{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:03:01Z","timestamp":1782774181501,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.numecd.2010.08.005","type":"journal-article","created":{"date-parts":[[2010,12,25]],"date-time":"2010-12-25T10:28:12Z","timestamp":1293272892000},"page":"426-433","source":"Crossref","is-referenced-by-count":104,"title":["Uric acid does not affect the prevalence and extent of coronary artery disease. Results from a prospective study"],"prefix":"10.1016","volume":"22","author":[{"given":"G.","family":"De Luca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.G.","family":"Secco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Santagostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Venegoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Iorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Cassetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Verdoia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Coppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Di Mario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bellomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2010.08.005_bib1","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1161\/01.HYP.35.3.746","article-title":"Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension","volume":"35","author":"Butler","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.numecd.2010.08.005_bib2","doi-asserted-by":"crossref","first-page":"8604","DOI":"10.1016\/S0021-9258(18)93017-6","article-title":"Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression","volume":"266","author":"Rao","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.numecd.2010.08.005_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0002-8703(83)90209-0","article-title":"Serum uric acid and coronary heart disease","volume":"106","author":"Beard","year":"1983","journal-title":"Am Heart J"},{"key":"10.1016\/j.numecd.2010.08.005_bib4","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1136\/pgmj.62.733.1001","article-title":"Serum uric acid, serum glucose and diabetes: relationships in a population study","volume":"62","author":"Cook","year":"1986","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.numecd.2010.08.005_bib5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1023\/A:1007654507054","article-title":"Relationship between hyperuricemia and other cardiovascular disease risk factors among adult males in Taiwan","volume":"16","author":"Chu","year":"2000","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.numecd.2010.08.005_bib6","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/eurheartj\/ehi110","article-title":"Ageing, impaired myocardial perfusion, and mortality in patients with ST-segment elevation myocardial infarction treated by primary angioplasty","volume":"26","author":"De Luca","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.numecd.2010.08.005_bib7","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/qjmed\/93.11.707","article-title":"Uric acid as a risk factor for cardiovascular disease","volume":"93","author":"Waring","year":"2000","journal-title":"QJM"},{"key":"10.1016\/j.numecd.2010.08.005_bib8","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1111\/j.1523-1755.2005.00273.x","article-title":"Hyperuricemia induces endothelial dysfunction and vasoconstriction","volume":"67","author":"Khosla","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.numecd.2010.08.005_bib9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.5551\/jat.1594","article-title":"Effect of uric acid on coronary microvascular endothelial function in women: association with eGFR and ADMA","volume":"17","author":"Kuwahata","year":"2010","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.numecd.2010.08.005_bib10","doi-asserted-by":"crossref","first-page":"8604","DOI":"10.1016\/S0021-9258(18)93017-6","article-title":"Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression","volume":"266","author":"Rao","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.numecd.2010.08.005_bib11","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1161\/01.HYP.0000072820.07472.3B","article-title":"Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2","volume":"41","author":"Kanellis","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.numecd.2010.08.005_bib12","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1161\/01.RES.0000149571.96304.36","article-title":"Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2","volume":"95","author":"Ohtsubo","year":"2004","journal-title":"Circ Res"},{"issue":"Suppl. 1","key":"10.1016\/j.numecd.2010.08.005_bib13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1538-7836.2007.02498.x","article-title":"Resistance to antiplatelet drugs: molecular mechanisms and laboratory detection","volume":"5","author":"Cattaneo","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.numecd.2010.08.005_bib14","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1073\/pnas.85.11.4046","article-title":"Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues","volume":"85","author":"Zweier","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.numecd.2010.08.005_bib15","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.2337\/diabetes.51.4.1118","article-title":"Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol","volume":"51","author":"Desco","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2010.08.005_bib16","first-page":"270","article-title":"Podocyte architecture in puromycin aminoglycoside-treated rats administered tungsten or allopurinol","volume":"3","author":"Ricardo","year":"1995","journal-title":"Exp Nephrol"},{"key":"10.1016\/j.numecd.2010.08.005_bib17","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0891-5849(93)90143-I","article-title":"Towards the physiological function of uric acid","volume":"14","author":"Becker","year":"1993","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.numecd.2010.08.005_bib18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0021-9150(99)00214-2","article-title":"Uric acid and serum antioxidant capacity: a reaction to atherosclerosis?","volume":"148","author":"Nieto","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.numecd.2010.08.005_bib19","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/CIRCULATIONAHA.107.703389","article-title":"Independent impact of gout on mortality and risk for coronary heart disease","volume":"116","author":"Choi","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2010.08.005_bib20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0002-9149(01)02155-5","article-title":"Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease","volume":"89","author":"Bickel","year":"2002","journal-title":"Am J Cardiol"},{"issue":"2","key":"10.1016\/j.numecd.2010.08.005_bib21","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijcard.2007.11.094","article-title":"Serum uric acid is an independent predictor for all major forms of cardiovascular death in 28,613 elderly women: a prospective 21-year follow-up study","volume":"125","author":"Strasak","year":"2008","journal-title":"Int J\u00a0Cardiol"},{"issue":"4","key":"10.1016\/j.numecd.2010.08.005_bib22","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1053\/j.ajkd.2003.12.023","article-title":"Effect of statins versus untreated dyslipidemia on serum uric acid levels in patients with coronary heart disease: a subgroup analysis of the GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) study","volume":"43","author":"Athyros","year":"2004","journal-title":"Am J Kidney Dis"},{"issue":"10","key":"10.1016\/j.numecd.2010.08.005_bib23","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.numecd.2008.12.010","article-title":"Independent relationship of serum uric acid levels with leukocytes and coronary atherosclerotic burden","volume":"19","author":"Kocaman","year":"2009","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.numecd.2010.08.005_bib24","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000239860","article-title":"Serum uric acid for risk stratification of patients with coronary artery disease","volume":"114","author":"Brodov","year":"2009","journal-title":"Cardiology"},{"key":"10.1016\/j.numecd.2010.08.005_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7326\/0003-4819-131-1-199907060-00003","article-title":"Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study","volume":"131","author":"Culleton","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.numecd.2010.08.005_bib26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S1047-2797(99)00037-X","article-title":"Serum acid uric and risk of coronary heart disease: atherosclerosis Risk in Communities (ARIC) study","volume":"10","author":"Moriarity","year":"2000","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.numecd.2010.08.005_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1373\/clinchem.2007.094425","article-title":"Serum uric acid and risk of cardiovascular mortality: a prospective long-term study of 83 683 Austrian men","volume":"54","author":"Strasak","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.numecd.2010.08.005_bib28","doi-asserted-by":"crossref","DOI":"10.1053\/j.ajkd.2010.01.024","article-title":"Is high serum uric acid a risk marker or a target for treatment? Examination of its independent effect in a large cohort with low cardiovascular risk","author":"Wen","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.numecd.2010.08.005_bib29","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1523-1755.2004.00484.x","article-title":"The impact of serum uric acid on cardiovascular outcomes in the LIFE study","volume":"65","author":"H\u00f8ieggen","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.numecd.2010.08.005_bib30","first-page":"605","article-title":"Uric Acid is not an independent predictor of cardiovascular death in patients with angiographically proven coronary artery disease","volume":"32","author":"Tsai","year":"2009","journal-title":"Chang Gung Med J"},{"key":"10.1016\/j.numecd.2010.08.005_bib31","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/acr.20065","article-title":"Hyperuricemia and coronary heart disease: a systematic review and meta-analysis","volume":"62","author":"Kim","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475310001973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475310001973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T08:27:02Z","timestamp":1712046422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475310001973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0939475310001973"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2010.08.005","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}