{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:14:25Z","timestamp":1780395265633,"version":"3.54.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"William Jewell College"},{"name":"Oxbridge Research"},{"name":"Monte Harmon"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ntt.2019.01.005","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T11:40:51Z","timestamp":1550230851000},"page":"58-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Lead exposure reduces survival, neuronal determination, and differentiation of P19 stem cells"],"prefix":"10.1016","volume":"72","author":[{"given":"Clayton","family":"Mansel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaneann","family":"Fross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Dema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Klawinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupinder P.S.","family":"Vohra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ntt.2019.01.005_bb0005","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1101\/gad.224503","article-title":"Multipotent cell lineages in early mouse development depend on SOX2 function","volume":"17","author":"Avilion","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.ntt.2019.01.005_bb0010","series-title":"Pesticide Biotransformation and Disposition","first-page":"117","article-title":"Distribution and pharmacokinetics models","author":"Baynes","year":"2012"},{"key":"10.1016\/j.ntt.2019.01.005_bb0015","doi-asserted-by":"crossref","first-page":"6892","DOI":"10.1523\/JNEUROSCI.18-17-06892.1998","article-title":"N-cadherin redistribution during synaptogenesis in hippocampal neurons","volume":"18","author":"Benson","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ntt.2019.01.005_bb2005","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2003.08.061","article-title":"Neurosphere and neurosphere-forming cells: morphological and ultrastructural characterization","volume":"993","author":"Bez","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.ntt.2019.01.005_bb0020","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1474-9726.2005.00158.x","article-title":"Sox2 expression defines a heterogeneous population of neurosphere-forming cells in the adult murine brain","volume":"4","author":"Brazel","year":"2005","journal-title":"Aging Cell"},{"key":"10.1016\/j.ntt.2019.01.005_bb0025","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/toxsci\/kfn115","article-title":"Development of a high-throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells","volume":"105","author":"Breier","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2019.01.005_bb0030","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1196\/annals.1306.011","article-title":"Divalent metal transporter 1 in lead and cadmium transport","volume":"1012","author":"Bressler","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.ntt.2019.01.005_bb0035","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/jnr.490350513","article-title":"Optimized survival of hippocampal neurons in B27-supplemented neurobasal, a new serum-free medium combination","volume":"35","author":"Brewer","year":"1993","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ntt.2019.01.005_bb0040","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s13181-013-0348-1","article-title":"Role of chelation during pregnancy in the lead poisoned patient","volume":"9","author":"Brown","year":"2013","journal-title":"J. Med. Toxicol."},{"key":"10.1016\/j.ntt.2019.01.005_bb0045","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1097\/JOM.0b013e3181f86fee","article-title":"Critical windows of fetal lead exposure: adverse impacts on length of gestation and risk of premature delivery","volume":"52","author":"Cantonwine","year":"2010","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.ntt.2019.01.005_bb0050","series-title":"Adult Blood Lead Epidemiology and Surveillance","author":"CDC","year":"2018"},{"key":"10.1016\/j.ntt.2019.01.005_bb0055","doi-asserted-by":"crossref","first-page":"15007","DOI":"10.1038\/nrdp.2015.7","article-title":"Spina bifida","volume":"1","author":"Copp","year":"2015","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.ntt.2019.01.005_bb0060","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/ajcn\/61.3.514","article-title":"Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: a longitudinal study","volume":"61","author":"Cross","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ntt.2019.01.005_bb0065","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2307\/1943075","article-title":"Comparisons of treatments after an analysis of variance in ecology","volume":"59","author":"Day","year":"1989","journal-title":"Ecol. Monogr."},{"key":"10.1016\/j.ntt.2019.01.005_bb0070","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00439-005-1299-7","article-title":"SNPs in the neural cell adhesion molecule 1 gene (NCAM1) may be associated with human neural tube defects","volume":"117","author":"Deak","year":"2005","journal-title":"Hum. Genet."},{"key":"10.1016\/j.ntt.2019.01.005_bb0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1542\/peds.114.1.19","article-title":"Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry","volume":"114","author":"Dietrich","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.ntt.2019.01.005_bb0080","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jhazmat.2011.07.106","article-title":"Effects of lead on neurogenesis during zebrafish embryonic brain development","volume":"194","author":"Dou","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ntt.2019.01.005_bb0085","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.tiv.2015.05.001","article-title":"Lead decreases cell survival, proliferation, and neuronal differentiation of primary cultured adult neural precursor cells through activation of the JNK and p38 MAP