{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T09:17:21Z","timestamp":1777022241161,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","content-domain":{"domain":["nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.numecd.2013.11.011","type":"journal-article","created":{"date-parts":[[2013,12,25]],"date-time":"2013-12-25T00:31:17Z","timestamp":1387931477000},"page":"614-622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Dietary intake, plasma homocysteine, and repetitive element DNA methylation in the Multi-Ethnic Study of Atherosclerosis (MESA)"],"prefix":"10.1016","volume":"24","author":[{"given":"W.","family":"Perng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Villamor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.R.","family":"Shroff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Nettleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.R.","family":"Pilsner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.V.","family":"Diez-Roux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.numecd.2013.11.011_bib1","doi-asserted-by":"crossref","first-page":"e34615","DOI":"10.1371\/journal.pone.0034615","article-title":"Global DNA hypomethylation in peripheral blood leukocytes as a biomarker for cancer risk: a meta-analysis","volume":"7","author":"Woo","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.numecd.2013.11.011_bib2","doi-asserted-by":"crossref","DOI":"10.4161\/epi.6.10.17728","article-title":"Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders","volume":"6","author":"Cash","year":"2011","journal-title":"Epigenetics"},{"issue":"3","key":"10.1016\/j.numecd.2013.11.011_bib3","doi-asserted-by":"crossref","first-page":"e9692","DOI":"10.1371\/journal.pone.0009692","article-title":"DNA methylation as a biomarker for cardiovascular disease risk","volume":"5","author":"Kim","year":"2010","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.numecd.2013.11.011_bib4","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/jn\/128.7.1204","article-title":"Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women","volume":"128","author":"Jacob","year":"1998","journal-title":"J Nutr"},{"issue":"8","key":"10.1016\/j.numecd.2013.11.011_bib5","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1373\/49.8.1292","article-title":"Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease","volume":"49","author":"Castro","year":"2003","journal-title":"Clin Chem"},{"issue":"6 Suppl.","key":"10.1016\/j.numecd.2013.11.011_bib6","doi-asserted-by":"crossref","first-page":"1726S","DOI":"10.1093\/jn\/136.6.1726S","article-title":"The many facets of hyperhomocysteinemia: studies from the Framingham cohorts","volume":"136","author":"Selhub","year":"2006","journal-title":"J Nutr"},{"issue":"Suppl. 3","key":"10.1016\/j.numecd.2013.11.011_bib7","doi-asserted-by":"crossref","first-page":"941s","DOI":"10.1093\/jn\/133.3.941S","article-title":"Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism","volume":"133","author":"Mason","year":"2003","journal-title":"J Nutr"},{"issue":"6","key":"10.1016\/j.numecd.2013.11.011_bib8","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3945\/jn.110.134536","article-title":"Dietary patterns are associated with levels of global genomic DNA methylation in a cancer-free population","volume":"141","author":"Zhang","year":"2011","journal-title":"J Nutr"},{"issue":"6","key":"10.1016\/j.numecd.2013.11.011_bib9","doi-asserted-by":"crossref","DOI":"10.4161\/epi.20236","article-title":"White blood cell global methylation and IL-6 promoter methylation in association with diet and lifestyle risk factors in a cancer-free population","volume":"7","author":"Zhang","year":"2012","journal-title":"Epigenetics"},{"issue":"10","key":"10.1016\/j.numecd.2013.11.011_bib10","doi-asserted-by":"crossref","DOI":"10.4161\/epi.21915","article-title":"Micronutrient status and global DNA methylation in school-age children","volume":"7","author":"Perng","year":"2012","journal-title":"Epigenetics"},{"issue":"3","key":"10.1016\/j.numecd.2013.11.011_bib11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4161\/epi.7.3.19082","article-title":"Gestational intake of methyl donors and global LINE-1 DNA methylation in maternal and cord blood: prospective results from a folate-replete population","volume":"7","author":"Boeke","year":"2012","journal-title":"Epigenetics"},{"issue":"6","key":"10.1016\/j.numecd.2013.11.011_bib12","doi-asserted-by":"crossref","first-page":"394","DOI":"10.4161\/epi.4.6.9766","article-title":"LINE-1 DNA methylation is inversely correlated with cord plasma homocysteine in man: a preliminary study","volume":"4","author":"Fryer","year":"2009","journal-title":"Epigenetics"},{"issue":"1\u20133","key":"10.1016\/j.numecd.2013.11.011_bib13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.schres.2008.01.009","article-title":"No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients","volume":"101","author":"Bromberg","year":"2008","journal-title":"Schizophr Res"},{"issue":"9","key":"10.1016\/j.numecd.2013.11.011_bib14","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/aje\/kwf113","article-title":"Multi-ethnic study of atherosclerosis: objectives and design","volume":"156","author":"Bild","year":"2002","journal-title":"Am J Epidemiol"},{"issue":"6","key":"10.1016\/j.numecd.2013.11.011_bib15","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1089\/152460999319129","article-title":"Moderate physical activity patterns of minority women: the Cross-Cultural Activity Participation Study","volume":"8","author":"Ainsworth","year":"1999","journal-title":"J Womens Health Gend Based Med"},{"key":"10.1016\/j.numecd.2013.11.011_bib16","series-title":"Nutritional epidemiology","first-page":"296","article-title":"Implications of total energy intake for epidemiologic analyses","author":"Willett","year":"1998"},{"key":"10.1016\/j.numecd.2013.11.011_bib17","unstructured":"World Health Organization. BMI Classification. Global Database on Body Mass Index 21\/05\/2012 [cited 2012 5\/21]; Available from: http:\/\/apps.who.int\/bmi\/index.jsp?introPage=intro_3.html."