{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:23:04Z","timestamp":1773861784267,"version":"3.50.1"},"reference-count":88,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.numecd.2010.10.001","type":"journal-article","created":{"date-parts":[[2010,11,21]],"date-time":"2010-11-21T09:13:04Z","timestamp":1290330784000},"page":"754-760","source":"Crossref","is-referenced-by-count":105,"title":["Selenium status and cardiometabolic health: State of the evidence"],"prefix":"10.1016","volume":"20","author":[{"given":"S.","family":"Stranges","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Navas-Acien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.P.","family":"Rayman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Guallar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2010.10.001_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/MOL.0b013e3282f2b261","article-title":"Selenium intake and cardiovascular risk \u2013 what is new?","volume":"19","author":"Navas-Acien","year":"2008","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.numecd.2010.10.001_bib2","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.bbagen.2009.03.014","article-title":"Selenoproteins and human health: insights from epidemiological data","volume":"1790","author":"Rayman","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.numecd.2010.10.001_bib3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1523-5408.2002.00006.x","article-title":"Selenium, an antioxidant nutrient","volume":"5","author":"Burk","year":"2002","journal-title":"Nutr Clin Care"},{"key":"10.1016\/j.numecd.2010.10.001_bib4","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1089\/ars.2007.1528","article-title":"From selenium to selenoproteins: synthesis, identity, and their role in human health","volume":"9","author":"Papp","year":"2007","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.numecd.2010.10.001_bib5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/00043798-199602000-00006","article-title":"Selenium as a risk factor for cardiovascular diseases","volume":"3","author":"Neve","year":"1996","journal-title":"J\u00a0Cardiovasc Risk"},{"key":"10.1016\/j.numecd.2010.10.001_bib6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0163-7258(98)00014-X","article-title":"Chemopreventive agents: selenium","volume":"79","author":"Combs","year":"1998","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.numecd.2010.10.001_bib7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(00)02490-9","article-title":"The importance of selenium to human health","volume":"356","author":"Rayman","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2010.10.001_bib8","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1001\/jama.276.24.1957","article-title":"Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group","volume":"276","author":"Clark","year":"1996","journal-title":"JAMA"},{"key":"10.1016\/j.numecd.2010.10.001_bib9","first-page":"630","article-title":"Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial","volume":"11","author":"Duffield-Lillico","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.numecd.2010.10.001_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/jama.2008.864","article-title":"Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the selenium and vitamin E cancer prevention trial (SELECT)","volume":"301","author":"Lippman","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.numecd.2010.10.001_bib11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.7326\/0003-4819-147-4-200708210-00177","article-title":"Selenium and diabetes: more bad news for supplements","volume":"147","author":"Bleys","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.numecd.2010.10.001_bib12","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1007\/PL00000669","article-title":"Selenium: an insulin-mimetic","volume":"57","author":"Stapleton","year":"2000","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.numecd.2010.10.001_bib13","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jnutbio.2005.10.006","article-title":"Compendium of the antidiabetic effects of supranutritional selenate doses. In vivo and in vitro investigations with type II diabetic db\/db mice","volume":"17","author":"Mueller","year":"2006","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.numecd.2010.10.001_bib14","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2337\/dc06-1726","article-title":"Serum selenium and diabetes in U.S. adults","volume":"30","author":"Bleys","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.numecd.2010.10.001_bib15","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1289\/ehp.0900704","article-title":"Serum selenium concentrations and diabetes in US adults: national health and nutrition examination survey (NHANES 2003\u20132004)","volume":"117","author":"Laclaustra","year":"2009","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.numecd.2010.10.001_bib16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.7326\/0003-4819-147-4-200708210-00175","article-title":"Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial","volume":"147","author":"Stranges","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.numecd.2010.10.001_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0048-9697(99)00034-0","article-title":"Serum