{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T21:00:52Z","timestamp":1774040452036,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmcd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.numecd.2020.04.021","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T11:51:54Z","timestamp":1588679514000},"page":"1306-1314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["The role of C-reactive protein, adiponectin and leptin in the association between abdominal adiposity and insulin resistance in middle-aged individuals"],"prefix":"10.1016","volume":"30","author":[{"given":"Raymond","family":"Noordam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Boersma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Verkouter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2154-4923","authenticated-orcid":false,"given":"Saskia","family":"le Cessie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Christen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hildo J.","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frits R.","family":"Rosendaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko","family":"Willems van Dijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"van Heemst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9e","family":"de Mutsert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.numecd.2020.04.021_bib1","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1161\/CIRCULATIONAHA.116.026560","article-title":"Causal associations of adiposity and body fat distribution with coronary heart disease, stroke subtypes, and type 2 diabetes mellitus: a mendelian randomization analysis","volume":"135","author":"Dale","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2020.04.021_bib2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1001\/jama.2016.21042","article-title":"Genetic association of waist-to-hip ratio with cardiometabolic traits, type 2 diabetes, and coronary heart disease","volume":"317","author":"Emdin","year":"2017","journal-title":"Jama"},{"key":"10.1016\/j.numecd.2020.04.021_bib3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.genm.2009.02.002","article-title":"Gender differences in insulin resistance, body composition, and energy balance","volume":"6","author":"Geer","year":"2009","journal-title":"Gend Med"},{"key":"10.1016\/j.numecd.2020.04.021_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.diabres.2003.09.010","article-title":"Relationship between serum adiponectin and leptin concentrations and body fat distribution","volume":"63","author":"Park","year":"2004","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.numecd.2020.04.021_bib5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000443691","article-title":"Relations of visceral and abdominal subcutaneous adipose tissue, body mass index, and waist circumference to serum concentrations of parameters of chronic inflammation","volume":"9","author":"Schlecht","year":"2016","journal-title":"Obesity facts"},{"key":"10.1016\/j.numecd.2020.04.021_bib6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13098-016-0127-7","article-title":"Relationship between deep subcutaneous abdominal adipose tissue and metabolic syndrome: a case control study","volume":"8","author":"Kim","year":"2016","journal-title":"Diabetol Metab Syndrome"},{"key":"10.1016\/j.numecd.2020.04.021_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002936","article-title":"Adipose tissue depots and their cross-sectional associations with circulating biomarkers of metabolic regulation","volume":"5","author":"Lee","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.numecd.2020.04.021_bib8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2337\/diacare.23.4.465","article-title":"Visceral adiposity and risk of type 2 diabetes: a prospective study among Japanese Americans","volume":"23","author":"Boyko","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.numecd.2020.04.021_bib9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13098-016-0136-6","article-title":"The role of adipose tissue and adipokines in the manifestation of type 2 diabetes in the long-term period following myocardial infarction","volume":"8","author":"Barbarash","year":"2016","journal-title":"Diabetol Metab Syndrome"},{"key":"10.1016\/j.numecd.2020.04.021_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/CIRCULATIONAHA.106.675355","article-title":"Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study","volume":"116","author":"Fox","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.numecd.2020.04.021_bib11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1089\/met.2017.0128","article-title":"Associations of abdominal subcutaneous and visceral fat with insulin resistance and secretion differ between men and women: The Netherlands Epidemiology of obesity study","volume":"16","author":"de Mutsert","year":"2018","journal-title":"Metab Syndr Relat Disord"},{"key":"10.1016\/j.numecd.2020.04.021_bib12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/physrev.00033.2011","article-title":"Pathophysiology of human visceral obesity: an update","volume":"93","author":"Tchernof","year":"2013","journal-title":"Physiol Rev"},{"key":"10.1016\/j.numecd.2020.04.021_bib13","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1055\/s-2002-38256","article-title":"Depot-specific hormonal characteristics of subcutaneous and visceral adipose tissue and their relation to the metabolic syndrome","volume":"34","author":"Wajchenberg","year":"2002","journal-title":"Horm Metab Res \u2013 Hormon- und Stoffwechselforschung \u2013 Hormones et metabolisme"},{"key":"10.1016\/j.numecd.2020.04.021_bib14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.nut.2012.07.003","article-title":"Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: a need for screening tools to target interventions","volume":"29","author":"DeBoer","year":"2013","journal-title":"Nutrition"},{"key":"10.1016\/j.numecd.2020.04.021_bib15","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199602013340503","article-title":"Serum