{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T05:44:07Z","timestamp":1772948647885,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"am","delay-in-days":320,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.ntt.2023.107286","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T11:40:39Z","timestamp":1689075639000},"page":"107286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Spatiotemporal protein dynamics during early organogenesis in mouse conceptuses treated with valproic acid"],"prefix":"10.1016","volume":"99","author":[{"given":"Samantha","family":"Lapehn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin A.","family":"Colacino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ntt.2023.107286_bb0005","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s13059-018-1536-8","article-title":"Clust: automatic extraction of optimal co-expressed gene clusters from gene expression data","volume":"19","author":"Abu-Jamous","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.ntt.2023.107286_bb0010","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1590\/1414-431x20154739","article-title":"Rat visceral yolk sac cells: viability and expression of cell markers during maternal diabetes","volume":"48","author":"Aires","year":"2015","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.ntt.2023.107286_bb0015","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nrm.2017.11","article-title":"Planar cell polarity in development and disease","volume":"18","author":"Butler","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ntt.2023.107286_bb0020","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.ntt.2023.107286_bb0025","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/path.2643","article-title":"Genetics and development of neural tube defects: Genetics and development of neural tube defects","volume":"220","author":"Copp","year":"2010","journal-title":"J. Pathol."},{"key":"10.1016\/j.ntt.2023.107286_bb0030","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S1474-4422(13)70110-8","article-title":"Neural tube defects: recent advances, unsolved questions, and controversies","volume":"12","author":"Copp","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ntt.2023.107286_bb0035","doi-asserted-by":"crossref","first-page":"D794","DOI":"10.1093\/nar\/gkx1081","article-title":"The Encyclopedia of DNA elements (ENCODE): data portal update","volume":"46","author":"Davis","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ntt.2023.107286_bb0040","doi-asserted-by":"crossref","first-page":"D1138","DOI":"10.1093\/nar\/gkaa891","article-title":"Comparative toxicogenomics database (CTD): update 2021","volume":"49","author":"Davis","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ntt.2023.107286_bb0045","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"ENCODE Project Consortium","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ntt.2023.107286_bb0050","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/(SICI)1096-8628(19970613)70:3<303::AID-AJMG17>3.0.CO;2-P","article-title":"Strain-dependent alterations in the expression of folate pathway genes following teratogenic exposure to valproic acid in a mouse model","volume":"70","author":"Finnell","year":"1997","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ntt.2023.107286_bb0055","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1021\/pr200304u","article-title":"Improvements in proteomic metrics of low abundance proteins through proteome equalization using ProteoMiner prior to MudPIT","volume":"10","author":"Fonslow","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ntt.2023.107286_bb0060","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3109\/10715761003610745","article-title":"Redox regulation of Wnt signalling via nucleoredoxin","volume":"44","author":"Funato","year":"2010","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.ntt.2023.107286_bb0065","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1016\/j.celrep.2017.11.111","article-title":"Protein Expression Landscape of Mouse Embryos during Pre-implantation Development","volume":"21","author":"Gao","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.ntt.2023.107286_bb0070","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/FPC.0b013e32835ea0b2","article-title":"Valproic acid pathway: pharmacokinetics and pharmacodynamics","volume":"23","author":"Ghodke-Puranik","year":"2013","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.ntt.2023.107286_bb0075","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1128\/MCB.19.3.1720","article-title":"Correlation between Protein and mRNA Abundance in Yeast","volume":"19","author":"Gygi","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ntt.2023.107286_bb0080","doi-asserted-by":"crossref","first-page":"10159","DOI":"10.1021\/acs.est.0c02068","article-title":"Yolk Sac of zebrafish embryos as backpack for chemicals?","volume":"54","author":"Halbach","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ntt.2023.107286_bb0085","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1089\/ars.2019.7976","article-title":"The redox theory of development","volume":"32","author":"Hansen","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ntt.2023.107286_bb0090","series-title":"Developmental Toxicology Methods in Molecular Biology","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-1-61779-867-2_13","article-title":"Rodent Whole Embryo Culture","author":"Harris","year":"2012"},{"key":"10.1016\/j.ntt.2023.107286_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ntt.2023.107286_bb0100","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ntt.2023.107286_bb0105","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41419-021-04473-2","article-title":"Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects","volume":"13","author":"Huang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ntt.2023.107286_bb0110","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1056\/NEJMoa0907328","article-title":"Valproic acid monotherapy in pregnancy and major congenital malformations","volume":"362","author":"Jentink","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ntt.2023.107286_bb0115","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/toxsci\/kfp002","article-title":"Valproic acid\u2013induced deregulation in vitro of genes associated in vivo with neural tube defects","volume":"108","author":"Jergil","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ntt.2023.107286_bb0120","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/toxsci\/kfr070","article-title":"Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells","volume":"121","author":"Jergil","year":"2011","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"10.1016\/j.ntt.2023.107286_bb0125","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ntt.2023.107286_bb0130","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.reprotox.2010.05.014","article-title":"Early transcriptional responses in mouse embryos as a basis for selection of molecular markers predictive of valproic acid teratogenicity","volume":"30","author":"Kultima","year":"2010","journal-title":"Reprod. Toxicol. Elmsford N"},{"key":"10.1016\/j.ntt.2023.107286_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2021.03.001","article-title":"Spatiotemporal evaluation of the mouse embryonic redox environment and histiotrophic nutrition following treatment with valproic acid and 1,2-dithiole-3-thione during early organogenesis","author":"Lapehn","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ntt.2023.107286_bb0140","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41419-020-03313-z","article-title":"Aberrant