kinases","volume":"29","author":"Engstrom","year":"2015","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.ntt.2019.01.005_bb0090","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1242\/dev.01204","article-title":"Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain","volume":"131","author":"Ferri","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ntt.2019.01.005_bb0095","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1634\/stemcells.2008-0493","article-title":"SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity","volume":"27","author":"Gangemi","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.ntt.2019.01.005_bb0100","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3389\/fonc.2016.00222","article-title":"Targeting SOX2 as a therapeutic strategy in glioblastoma","volume":"6","author":"Garros-Regulez","year":"2016","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ntt.2019.01.005_bb0105","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1227\/00006123-198605000-00008","article-title":"Central nervous system anomalies associated with meningomyelocele, hydrocephalus, and the Arnold-Chiari malformation: reappraisal of theories regarding the pathogenesis of posterior neural tube closure defects","volume":"18","author":"Gilbert","year":"1986","journal-title":"Neurosurgery"},{"key":"10.1016\/j.ntt.2019.01.005_bb0110","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/toxsci\/kfi156","article-title":"Chronic developmental lead exposure reduces neurogenesis in adult rat hippocampus but does not impair spatial learning","volume":"86","author":"Gilbert","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2019.01.005_bb0115","first-page":"99","article-title":"Teratogenic causes of malformations","volume":"40","author":"Gilbert-Barness","year":"2010","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.ntt.2019.01.005_bb0120","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1289\/ehp.0800408","article-title":"Childhood lead poisoning: conservative estimates of the social and economic benefits of lead hazard control","volume":"117","author":"Gould","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ntt.2019.01.005_bb0125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1289\/ehp.9089101","article-title":"Transplacental transport of lead","volume":"89","author":"Goyer","year":"1990","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ntt.2019.01.005_bb0130","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10354-012-0074-3","article-title":"The role of the placenta in fetal exposure to heavy metals","volume":"162","author":"Gundacker","year":"2012","journal-title":"Wien. Med. Wochenschr."},{"key":"10.1016\/j.ntt.2019.01.005_bb0135","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1007\/s00018-008-8290-0","article-title":"Signaling mechanisms of neurite outgrowth induced by the cell adhesion molecules NCAM and N-cadherin","volume":"65","author":"Hansen","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ntt.2019.01.005_bb0140","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1523\/JNEUROSCI.05-12-03310.1985","article-title":"Identification of major cell classes in the developing mammalian nervous system","volume":"5","author":"Hockfield","year":"1985","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ntt.2019.01.005_bb0145","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/toxsci\/kfs186","article-title":"Arsenic exposure inhibits myogenesis and neurogenesis in P19 stem cells through repression of the \u03b2-catenin signaling pathway","volume":"129","author":"Hong","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2019.01.005_bb0150","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1289\/ehp.9067","article-title":"Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development","volume":"114","author":"Hu","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ntt.2019.01.005_bb0155","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuro.2010.12.007","article-title":"Low-level lead exposure attenuates the expression of three major isoforms of neural cell adhesion molecule","volume":"32","author":"Hu","year":"2011","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.ntt.2019.01.005_bb0160","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.neuro.2004.03.010","article-title":"Effects of lead exposure on proliferation and differentiation of neural stem cells derived from different regions of embryonic rat brain","volume":"25","author":"Huang","year":"2004","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.ntt.2019.01.005_bb0165","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/bmb\/ldg032","article-title":"Hazards of heavy metal contamination","volume":"68","author":"Jarup","year":"2003","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.ntt.2019.01.005_bb0170","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1083\/jcb.94.2.253","article-title":"Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells","volume":"94","author":"Jones-Villeneuve","year":"1982","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ntt.2019.01.005_bb0175","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1177\/43.8.7542682","article-title":"Intermediate filaments in cardiac myogenesis: nestin in the developing mouse heart","volume":"43","author":"Kachinsky","year":"1995","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.ntt.2019.01.005_bb0180","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bbrc.2012.01.100","article-title":"NeuroD1 is an upstream regulator of NSCL1","volume":"419","author":"Kim","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ntt.2019.01.005_bb0185","first-page":"417","article-title":"NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development","volume":"128","author":"Kim","year":"2001","journal-title":"Dev. Camb. Engl."