{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:09:44Z","timestamp":1779916184446,"version":"3.53.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"crossref","award":["BMBF\u20130313868"],"award-info":[{"award-number":["BMBF\u20130313868"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]},{"name":"German Obesity Network of Competence","award":["01 Gl0830"],"award-info":[{"award-number":["01 Gl0830"]}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.numecd.2017.07.001","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T08:55:28Z","timestamp":1499763328000},"page":"858-864","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Branched-chain amino acid catabolism rather than amino acids plasma concentrations is associated with diet-induced changes in insulin resistance in overweight to obese individuals"],"prefix":"10.1016","volume":"27","author":[{"given":"S.","family":"Haufe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Engeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kaminski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0076-1865","authenticated-orcid":false,"given":"D.","family":"Rein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kamlage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Utz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Fuhrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"M\u00e4hler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schulz-Menger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.C.","family":"Luft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Boschmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2017.07.001_bib1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm.2307","article-title":"Metabolite profiles and the risk of developing diabetes","volume":"17","author":"Wang","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.numecd.2017.07.001_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.numecd.2017.07.001_bib3","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2337\/diabetes.51.3.599","article-title":"Mechanism of amino acid-induced skeletal muscle insulin resistance in humans","volume":"51","author":"Krebs","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2017.07.001_bib4","first-page":"105","article-title":"Branched-chain amino acid-enriched supplementation improves insulin resistance in patients with chronic liver disease","volume":"22","author":"Kawaguchi","year":"2008","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.numecd.2017.07.001_bib5","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.3945\/jn.111.138495","article-title":"Prolonged leucine supplementation does not augment muscle mass or affect glycemic control in elderly type 2 diabetic men","volume":"141","author":"Leenders","year":"2011","journal-title":"J Nutr"},{"key":"10.1016\/j.numecd.2017.07.001_bib6","doi-asserted-by":"crossref","first-page":"E1175","DOI":"10.1152\/ajpendo.00630.2012","article-title":"Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity","volume":"304","author":"Lackey","year":"2013","journal-title":"Am J Physiol Endocrinol Metabol"},{"key":"10.1016\/j.numecd.2017.07.001_bib7","doi-asserted-by":"crossref","first-page":"E1552","DOI":"10.1152\/ajpendo.00134.2007","article-title":"Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism","volume":"293","author":"She","year":"2007","journal-title":"Am J Physiol Endocrinol Metabol"},{"key":"10.1016\/j.numecd.2017.07.001_bib8","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrendo.2014.171","article-title":"Branched-chain amino acids in metabolic signalling and insulin resistance","volume":"10","author":"Lynch","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.numecd.2017.07.001_bib9","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nm.4057","article-title":"A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance","volume":"22","author":"Jang","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.numecd.2017.07.001_bib10","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.2337\/db16-1475","article-title":"Alterations in 3-hydroxyisobutyrate and FGF21 metabolism are associated with protein ingestion-induced insulin resistance","volume":"66","author":"Harris","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2017.07.001_bib11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cmet.2013.12.003","article-title":"Beta-aminoisobutyric acid induces browning of white fat and hepatic beta-oxidation and is inversely correlated with cardiometabolic risk factors","volume":"19","author":"Roberts","year":"2014","journal-title":"Cell Metabol"},{"key":"10.1016\/j.numecd.2017.07.001_bib12","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/hep.24242","article-title":"Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects","volume":"53","author":"Haufe","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.numecd.2017.07.001_bib13","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0009-8981(71)90452-9","article-title":"Creatinine assay in the presence of protein","volume":"32","author":"Cook","year":"1971","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.numecd.2017.07.001_bib14","doi-asserted-by":"crossref","first-page":"11348","DOI":"10.1074\/jbc.M109.075184","article-title":"Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels","volume":"285","author":"Herman","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.numecd.2017.07.001_bib15","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.2337\/db11-1378","article-title":"Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men","volume":"61","author":"Stancakova","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2017.07.001_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2337\/db14-0312","article-title":"Impaired