{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:20:53Z","timestamp":1790871653937,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuclear Medicine and Biology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.nucmedbio.2011.09.006","type":"journal-article","created":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T14:49:33Z","timestamp":1323701373000},"page":"347-359","source":"Crossref","is-referenced-by-count":27,"title":["Difficulties in dopamine transporter radioligand PET analysis: the example of LBT-999 using [18F] and [11C] labelling"],"prefix":"10.1016","volume":"39","author":[{"given":"Marie-Anne","family":"Peyronneau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wadad","family":"Saba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Doll\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Goutal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Coulon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Bottlaender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ric","family":"Valette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.nucmedbio.2011.09.006_bb0005","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/jlcr.1092","article-title":"Radiosynthesis of [18F]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET","volume":"49","author":"Doll\u00e9","year":"2006","journal-title":"J Label Compds Radiopharm"},{"issue":"8","key":"10.1016\/j.nucmedbio.2011.09.006_bb0010","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/jlcr.1412","article-title":"One-step radiosynthesis of [18F]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET","volume":"50","author":"Doll\u00e9","year":"2007","journal-title":"J Label Compds Radiopharm"},{"issue":"Suppl 1","key":"10.1016\/j.nucmedbio.2011.09.006_bb0015","first-page":"S279","article-title":"Production of the DAT PET-radioligand [18F]LBT-999 on a TRACERLab FX-FN synthesizer","volume":"52","author":"Kuhnast","year":"2009","journal-title":"J Label Compounds Radiopharm"},{"issue":"4","key":"10.1016\/j.nucmedbio.2011.09.006_bb0020","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.bmc.2005.09.035","article-title":"Synthesis, radiosynthesis and in vivo preliminary evaluation of [11C]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET","volume":"14","author":"Doll\u00e9","year":"2006","journal-title":"Bioorg Med Chem"},{"issue":"1","key":"10.1016\/j.nucmedbio.2011.09.006_bb0025","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1124\/jpet.105.096792","article-title":"Pharmacological characterization of (E)-N-(4-fluorobut-2-enyl)-2beta-carbomethoxy-3beta-(4\u2032tolyl)nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter","volume":"317","author":"Chalon","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1016\/j.nucmedbio.2011.09.006_bb0030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/syn.20337","article-title":"[11C]LBT-999: A suitable radioligand for investigation of extra-striatal dopamine transporter with PET","volume":"61","author":"Saba","year":"2007","journal-title":"Synapse"},{"issue":"17","key":"10.1016\/j.nucmedbio.2011.09.006_bb0035","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.2174\/156802606778249775","article-title":"Dopamine transporter ligands: recent developments and therapeutic potential","volume":"6","author":"Runyon","year":"2006","journal-title":"Curr Top Med Chem"},{"issue":"5","key":"10.1016\/j.nucmedbio.2011.09.006_bb0040","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.nucmedbio.2007.04.007","article-title":"New 2-alpha-tropane amides as potential PET ligands for the dopamine transporter","volume":"34","author":"Drewes","year":"2007","journal-title":"Nucl Med Biol"},{"issue":"2","key":"10.1016\/j.nucmedbio.2011.09.006_bb0045","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.nucmedbio.2006.11.005","article-title":"Evaluation of novel tropane analogues in comparison with the binding characteristics of [18F]FP-CIT and [131I]beta-CIT","volume":"34","author":"Sihver","year":"2007","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.nucmedbio.2011.09.006_bb0050","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1021\/jm960795d","article-title":"Synthesis and ligand binding of nortropane derivatives","volume":"40","author":"Emond","year":"1997","journal-title":"J Med Chem"},{"key":"10.1016\/j.nucmedbio.2011.09.006_bb0055","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0022-3565(24)35151-1","article-title":"Pharmacological characterization of (E)-N-(3-iodoprop-2-enyl)-2\u03b2-carbomethoxy-3\u03b2-(4'-methylphenyl)nortropane as a selective and potent inhibitor of the neuronal dopamine transporter","volume":"291","author":"Chalon","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"issue":"10","key":"10.1016\/j.nucmedbio.2011.09.006_bb0060","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/1099-1344(200009)43:10<997::AID-JLCR385>3.0.CO;2-#","article-title":"Highly efficient synthesis of [11C]PE2I, a selective radioligand for the quantification of the dopamine transporter using PET","volume":"43","author":"Doll\u00e9","year":"2000","journal-title":"J Label Compds Radiopharm"},{"issue":"7","key":"10.1016\/j.nucmedbio.2011.09.006_bb0065","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/00004647-200107000-00003","article-title":"Anatomic and biochemical correlates of the dopamine transporter ligand 11C-PE2I in normal and parkinsonian primates: comparison with 6-[18F]fluoro-l-dopa","volume":"21","author":"Poyot","year":"2001","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"10.1016\/j.nucmedbio.2011.09.006_bb0070","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.nucmedbio.2007.02.005","article-title":"Whole-body distribution and radiation dosimetry of the dopamine transporter