{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:39:31Z","timestamp":1760549971501},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["nmcd-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.numecd.2016.03.005","type":"journal-article","created":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T07:08:06Z","timestamp":1458112086000},"page":"525-533","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case\u2013control study"],"prefix":"10.1016","volume":"26","author":[{"given":"Y.N.","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.T.","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.H.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.H.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.J.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2016.03.005_bib1","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2016.03.005_bib2","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/archpedi.157.8.821","article-title":"Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third national health and nutrition examination survey, 1988-1994","volume":"157","author":"Cook","year":"2003","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.numecd.2016.03.005_bib3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1089\/met.2014.0055","article-title":"Prevalence of metabolic syndrome and individual criterion in US adolescents: 2001-2010 national health and nutrition examination survey","volume":"12","author":"Miller","year":"2014","journal-title":"Metab Syndr Relat Disord"},{"key":"10.1016\/j.numecd.2016.03.005_bib4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2458-12-13","article-title":"Prevalence of the metabolic syndrome among children from six cities of China","volume":"12","author":"Xu","year":"2012","journal-title":"BMC Public Health"},{"key":"10.1016\/j.numecd.2016.03.005_bib5","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s00467-014-2836-1","article-title":"Subclinical atherosclerosis and ambulatory blood pressure in children with metabolic syndrome","volume":"29","author":"Civilibal","year":"2014","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.numecd.2016.03.005_bib6","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s12265-014-9551-y","article-title":"Iron and atherosclerosis: nailing down a novel target with magnetic resonance","volume":"7","author":"Sharkey-Toppen","year":"2014","journal-title":"J Cardiovasc Transl Res"},{"key":"10.1016\/j.numecd.2016.03.005_bib7","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.3109\/14767058.2013.770462","article-title":"Serum hepcidin is associated with parameters of glucose metabolism in women with gestational diabetes mellitus","volume":"26","author":"Derbent","year":"2013","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.numecd.2016.03.005_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000351941","article-title":"Iron homeostasis and serum hepcidin-25 levels in obese children and adolescents: relation to body mass index","volume":"80","author":"Hamza","year":"2013","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.numecd.2016.03.005_bib9","doi-asserted-by":"crossref","first-page":"e48250","DOI":"10.1371\/journal.pone.0048250","article-title":"Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study","volume":"7","author":"Martinelli","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2016.03.005_bib10","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1758-5996-6-114","article-title":"Serum ferritin levels and the development of metabolic syndrome and its components: a 6.5-year follow-up study","volume":"6","author":"Hamalainen","year":"2014","journal-title":"Diabetol Metab Syndr"},{"key":"10.1016\/j.numecd.2016.03.005_bib11","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/mnfr.201500038","article-title":"Distribution of serum transferrin, and its associations with metabolic disorders among Chinese: a nation-wide, health and nutrition survey","volume":"8","author":"Zhao","year":"2015","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.numecd.2016.03.005_bib12","doi-asserted-by":"crossref","first-page":"604","DOI":"10.2337\/dc06-1138","article-title":"Circulating soluble transferrin receptor according to glucose tolerance status and insulin sensitivity","volume":"30","author":"Fernandez-Real","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.numecd.2016.03.005_bib13","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.numecd.2015.07.005","article-title":"Iron metabolism and incidence of metabolic syndrome","volume":"25","author":"Kilani","year":"2015","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.numecd.2016.03.005_bib14","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1161\/ATVBAHA.110.214858","article-title":"Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations","volume":"31","author":"Valenti","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.numecd.2016.03.005_bib15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jpeds.2007.06.004","article-title":"Metabolic syndrome rates in United States adolescents, from the national health and nutrition examination survey, 1999-2002","volume":"152","author":"Cook","year":"2008","journal-title":"J Pediatr"},{"key":"10.1016\/j.numecd.2016.03.005_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0895-3988(10)60027-X","article-title":"Waist circumference reference values for screening cardiovascular risk factors in Chinese children and adolescents","volume":"23","author":"Ma","year":"2010","journal-title":"Biomed Environ Sci"},{"key":"10.1016\/j.numecd.2016.03.005_bib17","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1542\/peds.114.2.S2.555","article-title":"The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents","volume":"114","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.numecd.2016.03.005_bib18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.5223\/pghn.2014.17.2.85","article-title":"Dyslipidemia in children and adolescents: when and how to diagnose and treat?","volume":"17","author":"Yoon","year":"2014","journal-title":"Pediatr Gastroenterol Hepatol Nutr"},{"issue":"Suppl. 