{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:30:57Z","timestamp":1786995057441,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.numecd.2012.11.009","type":"journal-article","created":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T19:47:12Z","timestamp":1361389632000},"page":"1107-1114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Factors involved in rosuvastatin induction of insulin sensitization in rats fed a high fat diet"],"prefix":"10.1016","volume":"23","author":[{"given":"N.","family":"de las Heras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Valero-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ballesteros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"G\u00f3mez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Mart\u00edn-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Blanco-Rivero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Cachofeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Benito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Balfag\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Lahera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2012.11.009_bib1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1476-511X-10-99","article-title":"Analysis of time-dependent adaptations in whole-body energy balance in obesity induced by high-fat diet in rats","volume":"10","author":"So","year":"2011","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.numecd.2012.11.009_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1034\/j.1600-0854.2001.020102.x","article-title":"GLUT4\u2013at the cross roads between membrane trafficking and signal transduction","volume":"2","author":"Simpson","year":"2001","journal-title":"Traffic"},{"key":"10.1016\/j.numecd.2012.11.009_bib3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1365-2362.2005.01456.x","article-title":"Peroxisome proliferator-activated receptor gamma: the more the merrier?","volume":"35","author":"Argmann","year":"2005","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.numecd.2012.11.009_bib4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3109\/07853890.2010.547211","article-title":"Sirtuin 1 in lipid metabolism and obesity","volume":"43","author":"Schug","year":"2011","journal-title":"Ann Med"},{"key":"10.1016\/j.numecd.2012.11.009_bib5","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cell.2005.01.029","article-title":"Calorie restriction\u2013the SIR2 connection","volume":"120","author":"Guarente","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.numecd.2012.11.009_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1152\/advan.00052.2006","article-title":"PGC-1alpha: a key regulator of energy metabolism","volume":"30","author":"Liang","year":"2006","journal-title":"Adv Physiol Educ"},{"key":"10.1016\/j.numecd.2012.11.009_bib7","doi-asserted-by":"crossref","first-page":"15439","DOI":"10.1074\/jbc.M611214200","article-title":"Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation","volume":"282","author":"Crunkhorn","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.numecd.2012.11.009_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00109-011-0735-5","article-title":"Metabolic regulation by p53","volume":"89","author":"Maddocks","year":"2011","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.numecd.2012.11.009_bib9","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1128\/MCB.00347-10","article-title":"Requirement of the ATM\/p53 tumor suppressor pathway for glucose homeostasis","volume":"30","author":"Armata","year":"2010","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.numecd.2012.11.009_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.diabet.2007.09.004","article-title":"Adipokines: the missing link between insulin resistance and obesity","volume":"34","author":"Antuna-Puente","year":"2008","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.numecd.2012.11.009_bib11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1055\/s-0029-1212086","article-title":"Mechanisms of TNF-alpha-induced insulin resistance","volume":"107","author":"Hotamisligil","year":"1999","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.numecd.2012.11.009_bib12","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJMoa050461","article-title":"Intensive lipid lowering with atorvastatin in patients with stable coronary disease","volume":"352","author":"LaRosa","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2012.11.009_bib13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0306-3623(00)00074-4","article-title":"Effect of atorvastatin on endothelium-dependent constrictor factors in dyslipidemic rabbits","volume":"34","author":"Maeso","year":"2000","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.numecd.2012.11.009_bib14","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1742-1241.2011.02655.x","article-title":"Comparative effects of rosuvastatin and atorvastatin on glucose metabolism and adipokine levels in non-diabetic patients with dyslipidaemia: a prospective randomized open-label study","volume":"65","author":"Anagnostis","year":"2011","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.numecd.2012.11.009_bib15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.metabol.2007.07.021","article-title":"Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet","volume":"57","author":"Lalli","year":"2008","journal-title":"Metabolism"},{"key":"10.1016\/j.numecd.2012.11.009_bib16","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.atherosclerosis.2005.05.009","article-title":"Atorvastatin induces insulin sensitization in Zucker lean and fatty rats","volume":"184","author":"Wong","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.numecd.2012.11.009_bib17","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1248\/bpb.26.1681","article-title":"Effects of atorvastatin and pravastatin on glucose tolerance in diabetic rats mildly induced by streptozotocin","volume":"26","author":"Kanda","year":"2003","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.numecd.2012.11.009_bib18","first-page":"244","article-title":"Insulin-resistance and lipoprotein abnormalities","volume":"17","author":"Fruchart","year":"1991","journal-title":"Diabete Metab"},{"key":"10.1016\/j.numecd.2012.11.009_bib19","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/sj.ijo.0802053","article-title":"Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-alpha reduction and GLUT4 expression enhancement","volume":"26","author":"Mingrone","year":"2002","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.numecd.2012.11.009_bib20","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/sj.bjp.0707250","article-title":"Anti-adipogenic action of pitavastatin occurs through the coordinate regulation of PPARgamma and Pref-1 expression","volume":"151","author":"Nicholson","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.numecd.2012.11.009_bib21","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/oby.2003.144","article-title":"Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance","volume":"11","author":"Monzillo","year":"2003","journal-title":"Obes Res"},{"key":"10.1016\/j.numecd.2012.11.009_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12020-009-9278-8","article-title":"Adiponectin action from head to toe","volume":"37","author":"Brochu-Gaudreau","year":"2010","journal-title":"Endocrine"},{"key":"10.1016\/j.numecd.2012.11.009_bib23","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1172\/JCI34260","article-title":"Insulin sensitivity: modulation by nutrients and inflammation","volume":"118","author":"Schenk","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.numecd.2012.11.009_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1056-8727(01)00206-9","article-title":"The role of PPARgamma in high-fat diet-induced obesity and insulin resistance","volume":"16","author":"Kadowaki","year":"2002","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.numecd.2012.11.009_bib25","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1194\/jlr.M500540-JLR200","article-title":"Type II nuclear hormone receptors, coactivator, and target gene repression in adipose tissue in the acute-phase response","volume":"47","author":"Lu","year":"2006","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.numecd.2012.11.009_bib26","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2337\/db10-0650","article-title":"Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice","volume":"60","author":"Zhang","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2012.11.009_bib27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1463-1326.2004.00387.x","article-title":"High-fat diet enhances visceral advanced glycation end products, nuclear O-Glc-Nac modification, p38 mitogen-activated protein kinase activation and apoptosis","volume":"7","author":"Li","year":"2005","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.numecd.2012.11.009_bib28","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/ajpendo.00417.2009","article-title":"SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity","volume":"298","author":"Yoshizaki","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.numecd.2012.11.009_bib29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1126\/science.275.5296.90","article-title":"Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK\/JNK and p38 signaling pathways","volume":"275","author":"Ichijo","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.numecd.2012.11.009_bib30","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1530\/eje.0.1420315","article-title":"Defective nitric oxide synthesis: a link between metabolic insulin resistance, sympathetic overactivity and cardiovascular morbidity","volume":"142","author":"Scherrer","year":"2000","journal-title":"Eur J Endocrinol"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475312002797?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475312002797?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T10:26:13Z","timestamp":1539858373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475312002797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0939475312002797"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2012.11.009","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Factors involved in rosuvastatin induction of insulin sensitization in rats fed a high fat diet","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2012.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}