{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:50:36Z","timestamp":1763988636835,"version":"build-2065373602"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"am","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01EB034586"],"award-info":[{"award-number":["R01EB034586"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.nuclcard.2025.102270","type":"journal-article","created":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T18:28:19Z","timestamp":1749320899000},"page":"102270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["82Rb positron emission tomography myocardial blood flow quantification: Influence of arterial input curve quality on diagnostic accuracy"],"prefix":"10.1016","volume":"50","author":[{"given":"Hidesato","family":"Fujito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-880X","authenticated-orcid":false,"given":"Mark","family":"Lemley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Builoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6053-6454","authenticated-orcid":false,"given":"Wenhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichiro","family":"Kuronuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3730-5075","authenticated-orcid":false,"given":"Giselle","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3831-5676","authenticated-orcid":false,"given":"Aditya","family":"Killekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna X.","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-1936","authenticated-orcid":false,"given":"Paul","family":"Kavanagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0359-883X","authenticated-orcid":false,"given":"Mark C.","family":"Hyun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean W.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7492-7827","authenticated-orcid":false,"given":"Louise E.J.","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4947-9158","authenticated-orcid":false,"given":"Serge D.","family":"Van Kriekinge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo F.","family":"Di Carli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damini","family":"Dey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-9578","authenticated-orcid":false,"given":"Daniel S.","family":"Berman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6110-938X","authenticated-orcid":false,"given":"Piotr J.","family":"Slomka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nuclcard.2025.102270_bib1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s12350-011-9506-5","article-title":"Does quantification of myocardial flow reserve using rubidium-82 positron emission tomography facilitate detection of multivessel coronary artery disease?","volume":"19","author":"Ziadi","year":"2012","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102270_bib2","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jacc.2011.01.065","article-title":"Impaired myocardial flow reserve on rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia","volume":"58","author":"Ziadi","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102270_bib3","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.2967\/jnumed.121.261989","article-title":"Practical guide for interpreting and reporting cardiac PET measurements of myocardial blood flow: an information statement from the American society of nuclear Cardiology, and the society of nuclear medicine and molecular imaging","volume":"62","author":"Bateman","year":"2021","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nuclcard.2025.102270_bib4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2967\/jnumed.117.201368","article-title":"Clinical quantification of myocardial blood flow using PET: joint position paper of the SNMMI cardiovascular Council and the ASNC","volume":"59","author":"Murthy","year":"2018","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nuclcard.2025.102270_bib5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s12350-020-02074-8","article-title":"Pitfalls in quantitative myocardial PET perfusion II: arterial input function","volume":"27","author":"Bui","year":"2020","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102270_bib6","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.jcmg.2013.04.001","article-title":"In hot blood: quantifying the arterial input function","volume":"6","author":"Bacharach","year":"2013","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.nuclcard.2025.102270_bib7","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/ehjci\/jeac082","article-title":"Relationship between ischaemia, coronary artery calcium scores, and major adverse cardiovascular events","volume":"23","author":"Miller","year":"2022","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.nuclcard.2025.102270_bib8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s12350-011-9496-3","article-title":"Automated quantitative Rb-82 3D PET\/CT myocardial perfusion imaging: normal limits and correlation with invasive coronary angiography","volume":"19","author":"Nakazato","year":"2012","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102270_bib9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2967\/jnumed.123.266208","article-title":"Automated motion correction for myocardial blood flow measurements and diagnostic performance of (82)Rb PET myocardial perfusion imaging","volume":"65","author":"Kuronuma","year":"2024","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nuclcard.2025.102270_bib10","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1093\/eurheartj\/ehi496","article-title":"Correspondence between left ventricular 17 myocardial segments and coronary