{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:44:57Z","timestamp":1790847897480,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["PZ00P3_121772"],"award-info":[{"award-number":["PZ00P3_121772"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["PZ00P3_138834"],"award-info":[{"award-number":["PZ00P3_138834"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","nucmedbio.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nuclear Medicine and Biology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.nucmedbio.2014.10.010","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T19:16:51Z","timestamp":1414523811000},"page":"226-233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Investigation of the chick embryo as a potential alternative to the mouse for evaluation of radiopharmaceuticals"],"prefix":"10.1016","volume":"42","author":[{"given":"Stephanie","family":"Haller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon M.","family":"Ametamey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Schibli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0005","series-title":"The principles of humane experimental technique","author":"Russell","year":"1959"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0010","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/bies.200800168","article-title":"The chick embryo: hatching a model for contemporary biomedical research","volume":"31","author":"Rashidi","year":"2009","journal-title":"BioEssays"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0015","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.addr.2007.04.019","article-title":"The chick embryo and its chorioallantoic membrane (CAM) for the in vivo evaluation of drug delivery systems","volume":"59","author":"Vargas","year":"2007","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0020","doi-asserted-by":"crossref","first-page":"9959","DOI":"10.3390\/ijms13089959","article-title":"Chick chorioallantoic membrane (CAM) assay as an in vivo model to study the effect of newly identified molecules on ovarian cancer invasion and metastasis","volume":"13","author":"Lokman","year":"2012","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0025","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/dvdy.24093","article-title":"The chick embryo as an expanding experimental model for cancer and cardiovascular research","volume":"243","author":"Kain","year":"2014","journal-title":"Dev Dyn"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0030","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s11307-012-0550-6","article-title":"Insights into bone metabolism of avian embryos in ovo via 3D and 4D 18F-fluoride positron emission tomography","volume":"14","author":"W\u00fcrbach","year":"2012","journal-title":"Mol Imaging Biol"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0035","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.2967\/jnumed.112.117150","article-title":"In vivo PET\/CT in a human glioblastoma chicken chorioallantoic membrane model: a new tool for oncology and radiotracer development","volume":"54","author":"Warnock","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0040","first-page":"371","article-title":"Dynamic behaviour of selected PET tracers in embryonated chicken eggs","volume":"32","author":"Gebhardt","year":"2013","journal-title":"Rev Esp Med Nucl Imagen Mol"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0045","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1021\/bc300483a","article-title":"Radiosynthesis and preclinical evaluation of 3\u2032-aza-2\u2032-[18F]fluorofolic acid: a novel PET radiotracer for folate receptor targeting","volume":"24","author":"Betzel","year":"2013","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0050","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1021\/mp200511t","article-title":"Radioiodinated folic acid conjugates: evaluation of a valuable concept to improve tumor-to-background contrast","volume":"9","author":"Reber","year":"2012","journal-title":"Mol Pharm"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0055","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0969-8051(00)00196-7","article-title":"Development of an in vitro model for assessing the in vivo stability of lanthanide chelates","volume":"28","author":"Li","year":"2001","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0060","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1007\/s00259-006-0118-2","article-title":"In vitro and in vivo targeting of different folate receptor-positive cancer cell lines with a novel 99mTc-radiofolate tracer","volume":"33","author":"M\u00fcller","year":"2006","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0065","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2533\/chimia.2012.201","article-title":"Development of [18F]-PSS223 as a PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGluR5)","volume":"66","author":"Sephton","year":"2012","journal-title":"Chimia"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0070","first-page":"14","article-title":"Synthesis, radiolabelling and in vitro and in vivo evaluation of a novel fluorinated ABP688 derivative for the PET imaging of metabotropic glutamate receptor subtype 5","volume":"2","author":"Sephton","year":"2012","journal-title":"Am Nucl Med Mol Imaging"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0075","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1007\/s00259-011-1818-9","article-title":"Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607","volume":"38","author":"Ocak","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0080","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2967\/jnumed.112.107235","article-title":"DOTA conjugate with an albumin-binding entity enables the first folic acid-targeted 177Lu-radionuclide tumor therapy in mice","volume":"54","author":"M\u00fcller","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0085","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s00259-002-1054-4","article-title":"The addition of DTPA to [177Lu-DOTA0, Tyr3]-octreotate prior to administration reduces rat skeleton uptake of radioactivity","volume":"30","author":"Breeman","year":"2003","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0090","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0969-8051(94)00117-3","article-title":"Fluorinated benzamide neuroleptics\u2013III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer","volume":"22","author":"Mukherjee","year":"1995","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0095","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.2967\/jnumed.112.114926","article-title":"Evaluation