{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T20:33:23Z","timestamp":1747168403057,"version":"3.40.5"},"reference-count":60,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["nmcd-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.numecd.2019.05.051","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T18:57:11Z","timestamp":1557601031000},"page":"856-864","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Putative Nox2 inhibitors worsen homocysteine-induced impaired acetylcholine-mediated relaxation"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-622X","authenticated-orcid":false,"given":"Renee M.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudarshan","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kruzliak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Zulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2019.05.051_bib1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.vph.2015.05.008","article-title":"The critical role of Akt in cardiovascular function","volume":"74","author":"Abeyrathna","year":"2015","journal-title":"Vasc Pharmacol"},{"issue":"48","key":"10.1016\/j.numecd.2019.05.051_bib2","doi-asserted-by":"crossref","first-page":"35373","DOI":"10.1074\/jbc.M702175200","article-title":"NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways","volume":"282","author":"Abid","year":"2007","journal-title":"J Biol Chem"},{"issue":"14","key":"10.1016\/j.numecd.2019.05.051_bib3","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1007\/s00018-012-1010-9","article-title":"The NOX toolbox: validating the role of NADPH oxidases in physiology and disease","volume":"69","author":"Altenhofer","year":"2012","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"10.1016\/j.numecd.2019.05.051_bib4","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/ceo.13155","article-title":"Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells'","volume":"46","author":"Appukuttan","year":"2018","journal-title":"Clin Exp Ophthalmol"},{"issue":"8","key":"10.1016\/j.numecd.2019.05.051_bib5","first-page":"705","article-title":"Simvastin reduces endothelial NOS: caveolin-1 ratio but not the phosphorylation status of eNOS in\u00a0vivo'","volume":"19","author":"Arora","year":"2012","journal-title":"J Atheroscler Thromb"},{"issue":"6","key":"10.1016\/j.numecd.2019.05.051_bib6","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1016\/j.ijcard.2012.08.050","article-title":"Acute exercise induce endothelial nitric oxide synthase phosphorylation via Akt and AMP-activated protein kinase in aorta of rats: role of reactive oxygen species","volume":"167","author":"Barbosa","year":"2013","journal-title":"Int J Cardiol"},{"issue":"3\u20134","key":"10.1016\/j.numecd.2019.05.051_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.vph.2012.01.004","article-title":"Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of beta-catenin in response to homocysteine","volume":"56","author":"Beard","year":"2012","journal-title":"Vasc Pharmacol"},{"issue":"1","key":"10.1016\/j.numecd.2019.05.051_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol Rev"},{"issue":"4","key":"10.1016\/j.numecd.2019.05.051_bib9","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1080\/pat.32.4.262.273","article-title":"Number 58: homocysteine and disease","volume":"32","author":"Beilby","year":"2000","journal-title":"Pathology"},{"issue":"6","key":"10.1016\/j.numecd.2019.05.051_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002803","article-title":"Patterns of evolutionary conservation of essential genes correlate with their compensability","volume":"8","author":"Bergmiller","year":"2012","journal-title":"PLoS Genet"},{"issue":"2","key":"10.1016\/j.numecd.2019.05.051_bib11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.chembiol.2011.12.017","article-title":"Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation","volume":"19","author":"Bosco","year":"2012","journal-title":"Chem Biol"},{"issue":"4","key":"10.1016\/j.numecd.2019.05.051_bib12","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/labinvest.2017.2","article-title":"APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db\/db mice from renal injury","volume":"97","author":"Cha","year":"2017","journal-title":"Lab Invest"},{"issue":"6","key":"10.1016\/j.numecd.2019.05.051_bib13","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1172\/JCI72063","article-title":"Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination","volume":"124","author":"da Silva","year":"2014","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.numecd.2019.05.051_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.5483\/BMBRep.2008.41.3.223","article-title":"The bimodal regulation of vascular function by superoxide anion: role of endothelium","volume":"41","author":"Demirci","year":"2008","journal-title":"BMB