70","author":"DiNieri","year":"2011","journal-title":"Biol. Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.ntt.2018.01.009_bb0105","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/13547500902965898","article-title":"Early life insult from cigarette smoke may be predictive of chronic diseases later in life","volume":"14","author":"Doherty","year":"2009","journal-title":"Biomarkers"},{"issue":"8","key":"10.1016\/j.ntt.2018.01.009_bb0110","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/j.1360-0443.2009.02631.x","article-title":"The need for more quasi-experimental studies of alcohol consumption during pregnancy","volume":"104","author":"D'Onofrio","year":"2009","journal-title":"Addiction"},{"issue":"8","key":"10.1016\/j.ntt.2018.01.009_bb0115","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/1469-7610.00196","article-title":"The role of the children of twins design in elucidating causal relations between parent characteristics and child outcomes","volume":"44","author":"D'Onofrio","year":"2003","journal-title":"J. Child Psychol. Psychiatry"},{"issue":"11","key":"10.1016\/j.ntt.2018.01.009_bb0120","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1001\/archpsyc.64.11.1296","article-title":"Causal inferences regarding prenatal alcohol exposure and childhood externalizing problems","volume":"64","author":"D'Onofrio","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0125","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1017\/S0954579408000072","article-title":"Smoking during pregnancy and offspring externalizing problems: an exploration of genetic and environmental confounds","volume":"20","author":"D'Onofrio","year":"2008","journal-title":"Dev. Psychopathol."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0130","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/archgenpsychiatry.2010.33","article-title":"Familial confounding of the association between maternal smoking during pregnancy and offspring criminality: a population-based study in sweden","volume":"67","author":"D'Onofrio","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"issue":"2","key":"10.1016\/j.ntt.2018.01.009_bb0135","first-page":"e185","article-title":"Maternal methamphetamine use in pregnancy and long-term neurodevelopmental and behavioral deficits in children","volume":"21","author":"Dyk","year":"2014","journal-title":"J. Popul. Ther. Clin. Pharmacol."},{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0140","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00228-008-0609-0","article-title":"Smoking in pregnancy and lactation: a review of risks and cessation strategies","volume":"65","author":"Einarson","year":"2009","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ntt.2018.01.009_bb0145","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.neubiorev.2016.11.013","article-title":"Developmental toxicity of nicotine: a transdisciplinary synthesis and implications for emerging tobacco products","volume":"72","author":"England","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"12","key":"10.1016\/j.ntt.2018.01.009_bb0150","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1158\/1055-9965.EPI-11-0553","article-title":"Prenatal smoke exposure and genomic DNA methylation in a multiethnic birth cohort","volume":"20","author":"Flom","year":"2011","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.ntt.2018.01.009_bb0155","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.7645.1","article-title":"Substance use during pregnancy","volume":"5","author":"Forray","year":"2016","journal-title":"F1000Res"},{"issue":"11","key":"10.1016\/j.ntt.2018.01.009_bb0160","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11920-015-0626-5","article-title":"Substance use in the perinatal period","volume":"17","author":"Forray","year":"2015","journal-title":"Curr. Psychiatry Rep."},{"issue":"9","key":"10.1016\/j.ntt.2018.01.009_bb0165","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1001\/jamapsychiatry.2013.127","article-title":"Maternal smoking during pregnancy and offspring conduct problems: evidence from 3 independent genetically sensitive research designs","volume":"70","author":"Gaysina","year":"2013","journal-title":"JAMA Psychiat."},{"issue":"6","key":"10.1016\/j.ntt.2018.01.009_bb0170","doi-asserted-by":"crossref","first-page":"539","DOI":"10.4161\/epi.5.6.12378","article-title":"Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds","volume":"5","author":"Guerrero-Preston","year":"2010","journal-title":"Epigenetics"},{"issue":"2","key":"10.1016\/j.ntt.2018.01.009_bb0175","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tips.2008.10.010","article-title":"Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling","volume":"30","author":"Guidotti","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0180","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ydbio.2008.04.025","article-title":"Altered gene expression and methylation of the human chromosome 11 imprinted region in small for gestational age (SGA) placentae","volume":"320","author":"Guo","year":"2008","journal-title":"Dev. Biol."},{"issue":"12","key":"10.1016\/j.ntt.2018.01.009_bb0185","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1124\/dmd.107.016253","article-title":"Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines","volume":"35","author":"Haarmann-Stemmann","year":"2007","journal-title":"Drug Metab. Dispos."