adiponectin signaling contributes to disturbed catabolism of branched-chain amino acids in diabetic mice","volume":"64","author":"Lian","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2017.07.001_bib17","doi-asserted-by":"crossref","first-page":"207s","DOI":"10.1093\/jn\/136.1.207S","article-title":"Branched-chain amino acids: enzyme and substrate regulation","volume":"136","author":"Brosnan","year":"2006","journal-title":"J Nutr"},{"key":"10.1016\/j.numecd.2017.07.001_bib18","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.molmet.2016.08.001","article-title":"Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism","volume":"5","author":"Lerin","year":"2016","journal-title":"Mol Metabol"},{"key":"10.1016\/j.numecd.2017.07.001_bib19","doi-asserted-by":"crossref","first-page":"9728","DOI":"10.1073\/pnas.1303220110","article-title":"Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase","volume":"110","author":"Tso","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.numecd.2017.07.001_bib20","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.cell.2012.02.017","article-title":"Mechanisms for insulin resistance: common threads and missing links","volume":"148","author":"Samuel","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.numecd.2017.07.001_bib21","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/S0022-2275(20)38227-4","article-title":"Contribution of 3-hydroxyisobutyrate to the measurement of 3-hydroxybutyrate in human plasma: comparison of enzymatic and gas-liquid chromatography-mass spectrometry assays in normal and in diabetic subjects","volume":"30","author":"Avogaro","year":"1989","journal-title":"J Lipid Res"},{"key":"10.1016\/j.numecd.2017.07.001_bib22","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cmet.2012.01.024","article-title":"Interplay between lipids and branched-chain amino acids in development of insulin resistance","volume":"15","author":"Newgard","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.numecd.2017.07.001_bib23","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.ijcard.2016.08.307","article-title":"Associations between branched chain amino acid intake and biomarkers of adiposity and cardiometabolic health independent of genetic factors: a twin study","volume":"223","author":"Jennings","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.numecd.2017.07.001_bib24","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s12603-015-0521-0","article-title":"Consumption of branched-chain amino acids is inversely associated with central obesity and cardiometabolic features in a population of Brazilian middle-aged men: potential role of leucine intake","volume":"19","author":"Cogate","year":"2015","journal-title":"J Nutr Health Aging"},{"key":"10.1016\/j.numecd.2017.07.001_bib25","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.numecd.2016.03.013","article-title":"Branched-chain and aromatic amino acids, insulin resistance and liver specific ectopic fat storage in overweight to obese subjects","volume":"26","author":"Haufe","year":"2016","journal-title":"Nutr Metabol Cardiovasc Dis NMCD"},{"key":"10.1016\/j.numecd.2017.07.001_bib26","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3945\/jn.114.203943","article-title":"Whey protein supplementation does not alter plasma branched-chained amino acid profiles but results in unique metabolomics patterns in obese women enrolled in an 8-week weight loss trial","volume":"145","author":"Piccolo","year":"2015","journal-title":"J Nutr"},{"key":"10.1016\/j.numecd.2017.07.001_bib27","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.cmet.2010.08.016","article-title":"Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice","volume":"12","author":"D'Antona","year":"2010","journal-title":"Cell Metabol"},{"key":"10.1016\/j.numecd.2017.07.001_bib28","doi-asserted-by":"crossref","first-page":"e74705","DOI":"10.1371\/journal.pone.0074705","article-title":"Leucine supplementation protects from insulin resistance by regulating adiposity levels","volume":"8","author":"Binder","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2017.07.001_bib29","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1093\/aje\/kwt112","article-title":"Branched-chain amino acid intake and the risk of diabetes in a Japanese community: the Takayama study","volume":"178","author":"Nagata","year":"2013","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.numecd.2017.07.001_bib30","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ejcn.2014.123","article-title":"High dietary protein intake, reducing or eliciting insulin resistance?","volume":"68","author":"Rietman","year":"2014","journal-title":"Eur J Clin Nutr"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475317301424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475317301424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T12:10:04Z","timestamp":1656936604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475317301424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0939475317301424"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2017.07.001","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Branched-chain amino acid catabolism rather than amino acids plasma concentrations is associated with diet-induced changes in insulin resistance in overweight to obese individuals","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2017.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}