Rep"},{"issue":"2","key":"10.1016\/j.numecd.2019.05.051_bib15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/ars.2012.4918","article-title":"Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension","volume":"20","author":"Dikalov","year":"2014","journal-title":"Antioxid Redox Signal"},{"issue":"9","key":"10.1016\/j.numecd.2019.05.051_bib16","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.tem.2014.06.012","article-title":"Endothelial NADPH oxidases: which NOX to target in vascular disease?","volume":"25","author":"Drummond","year":"2014","journal-title":"Trends Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.numecd.2019.05.051_bib17","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1385\/CT:4:4:375","article-title":"The oxygen radical generator pyrogallol impairs cardiomyocyte contractile function via a superoxide and p38 MAP kinase-dependent pathway: protection by anisodamine and tetramethylpyrazine","volume":"4","author":"Esberg","year":"2004","journal-title":"Cardiovasc Toxicol"},{"issue":"4","key":"10.1016\/j.numecd.2019.05.051_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s11906-010-0118-2","article-title":"Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets","volume":"12","author":"Feletou","year":"2010","journal-title":"Curr Hypertens Rep"},{"issue":"1","key":"10.1016\/j.numecd.2019.05.051_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/10915819109078623","article-title":"Final report on the safety assessment of pyrogallol","volume":"10","year":"1991","journal-title":"J Am Coll Toxicol"},{"issue":"7","key":"10.1016\/j.numecd.2019.05.051_bib20","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"F\u00f6rstermann","year":"2012","journal-title":"Eur Heart J"},{"issue":"3","key":"10.1016\/j.numecd.2019.05.051_bib21","doi-asserted-by":"crossref","first-page":"H725","DOI":"10.1152\/ajpheart.00696.2009","article-title":"Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries","volume":"300","author":"Gauthier","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"10.1016\/j.numecd.2019.05.051_bib22","first-page":"169","article-title":"Association of matrix metalloproteinase-2 and matrix metalloproteinase-9 with endothelial dysfunction, cardiovascular disease risk factors and thrombotic events in children with end-stage renal disease","volume":"12","author":"Gheissari","year":"2018","journal-title":"Iran J Kidney Dis"},{"issue":"5","key":"10.1016\/j.numecd.2019.05.051_bib23","doi-asserted-by":"crossref","first-page":"H710","DOI":"10.1152\/ajpheart.00890.2013","article-title":"NADPH oxidase-2 inhibition restores contractility and intracellular calcium handling and reduces arrhythmogenicity in dystrophic cardiomyopathy","volume":"307","author":"Gonzalez","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"9","key":"10.1016\/j.numecd.2019.05.051_bib24","doi-asserted-by":"crossref","first-page":"H1501","DOI":"10.1152\/ajpheart.00443.2015","article-title":"Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway","volume":"309","author":"Han","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.numecd.2019.05.051_bib25","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2014.2249","article-title":"Aberrant DNA methylation of the PDGF gene in homocysteine-mediated VSMC proliferation and its underlying mechanism","author":"Han","year":"2014","journal-title":"Mol Med Rep"},{"issue":"2","key":"10.1016\/j.numecd.2019.05.051_bib26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.chembiol.2012.02.001","article-title":"Exploiting effectors of rac GTPase","volume":"19","author":"Jo","year":"2012","journal-title":"Chem Biol"},{"issue":"26","key":"10.1016\/j.numecd.2019.05.051_bib27","doi-asserted-by":"crossref","first-page":"10581","DOI":"10.1073\/pnas.1202810109","article-title":"Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death","volume":"109","author":"Jo","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.numecd.2019.05.051_bib28","article-title":"'NADPH oxidases in vascular pathology","author":"Konior","year":"2013","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"10.1016\/j.numecd.2019.05.051_bib29","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bcp.2011.04.001","article-title":"Ginsenoside Rb1 prevents homocysteine-induced endothelial dysfunction via PI3K\/Akt activation and PKC inhibition","volume":"82","author":"Lan","year":"2011","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"10.1016\/j.numecd.2019.05.051_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF02257986","article-title":"Generation of hydrogen peroxide, superoxide anion and the hydroxyl free radical from polyphenols and active benzene metabolites: their possible role in mutagenesis","volume":"1","author":"Lee","year":"1994","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.numecd.2019.05.051_bib31","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","author":"Lonn","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2019.05.051_bib32","doi-asserted-by":"crossref","first-page":"7111","DOI":"10.1038\/s41598-017-07768-7","article-title":"Compensatory