},{"issue":"7","key":"10.1016\/j.ntt.2018.01.009_bb0190","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/BF00400248","article-title":"Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis","volume":"35","author":"Hales","year":"1992","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.ntt.2018.01.009_bb0195","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1465-3362.2010.00214.x","article-title":"Illicit drug use before and during pregnancy at a tertiary maternity hospital 2000\u20132006","volume":"30","author":"Hayatbakhsh","year":"2011","journal-title":"Drug Alcohol Rev."},{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0200","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1095\/biolreprod.108.074690","article-title":"Fetal alcohol spectrum disorders: the epigenetic perspective","volume":"81","author":"Haycock","year":"2009","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0205","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1095\/biolreprod.108.074682","article-title":"Exposure of mouse embryos to ethanol during preimplantation development: effect on DNA methylation in the h19 imprinting control region","volume":"81","author":"Haycock","year":"2009","journal-title":"Biol. Reprod."},{"issue":"18","key":"10.1016\/j.ntt.2018.01.009_bb0210","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1001\/jama.2012.4526","article-title":"Epidemic of prescription opiate abuse and neonatal abstinence","volume":"307","author":"Hayes","year":"2012","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0215","first-page":"635","article-title":"Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight","volume":"23","author":"Hoyo","year":"2012","journal-title":"Cancer Causes Control"},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0220","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neubiorev.2005.04.005","article-title":"Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and cognitive functioning in human offspring","volume":"30","author":"Huizink","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.ntt.2018.01.009_bb0225","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/mp.2014.7","article-title":"Long-term parental methamphetamine exposure of mice influences behavior and hippocampal DNA methylation of the offspring","volume":"20","author":"Itzhak","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ntt.2018.01.009_bb0230","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12967-015-0384-5","article-title":"DNA methylation patterns in newborns exposed to tobacco in utero","volume":"13","author":"Ivorra","year":"2015","journal-title":"J. Transl. Med."},{"issue":"11","key":"10.1016\/j.ntt.2018.01.009_bb0235","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1038\/npp.2016.92","article-title":"Preconception alcohol increases offspring vulnerability to stress","volume":"41","author":"Jabbar","year":"2016","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"10.1016\/j.ntt.2018.01.009_bb0240","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0168-9525(97)01180-3","article-title":"DNA methylation and imprinting: why bother?","volume":"13","author":"Jaenisch","year":"1997","journal-title":"Trends Genet."},{"issue":"2","key":"10.1016\/j.ntt.2018.01.009_bb0245","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1037\/a0026020","article-title":"From correlates to causes: can quasi-experimental studies and statistical innovations bring us closer to identifying the causes of antisocial behavior?","volume":"138","author":"Jaffee","year":"2012","journal-title":"Psychol. Bull."},{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0250","doi-asserted-by":"crossref","first-page":"S182","DOI":"10.1016\/j.ajog.2015.07.011","article-title":"Epigenetic regulation of human placental function and pregnancy outcome: considerations for causal inference","volume":"213","author":"Januar","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.ntt.2018.01.009_bb0255","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/jp.2013.180","article-title":"Cannabis, the pregnant woman and her child: weeding out the myths","volume":"34","author":"Jaques","year":"2014","journal-title":"J. Perinatol."},{"issue":"10","key":"10.1016\/j.ntt.2018.01.009_bb0260","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1289\/ehp.1205412","article-title":"450\u202fK epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy","volume":"120","author":"Joubert","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"7","key":"10.1016\/j.ntt.2018.01.009_bb0265","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.3390\/ijerph110707261","article-title":"Transgenerational exposure to environmental tobacco smoke","volume":"11","author":"Joya","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"9","key":"10.1016\/j.ntt.2018.01.009_bb0270","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1042\/BC20080213","article-title":"Two new miR-16 targets: caprin-1 and HMGA1, proteins implicated in cell proliferation","volume":"101","author":"Kaddar","year":"2009","journal-title":"Biol. Cell."