and urine selenium concentrations as indicators of body status in patients with diabetes mellitus","volume":"228","author":"Navarro-Alarcon","year":"1999","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.numecd.2010.10.001_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1385\/BTER:83:3:223","article-title":"Selenium and glycogen levels in diabetic patients","volume":"83","author":"Kljai","year":"2001","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.numecd.2010.10.001_bib19","first-page":"584","article-title":"Lipid peroxidation level and antioxidant micronutrient status in a pre-aging population; correlation with chronic disease prevalence in a French epidemiological study","volume":"16","author":"Coudray","year":"1997","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1743-7075-7-21","article-title":"Plasma selenium and risk of dysglycemia in an elderly French population: results from the prospective epidemiology of vascular ageing study","volume":"7","author":"Akbaraly","year":"2010","journal-title":"Nutr Metab"},{"key":"10.1016\/j.numecd.2010.10.001_bib21","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/ajcn\/84.2.395","article-title":"Antioxidant supplementation does not affect fasting plasma glucose in the supplementation with antioxidant vitamins and minerals (SU.VI.MAX) study in France: association with dietary intake and plasma concentrations","volume":"84","author":"Czernichow","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib22","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/07315724.2005.10719472","article-title":"Toenail selenium and cardiovascular disease in men with diabetes","volume":"24","author":"Rajpathak","year":"2005","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib23","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/ajcn\/88.2.416","article-title":"Serum selenium and serum lipids in US adults","volume":"88","author":"Bleys","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib24","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.atherosclerosis.2010.01.005","article-title":"Serum selenium and plasma lipids in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004","volume":"210","author":"Laclaustra","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.numecd.2010.10.001_bib25","first-page":"81","article-title":"Higher selenium status is associated with adverse blood lipid profile in British adults","volume":"140","author":"Stranges","year":"2010","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/bmj.314.7078.387","article-title":"Dietary selenium: time to act","volume":"314","author":"Rayman","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.numecd.2010.10.001_bib27","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1743-7075-7-38","article-title":"Serum selenium concentration is associated with metabolic factors in the elderly: a cross-sectional study","volume":"7","author":"Yang","year":"2010","journal-title":"Nutr Metab"},{"key":"10.1016\/j.numecd.2010.10.001_bib28","first-page":"27","article-title":"The Tromso heart study: relationships between the concentration of selenium in serum and risk factors for coronary heart disease","volume":"1","author":"Ringstad","year":"1987","journal-title":"J Trace Elem Electrolytes Health Dis"},{"key":"10.1016\/j.numecd.2010.10.001_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0021-9150(91)90015-U","article-title":"Serum selenium and coronary heart disease risk factors in southern Italian men","volume":"87","author":"Jossa","year":"1991","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.numecd.2010.10.001_bib30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0021-9150(92)90035-F","article-title":"Serum selenium concentration and risk of ischaemic heart disease in a prospective cohort study of 3000 males","volume":"96","author":"Suadicani","year":"1992","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.numecd.2010.10.001_bib31","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/clinchem\/43.4.693","article-title":"Serum selenium in institutionalized elderly subjects and relation to other nutritional markers","volume":"43","author":"Gamez","year":"1997","journal-title":"Clin Chem"},{"key":"10.1016\/j.numecd.2010.10.001_bib32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11745-006-1391-3","article-title":"Alterations of the lipid profile after 7.5 years of low-dose antioxidant supplementation in the SU.VI.MAX study","volume":"40","author":"Hercberg","year":"2005","journal-title":"Lipids"},{"key":"10.1016\/j.numecd.2010.10.001_bib33","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1093\/ajcn\/84.4.912","article-title":"A randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-wk antibiotic treatment for Helicobacter pylori infection on serum cholesterol and lipoproteins","volume":"84","author":"Zhang","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib34","first-page":"469","article-title":"Serum selenium, glutathione peroxidase activity and high-density lipoprotein cholesterol\u2013effect of selenium supplementation","volume":"46","author":"Luoma","year":"1984","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1016\/j.numecd.2010.10.001_bib35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF02917199","article-title":"Intervention trial with selenium for the prevention of lung cancer among tin miners in Yunnan, China. A pilot study","volume":"24","author":"Yu","year":"1990","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.numecd.2010.10.001_bib36","unstructured":"Rayman MP, Stranges S, Griffin B, Wong MCY, Guallar E. Effect of supplementation with high-selenium yeast on plasma lipids: a randomized, controlled trial. Proc Nutr Soc, in press."