{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:03:39Z","timestamp":1781553819528,"version":"3.54.5"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["RGP.2\/533\/44"],"award-info":[{"award-number":["RGP.2\/533\/44"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotoxicology and Teratology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ntt.2025.107517","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T11:43:35Z","timestamp":1750851815000},"page":"107517","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Salvianolic acid A enhances sedative effect of diazepam through the GABAergic pathway: In vivo, molecular docking, and pharmacokinetics approaches"],"prefix":"10.1016","volume":"110","author":[{"given":"Imam Hossen","family":"Rakib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Shahnawaz","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arusha","family":"Ayub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Sakib","family":"Al Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alfaifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Shimul","family":"Bhuia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emon","family":"Mia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noshin Tasnim","family":"Yana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Nasimul Haque","family":"Shipon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Torequl Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ntt.2025.107517_bb0005","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/7854_2014_365","article-title":"Pharmacological treatment of sleep disorders and its relationship with neuroplasticity","author":"Abad","year":"2015","journal-title":"Sleep, Neuronal Plasticity Brain Funct."},{"key":"10.1016\/j.ntt.2025.107517_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118252","article-title":"Exploring the anti-inflammatory, sedative, antidiabetic, and antioxidant potential in in-vitro and in-vivo models and phenolic profiling of Atractylis aristata batt","volume":"330","author":"Abid","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.ntt.2025.107517_bb0015","doi-asserted-by":"crossref","first-page":"16565","DOI":"10.1038\/s41598-023-43175-x","article-title":"Novel computational and drug design strategies for inhibition of human papillomavirus-associated cervical cancer and DNA polymerase theta receptor by Apigenin derivatives","volume":"13","author":"Akash","year":"2023","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.ntt.2025.107517_bb0020","first-page":"6419","article-title":"Synergistic hypnotic effects of sesamol and thymol possibly through GABAergic interaction pathway: in vivo and in silico studies","volume":"37","author":"Akbor","year":"2023","journal-title":"J. Biol. Regul. Homeost. Agents"},{"issue":"12","key":"10.1016\/j.ntt.2025.107517_bb0025","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202400874","article-title":"An insight of plant source, toxicological profile, and pharmacological activities of Iridoid Loganic acid: A ComprehensiveReview","volume":"21","author":"Aktar","year":"2024","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.ntt.2025.107517_bb0030","article-title":"Allium cepa bioactive phytochemicals as potent ALK (anaplastic lymphoma kinase) inhibitors and therapeutic agents against non-small cell lung cancer (NSCLC): a computational study","volume":"100124","author":"Al Hasan","year":"2024","journal-title":"Pharmacol. Res.-Nat. Prod."},{"key":"10.1016\/j.ntt.2025.107517_bb0035","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.sleep.2024.12.007","article-title":"Assessment of sedative activity of Chrysin: Behavioral approach with pharmacokinetics, toxicological profile and molecular docking","volume":"126","author":"Al Hasan","year":"2024","journal-title":"Sleep Med."},{"key":"10.1016\/j.ntt.2025.107517_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2025.03.004","article-title":"Tangeretin enhances sedative activity of diazepam in Swiss mice through GABAA receptor interaction: in vivo and in silico approaches","volume":"572","author":"Al Hasan","year":"2025","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.ntt.2025.107517_bb0045","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2174\/2215083805666190314112755","article-title":"Review of the Phytochemistry and pharmacological properties of Valeriana officinalis","volume":"6","author":"Al-Attraqchi","year":"2020","journal-title":"Curr. Tradit. Med."