{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:47:18Z","timestamp":1775306838890,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.numecd.2016.09.005","type":"journal-article","created":{"date-parts":[[2016,9,18]],"date-time":"2016-09-18T16:30:31Z","timestamp":1474216231000},"page":"168-175","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Homocysteine concentration in coronary artery disease: Influence of three common single nucleotide polymorphisms"],"prefix":"10.1016","volume":"27","author":[{"given":"C.","family":"Bickel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.B.","family":"Schnabel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Zengin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lubos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Rupprecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Lackner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Proust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Tregouet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Blankenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Westermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sinning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2016.09.005_bib1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1056\/NEJM199104253241701","article-title":"Hyperhomocysteinemia: an independent risk factor for vascular disease","volume":"324","author":"Clarke","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2016.09.005_bib2","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","article-title":"Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis","volume":"325","author":"Wald","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.numecd.2016.09.005_bib3","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1161\/01.CIR.94.10.2410","article-title":"Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians","volume":"94","author":"Ma","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2016.09.005_bib4","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/01.CIR.96.2.412","article-title":"Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene","volume":"96","author":"Schwartz","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2016.09.005_bib5","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1001\/jama.288.16.2023","article-title":"MTHFR 677C\u2192T polymorphism and risk of coronary heart disease: a meta-analysis","volume":"288","author":"Klerk","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.numecd.2016.09.005_bib6","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1136\/heartjnl-2013-304460","article-title":"The association between plasma homocysteine and coronary heart disease is modified by the MTHFR 677C>T polymorphism","volume":"99","author":"Mehlig","year":"2013","journal-title":"Heart"},{"key":"10.1016\/j.numecd.2016.09.005_bib7","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","author":"Lonn","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2016.09.005_bib8","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1161\/CIRCULATIONAHA.107.725481","article-title":"High-dose folic acid pretreatment blunts cardiac dysfunction during ischemia coupled to maintenance of high-energy phosphates and reduces postreperfusion injury","volume":"117","author":"Moens","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2016.09.005_bib9","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1161\/CIRCULATIONAHA.108.766105","article-title":"How does folic acid cure heart attacks?","volume":"117","author":"Tian","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2016.09.005_bib10","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0021-9150(00)00469-X","article-title":"Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction","volume":"154","author":"Chen","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.numecd.2016.09.005_bib11","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1161\/01.CIR.99.18.2383","article-title":"Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS)","volume":"99","author":"McQuillan","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2016.09.005_bib12","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00395-012-0316-y","article-title":"Mapping genetic determinants of coronary microvascular remodeling in the spontaneously hypertensive rat","volume":"108","author":"Mancini","year":"2013","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.numecd.2016.09.005_bib13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00395-013-0387-4","article-title":"Role of genetic polymorphisms of ion channels in the pathophysiology of coronary microvascular dysfunction and ischemic heart disease","volume":"108","author":"Fedele","year":"2013","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.numecd.2016.09.005_bib14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00395-012-0245-9","article-title":"Epigenetic modifications in cardiovascular disease","volume":"107","author":"Lorenzen","year":"2012","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.numecd.2016.09.005_bib15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s00395-008-0748-6","article-title":"Identification of mutational hot spots in LMNA encoding lamin A\/C in patients with familial dilated cardiomyopathy","volume":"104","author":"Perrot","year":"2009","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.numecd.2016.09.005_bib16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/humu.9214","article-title":"The molecular basis of cystathionine beta-synthase (CBS) deficiency in UK and US patients with homocystinuria","volume":"23","author":"Moat","year":"2004","journal-title":"Hum Mutat"},{"key":"10.1016\/j.numecd.2016.09.005_bib17","doi-asserted-by":"crossref","first-page":"e0131434","DOI":"10.1371\/journal.pone.0131434","article-title":"Risk factors of coronary artery disease in secondary prevention\u2013results from the AtheroGene\u2013study","volume":"10","author":"Zengin","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2016.09.005_bib18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1161\/hc2901.093115","article-title":"Maternal and paternal history of myocardial infarction and risk of cardiovascular disease in men and women","volume":"104","author":"Sesso","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2016.09.005_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.chroma.2004.02.056","article-title":"Practical aspects of fast reversed-phase high-performance liquid chromatography using 3 microm particle packed columns and monolithic columns in pharmaceutical development and production working under current good manufacturing practice","volume":"1036","author":"Gerber","year":"2004","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.numecd.2016.09.005_bib20","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.numecd.2016.09.005_bib21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/324163a0","article-title":"Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes","volume":"324","author":"Saiki","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.numecd.2016.09.005_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0065-2571(98)00029-6","article-title":"Homocysteine metabolism in cardiovascular cells and tissues: implications for hyperhomocysteinemia and cardiovascular disease","volume":"39","author":"Chen","year":"1999","journal-title":"Adv Enzyme Regul"},{"key":"10.1016\/j.numecd.2016.09.005_bib23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/eurheartj\/ehi036","article-title":"Analysis of N-terminal-pro-brain natriuretic peptide and C-reactive protein for risk stratification in stable and unstable coronary artery disease: results from the AtheroGene study","volume":"26","author":"Schnabel","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.numecd.2016.09.005_bib24","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1093\/eurheartj\/ehl362","article-title":"Impact of C-reactive protein and fibrinogen on cardiovascular prognosis in patients with stable angina pectoris: the AtheroGene study","volume":"27","author":"Sinning","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.numecd.2016.09.005_bib25","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1515\/CCLM.2001.121","article-title":"Vascular dysfunction in hyperhomocyst(e)inemia. Implications for atherothrombotic disease","volume":"39","author":"Stanger","year":"2001","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.numecd.2016.09.005_bib26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/CIRCULATIONAHA.105.590927","article-title":"Comparative impact of multiple biomarkers and N-Terminal pro-brain natriuretic peptide in the context of conventional risk factors for the prediction of recurrent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study","volume":"114","author":"Blankenberg","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2016.09.005_bib27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/01.CIR.93.1.7","article-title":"Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations","volume":"93","author":"Jacques","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2016.09.005_bib28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0021-9150(01)00699-2","article-title":"Homocysteine and methylenetetrahydrofolate reductase genotype: association with risk of coronary heart disease and relation to inflammatory, hemostatic, and lipid parameters","volume":"162","author":"Rothenbacher","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.numecd.2016.09.005_bib29","doi-asserted-by":"crossref","first-page":"e16473","DOI":"10.1371\/journal.pone.0016473","article-title":"Reconciling the evidence on serum homocysteine and ischaemic heart disease: a meta-analysis","volume":"6","author":"Wald","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2016.09.005_bib30","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1161\/01.RES.0000232324.87983.4b","article-title":"Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk","volume":"99","author":"Blankenberg","year":"2006","journal-title":"Circ Res"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475316301600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475316301600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T12:09:25Z","timestamp":1656936565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475316301600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0939475316301600"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2016.09.005","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Homocysteine concentration in coronary artery disease: Influence of three common single nucleotide polymorphisms","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2016.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}