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0275","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1101\/gad.6.5.705","article-title":"Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line","volume":"6","author":"Kafri","year":"1992","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000811","article-title":"Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model","volume":"6","author":"Kaminen-Ahola","year":"2010","journal-title":"PLoS Genet."},{"issue":"3","key":"10.1016\/j.ntt.2018.01.009_bb0285","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s11064-012-0960-5","article-title":"Effects of ethanol exposure during early pregnancy in hyperactive, inattentive and impulsive behaviors and MeCP2 expression in rodent offspring","volume":"38","author":"Kim","year":"2013","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0290","doi-asserted-by":"crossref","DOI":"10.1080\/87565640802564366","article-title":"Maternal smoking during pregnancy and child outcomes: real or spurious effect?","volume":"34","author":"Knopik","year":"2009","journal-title":"Dev. Neuropsychol."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0295","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1017\/S0033291704004155","article-title":"Contributions of parental alcoholism, prenatal substance exposure, and genetic transmission to child ADHD risk: a female twin study","volume":"35","author":"Knopik","year":"2005","journal-title":"Psychol. Med."},{"issue":"10","key":"10.1016\/j.ntt.2018.01.009_bb0300","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1017\/S0033291706007884","article-title":"Maternal alcohol use disorder and offspring ADHD: disentangling genetic and environmental effects using a children-of-twins design","volume":"36","author":"Knopik","year":"2006","journal-title":"Psychol. Med."},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0305","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1375\/twin.12.1.53","article-title":"Paternal alcoholism and offspring ADHD problems: a children of twins design","volume":"12","author":"Knopik","year":"2009","journal-title":"Twin Res. Hum. Genet."},{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0310","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1017\/S0954579412000776","article-title":"The epigenetics of maternal cigarette smoking during pregnancy and effects on child development","volume":"24","author":"Knopik","year":"2012","journal-title":"Dev. Psychopathol."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0315","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1017\/thg.2015.46","article-title":"Missouri Mothers and Their Children: a family study of the effects of genetics and the prenatal environment","volume":"18","author":"Knopik","year":"2015","journal-title":"Twin Res. Hum. Genet."},{"issue":"7","key":"10.1016\/j.ntt.2018.01.009_bb0320","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/ajmg.b.32421","article-title":"Smoking during pregnancy and ADHD risk: a genetically informed, multiple rater approach","volume":"107","author":"Knopik","year":"2016","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"3","key":"10.1016\/j.ntt.2018.01.009_bb0325","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s10519-015-9750-6","article-title":"Maternal smoking during pregnancy and offspring birth weight: a genetically-informed approach comparing multiple raters","volume":"46","author":"Knopik","year":"2016","journal-title":"Behav. Genet."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0330","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s10519-014-9668-4","article-title":"Maternal smoking during pregnancy and adverse outcomes in offspring: genetic and environmental sources of covariance","volume":"44","author":"Kuja-Halkola","year":"2014","journal-title":"Behav. Genet."},{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0335","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/ije\/dyv048","article-title":"DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring","volume":"44","author":"Kupers","year":"2015","journal-title":"Int. J. Epidemiol."},{"issue":"2","key":"10.1016\/j.ntt.2018.01.009_bb0340","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s40572-015-0051-2","article-title":"Epigenetic signatures as biomarkers of exposure","volume":"2","author":"Ladd-Acosta","year":"2015","journal-title":"Curr. Environ. Health Rep."},{"issue":"Pt A","key":"10.1016\/j.ntt.2018.01.009_bb0345","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.envres.2015.11.014","article-title":"Presence of an epigenetic signature of prenatal cigarette smoke exposure in childhood","volume":"144","author":"Ladd-Acosta","year":"2016","journal-title":"Environ. Res."},{"issue":"8","key":"10.1016\/j.ntt.2018.01.009_bb0350","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.2217\/epi.15.60","article-title":"Associative DNA methylation changes in children with prenatal alcohol exposure","volume":"7","author":"Laufer","year":"2015","journal-title":"Epigenomics"},{"issue":"2","key":"10.1016\/j.ntt.2018.01.009_bb0355","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/acer.12635","article-title":"Changes in the methylation status of DAT, SERT, and MeCP2 gene promoters in the blood cell in families exposed to alcohol during the periconceptional period","volume":"39","author":"Lee","year":"2015","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.ntt.2018.01.009_bb0360","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.nbd.2013.08.011","article-title":"Promoter methylation represses AT2R gene and increases brain hypoxic-ischemic injury in neonatal rats","volume":"60","author":"Li","year":"2013","journal-title":"Neurobiol. Dis."