{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:40:54Z","timestamp":1791056454232,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuclear Medicine and Biology"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.nucmedbio.2006.02.002","type":"journal-article","created":{"date-parts":[[2006,5,5]],"date-time":"2006-05-05T06:30:33Z","timestamp":1146810633000},"page":"535-541","source":"Crossref","is-referenced-by-count":5,"title":["Acute treatment with pentobarbital alters the kinetics of in vivo receptor binding in the mouse brain"],"prefix":"10.1016","volume":"33","author":[{"given":"Yojiro","family":"Sakiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nucmedbio.2006.02.002_bib1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0014-2999(84)90321-2","article-title":"Barbiturate shift as a tool for determination of efficacy of benzodiazepine\u2013receptor ligands","volume":"100","author":"Honore","year":"1984","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF00216067","article-title":"Acute barbiturate administration increases benzodiazepine receptor binding in vivo","volume":"96","author":"Miller","year":"1988","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0014-2999(88)90461-X","article-title":"GABA shift in vivo: enhancement of benzodiazepine binding in vivo by modulation of endogenous GABA","volume":"148","author":"Miller","year":"1988","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib4","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0883-2897(88)90055-4","article-title":"Changes in in vivo binding of [3H]Ro15-1788 in mouse brain by reserpine","volume":"15","author":"Hashimoto","year":"1988","journal-title":"Int J Rad Appl Instrum B"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib5","first-page":"701","article-title":"Repeated swim stress alters brain benzodiazepine receptors measured in vivo","volume":"249","author":"Weizman","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/BF00442234","article-title":"Decreased in vivo binding to brain benzodiazepine receptors during social isolation","volume":"97","author":"Insel","year":"1989","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib7","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/syn.20057","article-title":"Discrepancy between cell injury and benzodiazepine receptor binding after transient middle cerebral artery occlusion in rats","volume":"53","author":"Abe","year":"2004","journal-title":"Synapse"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib8","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/BF02244235","article-title":"Chronic morphine administration augments benzodiazepine binding and GABAA receptor function","volume":"101","author":"Lopez","year":"1990","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/ana.410150302","article-title":"A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography","volume":"15","author":"Mintun","year":"1984","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib10","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/biomet\/63.3.655","article-title":"On closed testing procedure with special reference to ordered analysis of variance","volume":"63","author":"Marcus","year":"1976","journal-title":"Biometrika"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib11","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/44579","article-title":"Benzodiazepine actions mediated by specific \u03b3-aminobutyric acid A receptor subtypes","volume":"401","author":"Rudolph","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0301-0082(02)00013-8","article-title":"Drug interactions at GABAA receptors","volume":"67","author":"Korpi","year":"2002","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib13","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1074\/jbc.M311371200","article-title":"On the benzodiazepine binding pocket in GABAA receptors","volume":"279","author":"Berezhnoy","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib14","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/j.1471-4159.2004.02913.x","article-title":"Conformational changes at benzodiazepine binding sites of GABAA receptors detected with a novel technique","volume":"92","author":"Berezhnoy","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0028-3908(92)90020-P","article-title":"The effect of benzodiazepines on the binding of [3H]SCH 23390 in vivo","volume":"31","author":"Inoue","year":"1992","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0028-3908(93)90154-U","article-title":"An increase in the in vivo binding of [3H]SCH 23390 induced by MK-801 in the mouse striatum","volume":"32","author":"Kobayashi","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib17","first-page":"424","article-title":"Effects of barbiturates and ethanol on the physical properties of brain membranes","volume":"223","author":"Harris","year":"1982","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib18","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0278-5846(92)90100-S","article-title":"Effect of sedative drugs upon receptor binding in vivo","volume":"16","author":"Inoue","year":"1992","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib19","first-page":"118","article-title":"Concept of reaction volume in the in vivo ligand\u2013receptor model","volume":"37","author":"Delforge","year":"1996","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1615\/CritRevNeurobiol.v13.i2.40","article-title":"Changes in apparent rates of receptor binding in the intact brain in relation to the heterogeneity of reaction environments","volume":"13","author":"Inoue","year":"1999","journal-title":"Crit Rev Neurobiol"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib21","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0028-3908(85)90122-4","article-title":"The interaction between benzodiazepine antagonists and barbiturate-induced cerebrovascular and cerebral metabolic depression","volume":"24","author":"Albrecht","year":"1985","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib22","first-page":"H110","article-title":"Variation in local cerebral blood flow response to high-dose pentobarbital sodium in the rat","volume":"261","author":"Otsuka","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s007020050154","article-title":"Discrepancy of benzodiazepine receptor occupancy between [3H]flumazenil and [125I]iomazenil in intact mouse brain","volume":"106","author":"Hosoi","year":"1999","journal-title":"J Neural Transm"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF02988604","article-title":"Different sensitivities to competitive inhibition of benzodiazepine receptor binding of [11C]iomazenil and [11C]flumazenil in rhesus monkey brain","volume":"15","author":"Inoue","year":"2001","journal-title":"Ann Nucl Med"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib25","first-page":"1593","article-title":"Visualization of specific binding sites of benzodiazepine in human brain","volume":"27","author":"Shinotoh","year":"1986","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib26","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0022-3956(85)90080-9","article-title":"Imaging of [11C]-labelled Ro15-1788 binding to benzodiazepine receptors in the human brain by positron emission tomography","volume":"19","author":"Persson","year":"1985","journal-title":"J Psychiat Res"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0014-2999(85)90218-3","article-title":"Kinetics and displacement of [11C]Ro15-1788, a benzodiazepine antagonist, studied in human brain in vivo by positron tomography","volume":"110","author":"Samson","year":"1985","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib28","first-page":"457","article-title":"Clinical utility of [11C]-flumazenil positron emission tomography in intractable temporal lobe epilepsy","volume":"52","author":"Padma","year":"2004","journal-title":"Neurology (India)"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib29","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s00259-004-1458-4","article-title":"Use of a standardized uptake value for parametric in vivo imaging of benzodiazepine receptor distribution on [11C]-flumazenil brain PET","volume":"31","author":"Tsukamoto","year":"2004","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.nucmedbio.2006.02.002_bib30","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1213\/01.ANE.0000135409.81842.31","article-title":"Sevoflurane and propofol increase [11C]-flumazenil binding to gamma-aminobutyric acid A receptors in humans","volume":"99","author":"Salmi","year":"2004","journal-title":"Anesth Analg"}],"container-title":["Nuclear Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805106000199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805106000199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T16:21:53Z","timestamp":1555604513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969805106000199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0969805106000199"],"URL":"https:\/\/doi.org\/10.1016\/j.nucmedbio.2006.02.002","relation":{},"ISSN":["0969-8051"],"issn-type":[{"value":"0969-8051","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}