{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:48:52Z","timestamp":1777952932229,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["nmcd-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.numecd.2018.06.002","type":"journal-article","created":{"date-parts":[[2018,6,9]],"date-time":"2018-06-09T01:51:18Z","timestamp":1528509078000},"page":"865-876","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Oral antioxidant therapy for prevention and treatment of preeclampsia: Meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"28","author":[{"given":"M.B.","family":"Ten\u00f3rio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.C.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.A.","family":"Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.B.","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.O.F.","family":"Goulart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.C.M.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2018.06.002_bib1","series-title":"In WHO recommendations for prevention and treatment of pre-eclampsia and eclampsia","year":"2011"},{"key":"10.1016\/j.numecd.2018.06.002_bib2","series-title":"Encyclopedia of human nutrition","article-title":"Pregnancy: pre-eclampsia and diet","author":"Abalos","year":"2013"},{"key":"10.1016\/j.numecd.2018.06.002_bib3","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1007\/s10995-016-1983-3","article-title":"Gestational weight gain, body mass index, and risk of hypertensive disorders of pregnancy in a predominantly puerto rican population","volume":"20","author":"Chasan-Taber","year":"2016","journal-title":"Matern Child Health J"},{"key":"10.1016\/j.numecd.2018.06.002_bib4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2018.06.002_bib5","first-page":"5","article-title":"Endothelial dysfunction and preeclampsia: role of oxidative stress","volume":"372","author":"Sanchez-Aranguren","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.numecd.2018.06.002_bib6","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(15)00070-7","article-title":"Pre-eclampsia","volume":"387","author":"Mol","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2018.06.002_bib7","doi-asserted-by":"crossref","first-page":"7246","DOI":"10.4238\/2014.September.5.9","article-title":"Protection from vascular endothelial dysfunction in acute glycemic load-induced primary hypertension by vitamin C and E","volume":"13","author":"Xu","year":"2014","journal-title":"Genet Mol Res"},{"key":"10.1016\/j.numecd.2018.06.002_bib8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1365-2036.2006.02761.x","article-title":"Review article: complementary and alternative therapies for inflammatory bowel disease","volume":"23","author":"Langmead","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.numecd.2018.06.002_bib9","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.redox.2015.10.006","article-title":"Antioxidant therapy for treatment of inflammatory bowel disease: does it work?","volume":"6","author":"Moura","year":"2015","journal-title":"Redox Biol"},{"key":"10.1016\/j.numecd.2018.06.002_bib10","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/sj.ejcn.1600764","article-title":"Status of lipidsoluble antioxidants and TRAP in patients with Crohn's disease and healthy controls","volume":"53","author":"Genser","year":"1999","journal-title":"Eur J Clin Nutr"},{"issue":"2","key":"10.1016\/j.numecd.2018.06.002_bib11","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12011-015-0545-7","article-title":"Selenium and preeclampsia: a systematic review and meta-analysis","volume":"171","author":"Xu","year":"2016","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"10.1016\/j.numecd.2018.06.002_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejogrb.2011.04.010","article-title":"Prevention of pre-eclampsia with low-dose aspirin or vitamins C and E in women at high or low risk: a systematic review with meta-analysis","volume":"158","author":"Rossi","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.numecd.2018.06.002_bib13","first-page":"1","article-title":"Antioxidants for preventing pre-eclampsia","volume":"1","author":"Rumbold","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.numecd.2018.06.002_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1100\/2012\/243476","article-title":"Antioxidants for preventing preeclampsia: a systematic review","author":"Salles","year":"2012","journal-title":"Sci World J"},{"key":"10.1016\/j.numecd.2018.06.002_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3109\/10641955.2015.1137586","article-title":"Efficacy of L-arginine for preventing preeclampsia in high-risk pregnancies: a double-blind, randomized, clinical trial","volume":"35","author":"Pulido","year":"2016","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.numecd.2018.06.002_bib16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s13224-016-0885-z","article-title":"The effect of vitamin E and vitamin C on the prevention of preeclampsia and newborn outcome: a case\u2013control study","volume":"66","author":"Cardoso","year":"2016","journal-title":"J Obstet Gynaecol India"},{"key":"10.1016\/j.numecd.2018.06.002_bib17","first-page":"14","article-title":"The effects of vitamin C supplementation on pre-eclampsia in Mulago Hospital, Kampala, Uganda: a randomized placebo controlled clinical