{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:12:55Z","timestamp":1789780375284,"version":"4.0.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, M\u00e9xico","doi-asserted-by":"crossref","award":["CB-2014-01-243134"],"award-info":[{"award-number":["CB-2014-01-243134"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["nmcd-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.numecd.2018.06.019","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T18:10:37Z","timestamp":1530641437000},"page":"1188-1195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["(\u2212)-Epicatechin inhibits development of dilated cardiomyopathy in \u03b4 sarcoglycan null mouse"],"prefix":"10.1016","volume":"28","author":[{"given":"S.","family":"De los Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7150-7314","authenticated-orcid":false,"given":"C.","family":"Palma-Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Zentella-Dehesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Canto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6126-2002","authenticated-orcid":false,"given":"R.M.","family":"Coral-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.numecd.2018.06.019_bib1","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/mnfr.201200595","article-title":"Cardioprotective effects of cocoa: clinical evidence from randomized clinical intervention trials in humans","volume":"57","author":"Arranz","year":"2013","journal-title":"Mol Nutr Food Res"},{"issue":"3","key":"10.1016\/j.numecd.2018.06.019_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.numecd.2016.11.008","article-title":"Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance","volume":"27","author":"Sano","year":"2017","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"8","key":"10.1016\/j.numecd.2018.06.019_bib3","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1001\/jama.290.8.1030","article-title":"Vascular effects of cocoa rich in flavan-3-ols","volume":"290","author":"Heiss","year":"2003","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.numecd.2018.06.019_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00394-006-0627-6","article-title":"Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin","volume":"46","author":"Neukam","year":"2007","journal-title":"Eur J Nutr"},{"issue":"4","key":"10.1016\/j.numecd.2018.06.019_bib5","first-page":"411","article-title":"Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study","volume":"166","author":"Buijsse","year":"2006","journal-title":"Arch Intern Med"},{"issue":"6","key":"10.1016\/j.numecd.2018.06.019_bib6","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1161\/HYPERTENSIONAHA.109.147892","article-title":"(-)-epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways","volume":"55","author":"Ramirez-Sanchez","year":"2010","journal-title":"Hypertens"},{"issue":"6","key":"10.1016\/j.numecd.2018.06.019_bib7","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1161\/01.RES.0000013780.77774.75","article-title":"Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice","volume":"90","author":"Welch","year":"2002","journal-title":"Circ Res"},{"issue":"8","key":"10.1016\/j.numecd.2018.06.019_bib8","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1172\/JCI119730","article-title":"Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy","volume":"100","author":"Li","year":"1997","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.numecd.2018.06.019_bib9","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1152\/ajpheart.00562.2008","article-title":"Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function","volume":"296","author":"Rigor","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.numecd.2018.06.019_bib10","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1073\/pnas.0606663104","article-title":"Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy","volume":"104","author":"McMullen","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.numecd.2018.06.019_bib11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0167-5273(90)90082-G","article-title":"The incidence and evolution of cardiomyopathy in Duchenne muscular dystrophy","volume":"26","author":"Nigro","year":"1990","journal-title":"Int J Cardiol"},{"issue":"3","key":"10.1016\/j.numecd.2018.06.019_bib12","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/6543","article-title":"Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy","volume":"5","author":"Badorff","year":"1999","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.numecd.2018.06.019_bib13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0092-8674(00)81975-3","article-title":"Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy","volume":"98","author":"Coral-Vazquez","year":"1999","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.numecd.2018.06.019_bib14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1097-2765(00)80410-4","article-title":"Disruption of the beta-sarcoglycan gene reveals pathogenetic complexity of limb-girdle muscular dystrophy type 2E","volume":"5","author":"Durbeej","year":"2000","journal-title":"Mol Cell"},{"issue":"10","key":"10.1016\/j.numecd.2018.06.019_bib15","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1002\/1097-4598(200010)23:10<1456::AID-MUS2>3.0.CO;2-T","article-title":"Molecular basis of muscular dystrophies","volume":"23","author":"Cohn","year":"2000","journal-title":"Muscle Nerve"},{"issue":"6","key":"10.1016\/j.numecd.2018.06.019_bib16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S1050-1738(03)00101-4","article-title":"Sarcoglycans in vascular smooth and striated muscle","volume":"13","author":"Wheeler","year":"2003","journal-title":"Trends Cardiovasc Med"},{"issue":"9","key":"10.1016\/j.numecd.2018.06.019_bib17","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/sj.embor.7400221","article-title":"Duchenne muscular dystrophy and dystrophin: pathogenesis and opportunities