{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:16:32Z","timestamp":1791958592689,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008572","name":"University of Ottawa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008572","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.nuclcard.2024.101869","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T15:33:16Z","timestamp":1714231996000},"page":"101869","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Myocardial flow reserve recovery in patients with Takotsubo syndrome: Insights from positron emission tomography"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8333-2219","authenticated-orcid":false,"given":"Yoshito","family":"Kadoya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aun Yeong","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary R.","family":"Small","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9136-5563","authenticated-orcid":false,"given":"Robert","family":"deKemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0686-5449","authenticated-orcid":false,"given":"Terrence D.","family":"Ruddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7857-8169","authenticated-orcid":false,"given":"Rob","family":"Beanlands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2038-9178","authenticated-orcid":false,"given":"Andrew M.","family":"Crean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nuclcard.2024.101869_bib1","series-title":"Takotsubo type cardiomyopathy due to multivessel spasm. Clinical aspect of myocardial injury: from ischemia to heart failure","first-page":"56","author":"Sato","year":"1990"},{"key":"10.1016\/j.nuclcard.2024.101869_bib2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1253\/jcj.55.1061","article-title":"Transient segmental asynergy of the left ventricle of patients with various clinical manifestations possibly unrelated to the coronary artery disease","volume":"55","author":"Iga","year":"1991","journal-title":"Jpn Circ J"},{"key":"10.1016\/j.nuclcard.2024.101869_bib3","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.amjcard.2014.01.419","article-title":"Meta-analysis of clinical correlates of acute mortality in takotsubo cardiomyopathy","volume":"113","author":"Singh","year":"2014","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.nuclcard.2024.101869_bib4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijcard.2015.03.162","article-title":"Mortality in takotsubo syndrome is similar to mortality in myocardial infarction \u2013 a report from the SWEDEHEART","volume":"185","author":"Redfors","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.nuclcard.2024.101869_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/ejhf.2400","volume":"24","author":"Omerovic","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.nuclcard.2024.101869_bib6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/ejhf.2368","volume":"24","author":"Omerovic","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.nuclcard.2024.101869_bib7","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa043046","article-title":"Neurohumoral features of myocardial stunning due to sudden emotional stress","volume":"352","author":"Wittstein","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.nuclcard.2024.101869_bib8","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/01.CIR.0000153801.51470.EB","article-title":"Acute and reversible cardiomyopathy provoked by stress in women from the United States","volume":"111","author":"Sharkey","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.nuclcard.2024.101869_bib9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1067\/mhj.2002.120403","article-title":"Tako-tsubo-like left ventricular dysfunction with ST-segment elevation: a novel cardiac syndrome mimicking acute myocardial infarction","volume":"143","author":"Kurisu","year":"2002","journal-title":"Am Heart J"},{"key":"10.1016\/j.nuclcard.2024.101869_bib10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.echo.2007.05.024","article-title":"The coronary flow reserve is transiently impaired in Tako-Tsubo Cardiomyopathy: a prospective study using serial Doppler transthoracic echocardiography","volume":"21","author":"Meimoun","year":"2008","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.nuclcard.2024.101869_bib11","first-page":"1","article-title":"Diffuse, marked, reversible impairment in coronary microcirculation in stress cardiomyopathy: a Doppler transthoracic echo study","volume":"2","author":"Rigo","year":"2009","journal-title":"Ann Med"},{"key":"10.1016\/j.nuclcard.2024.101869_bib12","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1093\/cvr\/cvad053","article-title":"Takotsubo syndrome: getting closer to its causes","volume":"119","author":"Akhtar","year":"2023","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.nuclcard.2024.101869_bib13","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1161\/CIRCULATIONAHA.112.111591","article-title":"High levels of circulating epinephrine trigger apical cardiodepression in a \u03b22-adrenergic receptor\/Gi-dependent manner: a new model of Takotsubo cardiomyopathy","volume":"126","author":"Paur","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.nuclcard.2024.101869_bib14","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.echo.2009.07.012","article-title":"Microvascular function in Takotsubo cardiomyopathy with contrast echocardiography: prospective evaluation and review of literature","volume":"22","author":"Abdelmoneim","year":"2009","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.nuclcard.2024.101869_bib15","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.jacc.2021.07.042","article-title":"Coronary microvascular dysfunction across the spectrum of cardiovascular diseases: JACC state-of-the-art review","volume":"78","author":"Del Buono","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.nuclcard.2024.101869_bib16","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1093\/eurheartj\/ehy076","article-title":"International expert consensus document on takotsubo syndrome (part I): clinical characteristics, diagnostic criteria, and pathophysiology","volume":"39","author":"Ghadri","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.nuclcard.2024.101869_bib17","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ahj.2007.11.008","article-title":"Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction","volume":"155","author":"Prasad","year":"2008","journal-title":"Am Heart J"},{"key":"10.1016\/j.nuclcard.2024.101869_bib18","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.amjcard.2008.12.015","article-title":"Usefulness of two-dimensional speckle tracking echocardiography for assessment of Tako-Tsubo cardiomyopathy","volume":"103","author":"Mansencal","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.nuclcard.2024.101869_bib19","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/ejechocard\/jep062","article-title":"Global