trial","volume":"283","author":"Kiondo","year":"2014","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.numecd.2018.06.002_bib18","first-page":"1","article-title":"The favorable effects of garlic intake on metabolic profiles, hs-CRP, biomarkers of oxidative stress and pregnancy outcomes in pregnant women at risk for pre-eclampsia: randomized, double-blind, placebo controlled trial","author":"Alami- Harandi","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"06","key":"10.1016\/j.numecd.2018.06.002_bib19","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1016\/j.ajog.2010.06.063","article-title":"The myth of vitamins C and E for the prevention of preeclampsia: just when will the penny drop?","volume":"203","author":"Talaulikar","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.numecd.2018.06.002_bib20","series-title":"Free radicals in biology and medicine","author":"Halliwell","year":"1989"},{"key":"10.1016\/j.numecd.2018.06.002_bib21","series-title":"GRADE working group: the grading of recommendations assessment, development and evaluation","year":"2017"},{"key":"10.1016\/j.numecd.2018.06.002_bib22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5152\/jtgga.2011.08","article-title":"Effect of lycopene in prevention of preeclampsia in high risk pregnant women","volume":"12","author":"Antartani","year":"2011","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"10.1016\/j.numecd.2018.06.002_bib23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1447-0756.2008.00983.x","article-title":"Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects","volume":"35","author":"Banerjee","year":"2009","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.numecd.2018.06.002_bib24","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ajog.2004.09.005","article-title":"Vitamin C and E supplementation in women at high risk for preeclampsia: a double-blind, placebo-controlled trial","volume":"192","author":"Beazley","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.numecd.2018.06.002_bib25","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0140-6736(99)80010-5","article-title":"Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial","volume":"354","author":"Chappell","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2018.06.002_bib26","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3109\/10641955.2010.507840","article-title":"Vitamin C and E supplementation does not reduce the risk of superimposed PE in pregnancy","volume":"30","author":"Kalpedev","year":"2011","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.numecd.2018.06.002_bib27","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0140-6736(10)60630-7","article-title":"Diabetes and Pre-eclampsia Intervention Trial (DAPIT) Study Group, Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomized placebo-controlled trial","volume":"376","author":"McCance","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2018.06.002_bib28","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(06)68433-X","article-title":"Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial","volume":"367","author":"Poston","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.numecd.2018.06.002_bib29","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1056\/NEJMoa0908056","article-title":"Vitamins C and E to prevent complications of pregnancy-associated hypertension","volume":"362","author":"Roberts","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2018.06.002_bib30","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1056\/NEJMoa054186","article-title":"Vitamins C and E and the risks of preeclampsia and perinatal complications","volume":"354","author":"Rumbold","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2018.06.002_bib31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0020-7292(03)00040-7","article-title":"Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas","volume":"81","author":"Sharma","year":"2003","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.numecd.2018.06.002_bib32","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1097\/01.AOG.0000289576.43441.1f","article-title":"Antioxidant therapy to prevent preeclampsia: a randomized controlled trial","volume":"110","author":"Spinnato","year":"2007","journal-title":"Obstet Gynaecol"},{"key":"10.1016\/j.numecd.2018.06.002_bib33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1028-4559(10)60038-1","article-title":"Selenium supplementation and the incidence of preeclampsia in pregnant Iranian women: a randomized, double-blind, placebo-controlled pilot trial","volume":"49","author":"Tara","year":"2010","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.numecd.2018.06.002_bib34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijgo.2008.11.033","article-title":"Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia","volume":"105","author":"Teran","year":"2009","journal-title":"Int J Gynecol Obstet"},{"key":"10.1016\/j.numecd.2018.06.002_bib35","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1471-0528.2009.02158.x","article-title":"World Health Organisation multicenter randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries","volume":"116","author":"Villar","year":"2009","journal-title":"BJOG An Int J Obstet Gynaecol"},{"key":"10.1016\/j.numecd.2018.06.002_bib36","first-page":"e1","article-title":"An international trial of antioxidants in the prevention of preeclampsia (INTAPP)","volume":"239","author":"Xu","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.numecd.2018.06.002_bib37","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1530\/EC-17-0130","article-title":"Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia","volume":"6","author":"Ding","year":"2017","journal-title":"Endocr Connect"},{"key":"10.1016\/j.numecd.2018.06.002_bib38","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1471-0528.1997.tb11979.x","article-title":"Antioxidants in the treatment of severe pre-eclampsia: an explanatory randomised controlled trial","volume":"104","author":"Gulmezoglu","year":"1997","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.numecd.2018.06.002_bib39","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/01.AOG.0000207637.01824.fe","article-title":"Effect of l-arginine therapy on the glomerular injury of preeclampsia a randomized controlled trial","volume":"107","author":"Hladunewich","year":"2011","journal-title":"Am Coll Obstet Gynecol"},{"key":"10.1016\/j.numecd.2018.06.002_bib40","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijgo.2016.07.002","article-title":"The effects of N-acetyl cysteine on oxidative stress among patients with pre-eclampsia","volume":"135","author":"Motawei","year":"2016","journal-title":"Int J Gynecol Obstet"},{"key":"10.1016\/j.numecd.2018.06.002_bib41","article-title":"Circulating biomarkers of oxidative stress in preeclampsia and efficacy of antioxidant Vitamin C supplementation. Research Journal of Pharmaceutical","volume":"7","author":"Mujawar","year":"2016","journal-title":"Biol Chem Sci"},{"key":"10.1016\/j.numecd.2018.06.002_bib42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejogrb.2005.09.007","article-title":"Oral N-acetylcysteine administration does not stabilise the process of established severe preeclampsia","volume":"127","author":"Roes","year":"2006","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.numecd.2018.06.002_bib43","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1742-7843.2006.pto_468.x","article-title":"Effects of oral l-arginine on the foetal condition and neonatal outcome in preeclampsia: a preliminary report","volume":"99","author":"Rytlewsky","year":"2006","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.numecd.2018.06.002_bib44","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3164\/jcbn.2008067","article-title":"Role of vitamins C and E in regulationg antioxidant and pro- oxidant markers in Preeclampsia","volume":"43","author":"Suhail","year":"2008","journal-title":"J Clin Biochem Nutr"},{"key":"10.1016\/j.numecd.2018.06.002_bib45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0304-5013(09)70342-5","article-title":"Efecto de la terapia temprana con L-arginina em el crecimiento intrauterino restringido en la preclampsia. Estudio aleatorizado em mujeres latino-americanas","volume":"52","author":"Valdivia-Silva","year":"2009","journal-title":"Progressos de Obstetricia y Ginecologia"},{"key":"10.1016\/j.numecd.2018.06.002_bib46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s12291-010-0102-2","article-title":"Effect of vitamin E on sp-selectin levels in pre-eclampsia","volume":"26","author":"Wangkheimayum","year":"2011","journal-title":"Indian J Clin Biochem"},{"key":"10.1016\/j.numecd.2018.06.002_bib47","doi-asserted-by":"crossref","first-page":"20570","DOI":"10.3390\/molecules191220570","article-title":"Resveratrol inhibits trophoblast apoptosis through oxidative stress in preeclampsia-model rats","volume":"19","author":"Zou","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.numecd.2018.06.002_bib48","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.nut.2005.02.010","article-title":"Plasma levels of lipophilic antioxidant vitamins in acute ischemic stroke patients: correlation to inflammation markers and neurological deficits","volume":"21","author":"Chang","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.numecd.2018.06.002_bib49","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ejogrb.2004.04.033","article-title":"Effect of quercetine and glutathione on the level of superoxide dismutase, catalase, malonyldialdehyde, blood pressure and neonatal outcome in a rat model of pre-eclampsia induced by NG-nitro-L-arginine-methyl ester","volume":"118","author":"Tanir","year":"2005","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"8","key":"10.1016\/j.numecd.2018.06.002_bib50","doi-asserted-by":"crossref","first-page":"e0135192","DOI":"10.1371\/journal.pone.0135192","article-title":"Maternal antioxidant levels in pregnancy and risk of preeclampsia and small for gestational age birth: a systematic review and meta-analysis","volume":"10","author":"Cohen","year":"2015","journal-title":"PLoS One"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093947531830190X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093947531830190X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T14:44:33Z","timestamp":1533912273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S093947531830190X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S093947531830190X"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2018.06.002","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral antioxidant therapy for prevention and treatment of preeclampsia: Meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2018.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}