{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:12:48Z","timestamp":1756462368299},"reference-count":24,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP111118"],"award-info":[{"award-number":["MOP111118"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","nucmedbio.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nuclear Medicine and Biology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.nucmedbio.2016.07.006","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T04:19:54Z","timestamp":1469161194000},"page":"635-641","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Paradoxical effects of Auger electron-emitting 111 In-DTPA-NLS-CSL360 radioimmunoconjugates on hCD45 + cells in the bone marrow and spleen of leukemia-engrafted NOD\/SCID or NRG mice"],"prefix":"10.1016","volume":"43","author":[{"given":"Dane","family":"Bergstrom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey V.","family":"Leyton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arman","family":"Zereshkian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conrad","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongli","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond M.","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0005","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.exphem.2009.04.002","article-title":"Acute myelogenous leukemia","volume":"37","author":"Shipley","year":"2009","journal-title":"Exp Hematol"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0010","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1053\/j.semnuclmed.2015.10.007","article-title":"Radioimmunotherapy for treatment of acute leukemia","volume":"46","author":"Bodet-Milin","year":"2016","journal-title":"Semin Nucl Med"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0015","article-title":"Radioimmunotherapy of cancer with high linear energy transfer (LET) radiation delivered by radionuclides emitting alpha-particles or auger electrons","author":"Aghevlian","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0020","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1038\/sj.leu.2401903","article-title":"The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells","volume":"14","author":"Jordan","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0025","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","volume":"3","author":"Bonnet","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0030","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/leu.2008.246","article-title":"Targeting the leukemic stem cell: the holy grail of leukemia therapy","volume":"23","author":"Misaghian","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0035","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1182\/blood.V87.1.83.83","article-title":"Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor \u03b1-chain and functions as a specific IL-3 receptor antagonist","volume":"87","author":"Sun","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0040","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.2967\/jnumed.111.087668","article-title":"Auger electron radioimmunotherapeutic agent specific for the CD123+\/CD131\u2212 phenotype of the leukemia stem cell population","volume":"52","author":"Leyton","year":"2011","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0045","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.leukres.2014.09.005","article-title":"MicroSPECT\/CT imaging of primary human AML engrafted into the bone marrow and spleen of NOD\/SCID mice using 111In-DTPA-NLS-CSL360 radioimmunoconjugates recognizing the CD123+\/CD131\u2212 epitope expressed by leukemia stem cells","volume":"38","author":"Leyton","year":"2014","journal-title":"Leuk Res"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0050","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.nucmedbio.2014.02.003","article-title":"The human polynucleotide kinase\/phosphatase (hPNKP) inhibitor A12B4C3 radiosensitizes human myeloid leukemia cells to Auger electron-emitting anti-CD123 111In-NLS-7G3 radioimmunoconjugates","volume":"41","author":"Zereshkian","year":"2014","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.apradiso.2015.12.043","article-title":"Auger electron-emitting In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute myeloid leukemia (AML) cells displaying the CD123\/CD131 phenotype of leukemia stem cells","volume":"110","author":"Gao","year":"2015","journal-title":"Appl Radiat Isot"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0060","first-page":"55","article-title":"A radiolabeled antibody targeting CD123(+) leukemia stem cells - initial radioimmunotherapy studies in NOD\/SCID mice engrafted with primary human AML","volume":"4","author":"Leyton","year":"2015","journal-title":"Leuk Res Rep"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0065","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1073\/pnas.88.4.1394","article-title":"Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair","volume":"88","author":"Biedermann","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0070","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.stem.2009.04.018","article-title":"Monoclonal antibody-mediated targeting of CD123, IL-3 receptor \u03b1 chain, eliminates human acute myeloid leukemic stem cells","volume":"5","author":"Jin","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0075","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/nm1483","article-title":"Targeting of CD44 eradicates human acute myeloid leukemic stem cells","volume":"12","author":"Jin","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0080","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1365-2249.2008.03753.x","article-title":"Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment","volume":"154","author":"Pearson","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0085","series-title":"Leukemic stem cell-targeting Auger electron radioimmunotherapeutic agent for acute myeloid leukemia","author":"Bergstrom","year":"2014"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0090","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1182\/blood-2014-11-612770","article-title":"Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model","volume":"125","author":"Green","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0095","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00259-015-3175-6","article-title":"High treatment efficacy by dual targeting of Burkitt's lymphoma xenografted mice with a 177Lu-based CD22-specific radioimmunoconjugate and rituximab","volume":"43","author":"Weber","year":"2016","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0100","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s10620-014-3168-5","article-title":"NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer","volume":"59","author":"Maykel","year":"2014","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0105","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.4049\/jimmunol.136.12.4438","article-title":"Full reconstitution of the immune deficiency in scid mice with normal stem cells requires low-dose irradiation of the recipients","volume":"136","author":"Fulop","year":"1986","journal-title":"J Immunol"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0110","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1126\/science.2595371","article-title":"A model of human acute lymphoblastic leukemia in immune-deficient SCID mice","volume":"246","author":"Kamel-Reid","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0115","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1182\/blood-2011-05-353243","article-title":"Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rgamma null mice is enhanced by transgenic expression of membrane-bound human SCF","volume":"119","author":"Brehm","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.nucmedbio.2016.07.006_bb0120","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fimmu.2013.00076","article-title":"Natural killer cell mediated antibody-dependent cellular cytotoxicity in tumor immunotherapy with therapeutic antibodies","volume":"4","author":"Seidel","year":"2013","journal-title":"Front Immunol"}],"container-title":["Nuclear Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805116302049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805116302049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T09:09:06Z","timestamp":1692436146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969805116302049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0969805116302049"],"URL":"https:\/\/doi.org\/10.1016\/j.nucmedbio.2016.07.006","relation":{},"ISSN":["0969-8051"],"issn-type":[{"value":"0969-8051","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paradoxical effects of Auger electron-emitting 111In-DTPA-NLS-CSL360 radioimmunoconjugates on hCD45+ cells in the bone marrow and spleen of leukemia-engrafted NOD\/SCID or NRG mice","name":"articletitle","label":"Article Title"},{"value":"Nuclear Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nucmedbio.2016.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}