for treatment","volume":"5","author":"Nowak","year":"2004","journal-title":"EMBO Rep"},{"issue":"4","key":"10.1016\/j.numecd.2018.06.019_bib18","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0092-8674(94)90527-4","article-title":"Missense mutations in the adhalin gene linked to autosomal recessive muscular dystrophy","volume":"78","author":"Roberds","year":"1994","journal-title":"Cell"},{"issue":"5237","key":"10.1016\/j.numecd.2018.06.019_bib19","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.270.5237.819","article-title":"Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy","volume":"270","author":"Noguchi","year":"1995","journal-title":"Science"},{"issue":"39","key":"10.1016\/j.numecd.2018.06.019_bib20","doi-asserted-by":"crossref","first-page":"27989","DOI":"10.1074\/jbc.274.39.27989","article-title":"epsilon-sarcoglycan replaces alpha-sarcoglycan in smooth muscle to form a unique dystrophin-glycoprotein complex","volume":"274","author":"Straub","year":"1999","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.numecd.2018.06.019_bib21","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/j.1468-1331.2007.01979.x","article-title":"EFNS guideline on diagnosis and management of limb girdle muscular dystrophies","volume":"14","author":"Norwood","year":"2007","journal-title":"Eur J Neurol"},{"issue":"2","key":"10.1016\/j.numecd.2018.06.019_bib22","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/ng1096-195","article-title":"Autosomal recessive limb-girdle muscular dystrophy, LGMD2F, is caused by a mutation in the delta-sarcoglycan gene","volume":"14","author":"Nigro","year":"1996","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.numecd.2018.06.019_bib23","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/jmg.35.11.951","article-title":"A first missense mutation in the delta sarcoglycan gene associated with a severe phenotype and frequency of limb-girdle muscular dystrophy type 2F (LGMD2F) in Brazilian sarcoglycanopathies","volume":"35","author":"Moreira","year":"1998","journal-title":"J Med Genet"},{"issue":"4","key":"10.1016\/j.numecd.2018.06.019_bib24","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/(SICI)1097-4598(199904)22:4<473::AID-MUS8>3.0.CO;2-5","article-title":"Heart involvement in muscular dystrophies due to sarcoglycan gene mutations","volume":"22","author":"Melacini","year":"1999","journal-title":"Muscle Nerve"},{"issue":"2","key":"10.1016\/j.numecd.2018.06.019_bib25","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/jmg.37.2.102","article-title":"Disruption of heart sarcoglycan complex and severe cardiomyopathy caused by beta sarcoglycan mutations","volume":"37","author":"Barresi","year":"2000","journal-title":"J Med Genet"},{"issue":"11","key":"10.1016\/j.numecd.2018.06.019_bib26","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/(SICI)1097-4598(199911)22:11<1549::AID-MUS10>3.0.CO;2-A","article-title":"Cardiomyopathy in duchenne, becker, and sarcoglycanopathies: a role for coronary dysfunction?","volume":"22","author":"Gnecchi-Ruscone","year":"1999","journal-title":"Muscle Nerve"},{"issue":"1","key":"10.1016\/j.numecd.2018.06.019_bib27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jcpa.2011.11.196","article-title":"Diagnostic value of morphometry in feline hypertrophic cardiomyopathy","volume":"147","author":"Kershaw","year":"2012","journal-title":"J Comp Pathol"},{"issue":"12","key":"10.1016\/j.numecd.2018.06.019_bib28","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1016\/j.bmcl.2014.04.038","article-title":"Cell membrane mediated (-)-epicatechin effects on upstream endothelial cell signaling: evidence for a surface receptor","volume":"24","author":"Moreno-Ulloa","year":"2014","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.numecd.2018.06.019_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/691015","article-title":"Epicatechin and catechin modulate endothelial activation induced by platelets of patients with peripheral artery disease","volume":"2014","author":"Carnevale","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.numecd.2018.06.019_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6949020","article-title":"(-)-Epicatechin prevents blood pressure increase and reduces locomotor hyperactivity in young spontaneously hypertensive rats","volume":"2016","author":"Kluknavsky","year":"2016","journal-title":"Oxid Med Cell Longev"},{"issue":"13","key":"10.1016\/j.numecd.2018.06.019_bib31","article-title":"\u03b4-Sarcoglycan-deficient muscular dystrophy: from discovery to therapeutic approaches","volume":"1","author":"Blain","year":"2011","journal-title":"Skelet Muscle"},{"issue":"1","key":"10.1016\/j.numecd.2018.06.019_bib32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1373\/clinchem.2011.165720","article-title":"Emerging biomarkers in heart failure","volume":"58","author":"van Kimmenade","year":"2012","journal-title":"Clin Chem"},{"issue":"2","key":"10.1016\/j.numecd.2018.06.019_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600343","article-title":"(-)-Epicatechin induces physiological cardiac growth by activation of the PI3K\/Akt pathway in mice","volume":"61","author":"De Los Santos","year":"2017","journal-title":"Mol Nutr Food Res"},{"issue":"3","key":"10.1016\/j.numecd.2018.06.019_bib34","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/HCO.0b013e328337ba52","article-title":"The genetics of dilated cardiomyopathy","volume":"25","author":"Dellefave","year":"2010","journal-title":"Curr Opin Cardiol"},{"issue":"14","key":"10.1016\/j.numecd.2018.06.019_bib35","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1242\/jcs.113.14.2535","article-title":"Differential requirement for individual sarcoglycans and dystrophin in the assembly and function of the dystrophin-glycoprotein complex","volume":"113","author":"Hack","year":"2000","journal-title":"J Cell