and regional myocardial function quantification by two-dimensional strain in Takotsubo cardiomyopathy","volume":"10","author":"Heggemann","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.nuclcard.2024.101869_bib20","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/echo.13492","article-title":"Left ventricular myocardial function assessed by three-dimensional speckle tracking echocardiography in Takotsubo cardiomyopathy","volume":"34","author":"Kobayashi","year":"2017","journal-title":"Echocardiography"},{"key":"10.1016\/j.nuclcard.2024.101869_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4250\/jcvi.2019.0083","article-title":"Time course of functional recovery in takotsubo (stress) cardiomyopathy: a serial speckle tracking echocardiography and electrocardiography study","volume":"28","author":"Lee","year":"2020","journal-title":"J\u00a0Cardiovasc Imaging"},{"key":"10.1016\/j.nuclcard.2024.101869_bib22","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.jacc.2018.01.062","article-title":"PET assessment of epicardial intimal disease and microvascular dysfunction in cardiac allograft vasculopathy","volume":"71","author":"Chih","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.nuclcard.2024.101869_bib23","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00259-007-0478-2","article-title":"Quantification of myocardial blood flow with 82Rb dynamic PET imaging","volume":"34","author":"Lortie","year":"2007","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"10.1016\/j.nuclcard.2024.101869_bib24","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s12350-010-9225-3","article-title":"Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program","volume":"17","author":"Klein","year":"2010","journal-title":"J\u00a0Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2024.101869_bib25","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jacc.2011.01.065","article-title":"Impaired myocardial flow reserve on rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia","volume":"58","author":"Ziadi","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.nuclcard.2024.101869_bib26","first-page":"150","article-title":"Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography","volume":"54","author":"Herzog","year":"2009","journal-title":"Added value of coronary flow reserve. J Am Coll Cardiol"},{"key":"10.1016\/j.nuclcard.2024.101869_bib27","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jcmg.2011.12.014","article-title":"Integrating noninvasive absolute flow, coronary flow reserve, and ischemic thresholds into a comprehensive map of physiological severity","volume":"5","author":"Johnson","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.nuclcard.2024.101869_bib28","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1007\/s12350-017-1057-y","article-title":"ASNC imaging guidelines for nuclear cardiology procedures: standardized reporting of nuclear cardiology procedures","volume":"24","author":"Tilkemeier","year":"2017","journal-title":"J\u00a0Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2024.101869_bib29","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u201cEZR\u201d (Easy R) for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.nuclcard.2024.101869_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10877-009-9217-5","article-title":"Tako-tsubo cardiomyopathy and microcirculation","volume":"24","author":"Fazio","year":"2010","journal-title":"J\u00a0Clin Monit Comput"},{"key":"10.1016\/j.nuclcard.2024.101869_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ahj.2006.06.007","article-title":"Myocardial perfusion in apical ballooning syndrome correlate of myocardial injury","volume":"152","author":"Elesber","year":"2006","journal-title":"Am Heart J"},{"key":"10.1016\/j.nuclcard.2024.101869_bib32","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1253\/circj.69.934","article-title":"Assessment of coronary microcirculation in patients with takotsubo-like left ventricular dysfunction","volume":"69","author":"Kume","year":"2005","journal-title":"Circ J"},{"key":"10.1016\/j.nuclcard.2024.101869_bib33","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.nuclcard.2008.06.010","article-title":"Reversible impairment of coronary flow reserve in takotsubo cardiomyopathy: a myocardial PET study","volume":"15","author":"Feola","year":"2008","journal-title":"J\u00a0Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2024.101869_bib34","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1007\/s12350-020-02385-w","article-title":"Spectrum of radionuclide perfusion study abnormalities in takotsubo cardiomyopathy","volume":"29","author":"Anderson","year":"2022","journal-title":"J\u00a0Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2024.101869_bib35","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/MCA.0b013e3283645c4e","article-title":"Tako-tsubo cardiomyopathy and coronary artery disease: a possible association","volume":"24","author":"Parodi","year":"2013","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.nuclcard.2024.101869_bib36","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/qjmed\/hcx035","article-title":"Coincidental coronary artery disease impairs outcome in patients with takotsubo cardiomyopathy","volume":"110","author":"Bill","year":"2017","journal-title":"QJM"},{"key":"10.1016\/j.nuclcard.2024.101869_bib37","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1093\/eurheartj\/ehaa210","article-title":"Coexistence and outcome of coronary artery disease in Takotsubo syndrome","volume":"41","author":"Napp","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.nuclcard.2024.101869_bib38","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1093\/eurheartj\/ehy077","article-title":"International expert consensus document on takotsubo syndrome (Part II): diagnostic workup, outcome, and management","volume":"39","author":"Ghadri","year":"2018","journal-title":"Eur Heart J"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358124005105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358124005105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T03:39:06Z","timestamp":1721187546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358124005105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":38,"alternative-id":["S1071358124005105"],"URL":"https:\/\/doi.org\/10.1016\/j.nuclcard.2024.101869","relation":{},"ISSN":["1071-3581"],"issn-type":[{"value":"1071-3581","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial flow reserve recovery in patients with Takotsubo syndrome: Insights from positron emission tomography","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nuclcard.2024.101869","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2024 Published by Elsevier Inc. on behalf of American Society of Nuclear Cardiology. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101869"}}