{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:39:35Z","timestamp":1768293575062,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T00:00:00Z","timestamp":1439251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["nmcd-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.numecd.2015.07.008","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T03:24:47Z","timestamp":1438831487000},"page":"12-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Mild hyponatremia, hypernatremia and incident cardiovascular disease and mortality in older men: A population-based cohort study"],"prefix":"10.1016","volume":"26","author":[{"given":"S.G.","family":"Wannamethee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.G.","family":"Shaper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lennon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Papacosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Whincup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.numecd.2015.07.008_bib1","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1056\/NEJM200005253422107","volume":"342","author":"Adrogu\u00e9","year":"2000","journal-title":"Hyponatremia N Engl J Med"},{"issue":"1","key":"10.1016\/j.numecd.2015.07.008_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrneph.2012.246","article-title":"Hyponatremia: more than just a marker of disease severity?","volume":"9","author":"Schriers","year":"2012","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"10.1016\/j.numecd.2015.07.008_bib3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1053\/j.ajkd.2012.09.019","article-title":"Hyponatremia and mortality: moving beyond associations","volume":"62","author":"Hoorn","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.numecd.2015.07.008_bib4","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/eurjhf\/hfs099","volume":"14","author":"Rusinaru","year":"2012","journal-title":"Eur J Heart Fail"},{"issue":"7","key":"10.1016\/j.numecd.2015.07.008_bib5","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1001\/archinte.166.7.781","article-title":"Hyponatremia and long-term mortality in survivors of acute ST-elevation myocardial infarction","volume":"166","author":"Goldberg","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.numecd.2015.07.008_bib6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/CIRCULATIONAHA.111.065391","article-title":"Hyponatremia, hypernatremia, and mortality in patients with chronic kidney disease with and without congestive heart failure","volume":"125","author":"Kovesdy","year":"2012","journal-title":"Circulation"},{"issue":"7 Suppl 1","key":"10.1016\/j.numecd.2015.07.008_bib7","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1016\/j.amjmed.2006.05.013","article-title":"Is asymptomatic hyponatremia really asymptomatic?","volume":"119","author":"Decaux","year":"2006","journal-title":"Am J Med"},{"key":"10.1016\/j.numecd.2015.07.008_bib8","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/ki.2012.459","article-title":"Mild hyponatremia is associated with an increased risk of death in an ambulatory setting","volume":"83","author":"Gankam-Kengne","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.numecd.2015.07.008_bib9","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.amjmed.2008.11.033","article-title":"Mild hyponatremia carries a poor prognosis in community subjects","volume":"122","author":"Sajadieh","year":"2009","journal-title":"Am J Med"},{"key":"10.1016\/j.numecd.2015.07.008_bib10","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.amjmed.2012.06.037","article-title":"Electrolyte disorders in community subjects: prevalence and risk factors","volume":"126","author":"Liamis","year":"2013","journal-title":"Am J Med"},{"issue":"8","key":"10.1016\/j.numecd.2015.07.008_bib11","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/00004872-199408000-00017","article-title":"Serum sodium concentration and risk of stroke in middle-aged males","volume":"12","author":"Wannamethee","year":"1994","journal-title":"J Hypertens"},{"key":"10.1016\/j.numecd.2015.07.008_bib12","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1023\/A:1021216713504","article-title":"Predictors of stroke mortality in elderly people from the general population. The Cardiovascular Study in the Elderly","volume":"17","author":"Mazza","year":"2001","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.numecd.2015.07.008_bib13","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1053\/j.ackd.2010.03.008","article-title":"Electrolytes in the aging","volume":"17","author":"Schlanger","year":"2010","journal-title":"Adv Chronic Kidney Dis"},{"issue":"6285","key":"10.1016\/j.numecd.2015.07.008_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/bmj.283.6285.179","article-title":"British Regional Heart Study: cardiovascular risk factors in middle-aged men in 24 towns","volume":"283","author":"Shaper","year":"1981","journal-title":"BMJ"},{"issue":"15","key":"10.1016\/j.numecd.2015.07.008_bib15","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1161\/hc1502.107117","article-title":"Physical activity and hemostatic and inflammatory variables in elderly men","volume":"105","author":"Wannamethee","year":"2002","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.numecd.2015.07.008_bib16","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/ajcn\/86.5.1339","article-title":"Decreased