immunoreactive-leptin concentrations in normal-weight and obese humans","volume":"334","author":"Considine","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.numecd.2020.04.021_bib16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.peptides.2018.07.008","article-title":"Sex differences in body fat distribution are related to sex differences in serum leptin and adiponectin","volume":"107","author":"Christen","year":"2018","journal-title":"Peptides"},{"key":"10.1016\/j.numecd.2020.04.021_bib17","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1210\/jcem.86.5.7463","article-title":"Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia","volume":"86","author":"Weyer","year":"2001","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.numecd.2020.04.021_bib18","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.2337\/diabetes.52.7.1779","article-title":"Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression","volume":"52","author":"Kern","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2020.04.021_bib19","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1111\/j.1572-0241.2006.00724.x","article-title":"The inflammatory C-reactive protein is increased in both liver and adipose tissue in severely obese patients independently from metabolic syndrome, Type 2 diabetes, and NASH","volume":"101","author":"Anty","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.numecd.2020.04.021_bib20","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/90984","article-title":"The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity","volume":"7","author":"Yamauchi","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.numecd.2020.04.021_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/21623945.2017.1402151","article-title":"Adiponectin-leptin ratio: a promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk","volume":"7","author":"Fruhbeck","year":"2018","journal-title":"Adipocyte"},{"key":"10.1016\/j.numecd.2020.04.021_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/nu11020454","article-title":"Adiponectin-leptin ratio is a functional biomarker of adipose tissue inflammation","volume":"11","author":"Fruhbeck","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.numecd.2020.04.021_bib23","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1007\/s00125-009-1508-3","article-title":"Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals","volume":"52","author":"Finucane","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2020.04.021_bib24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2337\/dc12-0702","article-title":"Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis","volume":"36","author":"Wang","year":"2013","journal-title":"Diabetes Care"},{"issue":"8","key":"10.1016\/j.numecd.2020.04.021_bib25","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.numecd.2018.03.008","article-title":"High-sensitivity C-reactive protein, low-grade systemic inflammation and type 2 diabetes mellitus: a two-sample Mendelian randomization study","volume":"28","author":"Noordam","year":"2018","journal-title":"Nutr Metabol Cardiovasc Dis\u202f: NMCD"},{"key":"10.1016\/j.numecd.2020.04.021_bib26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/jama.2009.976","article-title":"Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis","volume":"302","author":"Li","year":"2009","journal-title":"Jama"},{"key":"10.1016\/j.numecd.2020.04.021_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002607","article-title":"Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals","volume":"8","author":"Dastani","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1016\/j.numecd.2020.04.021_bib28","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.2337\/db13-0128","article-title":"Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes","volume":"62","author":"Yaghootkar","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2020.04.021_bib29","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1301\/002966402320634931","article-title":"Peripheral actions of leptin and its involvement in disease","volume":"60","author":"Fruhbeck","year":"2002","journal-title":"Nutr Rev"},{"key":"10.1016\/j.numecd.2020.04.021_bib30","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/j.1464-5491.2010.03043.x","article-title":"Associations between leptin and the leptin\/adiponectin ratio and incident Type 2 diabetes in middle-aged men and women: results from the MONICA\/KORA Augsburg study 1984-2002","volume":"27","author":"Thorand","year":"2010","journal-title":"Diabet Med \u2013 J Br Diabet Assoc"},{"key":"10.1016\/j.numecd.2020.04.021_bib31","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.lfs.2015.02.008","article-title":"20 years of searching for glucose homeostasis","volume":"140","author":"Fernandez-Formoso","year":"2015","journal-title":"Life Sci"},{"key":"10.1016\/j.numecd.2020.04.021_bib32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.metabol.2014.10.015","article-title":"Leptin resistance and diet-induced obesity: central and peripheral actions of leptin","volume":"64","author":"Sainz","year":"2015","journal-title":"Metab Clin Exp"},{"key":"10.1016\/j.numecd.2020.04.021_bib33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s10654-013-9801-3","article-title":"The Netherlands Epidemiology of Obesity (NEO) study: study design and data collection","volume":"28","author":"de Mutsert","year":"2013","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.numecd.2020.04.021_bib34","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0895-4356(03)00220-8","article-title":"Reproducibility and relative validity of the short questionnaire to assess health-enhancing physical activity","volume":"56","author":"Wendel-Vos","year":"2003","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.numecd.2020.04.021_bib35","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.2105\/AJPH.81.9.1166","article-title":"Epidemiologic studies utilizing surveys: accounting for the sampling