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0365","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2147\/AGG.S61518","article-title":"Altered placental DNA methylation patterns associated with maternal smoking: current perspectives","volume":"2015","author":"Maccani","year":"2015","journal-title":"Adv. Genomics Genet."},{"issue":"2","key":"10.1016\/j.ntt.2018.01.009_bb0370","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0897.2009.00716.x","article-title":"Epigenetics in the placenta","volume":"62","author":"Maccani","year":"2009","journal-title":"Am. J. Reprod. Immunol."},{"issue":"6","key":"10.1016\/j.ntt.2018.01.009_bb0375","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2217\/epi.13.63","article-title":"Placental DNA methylation alterations associated with maternal tobacco smoking at the RUNX3 gene are also associated with gestational age","volume":"5","author":"Maccani","year":"2013","journal-title":"Epigenomics"},{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0380","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/0165025413489378","article-title":"Measurement and associations of pregnancy risk factors with genetic influences, postnatal environmental influences, and toddler behavior","volume":"37","author":"Marceau","year":"2013","journal-title":"Int. J. Behav. Dev."},{"issue":"3","key":"10.1016\/j.ntt.2018.01.009_bb0385","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150486","article-title":"The Perinatal Risk Index: early risks experienced by domestic adoptees in the united states","volume":"11","author":"Marceau","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ntt.2018.01.009_bb0390","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10519-016-9778-2","article-title":"Passive rGE or developmental gene-environment cascade? An investigation of the role of xenobiotic metabolism genes in the association between smoke exposure during pregnancy and child birth weight","volume":"46","author":"Marceau","year":"2016","journal-title":"Behav. Genet."},{"key":"10.1016\/j.ntt.2018.01.009_bb0395","first-page":"1","article-title":"Within-family effects of smoking during pregnancy on ADHD: the importance of phenotype","author":"Marceau","year":"2017","journal-title":"J. Abnorm. Child Psychol."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0400","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124931","article-title":"Early maternal alcohol consumption alters hippocampal DNA methylation, gene expression and volume in a mouse model","volume":"10","author":"Marjonen","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.ntt.2018.01.009_bb0405","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1289\/ehp.1307892","article-title":"Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy","volume":"122","author":"Markunas","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ntt.2018.01.009_bb0410","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fgene.2014.00154","article-title":"Fetal alcohol spectrum disorders and their transmission through genetic and epigenetic mechanisms","volume":"5","author":"Mead","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.ntt.2018.01.009_bb0415","article-title":"Inhibitory control in siblings discordant for exposure to maternal smoking during pregnancy","author":"Micalizzi","year":"2017","journal-title":"Dev. Psychol."},{"key":"10.1016\/j.ntt.2018.01.009_bb0420","article-title":"Maintenance agonist treatments for opiate-dependent pregnant women","volume":"12","author":"Minozzi","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"issue":"2","key":"10.1016\/j.ntt.2018.01.009_bb0425","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ajmg.b.32021","article-title":"Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers","volume":"159b","author":"Monick","year":"2012","journal-title":"Am. J. Med. Genet. B. Neuropsychiatr. Genet."},{"issue":"3","key":"10.1016\/j.ntt.2018.01.009_bb0430","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1242\/dev.99.3.371","article-title":"Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development","volume":"99","author":"Monk","year":"1987","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0435","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.gene.2011.11.062","article-title":"Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke","volume":"494","author":"Murphy","year":"2012","journal-title":"Gene"},{"issue":"3","key":"10.1016\/j.ntt.2018.01.009_bb0440","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/humupd\/dmq052","article-title":"Epigenetics and the placenta","volume":"17","author":"Nelissen","year":"2011","journal-title":"Hum. Reprod. Update"},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0445","doi-asserted-by":"crossref","first-page":"R613","DOI":"10.1152\/ajpregu.00075.2015","article-title":"Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain","volume":"309","author":"Ngai","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"3","key":"10.1016\/j.ntt.2018.01.009_bb0450","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4161\/epi.27248","article-title":"Postnatal