of the Genisys4, a bench-top preclinical PET scanner","volume":"54","author":"Herrmann","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0100","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S1055-937X(98)80044-3","article-title":"Comparative renal function in reptiles, birds, and mammals","volume":"7","author":"Braun","year":"1998","journal-title":"Semin Avian Exot Pet"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0105","series-title":"The atlas of chick development","author":"Bellairs","year":"2005"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0110","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/syn.10128","article-title":"Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2\/D-3 receptors","volume":"46","author":"Mukherjee","year":"2002","journal-title":"Synapse"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0115","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1089\/thy.2011.0348","article-title":"Micro-single-photon emission computed tomography image acquisition and quantification of sodium-iodide symporter-mediated radionuclide accumulation in mouse thyroid and salivary glands","volume":"22","author":"Brandt","year":"2012","journal-title":"Thyroid"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0120","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1089\/thy.2009.0213","article-title":"Distribution and dynamics of 99mTc-pertechnetate uptake in the thyroid and other organs assessed by single-photon emission computed tomography in living mice","volume":"20","author":"Franken","year":"2010","journal-title":"Thyroid"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0125","first-page":"244","article-title":"The sodium\/iodide symporter: state of the art of its molecular characterization","volume":"2014","author":"Darrouzet","year":"1838","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0130","doi-asserted-by":"crossref","first-page":"590","DOI":"10.2967\/jnumed.112.114298","article-title":"Dynamic bone imaging with 99mTc-labeled diphosphonates and 18F-NaF: mechanisms and applications","volume":"54","author":"Wong","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0135","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0047-0740(78)90087-6","article-title":"Organ distribution studies of lutetium-177 in mouse","volume":"5","author":"M\u00fcller","year":"1978","journal-title":"Int J Nucl Med Biol"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0140","first-page":"249","article-title":"The basics of renal imaging and function studies","volume":"46","author":"Durand","year":"2002","journal-title":"Q J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0145","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1039\/an9952000863","article-title":"Technetium-99m chelators in nuclear medicine. A review","volume":"120","author":"Hjelstuen","year":"1995","journal-title":"Analyst"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0150","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2967\/jnumed.112.110528","article-title":"Renal uptake of 99mTc-dimercaptosuccinic acid is dependent on normal proximal tubule receptor-mediated endocytosis","volume":"54","author":"Weyer","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0155","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nrendo.2009.105","article-title":"Peptide-receptor radionuclide therapy for endocrine tumors","volume":"5","author":"van Essen","year":"2009","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0160","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s002590100502","article-title":"Somatostatin receptor-mediated imaging and therapy: basic science, current knowledge, limitations and future perspectives","volume":"28","author":"Breeman","year":"2001","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0165","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1007\/s00259-005-1793-0","article-title":"Localisation and mechanism of renal retention of radiolabelled somatostatin analogues","volume":"32","author":"Melis","year":"2005","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0170","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/bj2800267","article-title":"High-affinity folate binding in human choroid plexus. Characterization of radioligand binding, immunoreactivity, molecular heterogeneity and hydrophobic domain of the binding protein","volume":"280","author":"Holm","year":"1991","journal-title":"Biochem J"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0175","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ab.2004.12.026","article-title":"Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay","volume":"338","author":"Parker","year":"2005","journal-title":"Anal Biochem"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0180","doi-asserted-by":"crossref","first-page":"624","DOI":"10.2967\/jnumed.112.108233","article-title":"In vivo visualization and quantification of (Disturbed) Oatp-mediated hepatic uptake and Mrp2-mediated biliary excretion of 99mTc-mebrofenin in mice","volume":"54","author":"Neyt","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0185","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/hep.1840090123","article-title":"Technetium-99m-iminodiacetic acid organic anions: review of biokinetics and clinical application in hepatology","volume":"9","author":"Krishnamurthy","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.nucmedbio.2014.10.010_bb0190","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s11095-008-9597-0","article-title":"Use of Tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies","volume":"25","author":"Ghibellini","year":"2008","journal-title":"Pharm Res"}],"container-title":["Nuclear Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805114005320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805114005320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T15:06:59Z","timestamp":1565968019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969805114005320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0969805114005320"],"URL":"https:\/\/doi.org\/10.1016\/j.nucmedbio.2014.10.010","relation":{},"ISSN":["0969-8051"],"issn-type":[{"value":"0969-8051","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of the chick embryo as a potential alternative to the mouse for evaluation of radiopharmaceuticals","name":"articletitle","label":"Article Title"},{"value":"Nuclear Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nucmedbio.2014.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}