{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:47:36Z","timestamp":1791978456456,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.numecd.2008.09.004","type":"journal-article","created":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T08:48:58Z","timestamp":1229590138000},"page":"431-439","source":"Crossref","is-referenced-by-count":81,"title":["Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands"],"prefix":"10.1016","volume":"19","author":[{"given":"C.","family":"Murgia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Devirgiliis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Donadel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Zalewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Perozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2008.09.004_bib1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1152\/physrev.1993.73.1.79","article-title":"The biochemical basis of zinc physiology","volume":"73","author":"Vallee","year":"1993","journal-title":"Physiol Rev"},{"key":"10.1016\/j.numecd.2008.09.004_bib2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00018-003-3148-y","article-title":"Overview of mammalian zinc transporters","volume":"61","author":"Kambe","year":"2004","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.numecd.2008.09.004_bib3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF02829937","article-title":"The ZnT4 mutation in lethal milk mice affects intestinal zinc homeostasis through the expression of other Zn transporters","volume":"1","author":"Murgia","year":"2006","journal-title":"Genes Nutr"},{"key":"10.1016\/j.numecd.2008.09.004_bib4","doi-asserted-by":"crossref","first-page":"24085","DOI":"10.1074\/jbc.R600011200","article-title":"Mammalian zinc transport, trafficking, and signals","volume":"281","author":"Cousins","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.numecd.2008.09.004_bib5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/07315724.1998.10718735","article-title":"Zinc, insulin and diabetes","volume":"17","author":"Chausmer","year":"1998","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.numecd.2008.09.004_bib6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10534-005-3686-x","article-title":"Zinc, the pancreas, and diabetes: insights from rodent studies and future directions","volume":"18","author":"Taylor","year":"2005","journal-title":"Biometals"},{"key":"10.1016\/j.numecd.2008.09.004_bib7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mrfmmm.2007.01.013","article-title":"Zinc fluxes and zinc transporter genes in chronic diseases","volume":"622","author":"Devirgiliis","year":"2007","journal-title":"Mutat Res"},{"key":"10.1016\/j.numecd.2008.09.004_bib8","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1210\/er.2006-0007","article-title":"Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains","volume":"28","author":"Gromada","year":"2007","journal-title":"Endocr Rev"},{"key":"10.1016\/j.numecd.2008.09.004_bib9","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.2337\/diabetes.53.9.2330","article-title":"Identification and cloning of a \u03b2-cell-specific zinc transporter, ZnT8, localized into insulin secretory granules","volume":"53","author":"Chimienti","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2008.09.004_bib10","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1189\/jlb.0307148","article-title":"Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9","volume":"83","author":"Overbeck","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.numecd.2008.09.004_bib11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mce.2006.10.010","article-title":"Zinc-transporter genes in human visceral and subcutaneous adipocytes: lean versus obese","volume":"264","author":"Smidt","year":"2007","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.numecd.2008.09.004_bib12","doi-asserted-by":"crossref","first-page":"10184","DOI":"10.1074\/jbc.M707005200","article-title":"Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells","volume":"283","author":"Gyulkhandanyan","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.numecd.2008.09.004_bib13","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.1242\/jcs.03164","article-title":"In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion","volume":"119","author":"Chimienti","year":"2006","journal-title":"J Cell Sci"},{"key":"10.1016\/j.numecd.2008.09.004_bib14","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrg2178","article-title":"Genome-wide association studies provide new insights into type 2 diabetes aetiology","volume":"8","author":"Frayling","year":"2007","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.numecd.2008.09.004_bib15","doi-asserted-by":"crossref","first-page":"17040","DOI":"10.1073\/pnas.0705894104","article-title":"The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes","volume":"104","author":"Wenzlau","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.numecd.2008.09.004_bib16","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1177\/42.7.8014471","article-title":"Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc","volume":"42","author":"Zalewski","year":"1994","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.numecd.2008.09.004_bib17","doi-asserted-by":"crossref","first-page":"17743","DOI":"10.1074\/jbc.M602470200","article-title":"Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells","volume":"281","author":"Ishihara","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.numecd.2008.09.004_bib18","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1258\/0007142991902538","article-title":"Thyroid