radioligand [11C]PE2I in healthy volunteers","volume":"34","author":"Ribeiro","year":"2007","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.nucmedbio.2011.09.006_bb0075","first-page":"S400","article-title":"Synthesis, characterization and in vivo evaluation of (N-((E)-4 [18F]fluorobut-2-en-1-yl)-2\u03b2-carbomethoxy-3\u03b2-(4-substituted-phenyl)nortropanes for imaging DAT by PET","volume":"42","author":"Chen","year":"1999","journal-title":"J Labeled Cmpds Radiopharm"},{"issue":"1","key":"10.1016\/j.nucmedbio.2011.09.006_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0969-8051(99)00080-3","article-title":"18F-Labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters","volume":"27","author":"Goodman","year":"2000","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.nucmedbio.2011.09.006_bb0085","series-title":"Substrate oxidation by cytochrome P450 enzymes, in cytochrome P450: structure, mechanism, and biochemistry","first-page":"183","author":"Ortiz De Montellano","year":"2005"},{"issue":"4","key":"10.1016\/j.nucmedbio.2011.09.006_bb0090","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/jbt.20174","article-title":"Mechanisms of cytochrome P450 substrate oxidation: minireview","volume":"21","author":"Guengerich","year":"2007","journal-title":"J Biochem Mol Toxicol"},{"issue":"3","key":"10.1016\/j.nucmedbio.2011.09.006_bb0095","first-page":"520","article-title":"PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements","volume":"47","author":"Zoghbi","year":"2006","journal-title":"J Nucl Med"},{"issue":"5","key":"10.1016\/j.nucmedbio.2011.09.006_bb0100","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00259-006-0277-1","article-title":"Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I","volume":"34","author":"Shetty","year":"2007","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"5","key":"10.1016\/j.nucmedbio.2011.09.006_bb0105","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0969-8051(96)00061-3","article-title":"Characterization of the radioactive metabolites of the 5-HT1A receptor radioligand, [O-methyl-11C]-WAY-100635, in monkey and human plasma by HPLC","volume":"23","author":"Osman","year":"1996","journal-title":"Nucl Med Biol"},{"issue":"2","key":"10.1016\/j.nucmedbio.2011.09.006_bb0110","first-page":"345","article-title":"PET imaging of brain 5-HT1A receptors in rat in vivo with 18F-FCWAY and improvement by successful inhibition of radioligand defluorination with miconazole","volume":"47","author":"Tipre","year":"2006","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2011.09.006_bb0115","doi-asserted-by":"crossref","first-page":"T132","DOI":"10.1016\/j.neuroimage.2006.04.116","article-title":"[18F]LBT-999, A new radioligand to study the dopamine transporter with PET: characterization in baboons","volume":"31","author":"Saba","year":"2006","journal-title":"NeuroImage"},{"key":"10.1016\/j.nucmedbio.2011.09.006_bb0120","doi-asserted-by":"crossref","unstructured":"Saba W, Peyronneau M-A, Doll\u00e9 F, Goutal S, Bottlaender M, and Valette H. Difficulties in dopamine transporter radioligand PET analysis: the example of LBT-999 using [18F] and [11C] labelling: Part I. PET studies. Nucl Med Biol (2011) (epub ahead of print).","DOI":"10.1016\/j.nucmedbio.2011.08.003"},{"key":"10.1016\/j.nucmedbio.2011.09.006_bb0125","first-page":"S304","article-title":"Metabolism of [18F]LBT-999, a selective ligand for PET examination of the dopamine transporter","volume":"33","author":"Schollhorn-Peyronneau","year":"2006","journal-title":"Eur J Nucl Med Mol Imag"},{"issue":"3","key":"10.1016\/j.nucmedbio.2011.09.006_bb0130","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1432-1033.1981.tb05561.x","article-title":"Cytochrome P-450 monooxygenase activities in human and rat liver microsomes","volume":"118","author":"Kremers","year":"1981","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.nucmedbio.2011.09.006_bb0135","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","article-title":"The carbon monoxide binding pigment of liver microsomes: I. Evidence for its hemoprotein nature","volume":"239","author":"Omura","year":"1964","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nucmedbio.2011.09.006_bb0140","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/jms.511","article-title":"Strategy for structural elucidation of drugs and drug metabolites using (MS)n fragmentation in an electrospray ion trap","volume":"38","author":"Tozuka","year":"2003","journal-title":"J Mass Spectrom"},{"issue":"8","key":"10.1016\/j.nucmedbio.2011.09.006_bb0145","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1021\/jm040185a","article-title":"Synthesis and monoamine transporter binding properties of 3beta-(3\u2032,4\u2032-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters","volume":"48","author":"Carroll","year":"2005","journal-title":"J Med Chem"},{"issue":"8","key":"10.1016\/j.nucmedbio.2011.09.006_bb0150","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.tips.2009.05.005","article-title":"PET radiotracers: crossing the blood\u2013brain barrier and surviving metabolism","volume":"30","author":"Pike","year":"2009","journal-title":"Trends Pharmacol Sci"}],"container-title":["Nuclear Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805111002198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805111002198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T14:53:03Z","timestamp":1742050383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969805111002198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0969805111002198"],"URL":"https:\/\/doi.org\/10.1016\/j.nucmedbio.2011.09.006","relation":{},"ISSN":["0969-8051"],"issn-type":[{"value":"0969-8051","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}