},{"issue":"1","key":"10.1016\/j.ntt.2025.107517_bb0050","doi-asserted-by":"crossref","first-page":"6680935","DOI":"10.1155\/2021\/6680935","article-title":"Natural phytochemicals as novel therapeutic strategies to prevent and treat Parkinson\u2019s disease: current knowledge and future perspectives","volume":"2021","author":"Balakrishnan","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"W1","key":"10.1016\/j.ntt.2025.107517_bb0055","doi-asserted-by":"crossref","first-page":"W513","DOI":"10.1093\/nar\/gkae303","article-title":"ProTox 3.0: a webserver for the prediction of toxicity of chemicals","volume":"52","author":"Banerjee","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.ntt.2025.107517_bb0060","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1002\/ptr.8139","article-title":"Quercetin increases the antidepressant-like effects of sclareol and antagonizes diazepam in thiopental sodium-induced sleeping mice: a possible GABAergic transmission intervention","volume":"38","author":"Bappi","year":"2024","journal-title":"Phytother. Res."},{"issue":"23","key":"10.1016\/j.ntt.2025.107517_bb0065","doi-asserted-by":"crossref","first-page":"10345","DOI":"10.1021\/acs.jmedchem.7b01922","article-title":"Why are the majority of active compounds in the CNS domain natural products? A critical analysis","volume":"61","author":"Bharate","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ntt.2025.107517_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ntt.2024.107403","article-title":"Trans-Ferulic acid reduces the sedative activity of diazepam in thiopental sodium-induced sleeping mice: A potential GABAergic transmission","volume":"106","author":"Bhuia","year":"2024","journal-title":"Neurotoxicol. Teratol."},{"issue":"4","key":"10.1016\/j.ntt.2025.107517_bb0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12032-025-02646-z","article-title":"Botanical sources, biopharmaceutical profile, anticancer effects with mechanistic insight, toxicological and clinical evidence of prunetin: a literature review","volume":"42","author":"Bithi","year":"2025","journal-title":"Med. Oncol. (Northwood, London, England)"},{"issue":"1","key":"10.1016\/j.ntt.2025.107517_bb0080","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/ddc3010011","article-title":"Plant-derived natural products: a source for drug discovery and development","volume":"3","author":"Chaachouay","year":"2024","journal-title":"Drugs and Drug Candidates"},{"key":"10.1016\/j.ntt.2025.107517_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2024.105704","article-title":"Anticonvulsant effect of (\u00b1) citronellal possibly through the GABAergic and voltage-gated sodium channel receptor interaction pathways: in vivo and in silico studies","volume":"175","author":"Chowdhury","year":"2024","journal-title":"Neurochem. Int."},{"issue":"3","key":"10.1016\/j.ntt.2025.107517_bb0090","first-page":"124","article-title":"Hepatoprotective essential oils: A review","volume":"23","author":"Daoudi","year":"2020","journal-title":"Aust. J. Pharm."},{"issue":"9","key":"10.1016\/j.ntt.2025.107517_bb0095","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1021\/acs.jmedchem.8b01610","article-title":"A survey of the structures of US FDA approved combination drugs","volume":"62","author":"Das","year":"2018","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.ntt.2025.107517_bb0105","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3390\/neurolint13040059","article-title":"Benzodiazepines: uses, dangers, and clinical considerations","volume":"13","author":"Edinoff","year":"2021","journal-title":"Neurol. Int."},{"key":"10.1016\/j.ntt.2025.107517_bb0110","series-title":"Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays","first-page":"1327","article-title":"Medicinal plants: Therapeutic potential, safety, and toxicity","author":"Emerald","year":"2024"},{"key":"10.1016\/j.ntt.2025.107517_bb0115","first-page":"1060949","article-title":"GABAA receptor subtypes and benzodiazepine use, misuse, and abuse","volume":"13","author":"Engin","year":"2023","journal-title":"Front. Psychol."},{"issue":"1","key":"10.1016\/j.ntt.2025.107517_bb0120","article-title":"Cardioprotective effects of salvianolic acid a on myocardial ischemia-reperfusion injury in vivo and in vitro","volume":"2012","author":"Fan","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"37","key":"10.1016\/j.ntt.2025.107517_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202403725","article-title":"Modulatory sedative activity of Abrine on diazepam in thiopental sodium mediated sleeping mice: an in vivo approach with receptor binding affinity of GABAergic transmission","volume":"9","author":"Ferdous","year":"2024","journal-title":"ChemistrySelect"},{"issue":"3","key":"10.1016\/j.ntt.2025.107517_bb0130","doi-asserted-by":"crossref","first-page":"20190098","DOI":"10.1098\/rsfs.2019.0098","article-title":"Sleep, circadian