stability, tissue, and time specific effects of AHRR methylation change in response to maternal smoking in pregnancy","volume":"9","author":"Novakovic","year":"2014","journal-title":"Epigenetics"},{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0455","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001919","article-title":"Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring","volume":"3","author":"Novikova","year":"2008","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.ntt.2018.01.009_bb0460","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1111\/acer.12569","article-title":"Effects of prenatal alcohol and cigarette exposure on offspring substance use in multiplex, alcohol-dependent families","volume":"38","author":"O'Brien","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"7368","key":"10.1016\/j.ntt.2018.01.009_bb0465","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature10491","article-title":"An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor","volume":"478","author":"Opitz","year":"2011","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.ntt.2018.01.009_bb0470","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/j.1471-0528.2008.01822.x","article-title":"Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life","volume":"115","author":"Painter","year":"2008","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"10.1016\/j.ntt.2018.01.009_bb0475","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2012.26","article-title":"Discovery of blood transcriptomic markers for depression in animal models and pilot validation in subjects with early-onset major depression","volume":"2","author":"Pajer","year":"2012","journal-title":"Transl. Psychiatry"},{"issue":"3","key":"10.1016\/j.ntt.2018.01.009_bb0480","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10519-016-9779-1","article-title":"Effects of maternal smoking during pregnancy on offspring externalizing problems: contextual effects in a sample of female twins","volume":"46","author":"Palmer","year":"2016","journal-title":"Behav. Genet."},{"issue":"8","key":"10.1016\/j.ntt.2018.01.009_bb0485","doi-asserted-by":"crossref","first-page":"796","DOI":"10.4161\/epi.25358","article-title":"Placental HTR2A methylation is associated with infant neurobehavioral outcomes","volume":"8","author":"Paquette","year":"2013","journal-title":"Epigenetics"},{"issue":"11","key":"10.1016\/j.ntt.2018.01.009_bb0490","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.4161\/epi.22520","article-title":"Demethylation of the aryl hydrocarbon receptor repressor as a biomarker for nascent smokers","volume":"7","author":"Philibert","year":"2012","journal-title":"Epigenetics"},{"key":"10.1016\/j.ntt.2018.01.009_bb0495","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13072-016-0074-4","article-title":"DNA methylation signature of human fetal alcohol spectrum disorder","volume":"9","author":"Portales-Casamar","year":"2016","journal-title":"Epigenetics Chromatin"},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0500","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1162\/jocn.1995.7.1.1","article-title":"Do rats have prefrontal cortex? The rose-woolsey-akert program reconsidered","volume":"7","author":"Preuss","year":"1995","journal-title":"J. Cogn. Neurosci."},{"key":"10.1016\/j.ntt.2018.01.009_bb0505","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/hmg\/4.suppl_1.1751","article-title":"DNA methylation in early development","volume":"4 Spec No","author":"Razin","year":"1995","journal-title":"Hum. Mol. Genet."},{"issue":"1\u20132","key":"10.1016\/j.ntt.2018.01.009_bb0510","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.mrrev.2008.01.003","article-title":"The next innovation cycle in toxicogenomics: environmental epigenetics","volume":"659","author":"Reamon-Buettner","year":"2008","journal-title":"Mutat. Res."},{"issue":"7143","key":"10.1016\/j.ntt.2018.01.009_bb0515","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature05918","article-title":"Stability and flexibility of epigenetic gene regulation in mammalian development","volume":"447","author":"Reik","year":"2007","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0520","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jaac.2012.10.011","article-title":"Adolescent initiation of drug use: effects of prenatal cocaine exposure","volume":"52","author":"Richardson","year":"2013","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"issue":"8","key":"10.1016\/j.ntt.2018.01.009_bb0525","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/hmg\/ddu739","article-title":"Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)","volume":"24","author":"Richmond","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.ntt.2018.01.009_bb0530","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0002-9378(00)70240-7","article-title":"A systematic review and meta-analysis of prospective studies on the association between maternal cigarette smoking and preterm