function","volume":"55","author":"Arthur","year":"1999","journal-title":"Br Med Bull"},{"key":"10.1016\/j.numecd.2008.09.004_bib19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF02789143","article-title":"Zinc acutely and temporarily inhibits adrenal cortisol secretion in humans. A preliminary report","volume":"24","author":"Brandao-Neto","year":"1990","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.numecd.2008.09.004_bib20","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.2337\/diab.43.12.1413","article-title":"Clonal insulinoma cell line that stably maintains correct glucose responsiveness","volume":"43","author":"Knaack","year":"1994","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2008.09.004_bib21","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2337\/diab.39.4.406","article-title":"Proglucagon processing similar to normal islets in pancreatic alpha-like cell line derived from transgenic mouse tumor","volume":"39","author":"Powers","year":"1990","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2008.09.004_bib22","first-page":"G1231","article-title":"Cloning, expression, and vesicular localization of zinc transporter Dri 27\/ZnT4 in intestinal tissue and cells","volume":"277","author":"Murgia","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.numecd.2008.09.004_bib23","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers","volume":"132","author":"Rozen","year":"2000","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.numecd.2008.09.004_bib24","series-title":"Methods in enzymology","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0076-6879(83)96012-3","article-title":"Immunoprecipitation of proteins from cell-free translations","author":"Anderson","year":"1983"},{"key":"10.1016\/j.numecd.2008.09.004_bib25","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1042\/bj2960403","article-title":"Correlation of apoptosis with change in intracellular labile Zn(II) using Zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II)","volume":"296","author":"Zalewski","year":"1993","journal-title":"Biochem J"},{"key":"10.1016\/j.numecd.2008.09.004_bib26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/1074-5521(94)90005-1","article-title":"Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe","volume":"3","author":"Zalewski","year":"1994","journal-title":"Zinquin. Chem Biol"},{"key":"10.1016\/j.numecd.2008.09.004_bib27","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2174\/138945006776818683","article-title":"Zinc and its specific transporters as potential targets in airway disease","volume":"7","author":"Murgia","year":"2006","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.numecd.2008.09.004_bib28","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1021\/pr050361j","article-title":"Counting the zinc-proteins encoded in the human genome","volume":"5","author":"Andreini","year":"2006","journal-title":"J Proteome Res"},{"key":"10.1016\/j.numecd.2008.09.004_bib29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12263-007-0061-2","article-title":"Sideways glance: genome wide association studies for type 2 diabetes mellitus","volume":"2","author":"Sambuy","year":"2007","journal-title":"Genes Nutr"},{"key":"10.1016\/j.numecd.2008.09.004_bib30","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nut.2003.09.005","article-title":"Diet\u2013disease gene interactions","volume":"20","author":"Kaput","year":"2004","journal-title":"Nutrition"},{"key":"10.1016\/j.numecd.2008.09.004_bib31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.numecd.2006.11.006","article-title":"Application of nutrigenomic concepts to type 2 diabetes mellitus","volume":"17","author":"Kaput","year":"2007","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.numecd.2008.09.004_bib32","doi-asserted-by":"crossref","first-page":"28811","DOI":"10.1074\/jbc.M505500200","article-title":"Heteromeric protein complexes mediate zinc transport into the secretory pathway of eukaryotic cells","volume":"280","author":"Ellis","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.numecd.2008.09.004_bib33","doi-asserted-by":"crossref","first-page":"30956","DOI":"10.1074\/jbc.M506902200","article-title":"Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells","volume":"280","author":"Suzuki","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.numecd.2008.09.004_bib34","first-page":"E774","article-title":"Thyroid hormones modulate zinc transport activity of rat intestinal and renal brush-border membrane","volume":"276","author":"Prasad","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.numecd.2008.09.004_bib35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bbaexp.2006.12.005","article-title":"Upregulation of Slc39a10 gene expression in response to thyroid hormones in intestine and kidney","volume":"1769","author":"Pawan","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.numecd.2008.09.004_bib36","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1081\/ERC-120026953","article-title":"Pinealectomy and zinc deficiency have opposite effects on thyroid hormones in rats","volume":"29","author":"Baltaci","year":"2003","journal-title":"Endocr Res"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475308001853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475308001853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T08:25:12Z","timestamp":1557995112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475308001853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0939475308001853"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2008.09.004","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}