rhythms and health","volume":"10","author":"Foster","year":"2020","journal-title":"Interface Focus"},{"issue":"2","key":"10.1016\/j.ntt.2025.107517_bb0135","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.jep.2014.06.029","article-title":"A cross-cultural analysis of Jammu, Kashmir and Ladakh (India) medicinal plant use","volume":"155","author":"Gairola","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.ntt.2025.107517_bb0140","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.pnpbp.2009.07.033","article-title":"Plants with neurobiological activity as potential targets for drug discovery","volume":"33","author":"Gomes","year":"2009","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ntt.2025.107517_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118300","article-title":"Differential effects of biogenic and chemically synthesized silver-nanoparticles application on physiological traits, antioxidative status and californidine content in California poppy (Eschscholzia californica Cham)","volume":"292","author":"Hajian","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ntt.2025.107517_bb0150","article-title":"Quercetin promises anticancer activity through PI3K-AKT-mTOR pathway: a literature review","volume":"100206","author":"Hasan","year":"2025","journal-title":"Pharmacol. Res.-Nat. Prod."},{"key":"10.1016\/j.ntt.2025.107517_bb0155","article-title":"Sclareol antagonizes the sedative effect of diazepam in thiopental sodium-induced sleeping animals: in vivo and in silico studies","volume":"176","author":"Hassan","year":"2024","journal-title":"Biomed. Pharmacother. = Biomedecine & Pharmacotherapie"},{"key":"10.1016\/j.ntt.2025.107517_bb0160","series-title":"The Dream Drugstore: Chemically Altered States of Consciousness","author":"Hobson","year":"2002"},{"issue":"10","key":"10.1016\/j.ntt.2025.107517_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0309793","article-title":"Role of Phyllanthus niruri on the modulation of stress and immune responses in Nile tilapia, Oreochromis niloticus","volume":"19","author":"Ibrahim","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.ntt.2025.107517_bb0170","article-title":"Phytol exerts sedative-like effects and modulates the diazepam and flumazenil\u2019s action, possibly through the GABAA receptor interaction pathway","volume":"138007","author":"Islam","year":"2024","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ntt.2025.107517_bb0175","series-title":"Unveiling the Anxiolytic and Analgesic Effects of Citronellal in Swiss Mice: In Vivo and In Silico Insights into COX and GABAA Receptor Pathways","first-page":"1","author":"Islam","year":"2024"},{"key":"10.1016\/j.ntt.2025.107517_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2024.138060","article-title":"GabaAergic sedative prospection of sclareol-linalool co-treatment: an antagonistic intervention through in vivo and in silico studies","volume":"845","author":"Islam","year":"2025","journal-title":"Neurosci. Lett."},{"issue":"8","key":"10.1016\/j.ntt.2025.107517_bb0185","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.3390\/molecules25081929","article-title":"Intranasal delivery of nanoformulations: a potential way of treatment for neurological disorders","volume":"25","author":"Islam","year":"2020","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.ntt.2025.107517_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/ddr.70064","article-title":"Assessment of antidiarrheal effect of Oleuropein through \u03bc-Oopioid receptor interaction pathway: in vivo and in silico studies","volume":"86","author":"Jahan","year":"2025","journal-title":"Drug Dev. Res."},{"issue":"5","key":"10.1016\/j.ntt.2025.107517_bb0195","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00702-019-02105-w","article-title":"Treatment of tics associated with Tourette syndrome","volume":"127","author":"Jankovic","year":"2020","journal-title":"J. Neural Transm."},{"issue":"10","key":"10.1016\/j.ntt.2025.107517_bb0200","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1021\/acschemneuro.0c00810","article-title":"Drug\u2013drug interaction between oxycodone and diazepam by a combined in silico pharmacokinetic and pharmacodynamic modeling approach","volume":"12","author":"Ji","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ntt.2025.107517_bb0205","series-title":"Sleep and Rehabilitation","first-page":"181","article-title":"Clinical pharmacology of sleep","author":"Julie","year":"2024"},{"key":"10.1016\/j.ntt.2025.107517_bb0210","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/978-981-15-3556-7_8","article-title":"Pharmacology of GABA and its receptors","author":"Kaur","year":"2020","journal-title":"Front. Pharmacol. Neurotransmitters"},{"issue":"3","key":"10.1016\/j.ntt.2025.107517_bb0215","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1080\/10454438.2022.2026269","article-title":"Role of elderberry (Sambucus nigra) on the modulation of stress and immune response of Nile tilapia, Oreochromis niloticus","volume":"35","author":"Khan","year":"2023","journal-title":"J. Appl. Aquac."