delivery","volume":"182","author":"Shah","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0535","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2217\/epi-2017-0095","article-title":"Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts","volume":"10","author":"Sharp","year":"2018","journal-title":"Epigenomics"},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0540","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/hmg\/dds488","article-title":"Epigenome-wide association study in the European prospective investigation into cancer and nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking","volume":"22","author":"Shenker","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0545","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/jcpp.12124","article-title":"Familial confounding of the association between maternal smoking during pregnancy and ADHD in offspring","volume":"55","author":"Skoglund","year":"2014","journal-title":"J. Child Psychol. Psychiatry"},{"issue":"9","key":"10.1016\/j.ntt.2018.01.009_bb0550","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1001\/jamapsychiatry.2013.1951","article-title":"MAternal smoking and conduct disorder in the offspring","volume":"70","author":"Slotkin","year":"2013","journal-title":"JAMA Psychiat."},{"issue":"3","key":"10.1016\/j.ntt.2018.01.009_bb0555","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s10519-016-9784-4","article-title":"Prenatal ischemia-hypoxia, the ischemia-hypoxia response pathway, and ADHD risk: a multi-omic perspective","volume":"46","author":"Smith","year":"2016","journal-title":"Behav. Genet."},{"key":"10.1016\/j.ntt.2018.01.009_bb0560","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ntt.2014.11.003","article-title":"Prenatal marijuana exposure predicts marijuana use in young adulthood","volume":"47","author":"Sonon","year":"2015","journal-title":"Neurotoxicol. Teratol."},{"issue":"14","key":"10.1016\/j.ntt.2018.01.009_bb0565","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.1073\/pnas.0508035103","article-title":"Gene expression patterns in human placenta","volume":"103","author":"Sood","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ntt.2018.01.009_bb0570","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1126\/science.178.4062.708","article-title":"Nutrition and mental performance","volume":"178","author":"Stein","year":"1972","journal-title":"Science"},{"key":"10.1016\/j.ntt.2018.01.009_bb0575","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1749-6632.2009.05142.x","article-title":"Cocaine addiction in mothers: potential effects on maternal care and infant development","volume":"1187","author":"Strathearn","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ntt.2018.01.009_bb0580","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.psyneuen.2014.05.017","article-title":"Maternal smoking during pregnancy and infant stress response: test of a prenatal programming hypothesis","volume":"48","author":"Stroud","year":"2014","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0585","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/cdev.12482","article-title":"Epigenetic regulation of placental NR3C1: mechanism underlying prenatal programming of infant neurobehavior by maternal smoking?","volume":"87","author":"Stroud","year":"2016","journal-title":"Child Dev."},{"issue":"10","key":"10.1016\/j.ntt.2018.01.009_bb0590","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.metabol.2010.01.013","article-title":"In utero tobacco exposure epigenetically modifies placental CYP1A1 expression","volume":"59","author":"Suter","year":"2010","journal-title":"Metab. Clin. Exp."},{"issue":"11","key":"10.1016\/j.ntt.2018.01.009_bb0595","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.4161\/epi.6.11.17819","article-title":"Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression","volume":"6","author":"Suter","year":"2011","journal-title":"Epigenetics"},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0600","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/bies.201300090","article-title":"Integrating DNA methylation dynamics into a framework for understanding epigenetic codes","volume":"36","author":"Szulwach","year":"2014","journal-title":"Bioessays"},{"issue":"37","key":"10.1016\/j.ntt.2018.01.009_bb0605","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.15585\/mmwr.mm6437a3","article-title":"Alcohol use and binge drinking among women of childbearing age - United States, 2011\u20132013","volume":"64","author":"Tan","year":"2015","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"issue":"9","key":"10.1016\/j.ntt.2018.01.009_bb0610","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1158\/1055-9965.EPI-08-0312","article-title":"Genomic DNA methylation among women in a multiethnic New York City birth cohort","volume":"17","author":"Terry","year":"2008","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"8","key":"10.1016\/j.ntt.2018.01.009_bb0615","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.biopsych.2009.05.032","article-title":"Prenatal smoking might not cause attention-deficit\/hyperactivity disorder: evidence from a novel design","volume":"66","author":"Thapar","year":"2009","journal-title":"Biol. Psychiatry"},{"issue":"7","key":"10.1016\/j.ntt.2018.01.009_bb0620","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1002\/ajmg.b.31109","article-title":"Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring","volume":"153b","author":"Toledo-Rodriguez","year":"2010","journal-title":"Am. J. Med. Genet. B. Neuropsychiatr. Genet."