arteries","volume":"26","author":"Pereztol-Valdes","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.nuclcard.2025.102270_bib11","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s00259-021-05643-2","article-title":"Improved myocardial blood flow estimation with residual activity correction and motion correction in (18)F-flurpiridaz PET myocardial perfusion imaging","volume":"49","author":"Otaki","year":"2022","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"10.1016\/j.nuclcard.2025.102270_bib12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.jcmg.2012.11.015","article-title":"Variation in quantitative myocardial perfusion due to arterial input selection","volume":"6","author":"Vasquez","year":"2013","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.nuclcard.2025.102270_bib13","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s12350-017-1049-y","article-title":"Technical aspects of acquiring and measuring myocardial blood flow: method, technique, and QA","volume":"25","author":"Votaw","year":"2018","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102270_bib14","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s12350-021-02774-9","article-title":"Clinical implications of compromised (82)Rb PET data acquisition","volume":"29","author":"Van Tosh","year":"2022","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102270_bib15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nuclcard.2004.10.006","article-title":"Automated quantification of myocardial perfusion SPECT using simplified normal limits","volume":"12","author":"Slomka","year":"2005","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102270_bib16","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.nuclcard.2025.102270_bib17","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jcmg.2014.08.003","article-title":"Quantification of myocardial blood flow in absolute terms using (82)Rb PET imaging: the RUBY-10 Study","volume":"7","author":"Nesterov","year":"2014","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.nuclcard.2025.102270_bib18","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s12350-019-01650-x","article-title":"How to detect and correct myocardial creep in myocardial perfusion imaging using Rubidium-82 PET?","volume":"26","author":"Koenders","year":"2019","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102270_bib19","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1007\/s00259-024-06611-2","article-title":"Downward myocardial creep during stress PET imaging is inversely associated with mortality","volume":"51","author":"Kuronuma","year":"2024","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"10.1016\/j.nuclcard.2025.102270_bib20","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1097\/MNM.0b013e3283567554","article-title":"Assessment of a protocol for routine simultaneous myocardial blood flow measurement and standard myocardial perfusion imaging with rubidium-82 on a high count rate positron emission tomography system","volume":"33","author":"Tout","year":"2012","journal-title":"Nucl Med Commun"},{"key":"10.1016\/j.nuclcard.2025.102270_bib21","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1007\/s00259-020-04811-0","article-title":"3D PET\/CT (82)Rb PET myocardial blood flow quantification: comparison of half-dose and full-dose protocols","volume":"47","author":"Lassen","year":"2020","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"10.1016\/j.nuclcard.2025.102270_bib22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12968-023-00945-w","article-title":"A simplified method to correct saturation of arterial input function for cardiac magnetic resonance first-pass perfusion imaging: validation with simultaneously acquired PET","volume":"25","author":"Li","year":"2023","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.nuclcard.2025.102270_bib23","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s12350-010-9256-9","article-title":"Quantification of myocardial blood flow and flow reserve: technical aspects","volume":"17","author":"Klein","year":"2010","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102270_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.124.016577","article-title":"Age- and sex-specific myocardial blood flow values in patients without coronary atherosclerosis on Rb-82 PET myocardial perfusion imaging","volume":"17","author":"Sperry","year":"2024","journal-title":"Circ Cardiovasc Imag"},{"key":"10.1016\/j.nuclcard.2025.102270_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11886-020-1261-2","article-title":"Microvascular angina diagnosed by absolute PET myocardial blood flow quantification","volume":"22","author":"Pelletier-Galarneau","year":"2020","journal-title":"Curr Cardiol Rep"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358125001448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358125001448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T17:17:21Z","timestamp":1762363041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358125001448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":25,"alternative-id":["S1071358125001448"],"URL":"https:\/\/doi.org\/10.1016\/j.nuclcard.2025.102270","relation":{},"ISSN":["1071-3581"],"issn-type":[{"type":"print","value":"1071-3581"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"82Rb positron emission tomography myocardial blood flow quantification: Influence of arterial input curve quality on diagnostic accuracy","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nuclcard.2025.102270","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society of Nuclear Cardiology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102270"}}