{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T17:33:57Z","timestamp":1788111237406,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.nuclcard.2025.102540","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T21:07:10Z","timestamp":1762463230000},"page":"102540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Beyond flow reserve: Comparative prognostic value of myocardial blood flow reserve, peak stress myocardial blood flow, and blood flow reserve corrected for resting rate pressure product in patients undergoing positron emission tomography myocardial perfusion imaging"],"prefix":"10.1016","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-9437","authenticated-orcid":false,"given":"Mirza S.","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7959-6159","authenticated-orcid":false,"given":"Timothy M.","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Case","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8210-6401","authenticated-orcid":false,"given":"Brett W.","family":"Sperry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nuclcard.2025.102540_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jacc.2009.02.069","article-title":"Long-term prognostic value of 13N-Ammonia myocardial perfusion positron emission tomography","volume":"54","author":"Herzog","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102540_bib2","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jacc.2011.01.065","article-title":"Impaired myocardial flow reserve on Rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia","volume":"58","author":"Ziadi","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102540_bib3","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1161\/CIRCULATIONAHA.113.008507","article-title":"Effects of sex on coronary microvascular dysfunction and cardiac outcomes","volume":"129","author":"Murthy","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.nuclcard.2025.102540_bib4","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.jcmg.2022.03.032","article-title":"Association of sex, reduced myocardial flow reserve, and long-term mortality across spectrum of atherosclerotic disease","volume":"15","author":"Patel","year":"2022","journal-title":"JACC, Cardiovasc Imaging"},{"key":"10.1016\/j.nuclcard.2025.102540_bib5","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1161\/CIRCULATIONAHA.111.050427","article-title":"Improved cardiac risk assessment with noninvasive measures of coronary flow reserve","volume":"124","author":"Murthy","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.nuclcard.2025.102540_bib6","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1161\/CIRCULATIONAHA.117.029992","article-title":"Integrated noninvasive physiological assessment of coronary circulatory function and impact on cardiovascular mortality in patients with stable coronary artery disease","volume":"136","author":"Gupta","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.nuclcard.2025.102540_bib7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12350-017-1110-x","article-title":"Clinical quantification of myocardial blood flow using PET: joint position paper of the SNMMI Cardiovascular Council and the ASNC","volume":"25","author":"Murthy","year":"2018","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102540_bib8","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.2967\/jnumed.121.261989","article-title":"Practical guide for interpreting and reporting cardiac PET measurements of myocardial blood flow: an information statement from the American Society of Nuclear Cardiology, and the Society of Nuclear Medicine and Molecular Imaging","volume":"62","author":"Bateman","year":"2021","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nuclcard.2025.102540_bib9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1161\/01.CIR.88.1.62","article-title":"Influence of age and hemodynamics on myocardial blood flow and flow reserve","volume":"88","author":"Czernin","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.nuclcard.2025.102540_bib10","first-page":"A15546","article-title":"Abstract 15546: Influence of rate pressure product correction on reclassification of myocardial flow reserve","volume":"140","author":"Sharma","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.nuclcard.2025.102540_bib11","article-title":"Rate pressure product corrections of 82Rb PET myocardial blood flow computations","volume":"59","author":"Tosh","year":"2018","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nuclcard.2025.102540_bib12","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jcmg.2022.12.015","article-title":"Myocardial perfusion PET for the detection and reporting of coronary microvascular dysfunction","volume":"16","author":"Schindler","year":"2023","journal-title":"JACC, Cardiovasc Imaging"},{"key":"10.1016\/j.nuclcard.2025.102540_bib13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/eurheartj\/ehz389","article-title":"Myocardial blood flow reserve assessed by positron emission tomography myocardial perfusion imaging identifies patients with a survival benefit from early revascularization","volume":"41","author":"Patel","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.nuclcard.2025.102540_bib14","doi-asserted-by":"crossref","first-page":"102222","DOI":"10.1016\/j.nuclcard.2025.102222","article-title":"The prognostic significance of rate pressure product corrected myocardial flow reserve","volume":"49","author":"Rifai","year":"2025","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102540_bib15","article-title":"Age- and