},{"issue":"6","key":"10.1016\/j.ntt.2018.01.009_bb0625","first-page":"1","article-title":"Trends in smoking before, during, and after pregnancy\u2013pregnancy risk assessment monitoring system, United States, 40 sites, 2000\u20132010","volume":"62","author":"Tong","year":"2013","journal-title":"Morb. Mortal. Wkly. Rep. Surveill. Summ."},{"key":"10.1016\/j.ntt.2018.01.009_bb0630","series-title":"National Survey on Drug Use and Health, 2013. ICPSR35509-v3","author":"United States Department of Health and Human Services. Substance Abuse and Mental Health Services Administration. Center for Behavioral Health Statistics and Quality","year":"2015"},{"key":"10.1016\/j.ntt.2018.01.009_bb0635","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.phrs.2015.09.011","article-title":"Epigenetic mechanisms: a possible link between autism spectrum disorders and fetal alcohol spectrum disorders","volume":"102","author":"Varadinova","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.ntt.2018.01.009_bb0640","first-page":"1","article-title":"Births: final data for 1999","volume":"49","author":"Ventura","year":"2001","journal-title":"Natl. Vital Stat. Rep."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0645","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1289\/ehp.1408459","article-title":"MicroRNAs as potential signatures of environmental exposure or effect: a systematic review","volume":"123","author":"Vrijens","year":"2015","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.ntt.2018.01.009_bb0650","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/humrep\/den439","article-title":"Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation","volume":"24","author":"Wang","year":"2009","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0655","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/cea.12108","article-title":"Prenatal smoke exposure, DNA methylation, and childhood atopic dermatitis","volume":"43","author":"Wang","year":"2013","journal-title":"Clin. Exp. Allergy"},{"issue":"4","key":"10.1016\/j.ntt.2018.01.009_bb0660","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.clp.2014.08.009","article-title":"It's not your mother's marijuana: effects on maternal-fetal health and the developing child","volume":"41","author":"Warner","year":"2014","journal-title":"Clin. Perinatol."},{"issue":"2","key":"10.1016\/j.ntt.2018.01.009_bb0665","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1289\/ehp.1103927","article-title":"In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placenta","volume":"120","author":"Wilhelm-Benartzi","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0670","doi-asserted-by":"crossref","first-page":"e1395","DOI":"10.1542\/peds.2015-3113","article-title":"Fetal alcohol spectrum disorders","volume":"136","author":"Williams","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.ntt.2018.01.009_bb0675","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ncomms1240","article-title":"5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming","volume":"2","author":"Wossidlo","year":"2011","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.ntt.2018.01.009_bb4000","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.lfs.2003.07.022","article-title":"Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells","volume":"74","author":"Yamamoto","year":"2004","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.ntt.2018.01.009_bb0680","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jaci.2012.07.052","article-title":"Epigenetic mechanisms and the development of asthma","volume":"130","author":"Yang","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.ntt.2018.01.009_bb0685","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063812","article-title":"Tobacco smoking leads to extensive genome-wide changes in DNA methylation","volume":"8","author":"Zeilinger","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ntt.2018.01.009_bb0690","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.nbd.2015.05.014","article-title":"Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation","volume":"82","author":"Zhao","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ntt.2018.01.009_bb0695","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/B978-0-12-801105-8.00010-2","article-title":"Gene expression in the addicted brain","volume":"116","author":"Zhou","year":"2014","journal-title":"Int. Rev. Neurobiol."}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036217301538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036217301538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:25:58Z","timestamp":1760210758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892036217301538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":140,"alternative-id":["S0892036217301538"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2018.01.009","relation":{},"ISSN":["0892-0362"],"issn-type":[{"value":"0892-0362","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal substance exposure and offspring development: Does DNA methylation play a role?","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2018.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}