{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:17:07Z","timestamp":1791958627383,"version":"4.3.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020771","name":"Natural Science Foundation for Young Scientists of Shanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofnuclearcardiology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.nuclcard.2026.102822","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:32:16Z","timestamp":1784356336000},"page":"102822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Incremental prognostic value of the hemodynamic gain index in patients undergoing exercise stress myocardial perfusion imaging"],"prefix":"10.1016","volume":"63","author":[{"given":"Shuai","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-982X","authenticated-orcid":false,"given":"Zhifang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nuclcard.2026.102822_bib1","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke Statistics-2019 update: a report from the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.nuclcard.2026.102822_bib2","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1161\/CIR.0000000000001168","article-title":"2023 AHA\/ACC\/ACCP\/ASPC\/NLA\/PCNA Guideline for the management of patients with Chronic Coronary Disease: a report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"148","author":"Virani","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.nuclcard.2026.102822_bib3","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.jacc.2023.03.410","article-title":"ACC\/AHA\/ASE\/ASNC\/ASPC\/HFSA\/HRS\/SCAI\/SCCT\/SCMR\/STS 2023 multimodality appropriate use criteria for the detection and risk assessment of chronic coronary disease","volume":"81","author":"Winchester","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib4","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s12350-015-0387-x","article-title":"ASNC imaging guidelines for SPECT nuclear cardiology procedures: stress, protocols, and tracers","volume":"23","author":"Henzlova","year":"2016","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib5","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/ehjci\/jev093","article-title":"Role of risk stratification by SPECT, PET, and hybrid imaging in guiding management of stable patients with ischaemic heart disease: expert panel of the EANM Cardiovascular Committee and EACVI","volume":"16","author":"Acampa","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.nuclcard.2026.102822_bib6","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jacc.2012.11.056","article-title":"Temporal trends in the frequency of inducible myocardial ischemia during cardiac stress testing: 1991 to 2009","volume":"61","author":"Rozanski","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.nuclcard.2025.102267","article-title":"The prevalence and prognostic impact of additive abnormal stress exercise markers in patients with normal stress myocardial perfusion imaging","volume":"50","author":"Scherping","year":"2025","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib8","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMoa011858","article-title":"Exercise capacity and mortality among men referred for exercise testing","volume":"346","author":"Myers","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nuclcard.2026.102822_bib9","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/j.amjcard.2015.08.037","article-title":"Prognostic contribution of exercise capacity, heart rate recovery, chronotropic incompetence, and myocardial perfusion single-photon emission computerized tomography in the prediction of cardiac death and all-cause mortality","volume":"116","author":"Arbit","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib10","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.amjcard.2019.05.015","article-title":"Prognostic value and clinical usefulness of the hemodynamic gain index in men","volume":"124","author":"Vainshelboim","year":"2019","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijcard.2020.03.066","article-title":"Hemodynamic gain index in women: a validation study","volume":"308","author":"Vainshelboim","year":"2020","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib12","first-page":"18","article-title":"Validation of prognostic value of the hemodynamic gain index in different groups of patients undergoing exercise stress testing","author":"Chaikijurajai","year":"2022","journal-title":"Am Heart J Plus"},{"key":"10.1016\/j.nuclcard.2026.102822_bib13","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/eurjpc\/zwaf046","article-title":"Risk stratification with the Haemodynamic Gain Index and peak rate-pressure product in patients with chronic heart failure undergoing treadmill exercise testing","volume":"32","author":"Chaikijurajai","year":"2025","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib14","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.nuclcard.2004.03.033","article-title":"Prognostic validation of a 17-segment score derived from a 20-segment score for myocardial perfusion SPECT interpretation","volume":"11","author":"Berman","year":"2004","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib15","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jcmg.2019.02.028","article-title":"5-year prognostic value of quantitative versus visual MPI in subtle perfusion defects: results from REFINE SPECT","volume":"13","author":"Otaki","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.nuclcard.2026.102822_bib16","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/01.CIR.57.3.549","article-title":"The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris","volume":"57","author":"Gobel","year":"1978","journal-title":"Circulation"},{"key":"10.1016\/j.nuclcard.2026.102822_bib17","doi-asserted-by":"crossref","first-page":"7252","DOI":"10.1158\/1078-0432.CCR-04-0713","article-title":"X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization","volume":"10","author":"Camp","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.nuclcard.2026.102822_bib18","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1002\/sim.5958","article-title":"Estimating and comparing time-dependent areas under receiver operating characteristic curves for censored event times with competing risks","volume":"32","author":"Blanche","year":"2013","journal-title":"Stat Med"},{"key":"10.1016\/j.nuclcard.2026.102822_bib19","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1007\/s12350-018-1283-y","article-title":"Single Photon Emission Computed Tomography (SPECT) myocardial perfusion imaging guidelines: instrumentation, acquisition, processing, and interpretation","volume":"25","author":"Dorbala","year":"2018","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib20","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1093\/eurjpc\/zwad236","article-title":"Haemodynamic gain index and heart failure incidence- prognostic and preventive value","volume":"30","author":"Vainshelboim","year":"2023","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib21","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/HCR.0000000000000777","article-title":"Hemodynamic gain index is associated with cardiovascular mortality and improves risk prediction: a prospective cohort study","volume":"43","author":"Laukkanen","year":"2023","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"10.1016\/j.nuclcard.2026.102822_bib22","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/ehjci\/jez172","article-title":"Transient ischaemic dilation and post-stress wall motion abnormality increase risk in patients with less than moderate ischaemia: analysis of the REFINE SPECT registry","volume":"21","author":"Miller","year":"2020","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.nuclcard.2026.102822_bib23","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1007\/s12350-020-02375-y","article-title":"The diagnostic and prognostic value of near-normal perfusion or borderline ischemia on stress myocardial perfusion imaging","volume":"29","author":"Kassab","year":"2022","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib24","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0735-1097(03)00125-6","article-title":"Determinants of risk and its temporal variation in patients with normal stress myocardial perfusion scans: what is the warranty period of a normal scan?","volume":"41","author":"Hachamovitch","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s12350-014-9957-6","article-title":"Warranty periods for normal myocardial perfusion stress SPECT","volume":"22","author":"Romero-Farina","year":"2015","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.nuclcard.2026.102822_bib26","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199910283411804","article-title":"Heart-rate recovery immediately after exercise as a predictor of mortality","volume":"341","author":"Cole","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nuclcard.2026.102822_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.amjcard.2022.11.049","article-title":"Hemodynamic gain index and exercise capacity in heart failure with preserved ejection fraction","volume":"190","author":"Morales-Oyarvide","year":"2023","journal-title":"Am J Cardiol"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358126002035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358126002035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:29:55Z","timestamp":1791912595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358126002035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"alternative-id":["S1071358126002035"],"URL":"https:\/\/doi.org\/10.1016\/j.nuclcard.2026.102822","relation":{},"ISSN":["1071-3581"],"issn-type":[{"value":"1071-3581","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incremental prognostic value of the hemodynamic gain index in patients undergoing exercise stress myocardial perfusion imaging","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nuclcard.2026.102822","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Nuclear Cardiology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102822"}}