{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:26:00Z","timestamp":1793838360889,"version":"4.6.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Center for Translational Molecular Medicine\u2013Mammary Carcinoma Molecular Imaging for Diagnosis and Therapeutics","award":["2010249"],"award-info":[{"award-number":["2010249"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","nucmedbio.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nuclear Medicine and Biology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.nucmedbio.2017.09.001","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T06:16:22Z","timestamp":1505369782000},"page":"19-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["DOTA-tetrazine probes with modified linkers for tumor pretargeting"],"prefix":"10.1016","volume":"55","author":[{"given":"Tilman","family":"L\u00e4ppchen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Rossin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiemen R.","family":"van Mourik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Gruntz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freek J.M.","family":"Hoeben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron M.","family":"Versteegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk M.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Lub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc S.","family":"Robillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0005","first-page":"13","article-title":"Radioimmunotherapy for non-Hodgkin's lymphoma; positioning, safety, and efficacy of 90Y-Ibritumomab. 10 years of experience and follow-up","volume":"36","author":"Martinez","year":"2017","journal-title":"Rev Esp Med Nucl Imagen Mol"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0010","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrc3925","article-title":"Radioimmunotherapy of human tumours","volume":"15","author":"Larson","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2013.00159","article-title":"Improvement of radioimmunotherapy using pretargeting","volume":"3","author":"Frampas","year":"2013","journal-title":"Front Oncol"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0020","article-title":"Pretargeted imaging and radioimmunotherapy of cancer using antibodies and bioorthogonal chemistry","volume":"1","author":"van de Watering","year":"2014","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0025","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1158\/1535-7163.MCT-09-0862","article-title":"Pretargeted immuno-positron emission tomography imaging of carcinoembryonic antigen-expressing tumors with a bispecific antibody and a 68Ga- and 18F-labeled hapten peptide in mice with human tumor xenografts","volume":"9","author":"Schoffelen","year":"2010","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0030","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s41181-017-0026-8","article-title":"Pretargeting for imaging and therapy in oncological nuclear medicine","volume":"2","author":"Bailly","year":"2017","journal-title":"EJNMMI Radiopharm Chem"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0035","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00259-002-1089-6","article-title":"Radioimmunotherapy: is avidin-biotin pretargeting the preferred choice among pretargeting methods?","volume":"30","author":"Goldenberg","year":"2003","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0040","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cbpa.2014.07.023","article-title":"Pretargeted imaging using bioorthogonal chemistry in mice","volume":"21","author":"Rossin","year":"2014","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0045","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1021\/acs.bioconjchem.6b00561","article-title":"Click chemistry and radiochemistry: the first 10 years","volume":"27","author":"Meyer","year":"2016","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0050","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1002\/anie.200906294","article-title":"In vivo chemistry for pretargeted tumor imaging in live mice","volume":"49","author":"Rossin","year":"2010","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0055","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1073\/pnas.1113466109","article-title":"Reactive polymer enables efficient in vivo bioorthogonal chemistry","volume":"109","author":"Devaraj","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0060","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2967\/jnumed.112.115840","article-title":"A pretargeted PET imaging strategy based on bioorthogonal Diels\u2013Alder click chemistry","volume":"54","author":"Zeglis","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0065","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.2967\/jnumed.113.123745","article-title":"Diels\u2013Alder reaction for tumor pretargeting: in vivo chemistry can boost tumor radiation dose compared with directly labeled antibody","volume":"54","author":"Rossin","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0070","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1021\/bc400153y","article-title":"Highly reactive trans-cyclooctene tags with improved stability for Diels\u2013Alder chemistry in living systems","volume":"24","author":"Rossin","year":"2013","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0075","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1021\/mp500275a","article-title":"Trans-cyclooctene tag with improved properties for tumor pretargeting with the Diels\u2013Alder reaction","volume":"11","author":"Rossin","year":"2014","journal-title":"Mol Pharm"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0080","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1021\/acs.molpharmaceut.5b00294","article-title":"Optimization of a pretargeted strategy for the PET imaging of colorectal carcinoma via the modulation of radioligand pharmacokinetics","volume":"12","author":"Zeglis","year":"2015","journal-title":"Mol Pharm"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0085","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1021\/acs.bioconjchem.5b00504","article-title":"(18)F-based pretargeted PET imaging based on bioorthogonal Diels\u2013Alder click chemistry","volume":"27","author":"Meyer","year":"2016","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0090","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2967\/jnumed.115.163824","article-title":"Pretargeted immuno-PET of pancreatic cancer: overcoming circulating antigen and internalized antibody to reduce radiation doses","volume":"57","author":"Houghton","year":"2016","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0095","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1158\/1535-7163.MCT-16-0503","article-title":"Establishment of the in vivo efficacy of pretargeted