Gcm1 expression mediates Wnt\/\u03b2-catenin pathway activation in folate deficiency involved in neural tube defects","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ntt.2023.107286_bb0145","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1021\/ac301572t","article-title":"Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses","volume":"84","author":"McAlister","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ntt.2023.107286_bb0150","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1021\/ac502040v","article-title":"MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes","volume":"86","author":"McAlister","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ntt.2023.107286_bb0155","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1\u03b1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ntt.2023.107286_bb0160","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2174\/138920212803759721","article-title":"Planar cell polarity signaling in collective cell movements during morphogenesis and disease","volume":"13","author":"Mu\u00f1oz-Soriano","year":"2012","journal-title":"Curr. Genomics"},{"key":"10.1016\/j.ntt.2023.107286_bb0165","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/bib\/bbx033","article-title":"Evaluating de novo sequencing in proteomics: already an accurate alternative to database-driven peptide identification?","volume":"19","author":"Muth","year":"2018","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.ntt.2023.107286_bb0170","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1242\/dev.145904","article-title":"Neural tube closure: cellular, molecular and biomechanical mechanisms","volume":"144","author":"Nikolopoulou","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.ntt.2023.107286_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2009.02.014","article-title":"Valproic acid in pregnancy: How much are we endangering the embryo and fetus?","volume":"28","author":"Ornoy","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ntt.2023.107286_bb0180","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ntt.2023.107286_bb0185","doi-asserted-by":"crossref","first-page":"107039","DOI":"10.1016\/j.ntt.2021.107039","article-title":"NRF2 activation inhibits valproic acid-induced neural tube defects in mice","volume":"89","author":"Piorczynski","year":"2022","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ntt.2023.107286_bb0190","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1038\/s41467-020-17575-w","article-title":"Origin and function of the yolk sac in primate embryogenesis","volume":"11","author":"Ross","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ntt.2023.107286_bb0195","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/ar.1092230212","article-title":"Neurulation in the mouse: Manner and timing of neural tube closure","volume":"223","author":"Sakai","year":"1989","journal-title":"Anat. Rec."},{"key":"10.1016\/j.ntt.2023.107286_bb0200","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1089\/scd.2014.0010","article-title":"Redox regulation of canonical Wnt signaling affects extraembryonic endoderm formation","volume":"23","author":"Sandieson","year":"2014","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.ntt.2023.107286_bb0205","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1083\/jcb.201612010","article-title":"Why proteomics is not the new genomics and the future of mass spectrometry in cell biology","volume":"216","author":"Sidoli","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ntt.2023.107286_bb0210","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ntt.2023.107286_bb0215","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ajmg.c.30053","article-title":"Role of Folbp1 in the regional regulation of apoptosis and cell proliferation in the developing neural tube and craniofacies","volume":"135C","author":"Tang","year":"2005","journal-title":"Am. J. Med. Genet. C: Semin. Med. Genet."},{"key":"10.1016\/j.ntt.2023.107286_bb0220","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1021\/ac0262560","article-title":"Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS\/MS","volume":"75","author":"Thompson","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ntt.2023.107286_bb0225","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1124\/mol.111.072314","article-title":"Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defects","volume":"80","author":"Tung","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ntt.2023.107286_bb0230","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/bdrb.20127","article-title":"Comparative proteome analysis of the embryo proper and yolk sac membrane of day 11.5 cultured rat embryos","volume":"80","author":"Usami","year":"2007","journal-title":"Birth Defects Res. B. Dev. Reprod. Toxicol."},{"key":"10.1016\/j.ntt.2023.107286_bb0235","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrg3185","article-title":"Insights into the regulation of protein abundance from proteomic and transcriptomic analyses","volume":"13","author":"Vogel","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ntt.2023.107286_bb0240","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.compbiolchem.2008.07.014","article-title":"Discrepancy between mRNA and protein abundance: insight from information retrieval process in computers","volume":"32","author":"Wang","year":"2008","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.ntt.2023.107286_bb0245","doi-asserted-by":"crossref","first-page":"10705","DOI":"10.1073\/pnas.1308998110","article-title":"Paternally expressed genes predominate in the placenta","volume":"110","author":"Wang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ntt.2023.107286_bb0250","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101198","article-title":"Update on the role of the non-canonical Wnt\/planar cell polarity pathway in neural tube defects","volume":"8","author":"Wang","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.ntt.2023.107286_bb0255","first-page":"75","article-title":"Cranial effects of retinoic acid in the loop-tail (Lp) mutant mouse","volume":"10","author":"Wilson","year":"1990","journal-title":"J. Craniofac. Genet. Dev. Biol."},{"key":"10.1016\/j.ntt.2023.107286_bb0260","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.cell.2020.02.012","article-title":"A quantitative tissue-specific landscape of protein redox regulation during aging","volume":"180","author":"Xiao","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ntt.2023.107286_bb0265","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/bdra.20705","article-title":"The visceral yolk sac endoderm provides for absorption of nutrients to the embryo during neurulation","volume":"88","author":"Zohn","year":"2010","journal-title":"Birt. Defects Res. A. Clin. Mol. Teratol."}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036223001368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036223001368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:29:08Z","timestamp":1760210948000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892036223001368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":53,"alternative-id":["S0892036223001368"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2023.107286","relation":{},"ISSN":["0892-0362"],"issn-type":[{"value":"0892-0362","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatiotemporal protein dynamics during early organogenesis in mouse conceptuses treated with valproic acid","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2023.107286","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107286"}}