},{"issue":"2","key":"10.1016\/j.ntt.2025.107517_bb0220","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1248\/bpb.31.255","article-title":"Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells","volume":"31","author":"Kim","year":"2008","journal-title":"Biol. Pharm. Bull."},{"issue":"4","key":"10.1016\/j.ntt.2025.107517_bb0225","doi-asserted-by":"crossref","first-page":"163","DOI":"10.12793\/tcp.2022.30.e21","article-title":"Melatonin and melatonergic drugs in sleep disorders","volume":"30","author":"Kim","year":"2022","journal-title":"Transl. Clin. Pharmacol."},{"issue":"10","key":"10.1016\/j.ntt.2025.107517_bb0230","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.3390\/molecules23102602","article-title":"Kappa opioid receptor agonist mesyl Sal B attenuates behavioral sensitization to cocaine with fewer aversive side-effects than salvinorin A in rodents","volume":"23","author":"Kivell","year":"2018","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.ntt.2025.107517_bb0235","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3390\/children11070871","article-title":"Antibiotics, analgesic sedatives, and Antiseizure medications frequently used in critically ill neonates: A narrative review","volume":"11","author":"Kontou","year":"2024","journal-title":"Children"},{"issue":"1","key":"10.1016\/j.ntt.2025.107517_bb0240","doi-asserted-by":"crossref","first-page":"148","DOI":"10.46624\/ajptr.2020.v10.i1.013","article-title":"Medicinal natural drug of valerian (Valerina officinalis): an-over review","volume":"10","author":"Lanje","year":"2020","journal-title":"Am. J. PharmTech Res."},{"issue":"3","key":"10.1016\/j.ntt.2025.107517_bb0245","doi-asserted-by":"crossref","first-page":"373","DOI":"10.4103\/1673-5374.228711","article-title":"Cerebral ischemia and neuroregeneration","volume":"13","author":"Lee","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ntt.2025.107517_bb0250","doi-asserted-by":"crossref","DOI":"10.1111\/nph.20110","article-title":"SmJAZs-SmbHLH37\/SmERF73-SmSAP4 module mediates jasmonic acid signaling to balance biosynthesis of medicinal metabolites and salt tolerance in Salvia miltiorrhiza","author":"Lv","year":"2024","journal-title":"New Phytol."},{"key":"10.1016\/j.ntt.2025.107517_bb0255","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.3389\/fmicb.2016.01934","article-title":"The neuro-endocrinological role of microbial glutamate and GABA signaling","volume":"7","author":"Mazzoli","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ntt.2025.107517_bb0260","series-title":"ADME Optimization in Drug Discovery","author":"McGinnity","year":"2023"},{"issue":"3","key":"10.1016\/j.ntt.2025.107517_bb0265","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1056\/NEJMcp2305655","article-title":"Management of insomnia","volume":"391","author":"Morin","year":"2024","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.ntt.2025.107517_bb0270","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/22221751.2020.1711817","article-title":"The combination of salvianolic acid A with latamoxef completely protects mice against lethal pneumonia caused by methicillin-resistant Staphylococcus aureus","volume":"9","author":"Mu","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.ntt.2025.107517_bb0275","doi-asserted-by":"crossref","DOI":"10.18632\/aging.206157","article-title":"Sleep deprivation in dementia comorbidities: focus on carSAL avascular disease, diabetes, anxiety\/depression and thyroid disorders","author":"Mukherjee","year":"2024","journal-title":"Aging"},{"issue":"6","key":"10.1016\/j.ntt.2025.107517_bb0280","doi-asserted-by":"crossref","DOI":"10.1002\/ddr.22250","article-title":"Assessment of sedative activity of fraxin: in vivo approach along with receptor binding affinity and molecular interaction with GABAergic system","volume":"85","author":"Mukty","year":"2024","journal-title":"Drug Dev. Res."