},{"key":"10.1016\/j.numecd.2010.10.001_bib37","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/eurheartj\/ehl479","article-title":"Blood pressure and blood selenium: a cross-sectional and longitudinal population study","volume":"28","author":"Nawrot","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.numecd.2010.10.001_bib38","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0021-9150(88)90109-8","article-title":"Relationship of serum selenium and antioxidants to plasma lipoproteins, platelet aggregability and prevalent ischaemic heart disease in Eastern Finnish men","volume":"70","author":"Salonen","year":"1988","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.numecd.2010.10.001_bib39","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/oxfordjournals.aje.a114099","article-title":"Serum selenium and the risk of coronary heart-disease and stroke","volume":"122","author":"Virtamo","year":"1985","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.numecd.2010.10.001_bib40","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/CIRCOUTCOMES.108.831552","article-title":"Serum selenium levels and hypertension in the US population","volume":"2","author":"Laclaustra","year":"2009","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.numecd.2010.10.001_bib41","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1056\/NEJMoa011090","article-title":"Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease","volume":"345","author":"Brown","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2010.10.001_bib42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00001648-199801000-00005","article-title":"Do nutritional supplements lower the risk of stroke or hypertension?","volume":"9","author":"Mark","year":"1998","journal-title":"Epidemiology"},{"key":"10.1016\/j.numecd.2010.10.001_bib43","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0140-6736(82)91028-5","article-title":"Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study","volume":"2","author":"Salonen","year":"1982","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2010.10.001_bib44","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/ajcn\/79.1.80","article-title":"Prospective study of serum selenium concentrations and esophageal and gastric cardia cancer, heart disease, stroke, and total death","volume":"79","author":"Wei","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib45","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/ajcn\/84.4.762","article-title":"Selenium and coronary heart disease: a meta-analysis","volume":"84","author":"Flores-Mateo","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib46","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1001\/archinternmed.2007.74","article-title":"Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults","volume":"168","author":"Bleys","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.numecd.2010.10.001_bib47","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/aje\/kwn414","article-title":"Serum selenium and peripheral arterial disease: results from the national health and nutrition examination survey (NHANES 2003\u20132004)","volume":"169","author":"Bleys","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.numecd.2010.10.001_bib48","first-page":"249","article-title":"Effect of selenium supplementation after acute myocardial infarction","volume":"65","author":"Korpela","year":"1989","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1016\/j.numecd.2010.10.001_bib49","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1016\/0098-2997(94)90023-X","article-title":"Coenzyme Q10 and antioxidants in acute myocardial infarction","volume":"15","author":"Kuklinski","year":"1994","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.numecd.2010.10.001_bib50","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/00008469-200106000-00009","article-title":"An intervention trial to inhibit the progression of precancerous gastric lesions: compliance, serum micronutrients and S-allyl cysteine levels, and toxicity","volume":"10","author":"You","year":"2001","journal-title":"Eur J Cancer Prev"},{"key":"10.1016\/j.numecd.2010.10.001_bib51","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1001\/archinte.164.21.2335","article-title":"The SU.VI.MAX study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals","volume":"164","author":"Hercberg","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.numecd.2010.10.001_bib52","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/aje\/kwj097","article-title":"Effects of selenium supplementation on cardiovascular disease incidence and mortality: secondary analyses in a randomized clinical