Sci"},{"issue":"10092","key":"10.1016\/j.numecd.2018.06.019_bib36","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0140-6736(16)31713-5","article-title":"Dilated cardiomyopathy","volume":"390","author":"Weintraub","year":"2017","journal-title":"Lancet Lond Engl"},{"issue":"5","key":"10.1016\/j.numecd.2018.06.019_bib37","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/nu9050523","article-title":"Effects of polyphenols on oxidative stress-mediated injury in cardiomyocytes","volume":"9","author":"Mattera","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.numecd.2018.06.019_bib38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yjmcc.2018.04.007","article-title":"Anti-oxidant effect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy: role of autophagy and c-kitposCD45negCD31neg cardiac stem cell activation","volume":"119","author":"Carresi","year":"2018","journal-title":"J Mol Cell Cardiol"},{"issue":"10","key":"10.1016\/j.numecd.2018.06.019_bib39","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1161\/CIRCULATIONAHA.108.827022","article-title":"Cocoa and cardiovascular health","volume":"119","author":"Corti","year":"2009","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.numecd.2018.06.019_bib40","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1073\/pnas.0510168103","article-title":"(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans","volume":"103","author":"Schroeter","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.numecd.2018.06.019_bib41","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ijcard.2015.02.007","article-title":"Oxidized LDL attenuates protective autophagy and induces apoptotic cell death of endothelial cells: role of oxidative stress and LOX-1 receptor expression","volume":"84","author":"Mollace","year":"2015","journal-title":"Int J Cardiol"},{"issue":"24","key":"10.1016\/j.numecd.2018.06.019_bib42","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1111\/febs.13098","article-title":"(-)-Epicatechin improves mitochondrial-related protein levels and ameliorates oxidative stress in dystrophic \u03b4-sarcoglycan null mouse striated muscle","volume":"281","author":"Ramirez-Sanchez","year":"2014","journal-title":"FEBS J"},{"issue":"9","key":"10.1016\/j.numecd.2018.06.019_bib43","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.bbadis.2008.05.002","article-title":"Cardioprotection with alpha-tocopheryl phosphate: amelioration of myocardial ischemia reperfusion injury is linked with its ability to generate a survival signal through Akt activation","volume":"1782","author":"Mukherjee","year":"2008","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"10.1016\/j.numecd.2018.06.019_bib44","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1152\/ajpheart.00073.2010","article-title":"Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on delta-opioid receptor stimulation","volume":"299","author":"Panneerselvam","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"18","key":"10.1016\/j.numecd.2018.06.019_bib45","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1113\/jphysiol.2011.209924","article-title":"(-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle","volume":"589","author":"Nogueira","year":"2011","journal-title":"J Physiol"},{"issue":"59","key":"10.1016\/j.numecd.2018.06.019_bib46","doi-asserted-by":"crossref","first-page":"99347","DOI":"10.18632\/oncotarget.19966","article-title":"Effects of nicorandil on PI3K\/Akt signaling pathway and its anti-apoptotic mechanisms in coronary microembolization in rats","volume":"8","author":"Su","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.numecd.2018.06.019_bib47","first-page":"10","article-title":"Natriuretic Peptide system and cardiovascular disease","volume":"11","author":"Federico","year":"2010","journal-title":"Heart Views Off J Gulf Heart Assoc"},{"issue":"1","key":"10.1016\/j.numecd.2018.06.019_bib48","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s10238-004-0037-0","article-title":"Plasma brain natriuretic peptide levels in coronary heart disease with preserved systolic function","volume":"4","author":"Palazzuoli","year":"2004","journal-title":"Clin Exp Med"},{"issue":"4","key":"10.1016\/j.numecd.2018.06.019_bib49","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.trsl.2006.04.004","article-title":"Presence and severity of coronary artery disease and changes in B-type natriuretic peptide levels in patients with a normal systolic function","volume":"148","author":"Kim","year":"2006","journal-title":"Transl Res J Lab Clin Med"},{"issue":"2","key":"10.1016\/j.numecd.2018.06.019_bib50","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1161\/CIRCULATIONAHA.111.063842","article-title":"Evaluation of multiple biomarkers of cardiovascular stress for risk prediction and guiding medical therapy in patients with stable coronary disease","volume":"125","author":"Sabatine","year":"2012","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.numecd.2018.06.019_bib51","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1159\/000475396","article-title":"(-)-Epicatechin suppresses Angiotensin II-induced cardiac hypertrophy via the activation of the SP1\/SIRT1 signaling pathway","volume":"41","author":"Dong","year":"2017","journal-title":"Cell Physiol Biochem Int J Exp Cell"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475318302229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475318302229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T22:53:11Z","timestamp":1661554391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475318302229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0939475318302229"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2018.06.019","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"(\u2212)-Epicatechin inhibits development of dilated cardiomyopathy in \u03b4 sarcoglycan null mouse","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2018.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}