{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:00:23Z","timestamp":1774418423149,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573170"],"award-info":[{"award-number":["81573170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nmcd-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.numecd.2019.05.058","type":"journal-article","created":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T10:22:07Z","timestamp":1558174927000},"page":"793-801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Physical activity attenuates the association between the IRS1 genotype and childhood obesity in Chinese children"],"prefix":"10.1016","volume":"29","author":[{"given":"Qiying","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieyun","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2019.05.058_bib1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/372186a0","article-title":"Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene","volume":"372","author":"Araki","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.numecd.2019.05.058_bib2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/372182a0","article-title":"Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1","volume":"372","author":"Tamemoto","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.numecd.2019.05.058_bib3","doi-asserted-by":"crossref","first-page":"T1","DOI":"10.1530\/JOE-13-0584","article-title":"Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms","volume":"220","author":"Guo","year":"2014","journal-title":"J Endocrinol"},{"key":"10.1016\/j.numecd.2019.05.058_bib4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/ng.866","article-title":"Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile","volume":"43","author":"Kilpelainen","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.numecd.2019.05.058_bib5","doi-asserted-by":"crossref","first-page":"10495","DOI":"10.1038\/ncomms10495","article-title":"New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk","volume":"7","author":"Lu","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.numecd.2019.05.058_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s12020-012-9693-0","article-title":"Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population","volume":"43","author":"Tang","year":"2013","journal-title":"Endocrine"},{"key":"10.1016\/j.numecd.2019.05.058_bib7","article-title":"Genetic association study with metabolic syndrome and metabolic-related traits in a cross-sectional sample and a 10-year longitudinal sample of Chinese elderly population","volume":"9","author":"Yang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2019.05.058_bib8","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.tem.2015.08.008","article-title":"The genetics of pediatric obesity","volume":"26","author":"Chesi","year":"2015","journal-title":"Trends Endocrinol Metabol"},{"key":"10.1016\/j.numecd.2019.05.058_bib9","article-title":"Physical activity and sedentary behaviors modify the association between melanocortin 4 receptor gene variant and obesity in Chinese children and adolescents","volume":"12","author":"Song","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2019.05.058_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001116","article-title":"Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children","volume":"8","author":"Kilpelainen","year":"2011","journal-title":"PLoS Med"},{"key":"10.1016\/j.numecd.2019.05.058_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000332","article-title":"Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study","volume":"7","author":"Li","year":"2010","journal-title":"PLoS Med"},{"key":"10.1016\/j.numecd.2019.05.058_bib12","article-title":"Genome-wide physical activity interactions in adiposity - a meta-analysis of 200,452 adults","volume":"13","author":"Graff","year":"2017","journal-title":"PLoS Genet"},{"key":"10.1016\/j.numecd.2019.05.058_bib13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1152\/jappl.2000.88.2.797","article-title":"Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle","volume":"88","author":"Kirwan","year":"1985","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.numecd.2019.05.058_bib14","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s00125-011-2123-7","article-title":"Genetic variants near the IRS1 gene, physical activity and type 2 diabetes in US men and women","volume":"54","author":"He","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2019.05.058_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186296","article-title":"Genetic variants and traits related to insulin-like growth factor-I and insulin resistance and their interaction with lifestyles on postmenopausal colorectal cancer risk","volume":"12","author":"Jung","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.numecd.2019.05.058_bib16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/oby.2009.268","article-title":"Association of the MC4R V103I polymorphism with obesity: a Chinese case-control study and meta-analysis in 55,195 individuals","volume":"18","author":"Wang","year":"2010","journal-title":"Obesity"},{"key":"10.1016\/j.numecd.2019.05.058_bib17","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0895-3988(09)60013-1","article-title":"Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents","volume":"21","author":"Wang","year":"2008","journal-title":"Biomed Environ Sci"},{"key":"10.1016\/j.numecd.2019.05.058_bib18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000471487","article-title":"Association study of three gene polymorphisms recently identified by a genome-wide association study with obesity-related phenotypes in Chinese children","volume":"10","author":"Song","year":"2017","journal-title":"Obes Facts"},{"key":"10.1016\/j.numecd.2019.05.058_bib19","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1186\/1471-2458-14-1282","article-title":"Effectiveness