},{"key":"10.1016\/j.ntt.2019.01.005_bb0190","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1523\/JNEUROSCI.22-03-00639.2002","article-title":"Neurogenesis in embryos and in adult neural stem cells","volume":"22","author":"Kintner","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ntt.2019.01.005_bb0195","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/aje\/kwf042","article-title":"Correlates of bone and blood lead levels among middle-aged and elderly women","volume":"156","author":"Korrick","year":"2002","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ntt.2019.01.005_bb0200","first-page":"13","article-title":"Basic helix-loop-helix genes in neural development","author":"Lee","year":"1997","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.ntt.2019.01.005_bb0205","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1126\/science.7754368","article-title":"Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein","volume":"268","author":"Lee","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.ntt.2019.01.005_bb0210","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0092-8674(90)90662-X","article-title":"CNS stem cells express a new class of intermediate filament protein","volume":"60","author":"Lendahl","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.ntt.2019.01.005_bb0215","doi-asserted-by":"crossref","first-page":"15207","DOI":"10.1074\/jbc.M109913200","article-title":"Rac1 and Cdc42 but not RhoA or rho kinase activities are required for neurite outgrowth induced by the netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells","volume":"277","author":"Li","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ntt.2019.01.005_bb0220","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/brain\/awg014","article-title":"Lead neurotoxicity in children: basic mechanisms and clinical correlates","volume":"126","author":"Lidsky","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.ntt.2019.01.005_bb0230","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1128\/MCB.16.10.5792","article-title":"NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family","volume":"16","author":"McCormick","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ntt.2019.01.005_bb0235","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1101\/gad.13.13.1647","article-title":"NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus","volume":"13","author":"Miyata","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.ntt.2019.01.005_bb0240","first-page":"1049","article-title":"N-CAM alterations in splotch neural tube defect mouse embryos","volume":"113","author":"Moase","year":"1991","journal-title":"Dev. Camb. Engl."},{"key":"10.1016\/j.ntt.2019.01.005_bb0245","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jneumeth.2011.11.008","article-title":"A method for generating high-yield enriched neuronal cultures from P19 embryonal carcinoma cells","volume":"204","author":"Monzo","year":"2012","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ntt.2019.01.005_bb0250","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1242\/dev.126.1.23","article-title":"NeuroD regulates multiple functions in the developing neural retina in rodent","volume":"126","author":"Morrow","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ntt.2019.01.005_bb0255","first-page":"1321","article-title":"Neural crest cell-cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins","volume":"121","author":"Nakagawa","year":"1995","journal-title":"Dev. Camb. Engl."},{"key":"10.1016\/j.ntt.2019.01.005_bb0260","doi-asserted-by":"crossref","first-page":"2D.9.1","DOI":"10.1002\/9780470151808.sc02d09s20","article-title":"Neural differentiation of P19 carcinoma cells and primary neurospheres: cell morphology, proliferation, viability, and functionality","volume":"20","author":"Negraes","year":"2012","journal-title":"Curr. Protoc. Stem Cell Biol."},{"key":"10.1016\/j.ntt.2019.01.005_bb0265","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0925-4773(01)00394-X","article-title":"The early steps of neural crest development","volume":"105","author":"Nieto","year":"2001","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ntt.2019.01.005_bb0270","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1134\/S0026893312040085","article-title":"N-acetylcysteine enhances neuronal differentiation of P19 embryonic stem cells via Akt and N-cadherin activation","volume":"46","author":"Noh","year":"2012","journal-title":"Mol. Biol."},{"key":"10.1016\/j.ntt.2019.01.005_bb0275","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.mcn.2007.04.012","article-title":"Cadherin inhibition of \u03b2-catenin signaling regulates the proliferation and differentiation of neural precursor cells","volume":"35","author":"Noles","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ntt.2019.01.005_bb0280","doi-asserted-by":"crossref","first-page":"35840","DOI":"10.1074\/jbc.M203617200","article-title":"Nerve growth factor signals through TrkA, phosphatidylinositol 3-kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 cells","volume":"277","author":"Nusser","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ntt.2019.01.005_bb0285","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1083\/jcb.200406030","article-title":"Cadherin activity is required for activity-induced spine remodeling","volume":"167","author":"Okamura","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ntt.2019.01.005_bb0290","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/PAS.0b013e31812f6ba6","article-title":"Sox2 expression in brain tumors: a reflection of the neuroglial differentiation pathway","volume":"32","author":"Phi","year":"2008","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.ntt.2019.01.005_bb2000","doi-asserted-by":"crossref","first-page":"8124","DOI":"10.1021\/acs.est.8b00791","article-title":"Evaluating Water Lead Levels During the Flint Water Crisis","volume":"52","author":"Pieper","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ntt.2019.01.005_bb0295","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1242\/jcs.146720","article-title":"Role of cell-cell adhesion complexes