sex-specific myocardial blood flow values in patients without coronary atherosclerosis on Rb-82 PET myocardial perfusion imaging","volume":"17","author":"Sperry","year":"2024","journal-title":"Circulation: Cardiovascular Imaging"},{"key":"10.1016\/j.nuclcard.2025.102540_bib16","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jcmg.2014.08.003","article-title":"Quantification of myocardial blood flow in absolute terms using 82Rb PET imaging","volume":"7","author":"Nesterov","year":"2014","journal-title":"JACC, Cardiovasc Imaging"},{"key":"10.1016\/j.nuclcard.2025.102540_bib17","series-title":"Regression modeling strategies: with applications to linear models, logistic and ordinal regression, and survival analysis","author":"Harrell","year":"2015"},{"key":"10.1016\/j.nuclcard.2025.102540_bib18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s41512-018-0037-2","article-title":"Quantifying the added value of new biomarkers: how and how not","volume":"2","author":"Cook","year":"2018","journal-title":"Diagn Progn Res"},{"key":"10.1016\/j.nuclcard.2025.102540_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228931","article-title":"The role of resting myocardial blood flow and myocardial blood flow reserve as a predictor of major adverse cardiovascular outcomes","volume":"15","author":"Guerraty","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.nuclcard.2025.102540_bib20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2967\/jnumed.119.229625","article-title":"Comparative prognostic and diagnostic value of myocardial blood flow and myocardial flow reserve after cardiac transplantation","volume":"61","author":"Miller","year":"2020","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nuclcard.2025.102540_bib21","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jcmg.2010.04.007","article-title":"Cardiac PET imaging for the detection and monitoring of coronary artery disease and microvascular health","volume":"3","author":"Schindler","year":"2010","journal-title":"JACC, Cardiovasc Imaging"},{"key":"10.1016\/j.nuclcard.2025.102540_bib22","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.jacc.2005.01.040","article-title":"Positron emission tomography-measured abnormal responses of myocardial blood flow to sympathetic stimulation are associated with the risk of developing cardiovascular events","volume":"45","author":"Schindler","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102540_bib23","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1007\/s12350-019-02000-7","article-title":"Prognostic value of coronary flow reserve in patients with suspected or known coronary artery disease referred to PET myocardial perfusion imaging: a meta-analysis","volume":"28","author":"Green","year":"2021","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102540_bib24","article-title":"Relative prognostic significance of positron emission tomography myocardial perfusion imaging markers in cardiomyopathy","volume":"14","author":"Thomas","year":"2021","journal-title":"Circ: Cardiovascular Imaging"},{"key":"10.1016\/j.nuclcard.2025.102540_bib25","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.2967\/jnumed.114.145342","article-title":"Comparison and prognostic validation of multiple methods of quantification of myocardial blood flow with82 Rb PET","volume":"55","author":"Murthy","year":"2014","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nuclcard.2025.102540_bib26","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2967\/jnumed.118.211953","article-title":"Regional, artery-specific thresholds of quantitative myocardial perfusion by PET associated with reduced myocardial infarction and death after revascularization in stable coronary artery disease","volume":"60","author":"Gould","year":"2019","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nuclcard.2025.102540_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.nuclcard.2024.101902","article-title":"Resting myocardial blood flow: to correct, or not to correct, that is the question","volume":"37","author":"Soman","year":"2024","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2025.102540_bib28","doi-asserted-by":"crossref","first-page":"101854","DOI":"10.1016\/j.nuclcard.2024.101854","article-title":"Prognostic value of myocardial flow reserve vs corrected myocardial flow reserve in patients without obstructive coronary artery disease","volume":"37","author":"Huck","year":"2024","journal-title":"J Nucl Cardiol"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358125004143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358125004143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:04:51Z","timestamp":1773932691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358125004143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"alternative-id":["S1071358125004143"],"URL":"https:\/\/doi.org\/10.1016\/j.nuclcard.2025.102540","relation":{},"ISSN":["1071-3581"],"issn-type":[{"value":"1071-3581","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beyond flow reserve: Comparative prognostic value of myocardial blood flow reserve, peak stress myocardial blood flow, and blood flow reserve corrected for resting rate pressure product in patients undergoing positron emission tomography myocardial perfusion imaging","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nuclcard.2025.102540","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.nuclcard.2025.102278","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society of Nuclear Cardiology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102540"}}