vasodilator mechanisms in the ophthalmic artery of endothelial nitric oxide synthase gene knockout mice","volume":"7","author":"Manicam","year":"2017","journal-title":"Sci Rep"},{"issue":"21","key":"10.1016\/j.numecd.2019.05.051_bib33","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1111\/bph.13773","article-title":"Signalling mechanisms underlying doxorubicin and Nox2 NADPH oxidase-induced cardiomyopathy: involvement of mitofusin-2'","volume":"174","author":"McLaughlin","year":"2017","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.numecd.2019.05.051_bib34","first-page":"1","volume":"vol. 86","author":"Montes","year":"1991"},{"key":"10.1016\/j.numecd.2019.05.051_bib35","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/1755-5922.12306","article-title":"Alamandine reverses hyperhomocysteinemia-induced vascular dysfunction via PKA-dependent mechanisms","volume":"35","author":"Qaradakhi","year":"2017","journal-title":"Cardiovasc Ther"},{"issue":"6","key":"10.1016\/j.numecd.2019.05.051_bib36","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1365-2613.2009.00668.x","article-title":"A physiologically relevant atherogenic diet causes severe endothelial dysfunction within 4 weeks in rabbit","volume":"90","author":"Rai","year":"2009","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.numecd.2019.05.051_bib37","first-page":"301","article-title":"NOX activation by subunit interaction and underlying mechanisms in disease","volume":"10","author":"Rastogi","year":"2016","journal-title":"Front Cell Neurosci"},{"issue":"3","key":"10.1016\/j.numecd.2019.05.051_bib38","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1159\/000443041","article-title":"Selenium inhibits homocysteine-induced endothelial dysfunction and apoptosis via activation of AKT","volume":"38","author":"Ren","year":"2016","journal-title":"Cell Physiol Biochem"},{"issue":"5","key":"10.1016\/j.numecd.2019.05.051_bib39","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/hh1701.096037","article-title":"Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O2- and systolic blood pressure in mice","volume":"89","author":"Rey","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.numecd.2019.05.051_bib40","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3389\/fphys.2018.00690","article-title":"Potential modulation of vascular function by nitric oxide and reactive oxygen species released from erythrocytes","volume":"9","author":"Rifkind","year":"2018","journal-title":"Front Physiol"},{"issue":"2","key":"10.1016\/j.numecd.2019.05.051_bib41","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1179\/174329210X12650506623401","article-title":"Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models","volume":"15","author":"Rivera","year":"2010","journal-title":"Redox Rep"},{"issue":"2","key":"10.1016\/j.numecd.2019.05.051_bib42","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1189\/jlb.2AB0514-273RR","article-title":"Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells'","volume":"97","author":"Samik","year":"2015","journal-title":"J Leukoc Biol"},{"issue":"4","key":"10.1016\/j.numecd.2019.05.051_bib43","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1152\/advan.00088.2014","article-title":"Aerobic exercise and other healthy lifestyle factors that influence vascular aging","volume":"38","author":"Santos-Parker","year":"2014","journal-title":"Adv Physiol Educ"},{"issue":"4","key":"10.1016\/j.numecd.2019.05.051_bib44","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1161\/STROKEAHA.108.529503","article-title":"Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial","volume":"40","author":"Saposnik","year":"2009","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.numecd.2019.05.051_bib45","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/cvr\/cvn326","article-title":"Norfuraneol dephosphorylates eNOS at threonine 495 and enhances eNOS activity in human endothelial cells","volume":"81","author":"Schmitt","year":"2009","journal-title":"Cardiovasc Res"},{"issue":"7","key":"10.1016\/j.numecd.2019.05.051_bib46","doi-asserted-by":"crossref","first-page":"515","DOI":"10.18632\/aging.100569","article-title":"Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK","volume":"5","author":"Shafique","year":"2013","journal-title":"Aging"},{"issue":"1\u20132","key":"10.1016\/j.numecd.2019.05.051_bib47","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11010-011-0973-4","article-title":"Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox)","volume":"358","author":"Sipkens","year":"2011","journal-title":"Mol Cell Biochem"},{"issue":"8","key":"10.1016\/j.numecd.2019.05.051_bib48","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/1440-1681.12427","article-title":"Role