},{"issue":"10","key":"10.1016\/j.numecd.2013.11.011_bib18","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrg2640","article-title":"The impact of retrotransposons on human genome evolution","volume":"10","author":"Cordaux","year":"2009","journal-title":"Nat Rev Genet"},{"issue":"38","key":"10.1016\/j.numecd.2013.11.011_bib19","doi-asserted-by":"crossref","first-page":"29318","DOI":"10.1074\/jbc.M002725200","article-title":"Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation","volume":"275","author":"Yi","year":"2000","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.numecd.2013.11.011_bib20","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1073\/pnas.0400658101","article-title":"S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism","volume":"101","author":"Baric","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.numecd.2013.11.011_bib21","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s10545-006-0240-0","article-title":"S-adenosylhomocysteine hydrolase deficiency in a 26-year-old man","volume":"29","author":"Buist","year":"2006","journal-title":"J Inherit Metab Dis"},{"issue":"1","key":"10.1016\/j.numecd.2013.11.011_bib22","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/01.CIR.99.1.178","article-title":"Homocyst(e)ine, diet, and cardiovascular diseases: a statement for healthcare professionals from the Nutrition Committee, American Heart Association","volume":"99","author":"Malinow","year":"1999","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.numecd.2013.11.011_bib23","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4161\/epi.4.8.10265","article-title":"The epigenome: archive of the prenatal environment","volume":"4","author":"Heijmans","year":"2009","journal-title":"Epigenetics"},{"issue":"1","key":"10.1016\/j.numecd.2013.11.011_bib24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/ije\/dyq154","article-title":"Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis","volume":"41","author":"Zhu","year":"2012","journal-title":"Int J Epidemiol"},{"issue":"2","key":"10.1016\/j.numecd.2013.11.011_bib25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3945\/ajcn.2009.28085","article-title":"Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction","volume":"91","author":"Bouchard","year":"2010","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"10.1016\/j.numecd.2013.11.011_bib26","doi-asserted-by":"crossref","first-page":"e31821","DOI":"10.1371\/journal.pone.0031821","article-title":"DNA methylation patterns in cord blood DNA and body size in childhood","volume":"7","author":"Relton","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.numecd.2013.11.011_bib27","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/oxfordjournals.aje.a117738","article-title":"Height and the risk of cardiovascular disease in women","volume":"142","author":"Rich-Edwards","year":"1995","journal-title":"Am J Epidemiol"},{"issue":"6","key":"10.1016\/j.numecd.2013.11.011_bib28","doi-asserted-by":"crossref","DOI":"10.4161\/epi.20221","article-title":"Different measures of \u201cgenome-wide\u201d DNA methylation exhibit unique properties in placental and somatic tissues","volume":"7","author":"Price","year":"2012","journal-title":"Epigenetics"},{"issue":"35","key":"10.1016\/j.numecd.2013.11.011_bib29","doi-asserted-by":"crossref","first-page":"5388","DOI":"10.1038\/sj.onc.1205599","article-title":"Gene silencing in mammalian cells and the spread of DNA methylation","volume":"21","author":"Turker","year":"2002","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.numecd.2013.11.011_bib30","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ygeno.2006.01.002","article-title":"The length of CpG islands is associated with the distribution of Alu and L1 retroelements","volume":"87","author":"Kang","year":"2006","journal-title":"Genomics"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475313003128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475313003128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T05:45:58Z","timestamp":1564983958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475313003128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0939475313003128"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2013.11.011","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary intake, plasma homocysteine, and repetitive element DNA methylation in the Multi-Ethnic Study of Atherosclerosis (MESA)","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2013.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}