muscle mass and increased central adiposity are independently related to mortality in older men","volume":"86","author":"Wannamethee","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.numecd.2015.07.008_bib17","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1161\/ATVBAHA.112.300826","article-title":"Alkaline phosphatase, serum phosphate, and incident cardiovascular disease and total mortality in older men","volume":"33","author":"Wannamethee","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.numecd.2015.07.008_bib18","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/ajcn\/36.4.680","article-title":"Anthropometric measurement of muscle mass: revised equations for calculating bone-free arm muscle area","volume":"36","author":"Heymsfield","year":"1982","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.numecd.2015.07.008_bib19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.numecd.2015.07.008_bib20","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1111\/j.1538-7836.2009.03574.x","article-title":"Circulating inflammatory and haemostatic biomarkers are associated with risk of myocardial infarction and coronary death, but not angina pectoris, in older men","volume":"7","author":"Wannamethee","year":"2009","journal-title":"J Throm Haemost"},{"key":"10.1016\/j.numecd.2015.07.008_bib21","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jacc.2011.02.041","article-title":"N-terminal pro-brain natriuretic peptide is a more useful predictor of cardiovascular disease risk than C-reactive protein in older men with and without pre-existing cardiovascular disease","volume":"58","author":"Wannamethee","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.numecd.2015.07.008_bib22","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1093\/clinchem\/27.8.1435","article-title":"Determination of sodium with ion-selective electrodes","volume":"27","author":"Levy","year":"1981","journal-title":"Clin Chem"},{"issue":"4","key":"10.1016\/j.numecd.2015.07.008_bib23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/pubmed\/22.4.479","article-title":"Twenty year follow-up of a cohort study based in general practices in 24 British towns","volume":"22","author":"Walker","year":"2000","journal-title":"J Publ Health Med"},{"key":"10.1016\/j.numecd.2015.07.008_bib24","series-title":"Cardiovascular survey methods","author":"Rose","year":"1982"},{"issue":"9123","key":"10.1016\/j.numecd.2015.07.008_bib25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0140-6736(97)12169-9","article-title":"Sodium","volume":"352","author":"Kumar","year":"1998","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.numecd.2015.07.008_bib26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2215\/CJN.09281209","article-title":"Bone disease as a new complication of hyponatremia: moving beyond brain injury","volume":"5","author":"Ayus","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.numecd.2015.07.008_bib27","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/jbmr.380","article-title":"Mild hyponatremia as a risk factor for fractures: the Rotterdam Study","volume":"26","author":"Hoorn","year":"2011","journal-title":"J Bone Min Res"},{"issue":"7A","key":"10.1016\/j.numecd.2015.07.008_bib28","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/j.amjmed.2006.05.003","article-title":"Brain volume regulation in response to hypo-osmolality and its correction","volume":"119","author":"Sterns","year":"2006","journal-title":"Am J Med"},{"issue":"7","key":"10.1016\/j.numecd.2015.07.008_bib29","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1056\/NEJMoa1311889","article-title":"Urinary sodium and potassium excretion, mortality, and cardiovascular events","volume":"371","author":"O'Donnell","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2015.07.008_bib30","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/01.HYP.0000149431.79450.a2","article-title":"Plasma sodium: ignored and underestimated","volume":"45","author":"He","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.numecd.2015.07.008_bib31","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/eurheartj\/ehq019","article-title":"Plasma aldosterone levels are associated with increased cardiovascular mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study","volume":"31","author":"Tomaschitz","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.numecd.2015.07.008_bib32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.7326\/0003-4819-124-2-199601150-00002","article-title":"Hypernatremia in hospitalized patients","volume":"124","author":"Palevsky","year":"1996","journal-title":"Ann Intern Med"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475315001817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475315001817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T22:37:01Z","timestamp":1599431821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475315001817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0939475315001817"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2015.07.008","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mild hyponatremia, hypernatremia and incident cardiovascular disease and mortality in older men: A population-based cohort study","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2015.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}