{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:17:15Z","timestamp":1760782635847},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuclear Medicine and Biology"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.nucmedbio.2003.11.001","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T17:47:39Z","timestamp":1088099259000},"page":"649-654","source":"Crossref","is-referenced-by-count":8,"title":["Synthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography"],"prefix":"10.1016","volume":"31","author":[{"given":"Jan","family":"Courtyn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"Cornelissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Oltenfreiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleen","family":"Vandecapelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Slegers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Strijckmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0091-3057(84)80020-9","article-title":"A homotaurine derivative reduces the voluntary intake of ethanol by rats\u2014are cerebral GABA receptors involved?","volume":"21","author":"Boismare","year":"1984","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0014-2999(96)00174-4","article-title":"Acamprosate and alcohol","volume":"305","author":"Spanagel","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0014-2999(96)00175-6","article-title":"Acamprosate and alcohol","volume":"305","author":"Spanagel","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB4","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/S0140-6736(85)91615-0","article-title":"Ability of calcium bis acetyl homotaurine, a GABA agonist, to prevent relapse in weaned alcoholics","volume":"8436","author":"Lhuintre","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/oxfordjournals.alcalc.a045057","article-title":"Acamprosate appears to decrease alcohol intake in weaned alcoholics","volume":"25","author":"Lhuintre","year":"1990","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB6","first-page":"239","article-title":"Double-blind randomized multicenter trial of acamprosate in maintaining abstinence from alcohol","volume":"30","author":"Paille","year":"1995","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB7","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1001\/archpsyc.1996.01830080023006","article-title":"Relapse prevention by acamprosate\u2014Results from a placebo-controlled study on alcohol dependence","volume":"53","author":"Sass","year":"1996","journal-title":"Archiv Gen Psych"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1192\/bjp.171.1.73","article-title":"Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients, a 90-day placebo-controlled dose-finding study","volume":"171","author":"Pelc","year":"1997","journal-title":"Brit J Psych"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB9","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/S0140-6736(96)91682-7","article-title":"Comparison of acamprosate and placebo in long-term treatment of alcohol dependence","volume":"347","author":"Whitworth","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/oxfordjournals.alcalc.a008159","article-title":"Alcohol dependence","volume":"31","author":"Hoffman","year":"1996","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB11","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1530-0277.1992.tb01407.x","article-title":"The involvement of NMDA receptors in acute and chronic effects of ethanol","volume":"16","author":"Danysz","year":"1992","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB12","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/j.1360-0443.1994.tb03736.x","article-title":"Current concepts of ethanol dependence","volume":"89","author":"Littleton","year":"1994","journal-title":"Addiction"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB13","first-page":"457","article-title":"Are gamma aminobutyric acid-ergic receptors involved in the voluntary intake of ethanol by rats","volume":"15","author":"Boismare","year":"1984","journal-title":"J Pharmacol"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB14","first-page":"108","article-title":"Calcium bis acetyl homotaurine\u2014a new GABAergic substance","volume":"16","author":"Daoust","year":"1985","journal-title":"J Pharmacol-Paris"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB15","first-page":"311","article-title":"Physiochemical, pharmacological and pharmacokinetic study of a new GABAergic compound, calcium acetylhomotaurinate","volume":"10","author":"Chabenat","year":"1988","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB16","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0091-3057(92)90210-7","article-title":"Acamprosate modulates synaptosomal GABA transmission in chronically alcoholized rats","volume":"41","author":"Daoust","year":"1992","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB17","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0091-3057(89)90005-1","article-title":"Reinforcing and discriminative stimulus effects of Ca-acetyl homotaurine in animals","volume":"32","author":"Grant","year":"1989","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB18","first-page":"552","article-title":"The enhanced excitability of central neurons following chronic alcohol intake is reduced by acamprosate","volume":"30","author":"Zieglg\u00e4nsberger","year":"1995","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1530-0277.1998.tb03636.x","article-title":"Acamprosate enhances N-methyl-D-aspartate receptor mediated neurotransmission but inhibits presynaptic GABAB receptors in nucleus accumbens neurons","volume":"22","author":"Berton","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-2999(93)90682-8","article-title":"Acamprosate (calcium acetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex","volume":"231","author":"Zeise","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB21","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1530-0277.1996.tb01667.x","article-title":"Acamprosate (calcium acetylhomotaurinate) enhances the N-methyl-D-aspartate component of excitatory neurotransmission in rat hyppocampal CA1 neurons in vitro","volume":"20","author":"Madamba","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB22","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1530-0277.1998.tb03871.x","article-title":"Mechanism of action of acamprosate. Part I. Characterization of spermidine-sensitive acamprosate bindingsite in rat brain","volume":"22","author":"Naassila","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB23","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1530-0277.1998.tb03872.x","article-title":"Mechanism of action of acamprosate. Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex","volume":"22","author":"al Qatari","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0925-4927(98)00016-X","article-title":"Central effects of acamprosate","volume":"82","author":"Dahchour","year":"1998","journal-title":"Psychiat Res-Neuroim"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0925-4927(98)00017-1","article-title":"Central effects of acamprosate","volume":"82","author":"Bolo","year":"1998","journal-title":"Psychiat Res-Neuroim"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB26","unstructured":"Durbin P, Hulot T, Chabac S. Pharmacodynamics and pharmacokinetics of acamprosate: an overview. In: Soyka M, editor. Proceedings of the 1st Campral-symposium ESBRA. Stuttgart, Germany: Springer, 1995, pp. 47\u201364"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0301-0082(99)00031-3","article-title":"Ethanol and amino acids in the central nervous system","volume":"60","author":"Dahchour","year":"2000","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB28","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.2165\/00003495-199753060-00008","article-title":"Acamprosate","volume":"53","author":"Wilde","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF01731847","article-title":"The role of positron emission tomography within the spectrum of medical imaging","volume":"23","author":"Jones","year":"1996","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB30","series-title":"PET for drug development and evaluation","author":"Comar","year":"1995"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB31","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/jlcr.490","article-title":"Synthesis of C-11-labelled acamprosate for PET studies","volume":"44","author":"Courtyn","year":"2001","journal-title":"J Labelled Compd Rad"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB32","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0883-2889(90)90007-4","article-title":"Preparation of some NCA [1-11C]acid chlorides as labelling agents","volume":"41","author":"Luthra","year":"1990","journal-title":"Appl Radiat Isot"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0969-8043(00)00269-4","article-title":"An admonition when measuring the lipophilicity of radiotracers using counting techniques","volume":"54","author":"Wilson","year":"2001","journal-title":"Appl Radiat Isot"},{"key":"10.1016\/j.nucmedbio.2003.11.001_BIB34","first-page":"548","article-title":"Rat pharmacokinetic profile of acamprosate in plasma, brain and CSF","volume":"30","author":"Durbin","year":"1995","journal-title":"Alcohol Alcohol"}],"container-title":["Nuclear Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805103001975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805103001975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T17:26:30Z","timestamp":1549473990000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969805103001975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0969805103001975"],"URL":"https:\/\/doi.org\/10.1016\/j.nucmedbio.2003.11.001","relation":{},"ISSN":["0969-8051"],"issn-type":[{"value":"0969-8051","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}