radioimmunotherapy utilizing inverse electron demand Diels\u2013Alder click chemistry","volume":"16","author":"Houghton","year":"2017","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0100","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1021\/bc200298v","article-title":"Synthesis of phosphine and antibody-azide probes for in vivo Staudinger ligation in a pretargeted imaging and therapy approach","volume":"22","author":"Vugts","year":"2011","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0105","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1096\/fj.10-178590","article-title":"Imaging sialylated tumor cell glycans in vivo","volume":"25","author":"Neves","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0110","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.nucmedbio.2012.12.006","article-title":"Evaluation of strained alkynes for Cu-free click reaction in live mice","volume":"40","author":"van den Bosch","year":"2013","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0115","doi-asserted-by":"crossref","first-page":"9557","DOI":"10.1039\/C4CC03903C","article-title":"A bioorthogonal (68)Ga-labelling strategy for rapid in vivo imaging","volume":"50","author":"Evans","year":"2014","journal-title":"Chem Commun (Camb)"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0120","doi-asserted-by":"crossref","first-page":"9655","DOI":"10.1002\/anie.201404277","article-title":"Development of a 18F-labeled tetrazine with favorable pharmacokinetics for bioorthogonal PET imaging","volume":"53","author":"Denk","year":"2014","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0125","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1039\/c3cc41027g","article-title":"Development of a (11)C-labeled tetrazine for rapid tetrazine-trans-cyclooctene ligation","volume":"49","author":"Herth","year":"2013","journal-title":"Chem Commun (Camb)"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0130","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1021\/acs.bioconjchem.6b00234","article-title":"Design, synthesis, and evaluation of a low-molecular-weight (11)C-labeled tetrazine for pretargeted PET imaging applying bioorthogonal in vivo click chemistry","volume":"27","author":"Denk","year":"2016","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0135","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.bmc.2016.01.046","article-title":"(99m)Tc-bioorthogonal click chemistry reagent for in vivo pretargeted imaging","volume":"24","author":"Garcia","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0140","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1021\/acs.bioconjchem.5b00609","article-title":"(125)I-tetrazines and inverse-electron-demand Diels\u2013Alder chemistry: a convenient radioiodination strategy for biomolecule labeling, screening, and biodistribution studies","volume":"27","author":"Albu","year":"2016","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0145","first-page":"887","article-title":"Melanoma targeting with DOTA-alpha-melanocyte-stimulating hormone analogs: structural parameters affecting tumor uptake and kidney uptake","volume":"46","author":"Froidevaux","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0150","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0969-8051(01)00241-4","article-title":"Effect of molecular charges on renal uptake of 111In-DTPA-conjugated peptides","volume":"28","author":"Akizawa","year":"2001","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0155","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1021\/acsmedchemlett.5b00330","article-title":"A new highly reactive and low lipophilicity fluorine-18 labeled tetrazine derivative for pretargeted PET imaging","volume":"7","author":"Kein\u00e4nen","year":"2016","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0160","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1021\/jo9518563","article-title":"Substituent effects on an inverse electron demand hetero Diels\u2212Alder reaction in aqueous solution and organic solvents: cycloaddition of substituted styrenes to di(2-pyridyl)-1,2,4,5-tetrazine","volume":"61","author":"Wijnen","year":"1996","journal-title":"J Org Chem"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0165","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.nucmedbio.2017.06.001","article-title":"Amide-to-triazole switch vs. in vivo NEP-inhibition approaches to promote radiopeptide targeting of GRPR-positive tumors","volume":"52","author":"Maina","year":"2017","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0170","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1007\/s00259-011-1818-9","article-title":"Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607","volume":"38","author":"Ocak","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0175","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1021\/bc9000189","article-title":"In vitro and in vivo metabolism of Lu-AMBA, a GRP-receptor binding compound, and the synthesis and characterization of its metabolites","volume":"20","author":"Linder","year":"2009","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0180","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.nucmedbio.2010.07.009","article-title":"Influence of biological assay conditions on stability assessment of radiometal-labelled peptides exemplified using a 177Lu-DOTA-minigastrin derivative","volume":"38","author":"Ocak","year":"2011","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0185","doi-asserted-by":"crossref","first-page":"7475","DOI":"10.1021\/acs.jmedchem.5b00994","article-title":"Probing the backbone function of tumor targeting peptides by an amide-to-triazole substitution strategy","volume":"58","author":"Valverde","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.nucmedbio.2017.09.001_bb0190","first-page":"287","article-title":"Radiolabeled gastrin\/CCK analogs in tumor diagnosis: towards higher stability and improved tumor targeting","volume":"59","author":"Kaloudi","year":"2015","journal-title":"Q J Nucl Med Mol Imaging"}],"container-title":["Nuclear Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805117301889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805117301889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T14:01:14Z","timestamp":1535378474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969805117301889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":38,"alternative-id":["S0969805117301889"],"URL":"https:\/\/doi.org\/10.1016\/j.nucmedbio.2017.09.001","relation":{},"ISSN":["0969-8051"],"issn-type":[{"value":"0969-8051","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DOTA-tetrazine probes with modified linkers for tumor pretargeting","name":"articletitle","label":"Article Title"},{"value":"Nuclear Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nucmedbio.2017.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}