5","key":"10.1016\/j.numecd.2016.03.005_bib19","first-page":"S213","article-title":"Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report","volume":"128","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.numecd.2016.03.005_bib20","series-title":"Joint World Health Organization\/centers for disease control and prevention technical consultation on the assessment of iron status at the population level","year":"2004"},{"key":"10.1016\/j.numecd.2016.03.005_bib21","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1172\/JCI21441","article-title":"Anemia of inflammation: the cytokine-hepcidin link","volume":"113","author":"Andrews","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.numecd.2016.03.005_bib22","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bbamcr.2012.01.014","article-title":"Hepcidin and iron homeostasis","volume":"1823","author":"Ganz","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.numecd.2016.03.005_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3389\/fphar.2014.00195","article-title":"The role of iron metabolism as a mediator of macrophage inflammation and lipid handling in atherosclerosis","volume":"5","author":"Habib","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.numecd.2016.03.005_bib24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s40618-014-0174-6","article-title":"The interplay among iron metabolism, endothelium and inflammatory cascade in dysmetabolic disorders","volume":"38","author":"Yegin","year":"2014","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.numecd.2016.03.005_bib25","first-page":"e116867","article-title":"Low serum high density lipoprotein cholesterol concentration is an independent predictor for enhanced inflammation and endothelial activation","volume":"10","author":"Wan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2016.03.005_bib26","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/CS20140300","article-title":"Metabolic alterations, HFE gene mutations and atherogenic lipoprotein modifications in patients with primary iron overload","volume":"128","author":"Merono","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.numecd.2016.03.005_bib27","first-page":"32","article-title":"The relation between body iron store and ferritin, and coronary artery disease","volume":"10","author":"Pourmoghaddas","year":"2014","journal-title":"ARYA Atheroscler"},{"key":"10.1016\/j.numecd.2016.03.005_bib28","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nrcardio.2015.109","article-title":"Iron deficiency and cardiovascular disease","volume":"12","author":"von Haehling","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.numecd.2016.03.005_bib29","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.3390\/nu5072384","article-title":"Iron: protector or risk factor for cardiovascular disease? Still controversial","volume":"5","author":"Munoz-Bravo","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.numecd.2016.03.005_bib30","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.phrp.2014.06.005","article-title":"Relationship between serum levels of body iron parameters and insulin resistance and metabolic syndrome in Korean children","volume":"5","author":"Lee","year":"2014","journal-title":"Osong Public Health Res Perspect"},{"key":"10.1016\/j.numecd.2016.03.005_bib31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1475-2840-11-116","article-title":"Erythropoietin, ferritin, haptoglobin, hemoglobin and transferrin receptor in metabolic syndrome: a case control study","volume":"11","author":"Hamalainen","year":"2012","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.numecd.2016.03.005_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0009-8981(03)00005-6","article-title":"Soluble transferrin receptor for the evaluation of erythropoiesis and iron status","volume":"329","author":"Beguin","year":"2003","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.numecd.2016.03.005_bib33","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1182\/blood.V96.3.1113","article-title":"The molecular defect in hypotransferrinemic mice","volume":"96","author":"Trenor","year":"2000","journal-title":"Blood"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475315300521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475315300521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T06:04:14Z","timestamp":1600322654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475315300521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0939475315300521"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2016.03.005","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case\u2013control study","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2016.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}