of Nox inhibitors plumbagin, ML090 and gp91ds-tat peptide on homocysteine thiolactone induced blood vessel dysfunction","volume":"42","author":"Smith","year":"2015","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"5","key":"10.1016\/j.numecd.2019.05.051_bib49","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12292","article-title":"Long-term methionine-diet induced mild hyperhomocysteinemia associated cardiac metabolic dysfunction in multiparous rats","volume":"3","author":"Song","year":"2015","journal-title":"Physiol Rep"},{"issue":"7","key":"10.1016\/j.numecd.2019.05.051_bib50","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1089\/ars.2010.3721","article-title":"Mechanisms of cardiovascular remodeling in hyperhomocysteinemia","volume":"15","author":"Steed","year":"2011","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"10.1016\/j.numecd.2019.05.051_bib51","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bcp.2014.08.001","article-title":"Doxycycline exerts multiple anti-allergy effects to attenuate murine allergic conjunctivitis and systemic anaphylaxis","volume":"91","author":"Su","year":"2014","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"10.1016\/j.numecd.2019.05.051_bib52","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/mnfr.201500618","article-title":"Dietary polyphenol morin rescues endothelial dysfunction in a diabetic mouse model by activating the Akt\/eNOS pathway","volume":"60","author":"Taguchi","year":"2016","journal-title":"Mol Nutr Food Res"},{"issue":"4","key":"10.1016\/j.numecd.2019.05.051_bib53","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1179\/1743132812Y.0000000021","article-title":"NADPH oxidase in stroke and cerebrovascular disease","volume":"34","author":"Tang","year":"2012","journal-title":"Neurol Res"},{"issue":"8","key":"10.1016\/j.numecd.2019.05.051_bib54","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1161\/01.ATV.0000083297.47245.DA","article-title":"Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice","volume":"23","author":"Virdis","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"10.1016\/j.numecd.2019.05.051_bib55","doi-asserted-by":"crossref","first-page":"22350","DOI":"10.3390\/ijms160922350","article-title":"Gardenamide a protects RGC-5 cells from H(2)O(2)-induced oxidative stress insults by activating PI3K\/Akt\/eNOS signaling pathway","volume":"16","author":"Wang","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.numecd.2019.05.051_bib56","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.vph.2015.07.004","article-title":"Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK\/PI3K\/Akt\/eNOS pathway","volume":"72","author":"Xing","year":"2015","journal-title":"Vasc Pharmacol"},{"issue":"2","key":"10.1016\/j.numecd.2019.05.051_bib57","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jphs.2015.09.002","article-title":"Vascular nitric oxide: beyond eNOS","volume":"129","author":"Zhao","year":"2015","journal-title":"J Pharmacol Sci"},{"issue":"12","key":"10.1016\/j.numecd.2019.05.051_bib58","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/abbs\/gmq102","article-title":"Homocysteine enhances cell proliferation in vascular smooth muscle cells: role of p38 MAPK and p47phox'","volume":"42","author":"Zou","year":"2010","journal-title":"Acta Biochim Biophys Sin"},{"issue":"3","key":"10.1016\/j.numecd.2019.05.051_bib59","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2613.2009.00649.x","article-title":"High dietary methionine plus cholesterol stimulates early atherosclerosis and late fibrous cap development which is associated with a decrease in GRP78 positive plaque cells","volume":"90","author":"Zulli","year":"2009","journal-title":"Int J Exp Pathol"},{"issue":"8","key":"10.1016\/j.numecd.2019.05.051_bib60","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1161\/01.ATV.0000080686.39871.54","article-title":"High methionine and cholesterol diet abolishes endothelial relaxation","volume":"23","author":"Zulli","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093947531930198X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093947531930198X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T17:09:38Z","timestamp":1563556178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S093947531930198X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":60,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S093947531930198X"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2019.05.051","relation":{},"ISSN":["0939-4753"],"issn-type":[{"type":"print","value":"0939-4753"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Putative Nox2 inhibitors worsen homocysteine-induced impaired acetylcholine-mediated relaxation","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2019.05.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}