},{"issue":"12","key":"10.1016\/j.ntt.2025.107517_bb0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0295137","article-title":"Potentials of Gynura procumbens to modulate chronic stress and immunological responses in Oreochromis niloticus","volume":"18","author":"Mumu","year":"2023","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.ntt.2025.107517_bb0290","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1002\/ptr.3400","article-title":"A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality","volume":"25","author":"Ngan","year":"2011","journal-title":"Phytother. Res."},{"issue":"4","key":"10.1016\/j.ntt.2025.107517_bb0295","doi-asserted-by":"crossref","first-page":"119","DOI":"10.9734\/bji\/2024\/v28i4732","article-title":"The synergy of molecular docking and bioinformatics: an in depth review in drug discovery","volume":"28","author":"Okpo","year":"2024","journal-title":"Biotechnol. J. Int."},{"issue":"13","key":"10.1016\/j.ntt.2025.107517_bb0300","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.3390\/molecules26133970","article-title":"Cheminformatic characterization of natural antimicrobial products for the development of new lead compounds","volume":"26","author":"Oselusi","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ntt.2025.107517_bb0305","series-title":"NeuroPsychopharmacotherapy","first-page":"1","article-title":"Hypnotics: Course and duration of therapy, side effects, contraindications, interactions, withdrawal syndromes, and resistance to therapy","author":"Pepe","year":"2021"},{"issue":"112","key":"10.1016\/j.ntt.2025.107517_bb0310","first-page":"2","article-title":"The medical use of lemon balm (Melissa officinalis) and valerian (Valeriana officinalis) as natural sedatives: insight into their interactions with GABA transmission","volume":"1","author":"Pineau","year":"2016","journal-title":"Int J Clin Pharmacol Pharmacother"},{"issue":"22","key":"10.1016\/j.ntt.2025.107517_bb0315","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.3390\/molecules25225384","article-title":"Biseugenol exhibited anti-inflammatory and anti-asthmatic effects in an asthma mouse model of mixed-granulocytic asthma","volume":"25","author":"Ponci","year":"2020","journal-title":"Molecules"},{"issue":"18","key":"10.1016\/j.ntt.2025.107517_bb0320","doi-asserted-by":"crossref","first-page":"14085","DOI":"10.1021\/acs.chemrev.1c00757","article-title":"Protein design: from the aspect of water solubility and stability","volume":"122","author":"Qing","year":"2022","journal-title":"Chem. Rev."},{"issue":"1","key":"10.1016\/j.ntt.2025.107517_bb0325","first-page":"1","article-title":"Fundamental principles of pharmacology","volume":"2","author":"Rahm","year":"2024","journal-title":"J. Clin. Med. Eng. live."},{"issue":"3","key":"10.1016\/j.ntt.2025.107517_bb0330","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/wps.20996","article-title":"Mental health care for older adults: recent advances and new directions in clinical practice and research","volume":"21","author":"Reynolds","year":"2022","journal-title":"World Psychiatry"},{"issue":"1","key":"10.1016\/j.ntt.2025.107517_bb0335","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41386-019-0411-y","article-title":"Sleep, insomnia, and depression","volume":"45","author":"Riemann","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ntt.2025.107517_bb0340","article-title":"The promising role of natural products in Alzheimer\u2019s disease","volume":"7","author":"da Rosa","year":"2022","journal-title":"Brain Disord."},{"key":"10.1016\/j.ntt.2025.107517_bb0345","article-title":"Assessment of clot-lysing and membrane-stabilizing activity of gallic acid through cyclooxygenase-1 and plasminogen interaction pathways","volume":"105673","author":"Sah","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.ntt.2025.107517_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107402","article-title":"Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders","volume":"204","author":"Sartori","year":"2019","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.ntt.2025.107517_bb0355","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3390\/plants13030350","article-title":"Phytochemical, technological, and pharmacological study on the Galenic dry extracts prepared from German chamomile (Matricaria Chamomilla L.) flowers","volume":"13","author":"Sepp","year":"2024","journal-title":"Plants"},{"issue":"6","key":"10.1016\/j.ntt.2025.107517_bb0360","article-title":"Evaluation of Ethanolic extract of red seaweed (Gracilariopsis lemaneiformis) on growth and haematological parameters of Nile Tilapia (Oreochromis niloticus)","volume":"4","author":"Shahabuddin","year":"2024","journal-title":"Aquacult. Fish Fisheries"},{"key":"10.1016\/j.ntt.2025.107517_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.focha.2025.100930","article-title":"Assessment of antiemetic and modulatory activity of dihydrocoumarin on copper sulfate induced emetic chicks: an in vivo investigation","volume":"6","author":"Sharma","year":"2025","journal-title":"Food Chem. Adv."