trial","volume":"163","author":"Stranges","year":"2006","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.numecd.2010.10.001_bib53","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1056\/NEJMoa030535","article-title":"Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease","volume":"349","author":"Blankenberg","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2010.10.001_bib54","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/ajcn\/70.5.896","article-title":"An estimation of selenium requirements for New Zealanders","volume":"70","author":"Duffield","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib55","first-page":"99","article-title":"Metabolism of sub-toxic levels of selenium in animals and humans","volume":"26","author":"Whanger","year":"1996","journal-title":"Ann Clin Lab Sci"},{"key":"10.1016\/j.numecd.2010.10.001_bib56","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1515\/REVEH.2001.16.4.233","article-title":"Adverse health effects of selenium in humans","volume":"16","author":"Vinceti","year":"2001","journal-title":"Rev Environ Health"},{"key":"10.1016\/j.numecd.2010.10.001_bib57","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00394-008-0696-9","article-title":"Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism","volume":"47","author":"Jablonska","year":"2008","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib58","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00439-007-0402-7","article-title":"Variation in the selenoprotein S gene locus is associated with coronary heart disease and ischemic stroke in two independent Finnish cohorts","volume":"122","author":"Alanne","year":"2007","journal-title":"Hum Genet"},{"key":"10.1016\/j.numecd.2010.10.001_bib59","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/S0024-3205(96)00550-4","article-title":"Insulin-like vs. non-insulin-like stimulation of glucose metabolism by vanadium, tungsten, and selenium compounds in rat muscle","volume":"59","author":"F\u00fcrnsinn","year":"1996","journal-title":"Life Sci"},{"key":"10.1016\/j.numecd.2010.10.001_bib60","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jtemb.2005.01.001","article-title":"Influence of alloxan-induced diabetes and selenite treatment on blood glucose and glutathione levels in mice","volume":"18","author":"Sheng","year":"2005","journal-title":"J Trace Elem Med Biol"},{"key":"10.1016\/j.numecd.2010.10.001_bib61","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11010-006-2387-2","article-title":"Influence of selenium (antioxidant) on gliclazide induced hypoglycaemia\/anti hyperglycaemia in normal\/alloxan-induced diabetic rats","volume":"283","author":"Satyanarayana","year":"2006","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.numecd.2010.10.001_bib62","doi-asserted-by":"crossref","first-page":"8852","DOI":"10.1073\/pnas.0308096101","article-title":"Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase","volume":"101","author":"McClung","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.numecd.2010.10.001_bib63","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.2337\/db05-1357","article-title":"Metallothionein and catalase sensitize to diabetes in nonobese diabetic mice: reactive oxygen species may have a protective role in pancreatic beta-cells","volume":"55","author":"Li","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2010.10.001_bib64","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s00125-008-1055-3","article-title":"Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice","volume":"51","author":"Wang","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2010.10.001_bib65","doi-asserted-by":"crossref","first-page":"5963","DOI":"10.1210\/jc.2003-030544","article-title":"Association of glutathione peroxidase activity with insulin resistance and dietary fat intake during normal pregnancy","volume":"88","author":"Chen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.numecd.2010.10.001_bib66","first-page":"385","article-title":"Interactions of selenium compounds with other antioxidants in DNA damage and apoptosis in human normal keratinocytes","volume":"10","author":"Shen","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.numecd.2010.10.001_bib67","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/biof.5520310106","article-title":"Oxidation of glutathione and superoxide generation by inorganic and organic selenium compounds","volume":"31","author":"Chen","year":"2007","journal-title":"Biofactors"},{"key":"10.1016\/j.numecd.2010.10.001_bib68","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cbi.2008.10.007","article-title":"Human erythrocyte hemolysis induced by selenium and tellurium compounds increased by GSH or glucose: a possible involvement of reactive oxygen species","volume":"177","author":"Schiar","year":"2009","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.numecd.2010.10.001_bib69","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.lfs.2009.02.026","article-title":"Oxidative stress and metabolic syndrome","volume":"84","author":"Roberts","year":"2009","journal-title":"Life Sci"},{"key":"10.1016\/j.numecd.2010.10.001_bib70","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1017\/S0007114508922522","article-title":"Food-chain selenium and human health: spotlight on speciation","volume":"100","author":"Rayman","year":"2008","journal-title":"Br J Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib71","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1523\/JNEUROSCI.1153-07.2007","article-title":"Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed","volume":"27","author":"Burk","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.numecd.2010.10.001_bib72","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/NEN.0b013e318160f347","article-title":"Neurodegeneration in mice resulting from loss of functional selenoprotein P or its receptor apolipoprotein E receptor 2","volume":"67","author":"Valentine","year":"2008","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.numecd.2010.10.001_bib73","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.bbagen.2009.03.026","article-title":"Selenoprotein P \u2013 expression, functions, and roles in mammals","volume":"1790","author":"Burk","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.numecd.2010.10.001_bib74","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.1074\/jbc.M709945200","article-title":"Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells","volume":"283","author":"Olson","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.numecd.2010.10.001_bib75","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bbrc.2007.10.189","article-title":"Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism","volume":"365","author":"Sengupta","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.numecd.2010.10.001_bib76","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0140-6736(04)15739-5","article-title":"Selenoprotein synthesis and side-effects of statins","volume":"363","author":"Moosmann","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2010.10.001_bib77","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jtemb.2008.08.001","article-title":"Fibrates but not statins increase plasma selenium in dyslipidemic aged patients \u2013 the EVA study","volume":"23","author":"Arnaud","year":"2009","journal-title":"J Trace Elem Med Biol"},{"key":"10.1016\/j.numecd.2010.10.001_bib78","series-title":"Dietary reference values for food energy and nutrients for the UK: Committee on medical aspects of food policy, report on health and social subjects number 41","year":"1991"},{"key":"10.1016\/j.numecd.2010.10.001_bib79","author":"Food and Nutrition Board, Institute of Medicine","year":"2000"},{"key":"10.1016\/j.numecd.2010.10.001_bib80","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1515\/REVEH.2009.24.3.231","article-title":"Risk of chronic low-dose selenium overexposure in humans: insights from epidemiology and biochemistry","volume":"24","author":"Vinceti","year":"2009","journal-title":"Rev Environ Health"},{"key":"10.1016\/j.numecd.2010.10.001_bib81","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jada.2004.03.022","article-title":"Use of vitamin, mineral, nonvitamin, and nonmineral supplements in the United States: the 1987, 1992, and 2000 national health interview survey results","volume":"104","author":"Millen","year":"2004","journal-title":"J Am Diet Assoc"},{"key":"10.1016\/j.numecd.2010.10.001_bib82","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1079\/PNS2006490","article-title":"Biofortification of UK food crops with selenium","volume":"65","author":"Broadley","year":"2006","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.numecd.2010.10.001_bib83","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/ajcn\/81.4.829","article-title":"Effectiveness of selenium supplements in a low selenium area of China","volume":"81","author":"Xia","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib84","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1158\/1055-9965.EPI-05-0950","article-title":"Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial","volume":"15","author":"Burk","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.numecd.2010.10.001_bib85","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1079\/BJN2000280","article-title":"Selenium in global food systems","volume":"85","author":"Combs","year":"2001","journal-title":"Br J Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib86","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1017\/S0007114508939830","article-title":"Food-chain selenium and human health: emphasis on intake","volume":"100","author":"Rayman","year":"2008","journal-title":"Br J Nutr"},{"key":"10.1016\/j.numecd.2010.10.001_bib87","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1080\/10715760903196925","article-title":"Selenium and diabetes: an enigma?","volume":"43","author":"Mueller","year":"2009","journal-title":"Free Radic Res"},{"key":"10.1016\/j.numecd.2010.10.001_bib88","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2166\/wh.2009.060","article-title":"Too much or too little? A review of the conundrum of selenium","volume":"8","author":"Gore","year":"2010","journal-title":"J Water Health"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475310002334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475310002334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T00:28:18Z","timestamp":1592094498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475310002334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":88,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0939475310002334"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2010.10.001","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}