design","volume":"81","author":"Korn","year":"1991","journal-title":"Am J Publ Health"},{"key":"10.1016\/j.numecd.2020.04.021_bib36","series-title":"Analysis of complex survey samples","author":"Lumley","year":"2004"},{"key":"10.1016\/j.numecd.2020.04.021_bib37","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","article-title":"The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations","volume":"51","author":"Baron","year":"1986","journal-title":"J Pers Soc Psychol"},{"key":"10.1016\/j.numecd.2020.04.021_bib38","first-page":"103","article-title":"Effects of acute and chronic sleep deprivation on cardiovascular regulation","volume":"152","author":"Tobaldini","year":"2014","journal-title":"Arch Ital Biol"},{"key":"10.1016\/j.numecd.2020.04.021_bib39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2337\/dbi17-0016","article-title":"The adiponectin paradox for all-cause and cardiovascular mortality","volume":"67","author":"Menzaghi","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2020.04.021_bib40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s00125-011-2284-4","article-title":"Do women exhibit greater differences in established and novel risk factors between diabetes and non-diabetes than men? The British Regional Heart Study and British Women's Heart Health Study","volume":"55","author":"Wannamethee","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.numecd.2020.04.021_bib41","article-title":"Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort study","volume":"9","author":"Langenberg","year":"2012","journal-title":"PLoS Med"},{"key":"10.1016\/j.numecd.2020.04.021_bib42","doi-asserted-by":"crossref","first-page":"e11376","DOI":"10.1371\/journal.pone.0011376","article-title":"Hyperleptinemia is required for the development of leptin resistance","volume":"5","author":"Knight","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.numecd.2020.04.021_bib43","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.tem.2010.08.002","article-title":"Obesity and leptin resistance: distinguishing cause from effect","volume":"21","author":"Myers","year":"2010","journal-title":"Trends Endocrinol Metabol"},{"key":"10.1016\/j.numecd.2020.04.021_bib44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.numecd.2020.04.021_bib45","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.atherosclerosis.2010.10.012","article-title":"Leptin upregulates caveolin-1 expression: implications for development of atherosclerosis","volume":"217","author":"Singh","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.numecd.2020.04.021_bib46","doi-asserted-by":"crossref","first-page":"C222","DOI":"10.1152\/ajpcell.00006.2003","article-title":"Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue","volume":"285","author":"Cohen","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.numecd.2020.04.021_bib47","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1006\/bbrc.1996.1059","article-title":"Leptin receptors expressed on pancreatic beta-cells","volume":"224","author":"Kieffer","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.numecd.2020.04.021_bib48","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2337\/diab.46.2.313","article-title":"Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion","volume":"46","author":"Emilsson","year":"1997","journal-title":"Diabetes"},{"issue":"Suppl. 1","key":"10.1016\/j.numecd.2020.04.021_bib49","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.2337\/diabetes.53.2007.S152","article-title":"Leptin effects on pancreatic beta-cell gene expression and function","volume":"53","author":"Seufert","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2020.04.021_bib50","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.2337\/db07-0127","article-title":"Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic\/knockout mice","volume":"56","author":"Lin","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.numecd.2020.04.021_bib51","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.cmet.2013.03.019","article-title":"An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice","volume":"17","author":"Holland","year":"2013","journal-title":"Cell Metabol"},{"key":"10.1016\/j.numecd.2020.04.021_bib52","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/EDE.0b013e318254f5de","article-title":"Quantification of bias in direct effects estimates due to different types of measurement error in the mediator","volume":"23","author":"le Cessie","year":"2012","journal-title":"Epidemiology"},{"key":"10.1016\/j.numecd.2020.04.021_bib53","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ajhg.2013.12.014","article-title":"Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis","volume":"94","author":"Holmes","year":"2014","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.numecd.2020.04.021_bib54","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature01137","article-title":"A central role for JNK in obesity and insulin resistance","volume":"420","author":"Hirosumi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.numecd.2020.04.021_bib55","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"}],"container-title":["Nutrition, Metabolism and Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475320301435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939475320301435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:11:51Z","timestamp":1760544711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939475320301435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0939475320301435"],"URL":"https:\/\/doi.org\/10.1016\/j.numecd.2020.04.021","relation":{},"ISSN":["0939-4753"],"issn-type":[{"value":"0939-4753","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of C-reactive protein, adiponectin and leptin in the association between abdominal adiposity and insulin resistance in middle-aged individuals","name":"articletitle","label":"Article Title"},{"value":"Nutrition, Metabolism and Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.numecd.2020.04.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}