{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:09:46Z","timestamp":1791230986055,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.numecd.2007.02.011","type":"journal-article","created":{"date-parts":[[2007,7,21]],"date-time":"2007-07-21T11:24:06Z","timestamp":1185017046000},"page":"409-414","source":"Crossref","is-referenced-by-count":213,"title":["Uric acid and oxidative stress: Relative impact on cardiovascular risk"],"prefix":"10.1016","volume":"17","author":[{"given":"Pasquale","family":"Strazzullo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Garcia","family":"Puig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.numecd.2007.02.011_bib1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1053\/j.ajkd.2003.12.023","article-title":"Effect of statins versus untreated dyslipidemia on serum uric acid levels in patients with coronary heart disease: a subgroup analysis of the GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) Study","volume":"43","author":"Athyros","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.numecd.2007.02.011_bib2","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1523-1755.2004.00484.x","article-title":"The impact of serum uric acid on cardiovascular outcomes in the LIFE study","volume":"65","author":"Hoieggen","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.numecd.2007.02.011_bib3","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1345\/aph.1D023","article-title":"Allopurinol as a cardioprotectant during coronary artery bypass graft surgery","volume":"37","author":"Weimert","year":"2003","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.numecd.2007.02.011_bib4","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1161\/hc4501.098928","article-title":"Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy","volume":"104","author":"Cappola","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2007.02.011_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1136\/heart.87.3.229","article-title":"Effect of allopurinol on mortality and hospitalizations in congestive heart failure: a retrospective cohort study","volume":"87","author":"Struthers","year":"2002","journal-title":"Heart"},{"key":"10.1016\/j.numecd.2007.02.011_bib6","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.7326\/0003-4819-34-6-1421","article-title":"Serum uric acid in relation to age and physique in health and in coronary heart disease","volume":"34","author":"Gertler","year":"1951","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.numecd.2007.02.011_bib7","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.numecd.2005.07.007","article-title":"Riskard 2005. New tools for prediction of cardiovascular disease risk derived from Italian population studies","volume":"15","author":"Menotti","year":"2005","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.numecd.2007.02.011_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.numecd.2004.12.001","article-title":"Definition of high risk individuals to optimise strategies for primary prevention of cardiovascular diseases","volume":"15","author":"Giampaoli","year":"2005","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.numecd.2007.02.011_bib9","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.amjmed.2005.03.043","article-title":"Serum uric acid and cardiovascular disease: recent developments, where do they leave us?","volume":"118","author":"Baker","year":"2005","journal-title":"Am J Med"},{"key":"10.1016\/j.numecd.2007.02.011_bib10","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.2174\/138161205774913200","article-title":"Serum uric acid and risk of coronary heart disease","volume":"11","author":"Wannamethee","year":"2005","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.numecd.2007.02.011_bib11","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/01.STR.29.3.635","article-title":"Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus","volume":"29","author":"Lehto","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.numecd.2007.02.011_bib12","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1053\/euhj.2001.2970","article-title":"Urate predicts subsequent cardiac death in stroke survivors","volume":"23","author":"Wong","year":"2002","journal-title":"Eur Heart J"},{"key":"10.1016\/j.numecd.2007.02.011_bib13","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/01.STR.0000081983.34771.D2","article-title":"Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke","volume":"34","author":"Weir","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.numecd.2007.02.011_bib14","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1161\/01.CIR.0000065637.10517.A0","article-title":"Uric acid and survival in chronic heart failure: validation and application in metabolic, functional and haemodynamic staging","volume":"107","author":"Anker","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2007.02.011_bib15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0002-9149(01)02155-5","article-title":"Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease","volume":"89","author":"Bickel","year":"2002","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.numecd.2007.02.011_bib16","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0891-5849(02)00956-5","article-title":"Structure and function of xanthine oxidoreductase: where are we now?","volume":"33","author":"Harrison","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.numecd.2007.02.011_bib17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/BF00163854","article-title":"Two independent mutational events in the loss of urate oxidase during hominoid evolution","volume":"34","author":"Wu","year":"1992","journal-title":"J Mol Evol"},{"key":"10.1016\/j.numecd.2007.02.011_bib18","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.2174\/138161205774913219","article-title":"Uric acid and the kidney: urate transport, stone disease and progressive renal failure","volume":"11","author":"Capasso","year":"2005","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.numecd.2007.02.011_bib19","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1097\/00004872-200112000-00007","article-title":"Altered renal sodium handling in men with abdominal adiposity and insulin resistance: a link to hypertension","volume":"19","author":"Strazzullo","year":"2001","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2007.02.011_bib20","first-page":"E1","article-title":"Effect of insulin on uric acid secretion in humans","volume":"268","author":"Quinines Galvan","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.numecd.2007.02.011_bib21","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/00004872-199917070-00001","article-title":"Uric acid as a cardiovascular risk factor in arterial hypertension","volume":"17","author":"Puig","year":"1999","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2007.02.011_bib22","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1001\/jama.270.3.354","article-title":"Uric acid metabolism and tubular sodium handling: results from a population-based study","volume":"270","author":"Cappuccio","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/j.numecd.2007.02.011_bib23","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1097\/01.hjh.0000239300.48130.07","article-title":"Abnormalities of renal sodium handling in the metabolic syndrome. Results of the Olivetti Heart Study","volume":"24","author":"Strazzullo","year":"2006","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2007.02.011_bib24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1042\/cs0740651","article-title":"Use of fractional lithium clearance in epidemiological and clinical investigation: a methodological assessment","volume":"74","author":"Strazzullo","year":"1988","journal-title":"Clin Sci"},{"key":"10.1016\/j.numecd.2007.02.011_bib25","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1097\/00004872-200309000-00034","article-title":"The increase in serum uric acid induced by diuretics could be beneficial to cardiovascular prognosis in hypertension: a hypothesis","volume":"21","author":"Reyes","year":"2003","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2007.02.011_bib26","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.2174\/138161205774913255","article-title":"Uric acid and oxidative stress","volume":"11","author":"Glantzounis","year":"2005","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.numecd.2007.02.011_bib27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00005344-200109000-00005","article-title":"Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers","volume":"38","author":"Waring","year":"2001","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.numecd.2007.02.011_bib28","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0891-5849(01)00631-1","article-title":"Allantoin formation and urate and glutathione exchange in human muscle during submaximal exercise","volume":"31","author":"Hellsten","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.numecd.2007.02.011_bib29","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1073\/pnas.0831097100","article-title":"Plasma antioxidant status and cell injury after physical exercise","volume":"100","author":"Chevion","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.numecd.2007.02.011_bib30","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0140-6736(05)60816-1","article-title":"Uric acid as an independent risk factor in the treatment of hypertension","volume":"352","author":"Ward","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2007.02.011_bib31","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1161\/01.HYP.0000072820.07472.3B","article-title":"Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2","volume":"41","author":"Kanellis","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.numecd.2007.02.011_bib32","doi-asserted-by":"crossref","unstructured":"Ferroni P, Basili S, Paoletti V, Dav\u00ec G. Endothelial dysfunction and oxidative stress in arterial hypertension. Nutr Metab Cardiovasc Dis;16:222\u201333.","DOI":"10.1016\/j.numecd.2005.11.012"},{"key":"10.1016\/j.numecd.2007.02.011_bib33","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.2174\/138161205774913246","article-title":"Uric acid and hypertension","volume":"11","author":"Schachter","year":"2005","journal-title":"Curr Pharm Des"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475307000543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475307000543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T11:25:52Z","timestamp":1556709952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475307000543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0939475307000543"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2007.02.011","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}