{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T02:51:54Z","timestamp":1767149514163,"version":"build-2238731810"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Italian Ministry of University","award":["062128-001"],"award-info":[{"award-number":["062128-001"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.numecd.2016.01.012","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T18:37:30Z","timestamp":1456166250000},"page":"400-406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["The combination of UCP3\u201355CT and PPAR\u03b32Pro12Ala polymorphisms affects BMI and substrate oxidation in two diabetic\u00a0populations"],"prefix":"10.1016","volume":"26","author":[{"given":"E.","family":"Lapice","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Monticelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cocozza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Massimino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Giacco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Rivellese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cocozza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Riccardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Vaccaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.numecd.2016.01.012_bib1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1001\/jama.2014.732","article-title":"Prevalence of childhood and adult obesity in the United States, 2011-2012","volume":"311","author":"Ogden","year":"2014","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.numecd.2016.01.012_bib2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ng1071","article-title":"Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common diseases","volume":"33","author":"Lohmueller","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.numecd.2016.01.012_bib3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/gtmb.2008.0145","article-title":"Gene-gene interactions among genetic variants from obesity candidate genes for nonobese and obese populations in type 2 diabetes","volume":"13","author":"Lin","year":"2009","journal-title":"Genet Test Mol Biomark"},{"issue":"Suppl. 1","key":"10.1016\/j.numecd.2016.01.012_bib4","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1007\/s00592-003-0038-6","article-title":"Genetics of food intake and body composition: lessons from twin studies","volume":"40","author":"Keller","year":"2003","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.numecd.2016.01.012_bib5","doi-asserted-by":"crossref","first-page":"672","DOI":"10.2337\/diacare.24.4.672","article-title":"Interactions between variants in the beta3-adrenergic receptor and peroxisome proliferator- activated receptor-gamma2 genes and obesity","volume":"24","author":"Hsueh","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.numecd.2016.01.012_bib6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/oby.2006.71","article-title":"The human obesity gene map: the 2005 update","volume":"14","author":"Rankinen","year":"2006","journal-title":"Obesity"},{"issue":"12","key":"10.1016\/j.numecd.2016.01.012_bib7","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s11883-014-0462-9","article-title":"Interaction between Pro12Ala polymorphism of PPAR\u03b32 and diet on adiposity phenotypes","volume":"16","author":"Lapice","year":"2014","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.numecd.2016.01.012_bib8","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s001250100596","article-title":"Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and type II diabetes","volume":"44","author":"Dalgaard","year":"2001","journal-title":"Diabetologia"},{"issue":"10","key":"10.1016\/j.numecd.2016.01.012_bib9","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.freeradbiomed.2007.08.011","article-title":"Mitochondrial uncoupling proteins-what is their physiological role?","volume":"43","author":"Echtay","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.numecd.2016.01.012_bib10","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2005.11.026","article-title":"The many faces of PPAR\u03b3","volume":"123","author":"Lehrke","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.numecd.2016.01.012_bib11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/3099","article-title":"A Pro12Ala substitution in PPAR\u03b32 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity","volume":"20","author":"Deeb","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.numecd.2016.01.012_bib12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s125-002-8257-y","article-title":"Reduced lipolysis as possible cause for greater weight gain in subjects with the Pro12Ala polymorphism in PPAR\u03b32","volume":"45","author":"Stumvoll","year":"2002","journal-title":"Diabetologia"},{"issue":"7","key":"10.1016\/j.numecd.2016.01.012_bib13","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/oby.20150","article-title":"Pro12Ala variant of the PPARG2 gene increases body mass index: an updated meta analysis encompassing 49,092 subjects","volume":"21","author":"Galbete","year":"2013","journal-title":"Obesity"},{"key":"10.1016\/j.numecd.2016.01.012_bib14","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1136\/jmg.40.10.773","article-title":"Effect of the peroxisome activated receptor \u03b3 gene Pro12Ala variant on body mass index: a meta-analysis","volume":"40","author":"Masud","year":"2003","journal-title":"J Med Genet"},{"key":"10.1016\/j.numecd.2016.01.012_bib15","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.2337\/dc06-1153","article-title":"Pro12Ala polymorphism of the PPARgamma2 locus modulates the relationship between energy intake and body weight in type 2 diabetic patients","volume":"30","author":"Vaccaro","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.numecd.2016.01.012_bib16","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1038\/sj.ijo.0801057","article-title":"A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle. UCP3 mRNA expression and obesity in male non-diabetic Pima Indians","volume":"23","author":"Schrauwen","year":"1999","journal-title":"Int J Obes"},{"key":"10.1016\/j.numecd.2016.01.012_bib17","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1007\/s001250051549","article-title":"An uncoupling protein 3 gene polymorphism associated with a lower risk of developing type II diabetes and with atherogenic lipid profile in a French cohort","volume":"43","author":"Meirhaeghe","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2016.01.012_bib18","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s001250050037","article-title":"A genetic variation in the 5\u2032 flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity","volume":"43","author":"Otabe","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2016.01.012_bib19","first-page":"1398","article-title":"A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population","volume":"86","author":"Dalgaard","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.numecd.2016.01.012_bib20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000086883","article-title":"Association of UCP3 gene -55C>T polymorphism and obesity in a Spanish population","volume":"49","author":"Alonso","year":"2005","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.numecd.2016.01.012_bib21","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1159\/000107685","article-title":"Lack of association of \u221255CT polymorphism of UCP3 gene with fat distribution in obese patients","volume":"51","author":"de Luis","year":"2007","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.numecd.2016.01.012_bib22","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.metabol.2007.10.019","article-title":"The common -55 C\/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population","volume":"57","author":"Hamada","year":"2008","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.numecd.2016.01.012_bib23","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/ijo.2013.174","article-title":"The Energy intake modulates the association of the -55CT polymorphism of UCP3 with body weight in type 2 diabetic patients","volume":"38","author":"Lapice","year":"2014","journal-title":"Int J Obes (Lond)"},{"issue":"4","key":"10.1016\/j.numecd.2016.01.012_bib24","doi-asserted-by":"crossref","first-page":"e58939","DOI":"10.1371\/journal.pone.0058939","article-title":"UCP2 -866G\/A, Ala55Val and UCP3 -55C\/T polymorphisms in association with obesity susceptibility - a meta-analysis study","volume":"8","author":"Qian","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.numecd.2016.01.012_bib25","doi-asserted-by":"crossref","first-page":"e96411","DOI":"10.1371\/journal.pone.0096411","article-title":"Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability","volume":"9","author":"Brondani","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2016.01.012_bib26","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1210\/en.2004-0321","article-title":"Peroxisome proliferator-activated receptor gamma agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob\/ob mice","volume":"145","author":"Sell","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.numecd.2016.01.012_bib27","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/BF00146383","article-title":"Progetto ATENA, a study on the etiology of major chronic diseases in women: design, rationale and objectives","volume":"8","author":"Panico","year":"1992","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.numecd.2016.01.012_bib28","series-title":"La Malattia Cardiovascolare Arteriosclerotica nella Donna: Una nuova generazione di studi epidemiologici. Eds. Ann Ist Sup San","first-page":"397","article-title":"Questionario alimentare semiquantitativo sviluppato per indagini epidemiologiche in Italia","volume":"28","author":"Trevisan","year":"1992"},{"issue":"1\u20132","key":"10.1016\/j.numecd.2016.01.012_bib29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0304-3835(97)04686-7","article-title":"A food composition database for epidemiological studies in Italy","volume":"114","author":"Salvini","year":"1997","journal-title":"Cancer Lett"},{"issue":"5","key":"10.1016\/j.numecd.2016.01.012_bib30","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.2144\/03345dd03","article-title":"Single nucleotide polymorphism genotyping using allele-specific PCR and fluorescence melting curves","volume":"34","author":"Papp","year":"2003","journal-title":"Biotechniques"},{"key":"10.1016\/j.numecd.2016.01.012_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1949.sp004363","article-title":"New methods for calculating metabolic rate with special reference to protein metabolism","volume":"109","author":"Weir","year":"1949","journal-title":"J Physiol"},{"issue":"3 Suppl.","key":"10.1016\/j.numecd.2016.01.012_bib32","doi-asserted-by":"crossref","first-page":"489S","DOI":"10.1093\/ajcn\/64.3.489S","article-title":"Prediction of body cell mass, fat-free mass, and total body water with bioelectrical impedance analysis: effects of race, sex, and disease","volume":"64","author":"Kotler","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.numecd.2016.01.012_bib33","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/447655a","article-title":"Replicating genotype-phenotype associations","volume":"447","author":"NCI-NHGRI Working Group on Replication in Association Studies","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.numecd.2016.01.012_bib34","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0026-0495(03)00071-4","article-title":"Increased insulin clearance in peroxisome proliferator activated receptor \u03b32 Pro12 Ala","volume":"52","author":"Tschritter","year":"2003","journal-title":"Metabolism"},{"key":"10.1016\/j.numecd.2016.01.012_bib35","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1365-2265.2002.01618.x","article-title":"Fasting plasma free fatty acid concentrations and Pro12Ala polymorphism of the peroxisome proliferator activated receptor PPAR \u03b32 gene in healthy individuals","volume":"57","author":"Vaccaro","year":"2002","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.numecd.2016.01.012_bib36","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1172\/JCI13579","article-title":"Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance","volume":"117","author":"Choi","year":"2007","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.numecd.2016.01.012_bib37","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/sj.ijo.0802589","article-title":"Insulin sensitivity is increased and fat oxidation after a high-fat meal is reduced in normal-weight healthy men with strong familial predisposition to overweight","volume":"28","author":"Giacco Clemente","year":"2004","journal-title":"Int J Obes Relat Metab Disord"}],"updated-by":[{"DOI":"10.1016\/j.numecd.2017.03.006","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000}}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475315300168?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475315300168?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:08:23Z","timestamp":1760544503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475315300168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0939475315300168"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2016.01.012","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The combination of UCP3\u201355CT and PPAR\u03b32Pro12Ala polymorphisms affects BMI and substrate oxidation in two diabetic\u00a0populations","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2016.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}