in embryonic stem cell biology","volume":"127","author":"Pieters","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ntt.2019.01.005_bb0300","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/jcp.10008","article-title":"Cadherins in neural crest cell development and transformation","volume":"189","author":"Pla","year":"2001","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ntt.2019.01.005_bb0305","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0896-6273(00)80216-0","article-title":"Cadherin function is required for axon outgrowth in retinal ganglion cells in vivo","volume":"17","author":"Riehl","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.ntt.2019.01.005_bb0310","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1007\/s11606-007-0253-x","article-title":"Lead poisoning in an adult: lead mobilization by pregnancy?","volume":"22","author":"Riess","year":"2007","journal-title":"J. Gen. Intern. Med."},{"key":"10.1016\/j.ntt.2019.01.005_bb0315","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1056\/NEJM200105103441902","article-title":"The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead","volume":"344","author":"Rogan","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ntt.2019.01.005_bb0320","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1515\/REVEH.2009.24.1.15","article-title":"Neurotoxic effects and biomarkers of lead exposure: a review","volume":"24","author":"Sanders","year":"2009","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.ntt.2019.01.005_bb0325","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/sj.bjc.6603696","article-title":"Identification of SOX2 as a novel glioma-associated antigen and potential target for T cell-based immunotherapy","volume":"96","author":"Schmitz","year":"2007","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ntt.2019.01.005_bb0330","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1289\/ehp.8552","article-title":"Reduced intellectual development in children with prenatal lead exposure","volume":"114","author":"Schnaas","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ntt.2019.01.005_bb0335","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuro.2004.06.006","article-title":"Inhibition of progenitor cell proliferation in the dentate gyrus of rats following post-weaning lead exposure","volume":"26","author":"Schneider","year":"2005","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.ntt.2019.01.005_bb0340","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1289\/ehp.919163","article-title":"Lead in bone: implications for toxicology during pregnancy and lactation","volume":"91","author":"Silbergeld","year":"1991","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ntt.2019.01.005_bb0345","series-title":"Biometry: The Principles and Practice of Statistics in Biological Research, [Extensively Rev.]","author":"Sokal","year":"2012"},{"key":"10.1016\/j.ntt.2019.01.005_bb0350","first-page":"1068","article-title":"Environmental lead exposure: a public health problem of global dimensions","volume":"78","author":"Tong","year":"2000","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.ntt.2019.01.005_bb0355","article-title":"Embryonic expression of the chicken Sox2, Sox3 and Soxll genes suggests an interactive role in neuronal development","volume":"14","author":"Uwanoghoa","year":"1995","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ntt.2019.01.005_bb0360","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1002\/jnr.22044","article-title":"N-cadherin mediates interaction between precursor cells in the subventricular zone and regulates further differentiation","volume":"87","author":"Yagita","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ntt.2019.01.005_bb0365","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/nn1132","article-title":"\u03b2-catenin is critical for dendritic morphogenesis","volume":"6","author":"Yu","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ntt.2019.01.005_bb0370","first-page":"2367","article-title":"Sox2 regulatory sequences direct expression of a (beta)-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells","volume":"127","author":"Zappone","year":"2000","journal-title":"Dev. Camb. Engl."},{"key":"10.1016\/j.ntt.2019.01.005_bb0375","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.devcel.2009.12.025","article-title":"Cortical neural precursors inhibit their own differentiation via N-cadherin maintenance of \u03b2-catenin signaling","volume":"18","author":"Zhang","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ntt.2019.01.005_bb0380","doi-asserted-by":"crossref","first-page":"11482","DOI":"10.1523\/JNEUROSCI.3655-14.2015","article-title":"Sox2 sustains recruitment of oligodendrocyte progenitor cells following CNS demyelination and primes them for differentiation during remyelination","volume":"35","author":"Zhao","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ntt.2019.01.005_bb0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/4937689","article-title":"Neurosphere based differentiation of human iPSC improves astrocyte differentiation","volume":"2016","author":"Zhou","year":"2016","journal-title":"Stem Cells Int."}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036218301272?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036218301272?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:25:23Z","timestamp":1760210723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892036218301272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":78,"alternative-id":["S0892036218301272"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2019.01.005","relation":{},"ISSN":["0892-0362"],"issn-type":[{"value":"0892-0362","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lead exposure reduces survival, neuronal determination, and differentiation of P19 stem cells","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2019.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}