of a school-based physical activity intervention on obesity in school children: a nonrandomized controlled trial","volume":"14","author":"Li","year":"2014","journal-title":"BMC Public Health"},{"key":"10.1016\/j.numecd.2019.05.058_bib20","series-title":"Screening standard for malnutrition of school-age children and adolescents","year":"2014"},{"key":"10.1016\/j.numecd.2019.05.058_bib21","first-page":"390","article-title":"Report on childhood obesity in China (1)\u2013body mass index reference for screening overweight and obesity in Chinese school-age children","volume":"18","author":"Ji","year":"2005","journal-title":"Biomed Environ Sci"},{"key":"10.1016\/j.numecd.2019.05.058_bib22","series-title":"WS\/T 586-2018, Screening for overweight and obesity among school-age children and adolescents","year":"2018"},{"key":"10.1016\/j.numecd.2019.05.058_bib23","author":"World Health Organization"},{"key":"10.1016\/j.numecd.2019.05.058_bib24","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","article-title":"Use and abuse of HOMA modeling","volume":"27","author":"Wallace","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.numecd.2019.05.058_bib25","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1542\/peds.114.2.S2.555","article-title":"The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents","volume":"114","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.numecd.2019.05.058_bib26","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12881-016-0352-9","article-title":"Physical activity and sedentary behavior can modulate the effect of the PNPLA3 variant on childhood NAFLD: a case-control study in a Chinese population","volume":"17","author":"Wang","year":"2016","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.numecd.2019.05.058_bib27","first-page":"214","article-title":"Investigation on physical activity among children and adolescents with different nutritional status in five cities in China","volume":"30","author":"Ma","year":"2009","journal-title":"Chin J Sch Health"},{"key":"10.1016\/j.numecd.2019.05.058_bib28","series-title":"Global recommendations on physical activity for health","year":"2010"},{"key":"10.1016\/j.numecd.2019.05.058_bib29","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1542\/peds.107.2.423","article-title":"Children, adolescents, and television","volume":"107","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.numecd.2019.05.058_bib30","article-title":"Association of common variants identified by recent genome-wide association studies with obesity in Chinese children: a case-control study","volume":"7","author":"Wang","year":"2016","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.numecd.2019.05.058_bib31","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/pr.2014.88","article-title":"Association study of childhood obesity with eight genetic variants recently identified by genome-wide association studies","volume":"76","author":"Meng","year":"2014","journal-title":"Pediatr Res"},{"key":"10.1016\/j.numecd.2019.05.058_bib32","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"Br Med J"},{"key":"10.1016\/j.numecd.2019.05.058_bib33","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/oxfordjournals.aje.a009981","article-title":"Evaluation of old and new tests of heterogeneity in epidemiologic meta-analysis","volume":"150","author":"Takkouche","year":"1999","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.numecd.2019.05.058_bib34","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature09270","article-title":"Biological, clinical and population relevance of 95 loci for blood lipids","volume":"466","author":"Teslovich","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.numecd.2019.05.058_bib35","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa072366","article-title":"Genomewide association analysis of coronary artery disease","volume":"357","author":"Samani","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2019.05.058_bib36","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/ng.443","article-title":"Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia","volume":"41","author":"Rung","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.numecd.2019.05.058_bib37","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1002\/oby.21624","article-title":"Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics\/Latinos","volume":"24","author":"Qi","year":"2016","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.numecd.2019.05.058_bib38","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1093\/aje\/kwr008","article-title":"Influence of physical inactivity on associations between single nucleotide polymorphisms and genetic predisposition to childhood obesity","volume":"173","author":"Xi","year":"2011","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.numecd.2019.05.058_bib39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1123\/pes.2017-0077","article-title":"Gene-by-Activity interactions on obesity traits of 6-year-old New Zealand European children: a children of SCOPE study","volume":"30","author":"Krishnan","year":"2018","journal-title":"Pediatr Exerc Sci"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475319302054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475319302054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T10:17:44Z","timestamp":1569320264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475319302054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0939475319302054"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2019.05.058","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physical activity attenuates the association between the IRS1 genotype and childhood obesity in Chinese children","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2019.05.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}