},{"issue":"3","key":"10.1016\/j.ntt.2025.107517_bb0370","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3390\/children11030323","article-title":"Melatonin use in pediatrics: a clinical review on indications, multisystem effects, and toxicity","volume":"11","author":"Shenoy","year":"2024","journal-title":"Children"},{"issue":"2","key":"10.1016\/j.ntt.2025.107517_bb0375","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3390\/ijms22020778","article-title":"Cannabis sativa L. as a natural drug meeting the criteria of a multitarget approach to treatment","volume":"22","author":"Stasi\u0142owicz","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ntt.2025.107517_bb0380","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41386-023-01728-8","article-title":"Modulators of GABAA receptor-mediated inhibition in the treatment of neuropsychiatric disorders: past, present, and future","volume":"49","author":"Thompson","year":"2024","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.ntt.2025.107517_bb0385","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1164\/ajrccm.163.1.9911120","article-title":"Propofol versus midazolam regarding their antioxidant activities","volume":"163","author":"Tsuchiya","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"7","key":"10.1016\/j.ntt.2025.107517_bb0390","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.phymed.2014.03.001","article-title":"Anti-nociceptive, anti-inflammatory and sedative activities of the extracts and chemical constituents of SAL Aspyros lotus L","volume":"21","author":"Uddin","year":"2014","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.ntt.2025.107517_bb0395","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/tcmj.tcmj_243_23","article-title":"The role of the GABAergic system on insomnia","volume":"36","author":"Varinthra","year":"2024","journal-title":"Tzu Chi Med. J."},{"issue":"1","key":"10.1016\/j.ntt.2025.107517_bb0400","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41392-020-00456-5","article-title":"Oral berberine improves brain dopa\/dopamine levels to ameliorate Parkinson\u2019s disease by regulating gut microbiota","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ntt.2025.107517_bb0405","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2147\/OAEM.S235288","article-title":"Management of alcohol withdrawal in the emergency department: current perspectives","author":"Wolf","year":"2020","journal-title":"Open Access Emerg. Med."},{"key":"10.1016\/j.ntt.2025.107517_bb0410","doi-asserted-by":"crossref","first-page":"1433590","DOI":"10.3389\/fimmu.2024.1433590","article-title":"Targeting post-stroke neuroinflammation with Salvianolic acid A: molecular mechanisms and preclinical evidence","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Immunol."},{"issue":"15","key":"10.1016\/j.ntt.2025.107517_bb0415","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.2174\/1381612827666210917145636","article-title":"BDZs, designer BDZs and Z-drugs: pharmacology and misuse insights","volume":"28","author":"Zaami","year":"2022","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"10.1016\/j.ntt.2025.107517_bb0420","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12917-024-04077-w","article-title":"Dietary algal-sourced zinc nanoparticles promote growth performance, intestinal integrity, and immune response of Nile tilapia (Oreochromis niloticus)","volume":"20","author":"Zahran","year":"2024","journal-title":"BMC Vet. Res."}],"container-title":["Neurotoxicology and Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036225000947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892036225000947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T14:55:21Z","timestamp":1755010521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892036225000947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":83,"alternative-id":["S0892036225000947"],"URL":"https:\/\/doi.org\/10.1016\/j.ntt.2025.107517","relation":{},"ISSN":["0892-0362"],"issn-type":[{"value":"0892-0362","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salvianolic acid A enhances sedative effect of diazepam through the GABAergic pathway: In vivo, molecular docking, and pharmacokinetics approaches","name":"articletitle","label":"Article Title"},{"value":"Neurotoxicology and Teratology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ntt.2025.107517","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107517"}}